[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"congenital-cataract\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:congenital-cataract":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,45,72,97,125,151],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100652933","guangke-lenses-in-congenital-cataract-100652933",false,"NCT07778797","Guangke Lenses in Congenital Cataract","Investigation of Guangke Lenses' Efficacy in Delaying Myopia Onset\u002FProgression in Postoperative Congenital Cataract Children","Inclusion Criteria:\n\nAged 4 to 12 years (inclusive) at the time of enrollment. Diagnosed with bilateral congenital cataracts. Has undergone bilateral cataract extraction with intraocular lens (IOL) implantation.\n\nTime since cataract surgery is between 1 to 6 months (inclusive) at the time of enrollment.\n\nAble to undergo regular ophthalmic examinations (including refraction, axial length measurement, and intraocular pressure assessment).\n\nParent(s) or legal guardian(s) are willing and able to provide written informed consent.\n\nExclusion Criteria:\n\nPresence of any systemic disease (e.g., metabolic disorders, autoimmune diseases, genetic syndromes, etc.).\n\nPresence of any ocular disease other than congenital cataracts (e.g., glaucoma, uveitis, retinal disorders, corneal diseases, strabismus, amblyopia, etc.).\n\nPrevious or current use of myopia control treatments, including but not limited to atropine eye drops, orthokeratology (Ortho-K) lenses, or other myopia control spectacle lenses.\n\nHistory of ocular trauma or intraocular surgery other than cataract extraction and IOL implantation.\n\nKnown allergy or hypersensitivity to any materials or components used in the study lenses.\n\nInability to comply with the study protocol or complete scheduled follow-up visits.\n\nParticipation in another interventional clinical trial within the past 30 days.","ALL","4 Years","12 Years",{"count":20,"type":21},50,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study aims to investigate whether individually customized bifocal + defocus spectacles can slow myopic shift in children after congenital cataract surgery.",[27],"Congenital Cataract",[29,27,30,31],"Photochromic Lenses","Axial length","Myopic shift","RECRUITING","2026-08-18",{"date":35,"type":36},"2026-08-21","ACTUAL",{"date":38,"type":36},"2025-08-06",{"date":40,"type":21},"2030-08-06",{"name":42,"class":43},"Eye & ENT Hospital of Fudan University","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":18,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":4},"100646355","augmented-reality-training-for-amblyopia-after-congenital-cataract-surgery-100646355","NCT07693790","Augmented Reality Training for Amblyopia After Congenital Cataract Surgery","Effectiveness and Safety of Augmented Reality-Based Amblyopia Training for Postoperative Congenital Cataract Patients: A Multicenter, Superiority, Randomized, Parallel-Controlled Trial Protocol","Inclusion Criteria:\n\n1. Aged 5 to 12 years, male or female.\n2. Diagnosed with unilateral amblyopia after congenital cataract surgery.\n3. Best-corrected visual acuity (BCVA) of the amblyopic eye ≤0.80 logMAR, BCVA of the fellow eye better than 0.15 logMAR, and interocular BCVA difference ≥0.20 logMAR.\n4. Underwent cataract extraction at age ≤5 years and has stable ocular status at least 2 months after intraocular lens implantation.\n5. If refractive error is present, optical correction has been worn for at least 3 months.\n6. Orthophoria, or if strabismus is present, manifest deviation at distance of 6 m is ≤4 prism diopters after strabismus correction as measured by prism cover test.\n7. Able to understand the study procedures, and written informed consent is obtained from the participant and\u002For legal guardian as required.\n\nExclusion Criteria:\n\n1. Childhood cataract caused by causes other than congenital cataract, including traumatic, drug-induced, steroid-related, secondary, or metabolic cataract.