[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"coronary-artery-bypass-grafting-cabg-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:coronary-artery-bypass-grafting-cabg-surgery":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,52,85,111,141],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100622832","espb-vs-spsip-for-postoperative-analgesia-after-cabg-100622832",false,"NCT07388745","ESPB vs SPSIP for Postoperative Analgesia After CABG","A Randomized Trial Comparing Erector Spinae Plane Block Versus Serratus Posterior Superior Intercostal Plane Block for Postoperative Analgesic Efficacy in Patients Undergoing Coronary Artery Bypass Graft Surgery","ESP-SPSIP-CABG","Inclusion Criteria:\n\n* Age 45-85 years\n* Scheduled for elective coronary artery bypass graft (CABG) surgery\n* American Society of Anesthesiologists (ASA) I-II-III\n* Patients who provide written informed consent and agree to participate in the study\n\nExclusion Criteria:\n\n* Emergency cases\n* ASA IV-V\n* Known allergy to local anesthetics\n* Coagulopathy (platelet count \\\u003C100,000\u002Fmm³, INR \\>1.5, aPTT \\>1.5× normal)\n* Infection at the block injection site\n* Pregnancy\n* Patients who do not provide written informed consent or decline to participate after being informed","ALL","45 Years","85 Years",{"count":21,"type":22},64,"ESTIMATED","INTERVENTIONAL",[25],"NA","This prospective, randomized, active-controlled, double-blind, parallel-group study compares the postoperative analgesic efficacy and safety of ultrasound-guided bilateral Erector Spinae Plane Block (ESPB) versus bilateral Serratus Posterior Superior Intercostal Plane Block (SPSIPB) in adult patients (45-85 years, ASA I-III) undergoing elective coronary artery bypass graft surgery. The primary outcome is postoperative pain intensity assessed by Numeric Rating Scale (NRS) at 2, 4, 8, 16, 24, and 48 hours after surgery. Secondary outcomes include intraoperative fentanyl\u002Fremifentanil consumption, postoperative morphine consumption, patient-controlled analgesia (PCA) demand\u002Fdelivery parameters (if PCA is used), need for rescue analgesics, extubation and mobilization times, peak inspiratory flow measured by incentive spirometry at predefined time points, ICU and hospital length of stay, recovery quality (QoR-15 at 0, 24, and 48 hours), mortality, and block-related adverse events.",[28,29,30],"Coronary Arterial Disease","Coronary Artery Bypass Grafting (CABG) Surgery","Postoperative Pain Management",[32,33,34,35,36,37,38],"Coronary Artery Bypass Grafting","Erector Spinae Plane Block","Serratus Posterior Superior Intercostal Plane Block","Regional Anesthesia","Ultrasound-Guided Nerve Block","Postoperative Pain","Numeric Rating Scale","RECRUITING","2026-08-04",{"date":42,"type":43},"2026-08-05","ACTUAL",{"date":45,"type":43},"2026-03-01",{"date":47,"type":22},"2026-09-30",{"name":49,"class":50},"Kutahya Health Sciences University","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":17,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":4,"studyType":23,"phases":64,"briefSummary":56,"conditions":67,"keywords":69,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":51},"100649479","phase-2-adductor-canal-block-efficacy-in-postoperative-pain-management-for-cardiac-surgery-100649479","NCT07732465","Adductor Canal Block: Efficacy in Postoperative Pain Management for Cardiac Surgery","Effectiveness of Adductor Canal Block in Postoperative Co-analgesia for Cardiac Surgery With Saphenous Vein Harvesting","AddEase","Inclusion Criteria:\n\n* Planned CABG with unilateral or bilateral great saphenous vein (GSV) harvesting, without concomitant valve surgery\n* Age ≥ 18 years\n* Ability to understand the protocol and provide written informed consent\n* ASA physical status I-IV\n\nExclusion Criteria:\n\n* Refusal to participate in the study or inability to provide written informed consent\n* Contraindication to adductor canal block (e.g., local infection, allergy to local