[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"creatine\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:creatine":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,55],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":33,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100651252","the-effects-of-tyrosol-and-creatine-on-exercise-performance-and-cognition-in-healthy-adults-100651252",false,"NCT07756658","The Effects of Tyrosol and Creatine on Exercise Performance and Cognition in Healthy Adults","The Effects of Tyrosol and Creatine on Exercise Performance and Cognition in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Trial","Inclusion Criteria:\n\n* Healthy males aged 20-55\n* Currently active (engaged in moderate to vigorous activity at least 2-days per week as defined by the American College of Sports Medicine Guidelines)\n* Estimated VO2 max greater than the 40th percentile of the population norm for age (assessed via ACSM guidelines, 2014). The VO2 max estimation at screening will be obtained by following a non-exercise regression model validated and described by Bradshaw et al. (2005).\n* Able to read and write in English\n* During the study, agree not to take any other supplements that may increase muscle strength or endurance (e.g. protein formulas, creatine, amino acids, tyrosol or stimulants other than caffeine).\n* During the study, subjects will not deviate from their normal daily routine unless it conflicts with study criteria. This includes maintaining their present workout routine and diet, without substantial changes.\n\nExclusion Criteria:\n\n* Known diagnosis of any cardiovascular, metabolic, endocrine, or renal disease\n* Uncontrolled stage II hypertension or higher\n* Recent musculoskeletal injury (\\\u003C3-months)\n* Recent orthopaedic surgery (\\\u003C12-months)\n* History of or current malignancy\n* Previous gastrointestinal surgery within the past 12 months\n* Regular smoker\n* Regular drinker (\\>14 drinks per week)\n* Current use (within the past 5 weeks) of creatine supplements\n* Current use (within past 3 months) of Tyrosol supplementation\n* Current use of dietary supplements that may enhance mitochondrial function, muscle hypertrophy, or muscle strength (e.g. protein formulas, creatine, amino acids, tyrosol, etc.).\n* Current use of prescription medications that may influence adaptation to exercise (hormone therapies, peptides, etc.)",true,"MALE","20 Years","55 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study will be a randomized, double-blind, placebo-controlled trial. It will be conducted over a 8-week intervention investigating the effects of creatine (5g Creatine monohydrate); placebo control (5g resistant dextrin), and a combination group containing both creatine and tyrosol (5g creatine monohydrate + 150mg tyrosol\u002Fday). Endurance, strength, cognition, and fatigue resistance will be examined through repeated strength and endurance testing (described below).\n\nParticipants who pass initial screening will be invited on-site for day one (Visit 1) of testing where the participants will proceed with a series of tests which will include the following: (1) body composition; (2) mood and cognitive testing; (3) full-body strength testing; (4) 5RM (repetition maximum) bench press, leading to multiple sets of bench press (based on the previous weight) completed to failure; (5) finally, a time to exhaustion endurance test will be conducted followed by (6) repeat cognitive testing.\n\nAfter the 8-week supplementation period (\\~56-60 days), all original measures will be repeated as before in the same order (Visit 2). Approximately 24 hours later (Visit 3) participants will complete a questionnaire for muscle soreness remotely, and again at 48 hours post-Visit 2 (visit 4).",[28,29,30,31,32],"Tyrosol","Creatine","Endurance Performance","Cognition","Mood",[34,35,36,37,38,39,40,41],"tyrosol","creatine","muscle strength","muscle endurance","muscle soreness","muscle performance","cognition","mood","NOT_YET_RECRUITING","2026-08-19",{"date":45,"type":46},"2026-08-21","ACTUAL",{"date":48,"type":22},"2026-08-17",{"date":50,"type":22},"2026-12-17",{"name":52,"class":53},"Applied Science & Performance Institute","INDUSTRY",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":4,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":62,"minAge":63,"maxAge":4,"enrollmentInfo":64,"targetDuration":4,"studyType":23,"phases":66,"briefSummary":67,"conditions":68,"keywords":71,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":48,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":54},"100588956","creatine-and-resistance-training-in-older-adults-with-mild-cognitive-impairment-100588956","NCT06948149","Creatine