[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"complex-regional-pain-syndrome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:complex-regional-pain-syndrome":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,46,74,96,123],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100652614","how-the-brain-and-body-recover-after-a-wrist-fracture-100652614",false,"NCT07777081","How the Brain and Body Recover After a Wrist Fracture","PERCIPIENT - An Evaluation of Pain Biomarkers and Body Representation Outcomes After Distal Radius Fracture","PERCIPIENT","Inclusion Criteria:\n\nDistal radius fracture (DRF) within past 6 weeks 18 and older Willing and competent to complete the informed consent process\n\nExclusion Criteria:\n\nInability to understand the informed consent process (Language, competence) Multiple trauma Significant neurological disease (multiple sclerosis, previous traumatic brain injury, previous stroke or cerebral haemorrhage and substantial tremor - including Parkinson's, significant resting tremor, or other aetiology) Amputation or medical confirmation of unilateral sensory deficit","ALL","18 Years",{"count":20,"type":21},200,"ESTIMATED","OBSERVATIONAL","What is the problem? A wrist fracture is a common injury, affecting about 100,000 people in the UK each year. While most people recover well, a significant minority, between 10% and 20%, develop persistent pain and disability that lasts long after the bone has healed. In some cases this leads to a severe chronic pain condition called Complex Regional Pain Syndrome (CRPS). Currently we cannot easily predict who will recover and who may not, making it challenging to provide early targeted support.\n\nWhat are we trying to find out? We want to see if we can identify \"signs\" in the body, such as genetic markers, chemical messengers in the blood, and heart rate rhythms, that predict a person's recovery. We are also investigating the brain's \"internal map\" of the body. After an injury, this map can sometimes become \"blurred\" or less precise, which we believe is linked to ongoing pain. Our goal is to use this information to help in identify patients at high risk of chronic pain so they could receive better treatment in the future.\n\nWhat will happen in the study? We are inviting 250 participants: 200 people with a recent wrist fracture and 50 people who already live with long-term CRPS to act as a comparison group.\n\nAll participants will first take part in a baseline assessment. This involves completing questionnaires (including a 0-10 pain rating scale), providing a blood sample, and taking part in simple bedside tests. These tests will also measure your internal body map by checking how accurately you can identify finger touches with your eyes closed and how you compare the size or weight of your limbs.\n\nBased on the results of these objective tests, we will invite some participants with recent wrist fractures to take part in specific sub-studies:\n\n* Brain Scans (24 people): If the bedside tests show changes in your internal map, we will invite you for two fMRI scans, six months apart, to watch the internal map in action whilst performing simple hand tasks.\n* Fitness Watches (50 people): Based on your pain rating scores, we will invite 25 people with higher pain and 25 people with lower pain to wear a watch for five days, at the beginning and end of their recovery, to track heart rate rhythms.\n* Virtual Reality (20 people): If you still have ongoing pain or a blurred internal map at 6 months, we may invite you to test at-home VR equipment to see if it helps re-train the brain.\n\nWho are we? Our research team includes experts in genetics, brain imaging, pain, and modern digital technologies who have experience in delivering clinical trials.\n\nHow will we tell people what we found out?