anesthetics)\n* Pre-existing chronic pain associated with chronic use of analgesic medications other than acetaminophen\n* Pre-existing peripheral neuropathy affecting the leg\n* Participation in two other interventional studies at the Montreal Heart Institute\n* Endoscopic vein harvesting performed by the surgical team instead of open saphenectomy technique","18 Years","110 Years",{"count":63,"type":22},120,[65,66],"PHASE2","PHASE3",[29,68],"Saphenectomy",[70,71,72,68,73,74],"Adductor canal block","Numeric Rating Scale (NRS)","Coronary artery bypass grafting (CABG)","Postoperative period","Placebo-controlled","NOT_YET_RECRUITING","2026-07-23",{"date":78,"type":43},"2026-07-29",{"date":80,"type":22},"2026-08-01",{"date":82,"type":22},"2027-12-31",{"name":84,"class":50},"Montreal Heart Institute",{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":91,"eligibilityCriteria":92,"healthyVolunteers":11,"sex":17,"minAge":60,"maxAge":4,"enrollmentInfo":93,"targetDuration":4,"studyType":23,"phases":95,"briefSummary":96,"conditions":97,"keywords":100,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":107,"leadSponsor":109,"locationsCount":51},"100648056","from-prehabilitation-to-rehabilitation-prehab2rehab-digitally-supported-short-term-prehabilitation-prior-to-cardiac-surgery-100648056","NCT07716761","From Prehabilitation to Rehabilitation (Prehab2Rehab): Digitally Supported Short-Term Prehabilitation Prior to Cardiac Surgery","From Prehabilitation to Rehabilitation (Prehab2Rehab): Digitally Supported Short-Term Prehabilitation Prior to Cardiac Surgery - A Prospective Observational Feasibility Trial","Prehab2Rehab","Inclusion Criteria:\n\n\\- Age ≥ 18 years\n\n* Classification as New York Heart Association (NYHA) functional class I-II\n* Low surgical risk profile, defined as a EuroSCORE between 0 and 3\n* Scheduled for one of the following elective cardiac surgical procedures:\n\n  * Open-heart valve surgery\n  * Coronary artery bypass grafting (CABG)\n  * Combined valve surgery and CABG\n  * Surgical closure of an atrial septal defect (ASD)\n* Primary residence in Vienna to ensure the feasibility of in-person assessments and supervised sessions\n* Sufficient German language proficiency to participate in assessments and educational components\n* Adequate digital literacy to engage with the digital support tools used in the intervention\n* Clinical and physical assessment confirming that participation in exercise training is medically safe\n\nExclusion Criteria:\n\n* Emergency, urgent, or otherwise non-elective cardiac surgery\n* Highly complex or specialized surgical procedures (e.g., aortic aneurysm repair, cardiac tumor resections)\n* Interventional cardiac procedures (e.g., transcatheter aortic valve implantation \\[TAVI\\], MitraClip interventions)\n* Neuromotor or physical impairments that might prevent adherence to the study protocol or informed participation\n* Contraindications to spiroergometry according to current guidelines:\n\nAbsolute contraindications:\n\n* Acute coronary syndrome\n* Symptomatic cardiac arrhythmias and\u002For hemodynamic instability\n* Decompensated heart failure\n* Acute pulmonary embolism\n* Acute endocarditis, myocarditis, or pericarditis\n* Febrile infections\n* Acute deep vein thrombosis of the lower extremities\n\nRelative contraindications:\n\n* Left main coronary artery stenosis\n* Electrolyte imbalances\n* Arterial hypertension (\\>160 mmHg systolic)\n* Tachyarrhythmias\n* Hypertrophic obstructive cardiomyopathy (HOCM)\n* High-grade atrioventricular block\n* Anemia\n* Physical or psychological impairments",{"count":94,"type":22},40,[25],"Prehab2Rehab is a prospective single-arm feasibility study evaluating the implementation of a multimodal, digitally supported prehabilitation program for adults awaiting elective cardiac surgery. During the routine preoperative waiting period, participants receive individualized education, psychosocial support, nutritional counselling, home-based physical activity guidance, and