[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cue-reactivity\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cue-reactivity":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100652678","closed-loop-tbs-targeting-rpo-for-the-core-clinical-features-of-the-methamphetamine-use-disorder-100652678",false,"NCT07775807","Closed-loop TBS Targeting rPO for the Core Clinical Features of the Methamphetamine Use Disorder","A Pilot Single-Arm Study of Closed-Loop TBS Theta-Burst Stimulation Targeting the Right Parietal-Occipital Cortex for Core Clinical Features of Methamphetamine Use Disorder","Inclusion Criteria:\n\n* Aged 18 years old or older, ....with at least 9 years of education (junior high school or above) or able to fully understand the task.\n* Meets DSM-5 for mild\u002Fsevere amphetamine-type substance use disorder.\n* History of amphetamine-type substance use for no less than 1 year, with use at least once per week.\n* Has not received pharmacological treatment for substance use.\n\nExclusion Criteria:\n\n* Presence of any organic disease, or diagnosis of any other psychiatric disorder according to DSM-5 (e.g., bipolar disorder, major depression disorder).\n* Contraindications to TMS, as assessed by the Transcranial Magnetic Stimulation Adult Safety Screen (TASS).\n* Inability to complete assessments, treatment procedures, or follow-up due to cognitive or behavioral limitations.","ALL","18 Years",{"count":19,"type":20},5,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this clinical trial is to evaluate whether closed-loop theta-burst stimulation (TBS) targeting the right parietal-occipital cortex (rPO) can improve core clinical symptoms in individuals with methamphetamine use disorder (MUD), such as cue-reactivity and impaired inhibitory control.\n\nThe main questions it aims to answer are:\n\nCan closed-loop rPO-TBS significantly reduce cue-reactivity, as measured by a Visual Analog Scale (VAS) and a cue-reactivity task? Does closed-loop stimulation enhance cognitive control, assessed by performance on the Stop Signal Task (SST)?\n\nResearchers will administer closed loop TBS to determine whether it can improve the core symptoms of MUD.\n\nParticipants will:\n\nComplete a single closed-loop sessions. Receive theta-burst stimulation targeting the right parietal-occipital cortex while complete the cue-reactivity task.\n\nUndergo cue-reactivity assessment using a Visual Analog Scale (VAS) and complete the Stop Signal Task (SST) before and after the stimulation session.",[26,27,28,29],"Methamphetamine Use Disorder","Substance Use Disorder","Cue-reactivity","Craving","NOT_YET_RECRUITING","2026-08-16",{"date":33,"type":34},"2026-08-20","ACTUAL",{"date":36,"type":20},"2026-08",{"date":38,"type":20},"2026-12",{"name":40,"class":41},"Shanghai Mental Health Center","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":21,"phases":52,"briefSummary":53,"conditions":54,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":55,"startDateStruct":57,"completionDateStruct":58,"leadSponsor":59,"locationsCount":42},"100604795","trial-of-device-that-is-not-approved-or-cleared-by-the-us-fda-100604795","NCT07154160","Closed-loop TMS for the Core Clinical Features of the Methamphetamine Use Disorder","A Single-blind, Randomized, Parallel Study of Closed-loop, Conventional and Random TMS for Core Clinical Features of Methamphetamine Use Disorder.","Inclusion Criteria:\n\nAged 18 years old or older, ....with at least 9 years of education (junior high school or above) or able to fully understand the task.\n\nMeets DSM-5 for mild\u002Fsevere amphetamine-type substance use disorder. History of amphetamine-type substance use for no less than 1 year, with use at least once per week.\n\nHas not received pharmacological treatment for substance use.\n\nExclusion Criteria:\n\nPresence of any organic disease, or diagnosis of any other psychiatric disorder according to DSM-5 (e.g., bipolar disorder, major depression disorder).\n\nContraindications to TMS, as assessed by the Transcranial Magnetic Stimulation Adult Safety Screen (TASS).\n\nInability to complete assessments, treatment procedures, or follow-up due to cognitive or behavioral limitations.",{"count":51,"type":20},21,[23],"The goal of this clinical trial is to evaluate whether closed-loop transcranial magnetic stimulation (TMS) can improve core clinical symptoms in individuals with methamphetamine use disorder (MUD), such as cue-reactivity and impaired inhibitory control.\n\nThe main questions it aims to answer are:\n\nCan closed-loop TMS significantly reduce cue-reactivity, as measured by a Visual Analog Scale (VAS) and cue-reactivity task, compared to a conventional treatment protocol and random TMS ? Does closed-loop stimulation enhance cognitive control, assessed by performance on the Stop Signal Task (SST), more effectively than the other stimulation modes? Researchers will compare closed-loop, conventional, and random TMS conditions to determine whether closed-loop yields superior symptom improvement.\n\nParticipants will:\n\nBe randomly assigned to one of the three stimulation group (closed-loop, conventional and random) according to a pre generated random number table, and receive the corresponding stimulation session.\n\nUndergo cue-reactivity assessment using VAS and cue-reactivity task, and complete the SST before and after each stimulation session.",[26,27,28,29],{"date":56,"type":34},"2026-08-19",{"date":36,"type":20},{"date":38,"type":20},{"name":40,"class":41}]