[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"combat-trauma\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:combat-trauma":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,54,82,118],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":33,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":50,"locationsCount":53},"100647332","drone-wound-study-severe-infection-after-drone-related-combat-trauma-100647332",false,"NCT07706608","DRONE-WOUND Study: Severe Infection After Drone-Related Combat Trauma","DRONE-WOUND Study: Tissue Devitalization and Severe Infection Following Drone-Related Combat Trauma: A Prospective Multicenter Observational Cohort Study","DRONE-WOUND","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Combat-related injury caused by a confirmed drone-related mechanism, including first-person view (FPV) drones, drone-delivered explosive munitions, or other unmanned aerial vehicle (UAV)-associated injuries.\n* Open extremity injury requiring operative surgical debridement.\n* Hospital admission within 24 hours after injury.\n* Written informed consent provided by the participant or legally authorized representative, in accordance with local regulations.\n\nExclusion Criteria:\n\n* Age younger than 18 years.\n* Isolated superficial soft tissue injuries not requiring operative treatment. Injuries requiring immediate primary amputation before initial surgical assessment.\n* Patients transferred more than 24 hours after injury.\n* Pre-existing active infection involving the injured limb before the combat injury.\n* Patients who die before completion of the initial surgical debridement.\n* Prisoners or other individuals unable to provide informed consent when no legally authorized representative is available.","ALL","18 Years","60 Years",{"count":21,"type":22},500,"ESTIMATED","OBSERVATIONAL","Drone-related combat injuries have become one of the most devastating mechanisms of injury in modern warfare. These injuries often cause extensive tissue devitalization, contamination, open fractures, vascular injuries, and complex soft tissue damage, which may substantially increase the risk of severe wound infection, multidrug-resistant bacterial infection, repeated surgical procedures, limb loss, and sepsis. However, the relationship between the extent of tissue devitalization and the development of severe infection has not been systematically investigated.\n\nThe DRONE-WOUND Study is a prospective observational cohort study designed to evaluate the association between tissue devitalization and severe wound infection in patients with drone-related combat trauma. The study will collect detailed clinical, surgical, microbiological, and radiological data from injured patients treated at participating trauma centers. Measures of tissue injury, contamination, surgical management, microbiological findings, and infection outcomes will be analyzed to identify factors associated with severe infection and poor clinical outcomes.\n\nThe findings of this study are expected to improve understanding of the mechanisms leading to infection after drone-related injuries, support early identification of high-risk patients, and inform future strategies for surgical management, antimicrobial therapy, and infection prevention in combat trauma. Ultimately, the study aims to improve limb salvage, reduce infectious complications, and enhance outcomes for patients with severe drone-related injuries.",[26,27,28,29,30,31,32],"Combat Related Symptoms","Combat Trauma","Infection","Infection Complication","Wound - in Medical Care","Wound Infection Post-Traumatic","Surgical Site Infection (SSI)",[34,27,35,36,37,38,39,40,41],"Drone-Related Injury","Tissue Devitalization","Wound Infection","Severe Wound Infection","Surgical Site Infection","Multidrug-Resistant Organisms","Antimicrobial Resistance","Soft Tissue Injury","NOT_YET_RECRUITING","2026-07-11",{"date":45,"type":46},"2026-07-16","ACTUAL",{"date":48,"type":22},"2026-10-23",{"date":48,"type":22},{"name":51,"class":52},"Ukrainian Society of Regional Anesthesia and Pain Therapy","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":62,"enrollmentInfo":63,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":64,"conditions":65,"keywords":70,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":81,"locationsCount":53},"100645688","block-trauma-study-100645688","NCT07702071","BLOCK-TRAUMA Study","Regional Anesthesia Burden and Clinical Outcomes in Polytrauma Patients: A Prospective Cohort Study","BLOCK-TRAUMA","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Diagnosis of polytrauma, defined as traumatic injuries involving two or more anatomical regions.\n* Injury Severity Score (ISS) ≥16.\n* Hospital admission within 48 hours after injury.\n* Requirement for acute pain management during hospital treatment.\n* Receipt of at least one ultrasound-guided peripheral nerve block and\u002For continuous peripheral nerve catheter as part of routine clinical care.\n* Ability to collect clinical data on regional anesthesia procedures, analgesic use, pain assessment, and early recovery outcomes.\n* Written informed consent provided by the patient or legally authorized representative, according to local regulations.\n\nExclusion Criteria:\n\n* Age younger than 18 years.\n* Isolated single-system injury without polytrauma. ISS \\\u003C16.\n* Expected survival less than 24 hours after admission.\n* Severe traumatic brain injury or impaired consciousness preventing reliable pain and functional assessment, unless validated behavioral pain scales can be used.\n* Known allergy or contraindication to local anesthetics.\n* Pre-existing severe neuromuscular disease affecting motor function assessment.\n* Chronic opioid therapy before injury.\n* Pregnancy.\n* Enrollment in another interventional trial that may affect pain management or functional recovery outcomes.\n* Missing essential data required for assessment of Regional Anesthesia Burden.","50 Years",{"count":21,"type":22},"This prospective cohort study will evaluate the association between the overall burden of regional anesthesia and early clinical outcomes in adult patients with polytrauma.