[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"consciousness-disorders\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:consciousness-disorders":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,55,87,118,151,174,201,220,251,274],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":33,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100649654","multimodal-assessment-and-prognosis-in-disorders-of-consciousness-after-severe-brain-injury-cydoc-map-100649654",false,"NCT07736820","Multimodal Assessment and Prognosis in Disorders of Consciousness After Severe Brain Injury (CyDoC-MAP)","Cyprus Disorders of Consciousness - Multimodal Assessment and Prognosis Study: A Single-Centre Prospective Observational Cohort Study of Clinical, Biochemical, Electrophysiological and Imaging Predictors of Long-Term Outcome After Severe Traumatic Brain Injury or Haemorrhagic Stroke","CyDoC-MAP","Inclusion Criteria:\n\n* Inclusion Criteria:\n* Age 16 years or older\n* Moderate-to-severe traumatic brain injury, or haemorrhagic stroke (intracerebral or subarachnoid haemorrhage)\n* Intubation for a reduced level of consciousness within 24 hours of the index event\n* Admitted to, or transferred to, Nicosia General Hospital\n* Classified as VS\u002FUWS or MCS on the Coma Recovery Scale-Revised after discharge from the intensive care unit\n* Written informed consent obtained from the next of kin (and from a legal guardian for participants aged 16-17)\n\nExclusion Criteria:\n\n* Severe pre-existing psychiatric disorder\n* History of ischaemic or haemorrhagic stroke\n* Pre-existing dementia\n* Reduction in Glasgow Coma Scale attributable to sedation or intoxicating substances\n* Reduction in Glasgow Coma Scale attributable to severe extracranial injury (massive haemorrhage, generalised hypoxia)\n* End-stage disease with a life expectancy of less than 6 months","ALL","16 Years",{"count":20,"type":21},40,"ESTIMATED","OBSERVATIONAL","After a severe brain injury some patients survive but cannot communicate, and deciding early which of them are likely to recover consciousness remains one of the hardest problems in neurocritical care. Bedside examination alone misclassifies a substantial proportion of these patients.\n\nCyDoC-MAP is a single-centre, prospective, observational cohort study conducted at Nicosia General Hospital, the sole trauma referral centre for Cyprus. It enrols patients aged 16 years or older who are intubated within 24 hours of a moderate-to-severe traumatic brain injury or a haemorrhagic stroke (intracerebral or subarachnoid haemorrhage), and who are subsequently classified as being in a vegetative state \u002F unresponsive wakefulness syndrome (VS\u002FUWS) or a minimally conscious state (MCS) on the Coma Recovery Scale-Revised (CRS-R).\n\nFour assessment modalities are recorded: (1) the CRS-R, performed at least twice with an interval of at least 48 hours; (2) serum neuron-specific enolase (NSE) sampled within 24 hours of intubation; (3) the bispectral index (BIS), recorded at least twice with an interval of at least 48 hours, after five minutes of standardised noxious and auditory stimulation; and (4) in the traumatic subgroup only, 1.5 T magnetic resonance imaging performed 7-28 days after injury and graded 1-4 by lesion depth by two independent raters.\n\nLevel of consciousness is reassessed with the CRS-R 6 to 12 months after the index event, and the total CRS-R score (0-23) at that reassessment is the primary outcome. The primary aim is to estimate the strength of the association between the bispectral index recorded on the ward and that later CRS-R score, and to quantify what the bispectral index adds beyond the baseline clinical assessment. The number of eligible patients at a single national centre does not support the development of a prognostic model; the study is designed to produce effect-size estimates with confidence intervals that will inform a subsequent multicentre study.