\n2. Other ocular organic diseases that may affect visual acuity assessment or amblyopia treatment evaluation, including but not limited to significant ptosis, corneal or other media opacity, glaucoma or persistent ocular hypertension, optic nerve disease, retinal disease, or cortical visual impairment.\n3. Uncontrolled or clinically unstable severe systemic disease that may affect study safety, adherence, or outcome assessment, including active malignancy, severe cardiovascular disease, uncontrolled hypertension, epilepsy, or history of photosensitive epilepsy.\n4. Implanted electronic medical devices that may be affected by the study device or may affect safe use of the device, such as a pacemaker or implantable cardioverter-defibrillator.\n5. Significant ocular inflammation, photophobia, tearing, eye pain, or other ocular surface or anterior segment disease at screening that may affect visual acuity testing, device wearing, or completion of training.\n6. Obvious dizziness, motion sickness, acrophobia, balance disorder, or sequelae of previous brain injury that may affect safe wearing of the augmented reality device or training adherence.\n7. Facial trauma, craniofacial deformity, or head and facial structural abnormality that may affect normal wearing, positioning, or safe use of the augmented reality device.\n8. Severe psychiatric, cognitive, developmental, or behavioral disorder that may prevent understanding of study procedures, completion of training, or follow-up.\n9. Current or planned use of medications that may affect visual acuity, refractive status, pupil status, or visual function assessment, except for short-term cycloplegic agents used for routine ophthalmic examination.\n10. Unable to simultaneously perceive binocular stimuli in the device or unable to complete binocular simultaneous vision training after device screening or calibration.\n11. Received amblyopia treatment other than spectacle correction within 2 weeks before screening, including patching, atropine penalization, visual training, binocular vision training, or other amblyopia-related interventions.\n12. Participation in another drug clinical trial within 3 months or another medical device clinical trial within 1 month before screening.\n13. Any other condition that, in the investigator's opinion, makes the participant unsuitable for the study.","5 Years",{"count":54,"type":21},88,[24],"This study will evaluate whether augmented reality training is effective and safe for treating unilateral amblyopia after congenital cataract surgery in children.\n\nChildren aged 5 to 12 years with unilateral amblyopia after congenital cataract surgery will be enrolled from three eye hospitals in China. Participants will be randomly assigned to one of two groups. One group will receive augmented reality amblyopia training for 2 hours per day for 4 months. The other group will receive conventional patching of the fellow eye for 4 hours per day for 4 months.\n\nThe main outcome is the change in best-corrected visual acuity of the amblyopic eye after 4 months of treatment. The study will also evaluate contrast sensitivity, binocular visual function, stereoacuity, vision-related symptoms, quality of life, and adverse events.",[58,27],"Deprivation Amblyopia",[60,61],"Amblyopia","Augmented Reality","NOT_YET_RECRUITING","2026-07-02",{"date":65,"type":36},"2026-07-09",{"date":67,"type":21},"2026-07-01",{"date":69,"type":21},"2028-01",{"name":71,"class":43},"Zhongshan Ophthalmic Center, Sun Yat-sen University",{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":79,"enrollmentInfo":80,"targetDuration":4,"studyType":22,"phases":82,"briefSummary":83,"conditions":84,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":96},"100589146","associations-between-dental-anomalies-and-ocular-cutaneous-and-skin-appendages-features-100589146","NCT06950619","Associations Between Dental Anomalies and Ocular, Cutaneous and Skin Appendages Features","A Clinical Investigation Into the Co-occurrence of Dental Anomalies With Ocular and Cutaneous Features","Inclusion Criteria:\n\n* Supernumerary teeth\n* oligodontia\n* screw driver sharped incisors\n* Hutchinson's teeth\n* mulberry molars\n* tooth agenesis\n* congenital cataract, keratitis, keratoconus, corneal dystrophies, ectopia