[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"critical-care-medicine\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:critical-care-medicine":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,52,81,112],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":31,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":4},"100647520","analysis-of-weaning-of-analgosedation-and-kinetics-of-emergence-in-critically-ill-patients-100647520",false,"NCT07710066","Analysis of Weaning of Analgosedation and Kinetics of Emergence in Critically Ill Patients","AWAKE-ICU: Analysis of Weaning of Analgosedation and Kinetics of Emergence in Critically Ill Patients","AWAKE-ICU","Inclusion Criteria:\n\nAdult critically ill patients with acute respiratory failure or requiring invasive mechanical ventilation in the context of critical illness will be consecutively enrolled. Eligible participants must meet all of the following criteria:\n\n* Age ≥18 years.\n* Receiving invasive mechanical ventilation for ≥24 hours.\n* Prior exposure to continuous analgosedation before undergoing a first valid Structured Awakening Evaluation (SAE) during the ICU stay, as defined by the study's operational criteria.\n* Availability of sufficient clinical information to identify the baseline time point (t0) and characterize the first valid Structured Awakening Evaluation according to the study's operational definitions.\n* Provision of informed consent for participation in the study.\n\nExclusion Criteria:\n\n1. Acute primary structural brain injury in which the level of consciousness is primarily determined by the neurological condition or constitutes a therapeutic target, including but not limited to:\n\n   * Moderate or severe traumatic brain injury.\n   * Subarachnoid hemorrhage.\n   * Ischemic or hemorrhagic stroke.\n   * Central nervous system infections.\n   * Other structural brain injuries requiring therapeutic sedation or goal-directed intensive neurological monitoring.\n2. Ongoing therapeutic sedation for neurological indications at the time of the first valid Structured Awakening Evaluation (SAE), including:\n\n   * Intracranial hypertension management.\n   * Status epilepticus.\n   * Other neuroprotective strategies requiring deep sedation.\n3. ICU admission following cardiac arrest with return of spontaneous circulation and suspected hypoxic-ischemic brain injury or the need for targeted therapeutic sedation.\n4. Insufficient clinical information to accurately identify the baseline time point (t0) and characterize the architecture of the first valid Structured Awakening Evaluation.\n5. Patients receiving extracorporeal life support (ECLS\u002FECMO), in whom assessment of hemodynamic and respiratory stability before initiation of awakening and liberation from invasive mechanical ventilation is substantially more complex.","ALL","18 Years",{"count":20,"type":21},500,"ESTIMATED","OBSERVATIONAL","The goal of this prospective multicenter observational study is to characterize early trajectories of consciousness recovery following the first valid structured awakening trial in mechanically ventilated critically ill adults, a phase that is not captured by current weaning classifications.\n\nThe main questions it aims to answer are:\n\n1. What trajectories of consciousness recovery occur during the first 72 hours after the first valid structured awakening trial?\n2. Are different early consciousness trajectories associated with clinically relevant outcomes, including successful liberation from mechanical ventilation, delirium, duration of mechanical ventilation, ventilator-free days, mortality, and long-term functional and cognitive outcomes?\n\nParticipants will:\n\n1. Undergo standardized serial assessments of consciousness during the first 72 hours after the first valid structured awakening trial using the Richmond Agitation-Sedation Scale (RASS) and a standardized motor command assessment.\n2. Receive daily assessments for delirium and weaning-related outcomes during the ICU stay.\n3. Be followed for clinical outcomes during hospitalization and for functional and cognitive recovery up to 1 year after ICU admission.",[25,26,27,28,29,30],"Critical Illness","Mechanical Ventilation","Weaning Invasive Mechanical Ventilation","Sedation and Analgesia","Critical Care Medicine","Delirium",[32,33,34,26,35,36,37,38,39],"Emergence from Analgosedation","Structured Awakening Evaluation","Recovery of Consciousness","Richmond Agitation-Sedation Scale (RASS)","Motor Command Assessment","Consciousness Trajectories","Mechanical Ventilation Weaning","Delayed Awakening","NOT_YET_RECRUITING","2026-07-16",{"date":43,"type":44},"2026-07-17","ACTUAL",{"date":46,"type":21},"2026-09-01",{"date":48,"type":21},"2028-09-01",{"name":50,"class":51},"Patricia Rodriguez Villamizar","OTHER",{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":61,"conditions":62,"keywords":66,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":80},"100632214","up-study---decipher-persistent-critical-illness-through-in-deep-clinical-phenotyping-100632214","NCT07510776","UP STUDY - Decipher Persistent Critical Illness Through in Deep Clinical Phenotyping.","UPSt_UCI","Inclusion Criteria:\n\n* Adult patients aged 18 years or older;\n* ICU length of stay equal to or greater than 5 days.\n\nExclusion Criteria:\n\n* Patients with an ICU stay \\\u003C 5 days;\n* Patients discharged from the ICU early due to lack of ward availability, rather than clinical recovery;\n* Patients who do not survive the early phase of critical illness (i.e., early ICU deaths).",{"count":60,"type":21},7000,"Persistent Critical Illness (PCI) is a condition that affects some patients who remain in the Intensive Care Unit (ICU) for a long time, usually more than 10-14 days. It is estimated to occur in 5-20% of critically ill patients. A recent Portuguese study found that more than 14% of ICU patients stayed longer than 14 days. PCI is often associated with ongoing need for life support, such as mechanical ventilation or medications to maintain blood pressure. However, patients may also experience severe muscle weakness, repeated infections, or other complications, which makes this group very diverse.