\n\nThe study is purely observational. No intervention is administered, no study procedure alters clinical management, and transfer to rehabilitation is never delayed for research purposes.",[25,26,27,28,29,30,31,32],"Consciousness Disorders","Persistent Vegetative State","Unresponsive Wakefulness Syndrome","Minimally Conscious State","Coma; Prolonged","Brain Injuries, Traumatic","Cerebral Hemorrhage","Subarachnoid Hemorrhage",[34,35,36,37,38,39,40,41],"cognitive motor dissociation","covert consciousness","Coma Recovery Scale-Revised","bispectral index","neuron-specific enolase","multimodal prognostication","neurocritical care","Cyprus","NOT_YET_RECRUITING","2026-07-27",{"date":45,"type":46},"2026-07-30","ACTUAL",{"date":48,"type":21},"2026-09-15",{"date":50,"type":21},"2030-09-30",{"name":52,"class":53},"Nicosia General Hospital","OTHER",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":4,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":17,"minAge":62,"maxAge":4,"enrollmentInfo":63,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":86},"100647752","cross-cultural-adaptation-and-multicenter-validation-of-the-italian-versions-of-the-brief-evaluation-of-receptive-aphasia-bera-and-swallowing-assessment-in-disorders-of-consciousness-swadoc-100647752","NCT07711119","Cross-cultural Adaptation and Multicenter Validation of the Italian Versions of the Brief Evaluation of Receptive Aphasia (BERA) and SWallowing Assessment in Disorders of Consciousness (SWADOC)","Adattamento Trans-culturale e Validazione Multicentrica Della Versione Italiana Delle Scale Brief Evaluation of Receptive Aphasia (BERA) e SWallowing Assessment in Disorders of Consciousness (SWADOC)","Inclusion Criteria:\n\n* Age \\>= 18 years.\n* Native Italian speaker.\n* Diagnosis of severe acquired brain injury.\n* At least 28 days since the acute event.\n* For SWADOC validation: stable clinical diagnosis of disorder of consciousness, including UWS, MCS, or EMCS, assessed with the Coma Recovery Scale-Revised repeated at least five times over two weeks.\n* For BERA validation: stable clinical diagnosis of MCS or EMCS assessed with the Coma Recovery Scale-Revised repeated at least five times over two weeks.\n* For BERA validation: presence of visual fixation and\u002For visual pursuit assessed with the Coma Recovery Scale-Revised.\n* No remote history of neurological, neurodegenerative, or psychiatric disease; for SWADOC validation, no remote history of otorhinolaryngological disease.\n* Written informed consent provided by the primary caregiver\u002Flegal representative according to local regulations.\n\nExclusion Criteria:\n\n* Occurrence of a second cerebral event between enrollment and data collection.\n* Unstable general clinical condition preventing assessment, including but not limited to need for ventilatory support, severe infection, or status epilepticus.","18 Years",{"count":64,"type":21},79,"Patients with severe acquired brain injury may evolve from coma into prolonged disorders of consciousness. In these patients, residual language comprehension and swallowing abilities are difficult to evaluate because standard assessments often depend on verbal or motor responses. The Brief Evaluation of Receptive Aphasia (BERA) assesses receptive language abilities through visual\u002Feye-movement responses, whereas the SWallowing Assessment in Disorders of Consciousness (SWADOC) assesses oral and pharyngeal components of swallowing in patients with disorders of consciousness. This national multicenter observational study aims to perform the Italian cross-cultural adaptation and validation of BERA and SWADOC. Consecutive adult inpatients with severe acquired brain injury and disorders of consciousness will be recruited from four Italian centers. SWADOC will be administered to 57 patients, and BERA will be administered to a nested subgroup of 22 patients who meet additional criteria. Inter-rater reliability, test-retest reliability over 24 hours, and convergent validity with Coma Recovery Scale-Revised scores will be analyzed.",[25,67],"Severe Acquired Brain Injury",[69,70,71,72,73,74,75,76],"disorders of consciousness","severe acquired brain injury","BERA","Brief Evaluation of Receptive Aphasia","SWADOC","swallowing assessment","Receptive Aphasia","rehabilitation","2026-07-14",{"date":79,"type":46},"2026-07-17",{"date":81,"type":21},"2026-09-01",{"date":83,"type":21},"2028-08-31",{"name":85,"class":53},"Alfonso