[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cornea-inflamed\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cornea-inflamed":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":5},"100645432","clinical-predictors-of-visual-outcome-in-patients-affected-with-ocular-surface-diseases-100645432",false,"NCT07694817","Clinical Predictors of Visual Outcome in Patients Affected With Ocular Surface Diseases","Clinical Predictors of Visual Outcome in Patients Affected With Ocular Surface Diseases: Single Center Retrospective-prospective Clinical Study","OSD","Inclusion Criteria:\n\n* The participant is willing and able to provide written informed consent for study participation (prospective cohort).\n* Adult participants aged ≥18 years at the time of inclusion.\n* Clinically confirmed diagnosis of OSD, including but not limited to inflammatory keratopathies, neurotrophic keratopathy, exposure keratopathy, limbal stem cell deficiency, post-surgical or post-traumatic corneal alterations.\n* Measurable BSCVA obtained through standardized manifest refraction and ETDRS chart testing at baseline.\n* Available dataset for the diagnostic tests required by the study (e.g., corneal topography, pachymetry, confocal microscopy, corneal sensitivity testing, slit-lamp imaging, tear cytokine analysis, impression cytology).\n* Willingness and ability to attend follow-up visits and complete all study-related procedures according to the study schedule.\n\nExclusion Criteria:\n\n* Change of retinal, optic nerve, or macular pathology that may affect best spectacle-corrected visual acuity independently of the cornea or ocular surface (e.g., age-related macular degeneration, diabetic macular edema, optic neuropathy) in the period of study\n* History of intraocular or corneal surgery within 3 months prior to baseline evaluation.\n* Active intraocular inflammation, glaucoma with uncontrolled intraocular pressure, or corneal conditions not compatible with accurate imaging or measurement (e.g., severe scarring, leukoma).\n* Uncontrolled systemic diseases that may impair vision or corneal health (e.g., advanced diabetes, autoimmune disease in active phase).\n* Inability or unwillingness to attend follow-up visits or complete study assessments.\n* Pregnant or breastfeeding women will not be enrolled, as hormonal fluctuations can alter tear film and ocular surface physiology","ALL",{"count":19,"type":20},1000,"ESTIMATED","OBSERVATIONAL","This retrospective-prospective study aims to identify the diagnostic parameters most predictive of BSCVA in patients with OSD. Clinical, structural, and biochemical data will be collected from standard-of-care examinations and patient-reported outcome questionnaires. The goal is to determine the most informative biomarkers for visual prognosis, streamline diagnostic workflows, and support individualized management of OSD.",[24,25,26,27,28,29],"Neurotrophic Keratopathy","Exposure Keratopathy","Limbal Stem Cell Deficiency (LSCD)","Cornea Abnormality","Cornea Disease","Cornea Inflamed","NOT_YET_RECRUITING","2026-07-10",{"date":33,"type":34},"2026-07-14","ACTUAL",{"date":36,"type":20},"2026-07",{"date":38,"type":20},"2029-12",{"name":40,"class":41},"IRCCS San Raffaele","OTHER"]