\n\nWe are committed to sharing what we learn with the people who make our research possible. We will therefore inform participants and public. Once the study is complete, we will:\n\n* Publish a plain English summary of the results to the public registry ClinicalTrials.gov within 12 months of the study ending\n* Provide a direct update to participants who have consented to be contacted for future research via email\n* Offer community sharing of our findings through our sponsor Cambridge Arthritis Research Endeavour (CARE) website\n* Publish in Academic literature the full scientific results in medical journals to ensure that other doctors and researchers can learn from this study",[25,26],"Wrist Fracture","Complex Regional Pain Syndrome",[28,29,30,31,32],"Chronic pain","Body representation","post- wrist fracture","functional MRI","Genes","RECRUITING","2026-08-17",{"date":36,"type":37},"2026-08-20","ACTUAL",{"date":39,"type":37},"2026-08-12",{"date":41,"type":21},"2032-08-12",{"name":43,"class":44},"Cambridge University Hospitals NHS Foundation Trust","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":73},"100627290","hyperbaric-oxygen-therapy-in-complex-regional-pain-syndrome-100627290","NCT07446712","Hyperbaric Oxygen Therapy in Complex Regional Pain Syndrome","Hyperbaric Oxygen Therapy in Complex Regional Pain Syndrome: a Randomised Controlled Trial","Inclusion Criteria:\n\n\\- Diagnosis of CRPS Type I (without nerve injury)\n\nExclusion Criteria:\n\n* HBOT contraindications (pregnancy; use of bleomycin, cisplatin, disulfiram, and doxorubicin; middle ear surgery; untreated pneumothorax or pneumomediastinum; ongoing acute infection; severe decompensation of organ functions or organ failure, severe claustrophobia)\n* Inability to sign the consent form",{"count":54,"type":21},60,"INTERVENTIONAL",[57],"NA","The aim of the study is to investigate the efficacy of hyperbaric oxygen therapy as an adjunct in the management of severe complex regional pain syndrome.",[60,26],"Chronic Pain",[26,60,62],"Hyperbaric Oxygen Therapy","NOT_YET_RECRUITING","2026-02-25",{"date":66,"type":37},"2026-03-03",{"date":68,"type":21},"2026-04",{"date":70,"type":21},"2029-04",{"name":72,"class":44},"University Hospital Ostrava",2,{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":55,"phases":84,"briefSummary":85,"conditions":86,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":45},"100247636","low-dose-naltrexone-for-the-treatment-of-complex-regional-pain-syndrome-100247636","NCT02502162","Low-Dose Naltrexone for the Treatment of Complex Regional Pain Syndrome","LDN-CRPS","Inclusion Criteria:\n\n* Upper and\u002For lower extremity CRPS\n* On stable treatment for 1 month\n* CRPS for at least 1 year\n* Meet the Budapest criteria for CRPS at time of the study.\n\nExclusion Criteria:\n\n* Any known allergy to naltrexone or naloxone\n* Use of prescription opioid analgesics or illegal opioid use\n* Current or planned pregnancy.","70 Years",{"count":83,"type":21},120,[57],"The investigators are testing treatment with low-dose naltrexone (LDN) for symptom relief of complex regional pain syndrome (CRPS). Study participants will be randomly assigned to receive either LDN or placebo for a period of several weeks. During this period participants will be asked to attend either in-person or virtual study visits and complete questionnaires.",[26],"2025-05-27",{"date":89,"type":37},"2025-05-29",{"date":91,"type":4},"2015-06",{"date":93,"type":21},"2027-07",{"name":95,"class":44},"Stanford University",{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":4,"eligibilityCriteria":102,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":81,"enrollmentInfo":103,"targetDuration":4,"studyType":55,"phases":105,"briefSummary":106,"conditions":107,"keywords":110,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":45},"100575214","the-effects-of-whirlpool-and-contrast-bath-in-patients-with-complex-regional-pain-syndrome-after-distal-radius-fracture-100575214","NCT06769373","The Effects of Whirlpool and Contrast Bath in Patients with Complex Regional Pain Syndrome After Distal Radius Fracture","The Effects of Whirlpool Bath and Contrast Bath Treatments on Pain, Disability, Functionality and Grip Strength in Patients with Complex Regional Pain Syndrome After Distal Radius Fracture","Inclusion Criteria:\n\n* Patients with complex regional pain syndrome type-1 (CRPS-type 1) after distal radius fracture, who were followed conservatively (long\u002Fshort arm splint-cast) between the ages of 18-70, who applied to AFSU Physical Medicine and Rehabilitation Clinic. It is planned to use the Budapest diagnostic criteria for the diagnosis of CRPS Type 1.