Magliacano",4,{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":4,"eligibilityCriteria":93,"healthyVolunteers":11,"sex":17,"minAge":94,"maxAge":4,"enrollmentInfo":95,"targetDuration":4,"studyType":97,"phases":98,"briefSummary":100,"conditions":101,"keywords":104,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":54},"100587617","paired-vagus-nerve-stimulation-in-mobilization-of-patients-with-prolonged-disorders-of-consciousness-100587617","NCT06930716","Paired Vagus Nerve Stimulation in Mobilization of Patients With Prolonged Disorders of Consciousness","Use of Paired Vagus Nerve Stimulation in Mobilization of Patients With Prolonged Disorders of Consciousness: A Pilot Feasibility Study","Inclusion Criteria:\n\n* Patients with a diagnosis of pDOC (includes coma, VS\u002FUWS, MCS, MCS +, MCS-) as defined as disorder of consciousness (DOC) greater than 6 weeks post onset\n* Patients deemed medically safe to participate in physical therapy (PT) as evaluated by the study physicians.\n\nExclusion Criteria:\n\n* Patients who have emerged from MCS (CRS-R score 6 on Motor Function scale and\u002For 2 on Communication Scale).\n* Patients medically unsafe for participation in PT as indicated by one of the study physicians (including but not limited to those receiving intravenous sedation, those with integumentary breakdown or known pressure injuries, those with cardiovascular or cerebrovascular conditions precluding initiation of physical therapy \\[ie uncontrolled intracranial pressure, severe symptomatic orthostatic hypotension, etc.).\n* Patients with DOC less than 6 weeks post onset will also be excluded.\n* Patients who do not meet technical requirements of the RTTM device will be excluded\n\n  * weighing greater than 135 kg\n  * length of legs below 75 cm or above 100 cm,\n  * fixed contractures of lower extremity including hip, knee, ankle, or foot).\n* Does not have an identified care partner or legally authorized representative to consent to participation","22 Years",{"count":96,"type":21},15,"INTERVENTIONAL",[99],"NA","Prolonged disorders of consciousness (pDOC) are defined as DOC lasting \\>1 year post injury for patients with Traumatic Brain Injury (TBI) and \\>3 months post injury for patients with non-TBI and at present there are limited treatments that reliably lead to enhanced prognosis. The rehabilitation process throughout the continuum of care for patients with pDOC necessitates restorative strategies to facilitate arousal and functional recovery and coordinated medical management. Rehabilitation interventions for patients with DOC and pDOC have evolved in the past decade, with an emerging body of evidence highlighting the benefits of rehabilitation intervention even in the acute. While there is data to support the individual utility of these modalities, no work to date has investigated the benefits of pairing transauricular vagus nerve stimulation (taVNS) and robotic tilt table mobilization (RTTM) to maximize functional recovery in patients with pDOC. This study will report on the safety, feasibility, and preliminary short- and long-term outcomes of RTTM with simultaneously paired Transcutaneous auricular vagus nerve stimulation (taVNS) for Severe Acquired Brain Injury (SABI) patients with pDOC . Fifteen (15) participants will be recruited and complete a 12-week rehabilitation protocol using paired taVNS and RTTM. Once participants have been screened and enrolled in the study, they will complete three study phases: T1: a baseline observation of standard of care T2, intervention, and T3 longitudinal follow up.",[25,102,103],"Brain Injury","Altered Level of Consciousness",[105,106,107],"Therapy","Rehabilitation","Neuromodulation","RECRUITING","2026-06-16",{"date":111,"type":46},"2026-06-18",{"date":113,"type":46},"2025-08-12",{"date":115,"type":21},"2027-12-30",{"name":117,"class":53},"Icahn School of Medicine at Mount Sinai",{"id":119,"slug":120,"hasResults":11,"nctId":121,"briefTitle":122,"officialTitle":122,"acronym":123,"eligibilityCriteria":124,"healthyVolunteers":11,"sex":17,"minAge":62,"maxAge":125,"enrollmentInfo":126,"targetDuration":4,"studyType":97,"phases":128,"briefSummary":129,"conditions":130,"keywords":132,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":150},"100614262","promoting-recovery-after-brain-injury-using-focused-ultrasound-100614262","NCT07277309","Promoting