\n\nPatients with severe trauma often experience pain from multiple injury sites and may require more than one peripheral nerve block or continuous regional anesthesia catheter. While regional anesthesia can improve pain control and reduce opioid use, multiple blocks and catheters may also increase treatment complexity, local anesthetic exposure, motor weakness, and monitoring challenges.\n\nThe study will prospectively collect data on the number and type of regional anesthesia procedures, local anesthetic exposure, catheter use, pain intensity, opioid consumption, mobility, complications, and early recovery outcomes. The goal is to determine whether increasing regional anesthesia burden is associated with improved analgesia, functional recovery, or increased risk in polytrauma patients.",[66,67,68,69,27],"Polytrauma","Regional Anaesthesia","Nerve Block","Acute Pain",[66,71,72,69,73,74],"Regional Anesthesia","Peripheral Nerve Block","Local Anesthetics","Combat Injury","2026-07-09",{"date":77,"type":46},"2026-07-14",{"date":79,"type":22},"2026-07-23",{"date":48,"type":22},{"name":51,"class":52},{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":88,"eligibilityCriteria":89,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":90,"targetDuration":4,"studyType":92,"phases":93,"briefSummary":95,"conditions":96,"keywords":100,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":117},"100640078","comparative-evaluation-of-intraneuroma-and-perineuroma-botulinum-toxin-type-a-injection-techniques-for-chronic-neuroma-pain-after-combat-related-amputation-100640078","NCT07624877","Comparative Evaluation of Intraneuroma and Perineuroma Botulinum Toxin Type A Injection Techniques for Chronic Neuroma Pain After Combat-Related Amputation","Comparative Evaluation of Intraneuroma and Perineuroma Botulinum Toxin Type A Injection Techniques for Chronic Neuroma Pain After Combat-Related Amputation: A Prospective Multicenter Study","IN-PERI NEUROM","Inclusion Criteria:\n\n* Age ≥18 years\n* Combat-related limb amputation\n* Chronic neuroma pain lasting ≥3 months\n* Ultrasound-confirmed painful neuroma\n* Average neuroma pain intensity ≥4\u002F10 on the Numeric Rating Scale\n* Ability to undergo ultrasound-guided injection\n* Stable analgesic regimen for at least 14 days before enrollment\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Active infection at or near the injection site\n* Open wound preventing safe injection\n* Previous botulinum toxin injection for neuroma pain within 6 months\n* Previous neuroma surgery within 3 months\n* Known allergy to botulinum toxin type A\n* Coagulopathy or anticoagulation contraindicating injection\n* Severe uncontrolled systemic disease\n* Inability to complete follow-up assessments",{"count":91,"type":22},100,"INTERVENTIONAL",[94],"NA","Patients with combat-related amputations frequently experience chronic neuroma pain that may interfere with rehabilitation, prosthesis use, mobility, sleep, and quality of life. Ultrasound-guided botulinum toxin type A injection has emerged as a potential treatment option for persistent neuroma pain; however, the optimal injection technique remains unclear.\n\nThis prospective multicenter study aims to compare two ultrasound-guided botulinum toxin injection techniques for chronic neuroma pain after combat-related amputation: intraneuroma injection and perineuroma injection.\n\nParticipants with ultrasound-confirmed painful neuromas will undergo one of the two injection approaches based on the treating physician's clinical decision and local practice. Pain intensity, neuropathic pain characteristics, phantom limb pain, prosthesis tolerance, functional outcomes, and adverse events will be evaluated during follow-up.\n\nThe goal of the study is to evaluate the feasibility, safety, and potential clinical effectiveness of intraneuroma and perineuroma botulinum toxin type A injection techniques in patients with chronic neuroma pain following combat-related amputation.",[97,98,99,27],"Chronic Pain","Neuroma","Botulinium Toxin-A",[101,102,103,104,105,106,107,108],"Chronic neuroma pain","Combat-related amputation","Botulinum toxin type A","Intraneuroma injection","Perineuroma injection","Ultrasound-guided injection","Residual limb pain","Painful neuroma","2026-05-30",{"date":111,"type":46},"2026-06-03",{"date":113,"type":22},"2026-05-27",{"date":115,"type":22},"2026-12-15",{"name":51,"class":52},2,{"id":119,"slug":120,"hasResults":11,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":124,"eligibilityCriteria":125,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":126,"targetDuration":128,"studyType":23,"phases":4,"briefSummary":129,"conditions":130,"keywords":134,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":53},"100631563","evacuation-time-and-tourniquet-use-as-risk-factors-for-ptsd-in-combat-related-amputation-100631563","NCT07502313","Evacuation Time and Tourniquet Use as Risk Factors for PTSD in Combat-Related Amputation","Evacuation Time and Tourniquet Use as Risk Factors for PTSD in Combat-Related Amputation: A Prospective Cohort Study","EVAC-PTSD Stud","Inclusion Criteria:\n\n* Ukrainian veterans with combat-related injury (post-February 2022)\n* Single limb amputation\n* Admission to rehabilitation within 2-4 months post-injury\n* Age ≥18 years\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Prior PTSD diagnosis before current injury\n* Multiple amputations\n* Rehabilitation duration \\>3 months\n* Return to active military duty before follow-up completion",{"count":127,"type":22},300,"6 Months","This study aims to evaluate the relationship between evacuation time, tourniquet use, and the development of post-traumatic stress disorder (PTSD) in patients with combat-related amputations. In the context of modern warfare, prolonged evacuation times and extended tourniquet application may contribute not only to physical injury but also to psychological trauma. The study will prospectively follow patients over 18 months to identify key predictors of PTSD and to assess their interaction.",[131,132,133,27],"Amputation","PTSD","Combat Posttraumatic Stess Disorder",[135,27,131,136,137],"Post-Traumatic Stress Disorder","Tourniquet Use","Evacuation Time","2026-03-30",{"date":140,"type":46},"2026-04-03",{"date":142,"type":22},"2026-03-15",{"date":144,"type":22},"2026-11-15",{"name":146,"class":52},"Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)"]