[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"contact-lens-discomfort\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:contact-lens-discomfort":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":4},"100658254","phase-4-contact-lens-wearing-dry-eye-subjects-who-are-treated-with-acoltremon-0003-100658254",false,"NCT07848373","Contact Lens-Wearing Dry Eye Subjects Who Are Treated With Acoltremon 0.003%","A Clinical Evaluation of Contact Lens-Wearing Dry Eye Subjects Who Are Treated With Acoltremon 0.003%","Inclusion Criteria:\n\n* • Adult subjects who are ≥18 years of age.\n\n  * Best corrected CL visual acuity of 0.1 Logarithm of the Minimum Angle of Resolution (logMAR) or better in both eyes (Snellen equivalent 20\u002F25).\n  * Willing to wear a new pair of CLs to the baseline study visit.\n  * Daily, soft, frequent replacement CL wearer (daily disposable, bi-weekly, or monthly CLs).\n  * An Eye Dryness VAS score of ≥40.\n  * CLDEQ-8 scores (CLDEQ-8 scores ≥12).\n  * A score of \\>7 dots on the Lexitas NEI staining scale (grade 1 in a single sector on the 5-sector scale).\n  * Habitual wearers of soft CLs for a minimum of 5 days per week for 6 hours or more per day during the month prior to enrollment.\n  * Willing to maintain habitual soft CL wear of a minimum of 5 days per week for 6 or more hours per day for the 1 month duration of the study.\n  * Habitual CLs have an acceptable fit (good centration, movement, and coverage\n\nExclusion Criteria:\n\n* Any history of acoltremon 0.003% use.\n* Are currently an overnight CL wearer.\n* Are currently hard or scleral CL wearers.\n* Have known systemic health conditions that are known to alter tear film physiology (e.g., primary and secondary Sjögren's syndrome).\n* Have a history of ocular surgery within the past 12 months.\n* Have a history of viral eye disease that may confound study results.\n* Have a history of severe ocular trauma, active ocular infection or inflammation.\n* Have ever used isotretinoin-derivates (e.g., Accutane).\n* Are currently taking ocular medications (including topical glaucoma medication) or plan to during the study.\n* Have had a physical meibomian gland treatment withing 1 month of enrollment (iLux, Lipiflow, Radio Frequency and IPL with manual expressions, microblepharoexfoliation etc.).\n* Have used a prescription DED medication in the last 1 month.\n* Unwilling to agree to discontinue artificial tear use the day before enrollment and throughout the study.\n* Have a condition or in a situation, which in the examiner's opinion, may put the subject at significant risk, may confound the study results, or may significantly interfere with their participation.\n* Are pregnant or breast feeding.","ALL","18 Years",{"count":19,"type":20},50,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","Dry Eye Disease is a multifaceted condition which has symptoms such as eye dryness, burning, and stinging sensation in the eyes. As well as clinical diagnosis such as a decreased ability to create tear film. Despite improvements in Contact Lenses (CL) DED still is responsible for a large percentage of CL dropouts due to discomfort. Thus, the purpose of this study is to determine if acoltremon 0.003% can improve the frequency and severity of DED symptoms in CL wearers.",[26,27,28],"Dry Eye","Contact Lens Discomfort","Eye Drops","NOT_YET_RECRUITING","2026-10-06",{"date":32,"type":33},"2026-10-08","ACTUAL",{"date":35,"type":20},"2026-10-10",{"date":37,"type":20},"2027-02-21",{"name":39,"class":40},"Eye Research Associates, LLC","OTHER"]