Recovery After Brain Injury Using Focused Ultrasound","ReBOUND","Inclusion Criteria:\n\n* Brain injury resulting in DoC diagnosis, following international guidelines\n* At least 18 years of age\n* Legally authorized representative (surrogate) available to consent\n\nExclusion Criteria:\n\n* History of neurological disorder other than the brain injury\n* Metal implant or other condition precluding MRI\n* Manifest continuous spontaneous movement (which would prevent safe\u002Fsuccessful MRI)\n* Participation in concurrent therapeutic study\n* Pregnancy","79 Years",{"count":127,"type":21},36,[99],"The overall aim of this study is to develop an intervention that can help recovery in patients surviving severe brain injury but failing to fully recover. In particular, this project aims to (1) determine neurobehavioral responses to low-intensity focused ultrasound (LIFUP) in patients with disorders of consciousness (DoC) following brain injury, (2) determine neurophysiologic (EEG) responses to LIFUP in patients with DoC and (3) identify and evaluate ethical perspectives of patient representatives (family members and surrogate decision-makers) surrounding investigation of therapeutic neuromodulation technologies such as LIFUP in patients with DoC.",[25,131],"Disorders of Consciousness Due to Severe Brain Injury",[133,134,28,135,136,137,138,139,140,29],"Disorder of Consciousness","Vegetative State","Minimally Conscious State Plus","Minimally Conscious State Minus","Traumatic Brain Injury","CVA (Cerebrovascular Accident)","Anoxia, Brain","Thalamic Infarction","2026-06-12",{"date":143,"type":46},"2026-06-15",{"date":145,"type":46},"2026-05-26",{"date":147,"type":21},"2029-07",{"name":149,"class":53},"Massachusetts General Hospital",2,{"id":152,"slug":153,"hasResults":11,"nctId":154,"briefTitle":155,"officialTitle":156,"acronym":157,"eligibilityCriteria":158,"healthyVolunteers":11,"sex":17,"minAge":62,"maxAge":125,"enrollmentInfo":159,"targetDuration":4,"studyType":97,"phases":161,"briefSummary":162,"conditions":163,"keywords":164,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":165,"lastUpdatePostDateStruct":166,"startDateStruct":168,"completionDateStruct":170,"leadSponsor":172,"locationsCount":86},"100588280","ultrasound-stimulation-for-patients-in-a-disorder-of-consciousness-100588280","NCT06939348","Ultrasound Stimulation for Patients in a Disorder of Consciousness","Safety and Efficacy of Thalamic Focused Ultrasound Stimulation (tFUS) for Promoting Recovery After Severe Traumatic Brain Injury","tFUS","Inclusion Criteria:\n\n1. Diagnosis of DoC, following international guidelines, as assessed with the CRS-R.\n2. Prolonged status (\\>28days post-injury)\n3. If on a psychotropic medication regimen, that regimen will be stable for at least 4 weeks prior to entry to the study and the patient will be willing to remain on a stable regimen during the protocol.\n4. legally authorized representative available to consent for the patient to participate in the study\n\nExclusion Criteria:\n\n1. History of neurological disorder (other than the brain injury).\n2. Metal implant or other condition precluding safe entry in the MR-environment.\n3. Manifest continuous spontaneous movement (which would prevent safe\u002Fsuccessful imaging).\n4. Participation in another concurrent clinical trial.\n5. Need for mechanical ventilation.\n6. Craniotomy (no bone flap).\n7. Cranioplasty spanning the left temporal bone window.",{"count":160,"type":21},60,[99],"The overall aim of this study is to develop an intervention that can help recovery in patients surviving severe brain injury but failing to fully recover. In particular, this multicenter project aims to (1) establish short-term efficacy of tFUS as a therapeutic to promote recovery in patients with prolonged DoC as compared to sham treatment, (2) establish dose-related safety and efficacy of tFUS as a therapeutic intervention in prolonged DoC patients and (3) explore preliminary predictors and biomarkers of susceptibility and response to thalamic sonication.",[25,131],[133,134,28,135,136,137,138,139,140,29],"2026-05-18",{"date":167,"type":46},"2026-05-22",{"date":169,"type":46},"2025-04-26",{"date":171,"type":21},"2028-09-29",{"name":173,"class":53},"University