[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"csa-aki\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:csa-aki":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":5},"100655507","discovery-and-validation-of-biomarkers-for-csa-aki-risk-prediction-100655507",false,"NCT07811570","Discovery and Validation of Biomarkers for CSA-AKI Risk Prediction","Early Prediction and Diagnosis of CSA-AKI","Inclusion Criteria:\n\n* 1\\. Age no less than 18 years old;\n* 2\\. Scheduled cardiovascular surgery is proposed;\n* 3\\. Pre-angiography and preoperative serum creatinine \\\u003C354 μ mol\u002FL;\n* 4\\. Informed consent.\n\nExclusion Criteria:\n\n* 1\\. Women who have a pregnancy plan within one year, are pregnant, or are breastfeeding;\n* 2\\. Patients who have severe side effects such as allergies to iodine contrast agents;\n* 3\\. Patients with hyperthyroidism;\n* 4\\. Those who had AKI before the contrast agent or within 2 weeks before the operation, or whose AKI has not been relieved after the operation;\n* 5\\. Patients undergoing kidney transplantation, peritoneal dialysis, or hemodialysis treatment;\n* 6\\. Patients with malignant tumors or those with an expected lifespan of less than 12 months;\n* 7\\. Angiography or preoperative acute heart failure;\n* 8\\. Patients who have a history of massive hemorrhage in the past 30 days or have contraindications to anticoagulant therapy.","ALL","18 Years",{"count":19,"type":20},1500,"ESTIMATED","OBSERVATIONAL","This study aims to discover and validate new biomarkers for predicting CSA-AKI before cardiovascular surgery.\n\nNested case-control studies embedded in prospective cohorts. Adult patients scheduled for cardiovascular surgery were continuously included. Blood\u002Furine\u002Fstool samples and clinical data before and after contrast agent exposure and before and after cardiovascular surgery were collected, and the occurrence, progression and outcome of CSA-AKI events were dynamically monitored. Based on the exposure to contrast agents and the occurrence of CSA-AKI, two case-controls were constructed in the prospective cohort. In the construction of two case-controls, biomarkers were identified and validated by using multi-omics analysis techniques and machine learning techniques, etc.",[24,25,26,27],"CSA-AKI","Acute Kidney Injury","Cardiovascular Surgery","Biomarkers","RECRUITING","2026-09-09",{"date":31,"type":32},"2026-09-10","ACTUAL",{"date":34,"type":32},"2026-03-01",{"date":36,"type":20},"2027-06-30",{"name":38,"class":39},"China National Center for Cardiovascular Diseases","OTHER_GOV"]