[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"convulsive-status-epilepticus\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:convulsive-status-epilepticus":66},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":26,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":4},"100658382","predictors-of-outcomes-of-convulsive-status-epilepticus-100658382",false,"NCT07853391","Predictors of Outcomes of Convulsive Status Epilepticus","Predictors of Outcomes of Convulsive Status Epilepticus: A Hospital-Based Study","Inclusion Criteria:\n\n* Age 18 years or older.\n* Presentation with convulsive status epilepticus, defined as continuous convulsive seizure activity lasting more than 5 minutes or two or more discrete seizures without full recovery of consciousness between episodes.\n\nExclusion Criteria:\n\n* Functional or dissociative (psychogenic non-epileptic) status.\n* Acute cardiac arrest with motor phenomena due to cerebral anoxia.\n* Movement disorders mimicking seizures (e.g., acute extrapyramidal side effects, chorea, or dyskinesias).\n* Age younger than 18 years.","ALL","18 Years",{"count":19,"type":20},100,"ESTIMATED","OBSERVATIONAL","Status epilepticus is a life-threatening neurological emergency characterized by prolonged seizures or multiple seizures occurring without the patient regaining consciousness between episodes. Convulsive status epilepticus is associated with high rates of morbidity and mortality if not promptly recognized and controlled. While prognostic factors have been studied in various populations, data regarding clinical predictors and hospital outcomes in Upper Egypt remain limited.\n\nThe purpose of this prospective, hospital-based observational study is to identify the clinical predictors of short-term outcomes among adult patients presenting with convulsive status epilepticus admitted to Assiut University Hospitals.\n\nAll eligible participants aged 18 years and older admitted with convulsive status epilepticus will receive standard-of-care medical management according to institutional clinical protocols. Researchers will systematically collect clinical data, including demographic factors, seizure semiology and duration, underlying etiologies, laboratory tests, neuroimaging findings, and electroencephalography (EEG) results.\n\nParticipants will be followed throughout their hospital stay to assess functional outcome at discharge using the Modified Rankin Scale (mRS), in-hospital mortality, response to antiseizure treatment, development of refractory or super-refractory status epilepticus, requirement for intensive care unit (ICU) admission or mechanical ventilation, and length of hospital stay.",[24,25],"Status Epilepticus","Convulsive Status Epilepticus",[27,28,29,30,31,32,33,34,35],"Convulsive status epilepticus","Predictors of outcome","Refractory status epilepticus","Super-refractory status epilepticus","In-hospital mortality","Modified Rankin Scale","Seizure control","Mechanical ventilation","Intensive care unit","NOT_YET_RECRUITING","2026-09-26",{"date":39,"type":40},"2026-10-01","ACTUAL",{"date":42,"type":20},"2026-10",{"date":44,"type":20},"2027-11",{"name":46,"class":47},"Assiut University","OTHER",{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":61,"briefSummary":64,"conditions":65,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":72,"leadSponsor":74,"locationsCount":76},"100600311","phase-2-prehospital-early-administration-of-ketamine-for-status-epilepticus-in-epileptic-kids-peak-seek-100600311","NCT07095842","Prehospital Early Administration of Ketamine for Status Epilepticus in Epileptic Kids (PEAK-SEEK)","Efficacy of Add-on Ketamine With Second-dose Midazolam for Prehospital Treatment of Epileptic Children With Status Epilepticus","PEAK-SEEK","Inclusion Criteria:\n\n* Age from 2 to 16 years.\n* Established diagnosis of epilepsy of at least 1 year duration.\n* History of at least 1 episode of convulsive status epilepticus in the preceding 12 months.\n\nExclusion Criteria:\n\n* Failure to obtain informed consent.\n* Known allergies or contraindications to ketamine.\n* Known contraindications to intramuscular injection.\n* Presence of another family member included in the same trial.\n* Having subsequent events (only the index event will be included).","2 Years","16 Years",{"count":59,"type":20},668,"INTERVENTIONAL",[62,63],"PHASE2","PHASE3","The goal of this pragmatic, decentralized, pre-consented, event-driven, randomized controlled trial is to investigate the efficacy of add-on ketamine to second-dose midazolam for prehospital treatment of epileptic children with convulsive status epilepticus.",[66],"Convulsive Status EPILEPTICUS","RECRUITING","2025-08-03",{"date":70,"type":40},"2025-08-05",{"date":68,"type":40},{"date":73,"type":20},"2026-08-01",{"name":75,"class":47},"Sohag University",1]