of California, Los Angeles",{"id":175,"slug":176,"hasResults":11,"nctId":177,"briefTitle":178,"officialTitle":179,"acronym":4,"eligibilityCriteria":180,"healthyVolunteers":181,"sex":17,"minAge":62,"maxAge":182,"enrollmentInfo":183,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":185,"conditions":186,"keywords":187,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":193,"startDateStruct":195,"completionDateStruct":197,"leadSponsor":199,"locationsCount":54},"100547318","micro-movements-in-patients-with-prolonged-disorders-of-consciousness-100547318","NCT06406413","Micro-movements in Patients With Prolonged Disorders of Consciousness","Study of Micro-movements in Patients With Prolonged Disorders of Consciousness","Inclusion Criteria:\n\n1. Patients with consciousness disorders for more than 28 days following severe brain injury, assessed by the CRS-R scale to meet the criteria for VS or MCS;\n2. Aged between 18 and 80 years;\n3. Stable vital signs;\n4. Voluntary participation of family members with signed informed consent;\n5. Good cooperation, minimal facial and spontaneous activities, no use of antiepileptic or sedative drugs.\n\nExclusion Criteria:\n\n1. Locked-in syndrome;\n2. Contraindications for EEG examination;\n3. Contraindications for MRI scanning, such as the presence of internal metallic implants;\n4. Diseases and factors that may affect brain function assessment, such as metabolic disorders, poisoning, shock, etc.",true,"80 Years",{"count":184,"type":21},179,"The goal of this observational study is to learn about the micro-movements in patients with prolonged disorders of consciousness. The main questions it aims to answer are:\n\nUse the neuropsychological paradigm model to monitor micro-movements, assess the patient's remaining level of consciousness and accurately classify it; screen out patients with cognitive-motor dissociation to improve the prognosis of cognitive function; explore the remaining brain function of patients with chronic disorders of consciousness and promote relevant study of neural mechanisms.\n\nParticipants will be subjected to consciousness assessment by CRS-r scale, and their micro-movement changes in response to various emotional stimuli will be captured, along with the collection of EEG and MRI data. Follow-up evaluations will be conducted using the CRS-R scale and GOS scale, with a follow-up period of 6 months.",[25],[69,188,189,190,191],"consciousness disorders","micro-movement","consciousness","Multidimensional paradigm stimulation","2026-01-13",{"date":194,"type":46},"2026-01-14",{"date":196,"type":46},"2024-05-01",{"date":198,"type":21},"2026-12",{"name":200,"class":53},"First Affiliated Hospital of Zhejiang University",{"id":202,"slug":203,"hasResults":11,"nctId":204,"briefTitle":205,"officialTitle":206,"acronym":4,"eligibilityCriteria":180,"healthyVolunteers":181,"sex":17,"minAge":62,"maxAge":182,"enrollmentInfo":207,"targetDuration":209,"studyType":22,"phases":4,"briefSummary":210,"conditions":211,"keywords":212,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":215,"startDateStruct":216,"completionDateStruct":218,"leadSponsor":219,"locationsCount":54},"100522900","micro-expressions-in-patients-with-prolonged-disorders-of-consciousness-100522900","NCT06088628","Micro-expressions in Patients With Prolonged Disorders of Consciousness","Study of Micro-expressions in Patients With Prolonged Disorders of Consciousness",{"count":208,"type":21},200,"6 Months","The goal of this observational study is to learn about the microexpressions in patients with prolonged disorders of consciousness. The main questions it aims to answer are:\n\n* Inducing micro-expression changes in patients with prolonged disorders of consciousness through various emotional stimuli, and further to achieve precise classification of their levels of consciousness.\n* Detecting micro-expressions in patients with prolonged disorders of consciousness to assist clinical diagnosis of levels of consciousness, e.g., complement the disgnosis of clinical scales such as CRS-r scale.\n* By monitoring micro-expression changes in patients with prolonged disorders of consciousness, researchers can explore their residual brain function, thereby advancing research into relevant neural mechanisms.