[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"contracture\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:contracture":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,41,75],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100646377","early-phase-1-collagenase-injection-for-contracture-management-100646377",false,"NCT07693556","Collagenase Injection for Contracture Management","Collagenase Injection for Contracture and Spasticity Management","Inclusion Criteria:\n\n* ≥ 6 months post stroke, brain injury or spinal cord injury, medically stable;\n* clinical diagnosis of tendon contracture\n\nExclusion Criteria:\n\n* Is hypersensitive to XIAFLEX or collagenase;\n* Is currently adjusting tone alternating medications (e.g., baclofen), or\n* Received botulinum toxin injection to target areas \\\u003C4 months, or phenol injections \\\u003C 9 months;\n* Received surgical release of tendons;\n* Is a pregnant woman;\n* Has coagulation disorders, including those who receive concomitant anticoagulants (except for low-dose aspirin).\n* has heritable connective tissue disorders, including those within the Ehlers-Danlos syndrome (EDS) spectrum.","ALL","18 Years","75 Years",{"count":20,"type":21},15,"ESTIMATED","INTERVENTIONAL",[24],"EARLY_PHASE1","The overall goal is to investigate the effectiveness of a novel intervention - Collagenase injection, for contracture management in patients with neurological impairments, such as stroke, brain injury, and spinal cord injury.",[27],"Contracture","NOT_YET_RECRUITING","2026-07-02",{"date":31,"type":32},"2026-07-09","ACTUAL",{"date":34,"type":21},"2026-09-01",{"date":36,"type":21},"2031-09-30",{"name":38,"class":39},"The University of Texas Health Science Center, Houston","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":5},"100539787","effectiveness-of-rehabilitation-protocol-in-patients-with-shortened-posterior-leg-muscles-100539787","NCT06308380","Effectiveness of Rehabilitation Protocol in Patients With Shortened Posterior Leg Muscles","Effectiveness of Rehabilitation Protocol in Patients With Shortened Posterior Leg Muscles, Whether or Not Combined With Ultrasound- Guided Surgery","EREPSOLM","Inclusion Criteria:\n\n* Patients with shortened posterior musculature.\n* Chronic ankle pain.\n* Limitations in activities of daily living.\n* Atypical gait.\n* Clubfoot.\n\nExclusion Criteria:\n\n* Previous MMII surgeries.\n* Neuropathic pain.\n* Bony cap equinus.\n* Analgesic physiotherapy.","20 Years","90 Years",{"count":52,"type":21},40,[54],"NA","The goal of this clinical study is to develop a specialized rehabilitation exercise protocol designed for patients diagnosed with foot pathologies and calf muscle shortening, regardless of their choice to undergo minimally invasive ultrasound-guided surgery. The primary focus is to assess disparities in outcomes, particularly in the recovery of ankle mobility degrees. Additionally, for patients opting for minimally invasive ultrasound-guided surgery, the study aims to evaluate the resumption of both sporting activities and daily routines using the aforementioned specific rehabilitation protocol.\n\nThe primary questions this study aims to answer are:\n\n* How does the proposed rehabilitation protocol impact ankle mobility recovery for patients with foot pathologies and calf muscle shortening?\n* What are the differences observed in the return to sporting activities and daily life among patients undergoing minimally invasive ultrasound-guided surgery, following the prescribed protocol?\n\nParticipants enrolled in this study will be engaged in:\n\nUndertaking the specified rehabilitation exercises tailored for foot pathologies and calf muscle shortening.\n\nThose opting for minimally invasive ultrasound-guided surgery will follow the same rehabilitation protocol post-surgery to assess its impact on their return to normal activities.\n\nIf there exists a comparison group:\n\nResearchers will compare participants who undergo minimally invasive ultrasound-guided surgery against those who choose other treatment options to discern any differential effects on ankle mobility recovery and resumption of activities.",[57,58,27],"Equinus Deformity of Foot","Gastrocnemius Equinus",[60,61,62,63,64],"foot deformity","calf shortening","foot and ankle disease","stretching and muscle strengthening","exercise post surgery","RECRUITING","2025-05-07",{"date":68,"type":32},"2025-05-11",{"date":70,"type":32},"2024-03-10",{"date":72,"type":21},"2025-06-10",{"name":74,"class":39},"Fundación Universidad Católica de Valencia San Vicente Mártir",{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":16,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":22,"phases":86,"briefSummary":88,"conditions":89,"keywords":101,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":40},"100473080","phase-4-percutaneous-needle-fasciotomy---corticosteroid-injection-for-dupuytrens-contracture-100473080","NCT05440240","Percutaneous Needle Fasciotomy +\u002F- Corticosteroid Injection for Dupuytren's Contracture","Percutaneous Needle Fasciotomy (PNF) +\u002F- Corticosteroid Injection for Dupuytren's Contracture (DC) Affecting Metacarpophalangeal Joints (MCP) . A Randomized Controlled Trial","Sufficient correction of metacarpophalangeal (MCP) joint during the PNF treatment, defined as \\\u003C20° passive extension deficit (PED), is a prerequisite for inclusion.\n\nInclusion Criteria:\n\n* Dupuytren contracture (DC) of ≥ 20° PED in MCP joint measured with a goniometer\n* DC of either II-V finger\n* Well-defined\u002Fpalpable cord\n\nExclusion Criteria:\n\n* Legally incapacitated\n* Previous study inclusion with another finger ray\n* Isolated proximal interphalangeal (PIP) or distal interphalangeal (DIP) joint contracture, defined as MCP joint contracture \\\u003C 20° PED regardless of the deficit in the PIP or DIP joint\n* Previous hand surgery of the affected finger for any reason\n* Known allergy to the study medication\n* Anticoagulant therapy (Acetylsalicylic acid is NOT an exclusion criterion)\n* Pregnant or lactation\n* Insulin dependent diabetes mellitus\n* Ongoing systemic infection or local infection at the site of the procedure\n* Rheumatoid arthritis\n* Amyloidosis or mucopolysaccharidosis\n* Unable to communicate, cooperate or participate in follow-up","45 Years","99 Years",{"count":85,"type":21},400,[87],"PHASE4","Comparing percutaneous needle fasciotomy +\u002F- corticosteroid injection for Dupuytren's contracture affecting metacarpophalangeal joints. A clinician-initiated, multicenter, randomized controlled trial.",[90,91,27,92,93,94,95,96,97,98,99,100],"Dupuytren Contracture","Dupuytren's Disease","Joint Diseases","Musculoskeletal Diseases","Fibroma","Neoplasm, Fibrous Tissue","Neoplasms, Connective Tissue","Neoplasms, Connective and Soft Tissue","Neoplasms by Histologic Type","Neoplasms","Connective Tissue Diseases",[102,103,104],"Percutaneous needle fasciotomy","Corticosteroid","Randomized controlled trial","2023-05-15",{"date":107,"type":32},"2023-05-17",{"date":109,"type":32},"2023-01-10",{"date":111,"type":21},"2030-03",{"name":113,"class":39},"Regionshospitalet Silkeborg"]