lentis, glaucoma, retinitis pigmentosa, coloboma and aniridia in probands or relatives\n* skin appendages anomalies in probands or relatives\n\nExclusion Criteria:\n\n* Previous orthodontic, restorative, endodontic, prosthetic and surgical treatment that could alter tooth morphology and position","70 Years",{"count":81,"type":21},5,[24],"Considering recent literature, it is possible to hypothesise a link between dental anomalies and ocular and\u002For cutaneous findings, given the existence of shared genetic and developmental mechanisms between these two anatomical areas. Both the eye and teeth develop from ectodermal and mesenchymal tissues, involving common molecular signalling pathways such as Wnt, BMP and PAX. Genetic variants affecting these pathways can therefore determine combined phenotypes, such as congenital cataracts associated with dental agenesis or enamel malformations. Some rare genetic syndromes, such as Nance-Horan syndrome and oculofacio-cardio-dental (OFCD) syndrome, support the hypothesis of a systemic correlation between odontogenesis and ocular development. In a previous study on congenital cataracts, nearly 10% of probands with variants in the BCOR, CWC27, IFIH1, NHS, and PAX6 genes had various dental abnormalities. Therefore, exploring the possible connection between eye and dental diseases may not only facilitate early and multidisciplinary diagnosis, but also open up new perspectives in genetic research and the development of personalised therapeutic approaches, for which whole genome sequencing (WGS) appears to be the first choice for investigating non-syndromic forms. Therefore, the current clinical study aims to identify variants in genes common to eye diseases and dental anomalies (agenesis, supernumerary teeth, Hutchinson's teeth, mulberry molars) in orthodontic patients over the age of 12 with dental anomalies who are about to begin orthodontic treatment or who are attending routine check-ups at the Orthodontics and Paediatric Dentistry Unit, Department of Clinical, Surgical, Diagnostic and Paediatrics Sciences at the University of Pavia who have a family history of ocular and cutaneous manifestations or presenting at the same time dental, ocular and\u002For cutaneous anomalies. Patients who are eligible will be invited to participate in the study. After signing the informed consent form, the Case Report Form will be completed to collect the data of interest for the study; previous medical reports will be asked to patients or parents\u002Flegal guardians in case of minors to ascertain ocular and cutaneous pathologies; a buccal swab will be taken to collect a DNA sample that will be analysed with Next Generation Sequencing. In addition, cephalometric evaluations will be performed if lateral teleradiographs will be available, if already performed in accordance with Good Clinical Practice for the purposes of orthodontic assessment of patients.",[27,85,86],"Tooth Abnormalities","Ocular Pathologies","2025-11-14",{"date":89,"type":36},"2025-11-19",{"date":91,"type":21},"2026-02",{"date":93,"type":21},"2027-04",{"name":95,"class":43},"University of Pavia",2,{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":4,"eligibilityCriteria":103,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":104,"enrollmentInfo":105,"targetDuration":4,"studyType":107,"phases":4,"briefSummary":108,"conditions":109,"keywords":111,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":44},"100598326","five-year-visual-function-and-refractive-outcomes-after-congenital-cataract-surgery-100598326","NCT07070037","Five-Year Visual Function and Refractive Outcomes After Congenital Cataract Surgery","Five-Year Visual Function and Refractive Outcomes After Congenital Cataract Surgery: A Multicenter Observational Cohort Study","Inclusion Criteria:\n\n* Diagnosis of congenital cataract\n* Underwent cataract extraction before 1 year of age\n* Available for regular follow-up for at least 5 years postoperatively\n* Written informed consent from legal guardian\n\nExclusion Criteria:\n\n* Acquired cataract or traumatic origin\n* Associated ocular malformations (e.g., microphthalmia, coloboma)\n* Systemic