[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"copd-exacerbation-aecopd\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:copd-exacerbation-aecopd":23},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,42,72],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":25,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100646088","dynamic-changes-in-right-ventricle-and-pulmonary-artery-coupling-among-copd-patients-with-acute-exacerbation-100646088",false,"NCT07694713","Dynamic Changes in Right Ventricle and Pulmonary Artery Coupling Among COPD Patients With Acute Exacerbation","Inclusion Criteria:\n\n* Patients aged more than 40 years diagnosed with COPD based on pulmonary function tests and admitted to ICU with severe AECOPD. Severe exacerbation is defined according to GOLD 2024 as an exacerbation requiring hospitalization or an emergency department visit, in addition to the acute worsening of respiratory symptoms occurring within ≤14 days.\n\nExclusion Criteria:\n\n* Presence of moderate to severe aortic, mitral, tricuspid, or pulmonary valvular disease\n* A known history of left-sided heart failure before enrolment\n* refusal to participate in the study","ALL","40 Years",{"count":18,"type":19},115,"ESTIMATED","OBSERVATIONAL","Chronic obstructive pulmonary disease (COPD) is a common, preventable, and manageable disease characterized by persistent respiratory symptoms and airflow limitation. Acute exacerbations of COPD (AECOPD) are major events in the course of the disease and are associated with increased hospital admissions, accelerated decline in lung function, impaired quality of life, and increased mortality. Assessment of exacerbation risk remains a key component of COPD management according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD).\n\nBeyond its respiratory manifestations, COPD may have important cardiovascular consequences. Chronic hypoxia, pulmonary vascular remodeling, inflammation, and increased pulmonary vascular resistance may contribute to elevated pulmonary artery pressures and right ventricular (RV) dysfunction. Pulmonary hypertension associated with chronic lung disease is clinically important because it may worsen symptoms, exercise tolerance, and prognosis.\n\nDuring acute exacerbations, worsening hypoxemia, hypercapnia, dynamic hyperinflation, and increased respiratory workload may further increase pulmonary vascular resistance and RV afterload. Transthoracic echocardiography provides a practical non-invasive method for evaluating right ventricular function and pulmonary hemodynamics through parameters such as tricuspid annular plane systolic excursion (TAPSE), pulmonary artery systolic pressure (PASP), and the TAPSE\u002FPASP ratio, a recognized marker of RV-pulmonary artery coupling.",[23,24],"COPD Exacerbation (AECOPD)","Pulmonary Hypertension",[26,27,28],"COPD","TAPSE","PASP","NOT_YET_RECRUITING","2026-07-05",{"date":32,"type":33},"2026-07-10","ACTUAL",{"date":35,"type":19},"2026-09-01",{"date":37,"type":19},"2028-10-01",{"name":39,"class":40},"Assiut University","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":58,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":41},"100639765","copd-flare-up-clinic-after-severe-exacerbations-100639765","NCT07629869","COPD Flare-Up Clinic After Severe Exacerbations","The Role of COPD Flare-up Clinic Service After Severe Exacerbations to Reduce Recurrent Exacerbations","FLARE-COPD","Inclusion Criteria:\n\n* Prior COPD diagnosis based on clinical and spirometry accepted criteria.\n* Acute exacerbation of COPD as the main reason for ED arrival.\n* Ability to perform in-person and telephone follow-up.\n* Agree to participate, with a signed informed consent.\n\nExclusion Criteria:\n\n* Symptomatic heart failure as the main reason for emergency department visit in the last 6 months.\n* Uncontrolled comorbidity.\n* Vulnerable Populations: To ensure ethical compliance and participant safety, the study will exclude vulnerable populations. This includes pregnant women, and any person lacking the mental or legal capacity to provide independent informed consent.","80 Years",{"count":52,"type":19},240,"INTERVENTIONAL",[55],"NA","This prospective randomized controlled trial evaluates whether a specialized \"COPD flare-up clinic service\" improves outcomes in patients following an acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Patients presenting to the emergency department with AECOPD and discharged or hospitalized will be randomized 1:1 to either structured follow-up in a dedicated flare-up clinic or standard follow-up by scheduled telephone interviews.\n\nThe researches hypothesize that structured follow-up in a specialized clinic will reduce recurrent exacerbations, optimize long-term COPD management, and improve patients' quality of life compared to standard care.",[26,23],[59,60,61],"COPD management","COPD flare-up","COPD exacerbation","2026-06-18",{"date":64,"type":33},"2026-06-23",{"date":66,"type":19},"2026-07-01",{"date":68,"type":19},"2028-12-31",{"name":70,"class":71},"Tel-Aviv Sourasky Medical Center","OTHER_GOV",{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":15,"minAge":4,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":53,"phases":82,"briefSummary":83,"conditions":84,"keywords":95,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":105,"locationsCount":41},"100620566","impact-of-a-multimodal-intervention-on-antibiotic-prescribing-for-respiratory-infections-in-primary-care-100620566","NCT07359287","Impact of a Multimodal Intervention on Antibiotic Prescribing for Respiratory Infections in Primary Care","Impact of a Multimodal Intervention on Antibiotic Prescribing for Respiratory Infections in Primary Care: A Cluster-Randomized Trial","GRASP","Inclusion Criteria:\n\n\\- Patient seen in consultation for an upper or lower respiratory tract infection (Angina, Acute bronchiolitis, Acute bronchitis, COPD exacerbation (AECOPD), Laryngitis, Acute otitis media (AOM), Serous or congestive otitis, Viral respiratory infection (e.g., influenza), Community-acquired pneumonia (CAP), Rhinitis \u002F Nasopharyngitis, Acute sinusitis)\n\nExclusion Criteria:\n\n\\- Patient under legal protection",{"count":81,"type":19},4500,[55],"Antimicrobial resistance (AMR), considered one of the greatest global threats by the WHO, justifies the development of initiatives to promote appropriate antibiotic use-especially in primary care, where most antibiotics in France are prescribed and where misuse remains common.\n\nWe are proposing a cluster-randomized controlled trial to evaluate the effectiveness of a bimodal intervention combining: (1) improved communication about the circulation of respiratory viruses, and (2) strengthened collaborative practices between general practitioners and pharmacists through a multidisciplinary protocol aimed at verifying that prescribed treatment durations comply with guidelines.\n\nThe study will include six primary care practices (24 physicians), with three practices in each study arm.\n\nThe aim of this project is to assess whether the bimodal intervention can reduce the duration of antibiotic treatments for upper and lower respiratory tract infections. The first component (a \"viral infection prescription\" tool) focuses on reducing unnecessary treatment initiation, while the second (pharmacist-led review) aims to shorten excessive prescription durations.",[85,86,87,23,88,89,90,91,92,93,94],"Angina","Acute Bronchiolitis","Acute Bronchitis","Laryngitis","Acute Otitis Media (AOM)","Serous or Congestive Otitis","Viral Respiratory Infection (e.g., Influenza)","Community-Acquired Pneumonia (CAP)","Rhinitis \u002F Nasopharyngitis","Acute Sinusitis",[96,97],"Upper respiratory tract infection","Lower respiratory tract infection","RECRUITING","2026-01-13",{"date":101,"type":33},"2026-01-22",{"date":103,"type":33},"2025-12-01",{"date":35,"type":19},{"name":106,"class":40},"University Hospital, Caen"]