\n\nExclusion Criteria:\n\n* Orthopedic injuries (other accompanying orthopedic fractures, such as ulna fracture, carpal bone fractures),\n* Other system injuries,\n* Patients whose distal radius fractures were surgically treated,\n* Patients who had previously undergone surgery on the same upper extremity,\n* Nerve, tendon and artery injuries accompanying the fracture,\n* Other neurological, orthopedic or rheumatological problems affecting the same upper extremity,\n* Serious cardiovascular disease,\n* Presence of active infection, active dermatitis, skin diseases such as pemphigus, febrile diseases,\n* Presence of a fixed catheter in the area,\n* Impaired temperature sensationin in the area.",{"count":104,"type":21},40,[57],"The aim of our study is to investigate the effects of whirlpool bath and contrast bath treatments on pain, disability, functionality and grip strength in patients with complex regional pain syndrome after distal radius fracture.",[108,109,26],"Distal Radius Fracture","Complex Regional Pain Syndrome Type I",[111,112,113],"Whirlpool","Contrast bath","hydrotherapy","2025-01-28",{"date":116,"type":37},"2025-01-30",{"date":118,"type":21},"2025-01-31",{"date":120,"type":21},"2025-06-15",{"name":122,"class":44},"Afyonkarahisar Health Sciences University",{"id":124,"slug":125,"hasResults":11,"nctId":126,"briefTitle":127,"officialTitle":128,"acronym":4,"eligibilityCriteria":129,"healthyVolunteers":11,"sex":17,"minAge":130,"maxAge":131,"enrollmentInfo":132,"targetDuration":4,"studyType":55,"phases":134,"briefSummary":136,"conditions":137,"keywords":138,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":73},"100546297","phase-1-the-effects-and-mechanisms-of-a-high-cbd-cannabis-extract-brc-002-for-the-treatment-of-pain-and-health-in-complex-regional-pain-syndrome-100546297","NCT06393101","The Effects and Mechanisms of a High CBD Cannabis Extract (BRC-002) for the Treatment of Pain and Health in Complex Regional Pain Syndrome","A Randomized, Double-blind, Placebo-controlled Study to Investigate the Effects and Mechanisms of a High CBD Cannabis Extract (BRC-002) for the Treatment of Pain and Health in Complex Regional Pain Syndrome","Inclusion Criteria:\n\n1. Provision of signed and dated informed consent form.\n2. Are between 21-75 years old\n3. Ability to communicate in English\n4. Volunteers with no previous medical history (e.g., cardiac or pulmonary disease)\n5. Are not currently using any type of cannabis, including hemp or CBD\n6. Currently 30 days cannabis free\n7. Participants with ongoing CRPS \\[Type 1 or Type 2)\\] for at least 3 months prior to participation (medical record confirmed)\n8. Agrees not to use cannabis, including hemp or CBD, outside of the study during participation in the study\n9. Agrees not to use opioids or barbiturates during participation in the study\n\nExclusion Criteria:\n\n1. Fail cannabis screening\n2. Active pulmonary disease\n3. Allergy or past adverse effects or negative past experiences from cannabis\n4. Positive urine drug test for THC, barbiturates, opioids, oxycodone, or methadone prior to study session 1 or session 2\n5. Any significant illness, including cardiovascular disease, diabetes, renal and liver disease\n6. Any current or history of an immunocompromising disease or condition (such as lupus, psoriasis, multiple sclerosis, etc.)\n7. Any current or history of neurologic conditions, including Parkinson disease, dementia, cognitive impairment, history of seizure disorder, and history of traumatic brain injury\u002Fhead injury\n8. Participant meets DSM-V criteria for current major psychiatric illness, such as bipolar disorder, major depression, psychosis, substance use disorder, or schizophrenia\n9. Any current or history of suicidal ideation or attempt\n10. Patients with clinically significant laboratory abnormalities","21 Years","75 Years",{"count":133,"type":21},52,[135],"PHASE1","The aim of this trial is to determine the potential effects and mechanisms of cannabinoid-induced pain relief in complex regional pain syndrome (CRPS). Multiple psychophysical approaches will be conducted in conjunction with psychological and inflammatory marker testing to determine if and how cannabinoids produce stabilized improvement in CRPS-related pain and comorbidities.\n\nThe trial consisted of a pre-treatment screening period, six-week treatment period and a two-week follow-up.",[26],[26,139,140,141],"CRPS","Cannabis","Pain","2024-06-05",{"date":144,"type":37},"2024-06-07",{"date":146,"type":21},"2024-06-01",{"date":148,"type":21},"2029-06-01",{"name":150,"class":44},"University of California, San Diego"]