[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cup\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cup":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,40],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":4},"100647772","living-without-answers---illuminate-cup-100647772",false,"NCT07712965","Living Without Answers - ILLUMINATE CUP","Illuminating the Lived Experience: Listening, Understanding and Meaning-makIng - A Narrative Analysis of the Diagnosis, Treatment and Experience of Cancer of Unknown Primary","ILLUMINATE CUP","Inclusion Criteria:\n\n* have a confirmed diagnosis of cancer of unknown primary, or care for someone who has a diagnosis of cancer of unknown primary\n* are 18 years old and above\n* have capacity to provide informed consent\n\nExclusion Criteria:\n\n* do not have capacity to provide informed consent\n* are deemed too unwell by the clinical team to take part in the research","ALL","18 Years",{"count":20,"type":21},20,"ESTIMATED","OBSERVATIONAL","This project aims to improve care, service delivery, and patient experience for people with Cancer of Unknown Primary (CUP) by addressing a critical gap in understanding the lived experiences of patients and carers. By exploring how individuals navigate diagnostic uncertainty, fragmented care pathways, and interactions with healthcare professionals, the study will identify key points of distress, unmet need, and communication breakdown.\n\nThe findings will support the development of more person-centred and compassionate care, including clearer communication, improved service coordination, and better recognition of the psychological and emotional impact of CUP. By highlighting the challenges of uncertainty and lack of diagnostic clarity, the project will inform more tailored support for both patients and carers.\n\nA unique strength of this study is the inclusion of a professional illustrator to visually capture focus group discussions, supporting the narrative inquiry approach and aiding the interpretation of shared meanings within the data. These visual summaries will enhance engagement, inclusivity, and accessibility, ensuring that complex experiences are communicated clearly to patients, carers, clinicians, and wider audiences.\n\nThrough strong PPIE involvement and accessible dissemination, patient and carer voices will directly inform service improvements and future care design.\n\nOverall, this project will help ensure CUP care is more coordinated, communicative, inclusive, and responsive to patient and carer needs, ultimately improving experience, wellbeing, and trust in healthcare services.",[25,26,27],"Cancer","CUP","Cancer Unknown Primary","NOT_YET_RECRUITING","2026-07-13",{"date":31,"type":32},"2026-07-20","ACTUAL",{"date":34,"type":21},"2026-09-01",{"date":36,"type":21},"2028-09-01",{"name":38,"class":39},"The Clatterbridge Cancer Centre NHS Foundation Trust","OTHER",{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":47,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":49,"conditions":50,"keywords":52,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":4},"100617540","evaluating-the-predictive-capability-of-transcriptomic-profiling-for-identifying-the-primary-site-of-metastatic-tumors-100617540","NCT07319949","Evaluating the Predictive Capability of Transcriptomic Profiling for Identifying the Primary Site of Metastatic Tumors","Evaluative Study on Predicting the Primary Site of Metastatic Tumors Using Transcriptomic Profiling for Tumor Tissue Origin Identification","Inclusion Criteria\n\n1. Clinically confirmed diagnosis of malignant tumor with metastasis;\n2. Metastatic lesions confirmed as malignant by histopathology;\n3. Sufficient surgical resection or biopsy specimens retained to meet the requirements for next-generation sequencing;\n4. The participant (or their legal representative\u002Fguardian) has signed the informed consent form, confirming full understanding of the study's purpose and procedures, and voluntarily agrees to participate.\n\nExclusion Criteria:\n\n1\\. The investigator deems the patient unable to provide informed consent.",{"count":48,"type":21},30,"This study will enroll patients with metastatic malignancies. Tumor samples (fresh or formalin-fixed paraffin-embedded tissue specimens) will undergo RNA extraction and next-generation sequencing (RNA-seq). Once the raw data is obtained, the system will analyze the transcriptomic feature values (cancer-specific RNA transcripts and tissue-specific RNA transcripts) expressed in the tumor tissue samples to further predict tissue origin using a machine learning model. The output includes probabilities and confidence intervals for tissue origin.",[51,26],"Malignant Tumor With Metastasis",[53,54,55,56,57],"Cancer of unknown primary","Specific RNA transcript","Tissue origin identification","Machine learning","Cancer diagnosis","2025-12-20",{"date":60,"type":32},"2026-01-06",{"date":62,"type":21},"2026-01-15",{"date":64,"type":21},"2026-10-13",{"name":66,"class":39},"Fudan University"]