[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"contrast-induced-nephropathy-cin\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:contrast-induced-nephropathy-cin":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":27,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":4},"100656476","beyond-the-mehran-risk-score-predictive-value-of-total-ischemic-time-for-contrast-induced-nephropathy-in-st-segment-elevation-myocardial-infarction-patients-undergoing-primary-percutaneous-coronary-intervention-100656476",false,"NCT07826572","Beyond the Mehran Risk Score: Predictive Value of Total Ischemic Time for Contrast-Induced Nephropathy in ST Segment Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention.","Inclusion Criteria:\n\n* Inclusion Criteria:\n\n  1. Patients aged \\>=18 years at the time of presentation.\n  2. Definitive diagnosis of acute ST-segment elevation myocardial infarction (STEMI) presenting within 12 hours of symptom onset, characterized by typical ischemic symptoms (e.g., retrosternal chest pain) and electrocardiographic criteria: persistent ST-segment elevation \\>=1 mm in \\>=2 contiguous limb leads, or \\>=2 mm in \\>=2 contiguous precordial leads (V2-V3 thresholds: \\>=2.5 mm in men \\\u003C40 years, \\>=2.0 mm in men \\>=40 years, and \\>=1.5 mm in women), or a validated new or presumably new left bundle branch block (LBBB).\n  3. Selection for immediate mechanical reperfusion via emergency primary percutaneous coronary intervention (PPCI) according to current guidelines.\n  4. A reliable and verifiable chronological timeline regarding the exact onset of chest pain or ischemic symptoms to ensure precise calculation of the total ischemic duration.\n  5. Willingness to participate, demonstrated by signed, informed consent obtained from the patient or an authorized family representative prior to data collection under approved institutional protocols.\n\n     .\n\n     Exclusion Criteria:\n\n  \u003C!-- -->\n\n  1. Pre-existing end-stage renal disease (ESRD) requiring long-term peritoneal dialysis or hemodialysis, or an admission baseline eGFR \\\u003C15 mL\u002Fmin\u002F1.73m2.\n  2. Prior exposure to iodinated contrast media within the past 7 days, or scheduled elective contrast procedures within the subsequent 72 hours.\n  3. Intentional pre-procedural administration of structured, high-volume intravenous fluid hydration regimens specifically designed to prevent contrast nephropathy (e.g., sodium bicarbonate protocols), which would confound baseline renal kinetics.\n  4. Known active treatment with high-potency nephrotoxic drugs within the 48 hours prior to admission (e.g., cisplatin, high-dose aminoglycosides, amphotericin B).\n  5. Active pregnancy, ongoing breastfeeding, or severe non-cardiac co-morbidities associated with a life expectancy \\\u003C30 days (e.g., advanced terminal malignancies)",true,"ALL","18 Years",{"count":19,"type":20},400,"ESTIMATED","OBSERVATIONAL","Contrast-Induced Nephropathy (CIN) is a serious complication following primary percutaneous coronary intervention (PCI) in patients presenting with acute ST-segment elevation myocardial infarction (STEMI). While the standard Mehran Risk Score uses static baseline clinical and procedural variables, it lacks dynamic parameters reflecting acute myocardial ischemic duration. Total ischemic time-from symptom onset to balloon inflation-drives systemic inflammation, forward cardiac failure, and renal hypoperfusion.\n\nThis prospective observational validation cohort study aims to evaluate the independent predictive value of Total Ischemic Time for CIN in acute STEMI patients undergoing primary PCI. Additionally, it investigates whether integrating total ischemic duration into the classic Mehran Risk Score enhances discrimination accuracy, net reclassification, and calibration performance for early pre-procedural risk stratification.",[24,25,26],"ST Elevation (STEMI) Myocardial Infarction","Contrast Induced Nephropathy (CIN)","Acute Kidney Injury",[28,29,30,31,32],"Primary Percutaneous Coronary Intervention","Total Ischemic Time","Mehran Risk Score","STEMI","Contrast Induced Acute Kidney Injury","NOT_YET_RECRUITING","2026-09-12",{"date":36,"type":37},"2026-09-17","ACTUAL",{"date":39,"type":20},"2026-10-01",{"date":41,"type":20},"2028-08-25",{"name":43,"class":44},"Assiut University","OTHER"]