digital self-management support. The study aims to determine the feasibility, acceptability, usability, and safety of integrating this multidisciplinary prehabilitation pathway into routine clinical care. Exploratory outcomes include functional capacity, psychological well-being, nutritional status, digital engagement, and selected perioperative clinical outcomes to inform the design of future confirmatory trials.",[29,98,99],"Heart Valve Surgery","Surgical Closure of an Atrial Septal Defect (ASD)",[101,102,103],"prehabilitation","cardiac surgery","outcomes research",{"date":105,"type":43},"2026-07-24",{"date":80,"type":22},{"date":108,"type":22},"2027-10-31",{"name":110,"class":50},"Ludwig Boltzmann Institute for Digital Health and Prevention",{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":117,"eligibilityCriteria":118,"healthyVolunteers":11,"sex":17,"minAge":119,"maxAge":120,"enrollmentInfo":121,"targetDuration":4,"studyType":23,"phases":123,"briefSummary":124,"conditions":125,"keywords":127,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":51},"100620484","impact-of-different-cardioplegia-solutions-on-indicators-of-myocardial-injury-during-coronary-surgery-100620484","NCT07358221","Impact of Different Cardioplegia Solutions on Indicators of Myocardial Injury During Coronary Surgery","Impact of Different Cardioplegia Solutions on Extracellular Vesicles-derived miRNAs, Complement System, and Neutrophil Extracellular Traps (NETs) as Indicators of Myocardial Injury During Coronary Artery Bypass Surgery","Cardioplegia2","Inclusion Criteria:\n\n* All consecutive patients undergoing elective primary coronary artery bypass grafting will be enrolled in this study.\n\nExclusion Criteria:\n\n* Patients will be excluded from this study if they had suffered from previous myocardial infarction, had reduced ejection fraction or were undergoing combined or repeated surgery","40 Years","75 Years",{"count":122,"type":22},30,[25],"The aim of the present study is to investigate intra-operative changes in markers of myocardial injury during ischemia and reperfusion, comparing three methods of myocardial protection; St. Thomas' cold crystalloid cardioplegia, Calafiore warm blood cardioplegia, or modified del Nido cold blood cardioplegia in routine coronary artery bypass grafting procedures.",[29,126],"Myocardial Protection",[128,129,130,131],"coronary surgery","cardioplegia","complement activation","myocardial injury","2026-01-14",{"date":134,"type":43},"2026-01-22",{"date":136,"type":22},"2026-02",{"date":138,"type":22},"2027-02",{"name":140,"class":50},"Damascus University",{"id":142,"slug":143,"hasResults":11,"nctId":144,"briefTitle":145,"officialTitle":146,"acronym":147,"eligibilityCriteria":148,"healthyVolunteers":11,"sex":17,"minAge":60,"maxAge":4,"enrollmentInfo":149,"targetDuration":4,"studyType":23,"phases":151,"briefSummary":152,"conditions":153,"keywords":4,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":51},"100593392","a-study-testing-the-elana-device-for-multi-artery-heart-bypass-surgery-100593392","NCT07005843","A Study Testing the Elana Device for Multi-Artery Heart Bypass Surgery","A Prospective Multicenter Trial to Evaluate the Elana Anastomotic System for Multi-Arterial Coronary Artery Bypass Grafting","MULTI-CAB","Inclusion Criteria:\n\n1. Able and willing to provide voluntary written Informed Consent and sign the Informed Consent Form to participate in the study prior to any study-related procedure,\n2. Is 18 years or older,\n3. Assigned for CABG by the cardiologist and\u002For cardiothoracic surgeon with one or more vessel disease requiring multiple distal anastomoses, including one on the left anterior descending coronary artery (LAD),\n4. Agrees to attend all follow-up assessments for up to 2 years and is willing to comply with specified follow-up evaluations at clinical investigational sites and\u002For obtain all protocol-specified diagnostic tests.