syndromes affecting vision (e.g., Down syndrome)\n* History of secondary surgery affecting visual outcome","18 Years",{"count":106,"type":21},400,"OBSERVATIONAL","This prospective multicenter observational study aims to evaluate the 5-year visual function and refractive outcomes in children undergoing surgery for congenital cataract. Key outcomes include best-corrected visual acuity, stereopsis, refractive error, and axial length growth. The study will help identify long-term trends and prognostic indicators after early cataract intervention in pediatric patients.",[27,110],"Pediatric Cataract",[27,112,113,114,60,115],"Pediatric Cataract Surgery","Visual Function","Stereopsis","Long-term Outcomes","2025-08-15",{"date":118,"type":36},"2025-08-20",{"date":120,"type":36},"2014-01-01",{"date":122,"type":21},"2035-12-31",{"name":124,"class":43},"Jin Yang",{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":4,"eligibilityCriteria":131,"healthyVolunteers":11,"sex":16,"minAge":132,"maxAge":133,"enrollmentInfo":134,"targetDuration":136,"studyType":107,"phases":4,"briefSummary":137,"conditions":138,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":44},"100290627","shanghai-pediatric-cataract-study-100290627","NCT03063216","Shanghai Pediatric Cataract Study","Visual Outcome Evaluation and Genetic Analysis: Shanghai Pediatric Cataract Study","Inclusion Criteria:\n\n* Clinical diagnosis of pediatric cataract\n* Must be able to cooperate with the ophthalmic examination\n\nExclusion Criteria:\n\n* Clinical diagnosis of mental illness\n* Mentally disabled","2 Months","20 Years",{"count":135,"type":21},10000,"10 Years","The purpose of this study is to evaluate the long-term visual outcome of the cataract surgery using a large-scale and comprehensive database of pediatric cataract participants, including congenital and traumatic cataract. The investigators will further investigate into the various genetic and environmental factors that may contribute to the pathogenesis of pediatric cataract.",[110,27,139,140,141],"Traumatic Cataract","Visual Outcome","Genetic Anticipation","2024-09-25",{"date":144,"type":36},"2024-09-27",{"date":146,"type":36},"2009-01-01",{"date":148,"type":21},"2045-12-31",{"name":150,"class":43},"Evidence Based Cataract Study Group",{"id":152,"slug":153,"hasResults":11,"nctId":154,"briefTitle":155,"officialTitle":156,"acronym":4,"eligibilityCriteria":157,"healthyVolunteers":11,"sex":16,"minAge":158,"maxAge":104,"enrollmentInfo":159,"targetDuration":4,"studyType":22,"phases":160,"briefSummary":161,"conditions":162,"keywords":163,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":167,"lastUpdatePostDateStruct":168,"startDateStruct":170,"completionDateStruct":172,"leadSponsor":174,"locationsCount":44},"100449724","comparison-of-posterior-continuous-curvilinear-capsulorhexis-with-or-without-anterior-vitrectomy-100449724","NCT05136209","Comparison of Posterior Continuous Curvilinear Capsulorhexis With or Without Anterior Vitrectomy","Comparison of Posterior Continuous Curvilinear Capsulorhexis With or Without Anterior Vitrectomy in Congenital Cataract Surgery","Inclusion Criteria:\n\n* Children with bilateral congenital cataracts without other ocular abnormalities\n* Gestational age at birth \\>37 weeks\n* No more than 18 years old\n* Pupils could dilate normally pre-operation\n* Have signed a consent form\n* Can be followed\n\nExclusion Criteria:\n\n* Intraocular pressure \\>21 mmHg\n* History of ocular trauma and intraocular surgery","1 Month",{"count":20,"type":21},[24],"Selecting the appropriate surgical approach for congenital cataracts presents challenging for ophthalmologists. This prospective, randomized controlled study aims to compare the prognosis of posterior continuous curvilinear capsulorhexis (PCCC) with or without anterior vitrectomy (A-Vit) in treating congenital cataracts.",[27],[164,165,166],"Congenital cataract surgery","anterior vitrectomy","postoperative complications","2021-11-25",{"date":169,"type":36},"2021-11-29",{"date":171,"type":36},"2021-11-01",{"date":173,"type":21},"2026-11-01",{"name":175,"class":43},"Sun Yat-sen University"]