\n\nParticipants will be subjected to consciousness assessment by CRS-r scale, and their micro-expression changes in response to various emotional stimuli will be captured, along with the collection of EEG and MRI data. Follow-up evaluations will be conducted using the CRS-R scale and GOS scale, with a follow-up period of 6 months.",[25],[69,188,213,214,190],"microexpressions","emotional stimuli",{"date":194,"type":46},{"date":217,"type":46},"2022-09-27",{"date":198,"type":21},{"name":200,"class":53},{"id":221,"slug":222,"hasResults":11,"nctId":223,"briefTitle":224,"officialTitle":225,"acronym":226,"eligibilityCriteria":227,"healthyVolunteers":11,"sex":17,"minAge":62,"maxAge":4,"enrollmentInfo":228,"targetDuration":4,"studyType":97,"phases":230,"briefSummary":231,"conditions":232,"keywords":233,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":243,"lastUpdatePostDateStruct":244,"startDateStruct":246,"completionDateStruct":248,"leadSponsor":250,"locationsCount":150},"100559776","measuring-brain-complexity-to-detect-and-predict-recovery-of-consciousness-in-the-icu-100559776","NCT06568536","Measuring Brain Complexity to Detect and Predict Recovery of Consciousness in the ICU","Measuring Brain Complexity to Detect and Predict Recovery of Consciousness in the ICU (COMPASS)","COMPASS","Inclusion Criteria:\n\n1. Age greater than or equal to 18\n2. Functionally independent at baseline\n3. Acquired brain injury within the last 28 days\n4. Disorder of consciousness, as defined by no instance of following commands (i.e., Glasgow Coma Scale motor score = 6) on two or more consecutive assessments\n5. Continuous intravenous sedation able to be discontinued for at least 10 minutes\n6. ICU clinicians approve safe placement of 64-electrode EEG cap on the scalp\n\nAdditional inclusion criteria are present in the study protocol.\n\nExclusion Criteria:\n\n1. Status epilepticus or uncontrolled seizure disorder\n2. No head CT scan from current hospital admission AND contraindications for MRI: conductive, ferromagnetic, or other magnetic-sensitive metals implanted in the head (e.g., cochlear implants, implanted electrodes\u002Fstimulators, aneurysm clips or coils, stents, bullet fragments)\n3. Medical instability, restlessness, or other factors identified by the PI that would either prevent safe participation or compromise data acquisition\n4. Hemicraniectomy\n\nIf a subject meets a contraindication for MR imaging, the subject may participate in all other aspects of the study except MRI.",{"count":229,"type":21},120,[99],"Disorders of consciousness (DoC) caused by severe brain injury affect millions of people worldwide each year. A patient's level of consciousness in the intensive care unit (ICU) significantly impacts the recovery from disability and is a primary determinant of family decisions about withdrawal of life-sustaining therapy (WLST). However, reliable assessment of consciousness in the ICU remains elusive. Transcranial magnetic stimulation-electroencephalography (TMS-EEG) is a tool that has shown the best performance in detecting signs of consciousness in patients with chronic DoC. The goals of this prospective, observational study are to demonstrate the diagnostic performance and prognostic utility of TMS-EEG in the ICU setting.",[25],[234,235,236,237,238,239,240,241,242],"unresponsive wakefulness syndrome","vegetative state","minimally conscious state","transcranial magnetic stimulation","electroencephalography","traumatic brain injury","coma recovery scale - revised","functional electroencephalogram","functional imaging","2025-05-12",{"date":245,"type":46},"2025-05-15",{"date":247,"type":46},"2024-11-08",{"date":249,"type":21},"2029-08-01",{"name":149,"class":53},{"id":252,"slug":253,"hasResults":11,"nctId":254,"briefTitle":255,"officialTitle":256,"acronym":4,"eligibilityCriteria":257,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":258,"enrollmentInfo":259,"targetDuration":4,"studyType":97,"phases":261,"briefSummary":262,"conditions":263,"keywords":4,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":265,"lastUpdatePostDateStruct":266,"startDateStruct":268,"completionDateStruct":270,"leadSponsor":272,"locationsCount":54},"100546008","effect-of-esketamine-on-conscious-state-in-patients-with-pdoc-100546008","NCT06389344","Effect