[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"corneal-opacity\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:corneal-opacity":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100324499","oct-in-diagnosis-of-irregular-corneas-100324499",false,"NCT03504800","OCT in Diagnosis of Irregular Corneas","Optical Coherence Tomography-Aided Differential Diagnosis and Treatment of Irregular Corneas","Inclusion Criteria:\n\nGROUP A:\n\n* Keratoconus:\n\n  1. CDVA ≥ 20\u002F25 in the better eye; and both of the following in the worse eye\n  2. Topography characteristic of keratoconus or pellucid marginal degeneration\n* Contact lens-related corneal warpage:\n\n  1. Contact lens use; and\n  2. Topography irregularities\n* Dry eye:\n\n  1. Symptoms of dry eye documented by Ocular Surface Disease Index (OSDI) questionnaire score ≥ 30; and\n  2. Topography irregularities\n  3. Presence of punctate epithelial erosion on exam with surface staining\n  4. Aqueous deficiency or evaporative dry eye\n* Epithelial basement membrane dystrophy (EBMD):\n\n  1. Negative corneal fluorescein staining; and\n  2. Corneal opacities; and\n  3. Topography irregularities\n* Stromal addition or subtraction:\n\n  1. Scars; or\n  2. Salzmann's degeneration; or\n  3. Stromal dystrophies; or\n  4. Complication (visual complaints) after LASIK or photorefractive keratectomy (PRK)\n* Stromal distortion:\n\n  1. Radial keratectomy (RK); or\n  2. Corneal transplants.\n* Normal controls:\n\n  1. Healthy eyes with no previous eye procedures\u002Fsurgeries.\n\nGROUP B:\n\nParticipants will be selected from the keratoconus population in Group A based on topography findings.\n\nGROUP C:\n\nParticipants will be selected from the stromal addition\u002Fsubtraction and stromal distortion populations of Group A if they have vision primarily limited by scars, dystrophy, or high astigmatism that could benefit from PTK.\n\nExclusion Criteria (all groups):\n\n* Inability to give informed consent.\n* Inability to maintain fixation for OCT imaging.\n* Inability to commit to required study visits.\n* Eyes with concurrent cataract, retinal disease, glaucoma, or other eye conditions that may limit the visual outcome after surgery.\n* Previous corneal surgeries if considered as a keratoconus participant.\n* Pregnancy or breastfeeding.",true,"ALL","14 Years","85 Years",{"count":21,"type":22},445,"ESTIMATED","OBSERVATIONAL","This main goal of this study is to improve the detection, classification, monitoring, and treatment of irregular corneas due to keratoconus, warpage, dry eye, scar, stromal dystrophies, and other corneal conditions.\n\nThe primary goal will be achieved by using optical coherence tomography (OCT) to:\n\n1. Develop an OCT-based system to classify and evaluate corneal-shape irregularities.\n2. Develop OCT metrics for more sensitive detection of keratoconus progression.\n3. Develop OCT-and-topography guided phototherapeutic keratectomy (PTK) for irregular corneas.",[26,27,28],"Keratoconus","Corneal Opacity","Corneal Dystrophy",[30,26],"OCT","RECRUITING","2025-09-05",{"date":34,"type":35},"2025-09-09","ACTUAL",{"date":37,"type":35},"2018-05-01",{"date":39,"type":22},"2031-02-28",{"name":41,"class":42},"Oregon Health and Science University","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":50,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":58,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":43},"100151502","optical-coherence-tomography-guided-transepithelial-phototherapeutic-keratectomy-100151502","NCT01243931","Optical Coherence Tomography Guided Transepithelial Phototherapeutic Keratectomy","Inclusion Criteria:\n\n* Patients with vision primarily limited by superficial opacities and irregularities that could be removed by PTK while leaving at least 250 µm.\n\nExclusion Criteria:\n\n* Inability to give informed consent\n* Inability to maintain stable fixation for OCT imaging\n* Inability to commit to required visits to complete the study\n* Deep corneal opacities and irregularities\n* Cataracts, retinal disease, glaucoma, or other eye conditions that may limit the visual outcome after surgery","18 Years",{"count":52,"type":22},80,"INTERVENTIONAL",[55],"NA","Optical Coherence Tomography (OCT) machines are non-contact instruments that can measure the depth of scars and other causes of cloudiness in the front of the cornea. The purpose of this study is to determine whether OCT-guided settings for the lasers used for removal of corneal scars and other partial-thickness corneal defects result in improved vision in patients receiving these procedures.",[27],[59,60,61,62],"Phototherapeutic keratectomy","Optical coherence tomography","Corneal opacity","Corneal dystrophy","2024-02-08",{"date":65,"type":35},"2024-02-12",{"date":67,"type":4},"2011-06",{"date":69,"type":22},"2026-12",{"name":41,"class":42}]