\n\nExclusion Criteria:\n\n1. Patient is unlikely to cooperate or is legally incompetent, including patients who are institutionalized by court or official order,\n2. Any condition which could interfere with the patient's ability to comply with the study,\n3. Ongoing participation in any other interventional clinical study,\n4. Female patients who are pregnant or lactating,\n5. Females who are of child-bearing potential and not taking adequate contraceptive precautions are excluded from the trial. Females of child-bearing potential taking acceptable contraceptive precautions can be included, Note: A highly effective method of birth control and one which is acceptable for this study, is defined as one that can achieve a low failure rate (i.e. less than 1% per year) when used consistently and correctly such as implants, injectables, combined oral contraceptives, some intrauterine devices (IUDs), sexual abstinence or vasectomized partner.\n6. History of cardiothoracic surgery,\n7. Active smokers, and smokers who have stopped smoking for less than 1 year,\n8. Patients with left ventricular ejection fraction (LVEF)\\\u003C30%,\n9. Concomitant cardiothoracic procedures (i.e. rhythm, aortic, valve surgery, etc.)\n10. Requires a planned therapeutic, interventional, or surgical procedure within 1 month (30 days) before or after the scheduled index procedure,\n11. Chronic or acute renal failure requiring renal replacement therapy,\n12. Cerebrovascular accident (CVA) or transient ischemic attack (TIA) within 3 months (90 days) prior to scheduled index procedure,\n13. History of bleeding disorders or coagulopathies,\n14. Contraindicated for internal thoracic artery (ITA) harvesting (i.e. obstruction \u002F aortoiliac occlusive disease \u002F radiation therapy at the thoracic region). For additional radial artery harvesting, a negative Allen test is contraindicated,\n15. Need for urgent and\u002For emergent surgery for any reason,\n16. During the operation, patients can still be excluded from the study in accordance to the instructions of use for the Elana Anastomotic System.",{"count":150,"type":22},25,[25],"The purpose of the trial is to evaluate the feasibility and safety of multiple Elana Anastomotic Systems to anastomose multiple arterial grafts during coronary artery bypass grafting (CABG). In the first trial performed with the Elana Anastomotic System, the SAFE-CAB trial, only a single anastomosis with the left internal mammary artery (LIMA) was created with the system to the left anterior descending (LAD) coronary artery or a large Diagonal side-branch of the LAD. This is the most important bypass for patients, often described as the anastomosis that guarantees the survival of patients.\n\nHowever, often multiple anastomoses need to be created during bypass surgery. In the previous study, those anastomoses were performed using vein grafts with standard-of-care hand-sewn techniques. A large body of evidence exists indicating that arterial grafts provide better long-term outcomes for patients undergoing CABG procedures, mainly using the right internal mammary artery (RIMA), but also the Radial Artery, for anastomosis to the Circumflex (Cx) artery and sometimes the Right Coronary Artery. With assurance of safety and effectiveness of the Elena Anastomotic System for LIMA-to-LAD anastomoses and the similarity of the LIMA-to-LAD anastomosis to other arterial anastomoses (e.g., RIMA-to-Cx and RA-to-RCA) as a result of similar vessel diameters and anatomical features, the Elana Anastomotic System is considered to be suitable for multi-arterial bypass procedures.\n\nTherefore, this study aims to expand on the evidence of using the Elana Anastomotic System in a more complete multi-arterial CABG operation, where two or three anastomoses will be created with the Elana Anastomotic System in order to present a more comprehensive solution.",[29],"2025-06-03",{"date":156,"type":43},"2025-06-05",{"date":158,"type":22},"2025-09-30",{"date":160,"type":22},"2028-12-30",{"name":162,"class":163},"AMT Medical BV","INDUSTRY"]