and Resistance Training in Older Adults With Mild Cognitive Impairment","Examining the Effects of Creatine Supplementation and Resistance Training on Cognition and Brain Health in Older Adults With Mild Cognitive Impairment: a 26 Week Randomized Controlled Trial","We will include participants who: 1) are aged \\>60; 2) are living independently in the community; 3) have normal or corrected-to-normal vision and hearing; 4) read, write, and speak English fluently; 5) are right-handed (if participating in the MRI component); 6) have subjective feelings of memory decline in the past five years; 7) have telephone Montreal Cognitive Assessment (T-MoCA) scores \\\u003C19\u002F22; 8) have high independence, as indicated by Instrumental Activities of Daily Living (IADL) scale \\>6\u002F8; 9) have a Geriatric Depression Scale (GDS) score \\\u003C6\u002F15; 10) are able to exercise at a moderate pace using resistance training for 60 minutes 3x\u002Fweek; and 11) receive clearance from a physician to participate in an exercise program at baseline.\n\nWe will exclude participants who: 1) cannot partake or commit to exercise training 3x\u002Fweek for 26 weeks or have engaged in resistance training \\>1x\u002Fweek over the past three months; 2) cannot partake or commit to consuming a daily supplement for 26 weeks or have consumed nutritional supplements containing creatine monohydrate over the past three months; 3) have a known allergy to creatine monohydrate or dextrose; 4) have been diagnosed with a neurological disorder (e.g., Alzheimer's disease, Parkinson's disease); 5) have pre-existing kidney disease, heart disease, or liver abnormalities; 6) have one or more uncontrolled chronic or psychiatric conditions (e.g., hypertension, diabetes, depression, anxiety); 7) are taking medication that may impact kidney function (e.g., non-steroidal anti-inflammatory drugs, such as ibuprofen and naproxen); or 8) are ineligible or uncomfortable with blood sampling.","ALL","60 Years",{"count":65,"type":22},140,[25],"The goal of this 26-week trial is to learn if creatine supplementation and resistance training (i.e., weightlifting; exercise that increases muscle mass), alone and together, impact cognition, brain health, and physical function in older adults with mild cognitive impairment. Previous studies have shown that resistance training improves cognition and brain health in older adults. Creatine is naturally occurring in the human body and is known to decline with age. Studies have shown that creatine increases muscle mass and bone density in older adults when supplemented. Some research has suggested that creatine may also improve cognition and brain health. However, little is known about how creatine supplementation affects the aging brain and body alone and when combined with resistance training, especially in those with known cognitive impairment.\n\nIn this study, participants will be randomly assigned to one of four groups: 1) creatine and resistance training, 2) placebo and resistance training, 3) creatine and active control (balance and tone classes), or 4) placebo and active control. Participants in the creatine groups will take creatine every day during the study. Participants in the placebo groups will take a look-alike substance that contains no drug every day during the study. Participants in the resistance training groups will attend three 60-minute classes per week that target each major muscle group and will increase in difficulty during the study. Participants in the active control group will attend three 60-minute classes per week that will consist of balance, stretching, and range of motion exercises. This group accounts for variables such as physical training received by traveling to the training centres, social interaction, and changes in lifestyle secondary to study participation.\n\nResearchers will collect information before and after the 26 weeks to see if creatine supplementation and\u002For resistance training have any effects on cognition, brain health, and\u002For physical function. The investigators suspect that both creatine supplementation and resistance training will improve cognition, brain health, and physical function alone. However, it is thought that the combination of creatine supplementation and resistance training will improve cognition, brain health, and physical function more.",[29,69,70],"Exercise","Mild Cognitive Impairment (MCI)",[72,73,40,74,75,76,35,77],"older adults","physical activity","neuroimaging","mobility","mild cognitive impairment","dietary supplementation","RECRUITING",{"date":80,"type":46},"2026-08-20",{"date":82,"type":46},"2026-01-01",{"date":84,"type":22},"2027-12",{"name":86,"class":87},"Western University, Canada","OTHER"]