of Esketamine on Conscious State in Patients With pDoC","Effect of Esketamine on Conscious State in Patients With Prolonged Disorders of Consciousness#a Prospective, Randomized, Exploratory Study","Inclusion Criteria:\n\n1.16-65 years old 2.Native Chinese language 3.pDoC after acquired brain injury 4.Scheduled to undergo surgery 5.Signed informed consent\n\nExclusion Criteria:\n\n1. Continuous sedation treatment was carried out within 72 hours before the study\n2. Airway stenosis and severe ventilation or ventilation dysfunction caused by various reasons\n3. Known or suspected to have serious cardiac, pulmonary and renal dysfunction 1)Severe cardiac dysfunction: a. unstable coronary syndrome b. Congestive heart failure: left ventricular ejection fraction less than 50%, elevated BNP c.Severe arrhythmia d. History of severe valvular disease 2)Severe pulmonary dysfunction: a. history of pulmonary heart disease b. History of chronic obstructive pulmonary disease 3)Severe renal dysfunction: a. Endogenous creatinine clearance (Ccr) less than 30ml\u002Fmin b. The glomerular filtration rate (GFR) was less than 30ml\u002Fmin•1.73m2\n4. Allergic history of sedative drugs\n5. Combined with other mental or nervous system diseases\n6. Other reasons are not suitable for this study.","65 Years",{"count":260,"type":21},116,[99],"The goal of this clinical trial is to learn about the effect of intraoperative infusion of subanesthetic dose of esketamine on conscious status in patients with prolonged disorders of consciousness under sevoflurane anesthesia.\n\nParticipants will be patients with prolonged disorders of consciousness undergoing surgery with general anesthesia at Beijing Tiantan Hospital. 0.3mg\u002Fkg esketamine or saline will be infused will be infused intravenously at a constant speed within 30 min after tracheal intubation\u002Fpneumatectomy fixation. Coma recovery scale-revised, Glasgow coma scale, Full Outline of UnResponsiveness scores, SedLine multi-channel electroencephalogram and perioperative adverse events after surgery will be investigated.",[264,25],"Esketamine","2024-07-29",{"date":267,"type":46},"2024-07-30",{"date":269,"type":46},"2024-05-20",{"date":271,"type":21},"2026-06-30",{"name":273,"class":53},"Beijing Tiantan Hospital",{"id":275,"slug":276,"hasResults":11,"nctId":277,"briefTitle":278,"officialTitle":279,"acronym":280,"eligibilityCriteria":281,"healthyVolunteers":11,"sex":17,"minAge":62,"maxAge":4,"enrollmentInfo":282,"targetDuration":4,"studyType":97,"phases":284,"briefSummary":285,"conditions":286,"keywords":289,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":293,"lastUpdatePostDateStruct":294,"startDateStruct":296,"completionDateStruct":298,"leadSponsor":300,"locationsCount":54},"100548870","connectivity-and-neural-signatures-of-consciousness-in-unresponsive-states-100548870","NCT06426615","Connectivity and Neural Signatures of Consciousness in Unresponsive States","Connectivity and Neural Signatures of Consciousness In Unresponsive States (CONSCIUS) - a Study of Brain Activity in Disorders of Consciousness","CONSCIUS","Inclusion Criteria:\n\n* 18 years old or older\n* Brain injury of any kind, with impaired consciousness or suspected seizures\n\nExclusion Criteria:\n\n* \\\u003C 18 years old\n* Known pregnancy\n* Any condition that, in the judgement of the investigator, makes participation in the study unsafe or unfeasible (e.g., irreversible coagulopathy, large intracranial tumors, surgical technical problems…)",{"count":283,"type":21},20,[99],"The CONSCIUS study is a prospective, interventional study including patients with acute brain injury and impaired consciousness implanted with intracranial electrodes. The aim of the study is to investigate seizures and thalamocortical neural dynamics underlying behavioral unresponsiveness.",[287,137,25,288],"Acute Brain Injury","Seizures",[290,288,291,292],"Consciousness","Neural dynamics","Intracranial recordings and stimulation","2024-05-17",{"date":295,"type":46},"2024-05-23",{"date":297,"type":46},"2024-01-01",{"date":299,"type":21},"2027-12-31",{"name":301,"class":53},"Universitaire Ziekenhuizen KU Leuven"]