\n\nOne of the main risk factors for prolonged ICU stay is sepsis, a severe infection that affects the whole body. Other factors-such as prior health conditions, use of corticosteroids, sedation practices, early versus late mobilization, fluid and antibiotic management, and delirium treatment-may also influence the development and course of PCI.\n\nThis study aims to identify different clinical patterns (\"clusters\") among critically ill patients who remain in the ICU for more than 10 days. Patients will be followed until hospital discharge, and up to one year if data are available. Understanding these different patterns will help develop more personalized and effective care strategies for each patient profile.\n\nThe study is a multicenter retrospective cohort including adult patients (≥18 years) admitted to participating ICUs for more than 5 days between 2021 and 2023. Data collected will include demographic, clinical, and laboratory information, details of organ support (such as mechanical ventilation or vasopressors), medications, nutrition, and rehabilitation practices.\n\nStatistical and machine learning methods will be used to identify groups of patients with similar clinical trajectories and to assess how these groups are related to outcomes such as survival, recovery of organ function, or long-term disability.\n\nExpected results are the identification of distinct clinical clusters of PCI that combine clinical and laboratory data, and the development of tailored management strategies to improve recovery and outcomes for patients with PCI.",[25,63,64,65,29],"Recovery Outcomes","Critical Care, Intensive Care","Critical Care",[67,68,25],"Persistant Critical Illness","Critical care","RECRUITING","2026-04-08",{"date":72,"type":44},"2026-04-13",{"date":74,"type":44},"2025-01-13",{"date":76,"type":21},"2027-12-31",{"name":78,"class":79},"Lisbon Academic Medical Center - Centro Académico de Medicina de Lisboa","NETWORK",7,{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":17,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":92,"studyType":22,"phases":4,"briefSummary":93,"conditions":94,"keywords":97,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":111},"100598343","pediatric-intensive-care-transport-registry-100598343","NCT07070258","Pediatric Intensive Care Transport Registry","PIT Registry","Inclusion Criteria:\n\n* Critically ill children aged at least 27 days and a corrected gestational age of over 41 weeks AND\n* Maximum age of 17 years AND\n* Interhospital transport AND\n* Critical care transport by a dedicated critical care transport team using an intensive care ambulance (Type C vehicle) or an air ambulance OR\n* The transport was accompanied by a specialist in intensive care or emergency medicine. OR\n* The in-hospital destination of the transport is a critical care area, such as an intensive care unit, a trauma room, a resuscitation area, an operating theatre, an emergency imaging procedure or an emergency intervention.","27 Days","17 Years",{"count":91,"type":21},1000,"1 Day","The aim is to establish a nationwide registry for pediatric intensive care transports in Germany. The project aims to describe and analyse the need for, and current practice of, specialised transports. These data could then be used for future demand planning.",[29,95,96],"Transportation of Patients","Pediatrics",[98,99,100,101],"intensive care transport","critical care transport","pediatrics","registry","2025-07-16",{"date":104,"type":44},"2025-07-20",{"date":106,"type":44},"2024-11-25",{"date":108,"type":21},"2029-12-31",{"name":110,"class":51},"Philipps University Marburg",2,{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":116,"acronym":117,"eligibilityCriteria":118,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":119,"targetDuration":4,"studyType":121,"phases":122,"briefSummary":124,"conditions":125,"keywords":128,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":142},"100581954","evaluating-the-clinical-effectiveness-of-endotracheal-tube-position-anomaly-alerting-system-100581954","NCT06857019","Evaluating the Clinical Effectiveness of \"Endotracheal Tube Position Anomaly Alerting System\"","ETPAAS-1","Inclusion Criteria:\n\n* Patients admitted to the intensive care unit\n* At least 18 years old\n\nExclusion Criteria:\n\n* Patients disagree to participate in the study",{"count":120,"type":21},200,"INTERVENTIONAL",[123],"NA","The goal of this clinical trial is to determine whether the Endotracheal Tube Position Anomaly Alerting System (ETPAAS) effectively reduces the duration of endotracheal tube malposition in patients admitted to the intensive care unit (ICU). Additionally, the study will assess the clinical impact, usability, and user satisfaction of ETPAAS.\n\nThe main questions it aims to answer are:\n\n* Does ETPAAS reduce the duration of endotracheal tube malposition?\n* What are healthcare workers' perspectives on the usability and satisfaction of ETPAAS?\n\nParticipants will receive standard care, with or without ETPAAS, in the intensive care unit.\n\nResearchers will evaluate the duration of endotracheal tube malposition. Healthcare workers will complete a questionnaire assessing the usability and satisfaction of ETPAAS.",[29,26,126,127],"Radiographic Image Interpretation, Computer-Assisted","Alarms",[129,130,131,132],"Chest X-ray","Chest radiograph","Endotracheal tube","Intubation, Intratracheal","2025-02-26",{"date":135,"type":44},"2025-03-04",{"date":137,"type":21},"2025-02-24",{"date":139,"type":21},"2025-12-31",{"name":141,"class":51},"Kaohsiung Medical University Chung-Ho Memorial Hospital",1]