[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"deep-infiltrating-endometriosis-die\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:deep-infiltrating-endometriosis-die":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,50,86],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100646122","phase-4-ultra-long-gnrh-a-pretreatment-for-fet-outcomes-in-patients-with-deep-infiltrating-endometriosis-100646122",false,"NCT07696351","Ultra-Long GnRH-a Pretreatment for FET Outcomes in Patients With Deep Infiltrating Endometriosis","A Randomized Controlled Study of Ultra-Long GnRH-a Pretreatment to Improve Frozen-Thawed Embryo Transfer Outcomes in Patients With Deep Infiltrating Endometriosis","DIE-GnRHa-FET","Inclusion Criteria:\n\n1. Female patients aged 18 to 39 years.\n2. Diagnosed with deep infiltrating endometriosis by ultrasound at the study center.\n3. Undergoing the first frozen-thawed embryo transfer cycle with hormone replacement therapy for endometrial preparation.\n4. Having at least one good-quality frozen embryo.\n5. Willing to participate in this randomized controlled study of GnRH-a pretreatment for deep infiltrating endometriosis and able to personally sign the written informed consent form.\n\nExclusion Criteria:\n\n1. Abnormal chromosomal karyotype.\n2. Other uterine diseases or conditions that may affect uterine cavity morphology or pregnancy outcomes, including intrauterine adhesions affecting the uterine cavity, intramural uterine fibroids, moderate to severe adenomyosis, congenital uterine malformation, endometrial tuberculosis, or endometrial thickness less than 8 mm on the transformation day.\n3. Recurrent implantation failure.\n4. Contraindications to hormone replacement therapy or long-acting GnRH-a treatment.\n5. Osteoporosis or depressed mood.\n6. Currently participating in another clinical study.\n7. Unable to adhere to study visits and follow-up, or planning to receive other treatment during the follow-up period.","FEMALE","18 Years","39 Years",{"count":21,"type":22},120,"ESTIMATED","INTERVENTIONAL",[25],"PHASE4","Deep infiltrating endometriosis is a severe form of endometriosis that may reduce fertility and negatively affect pregnancy outcomes after assisted reproductive treatment. Gonadotropin-releasing hormone agonist pretreatment may suppress endometriotic lesions, reduce inflammation, and improve endometrial receptivity, but its benefit before frozen-thawed embryo transfer remains uncertain.\n\nThis randomized controlled study will evaluate whether ultra-long GnRH-a pretreatment before hormone replacement therapy improves clinical pregnancy outcomes in patients with deep infiltrating endometriosis undergoing their first frozen-thawed embryo transfer cycle. Eligible participants will be randomly assigned to either the GnRH-a pretreatment group or the control group. Participants in the GnRH-a group will receive two injections of long-acting GnRH-a before hormone replacement therapy for endometrial preparation, while participants in the control group will receive routine hormone replacement therapy alone.\n\nThe primary outcome is clinical pregnancy rate, defined as the presence of a gestational sac on transvaginal ultrasound 30 ± 3 days after embryo transfer. Secondary outcomes include implantation rate, ectopic pregnancy rate, early spontaneous abortion rate, ongoing pregnancy rate at 12 weeks of gestation, and delivery rate. Safety will be evaluated by recording adverse events after GnRH-a injection. The planned enrollment is 120 participants.",[28,29],"Deep Infiltrating Endometriosis (DIE)","Infertility",[31,32,33,34,35,36,29],"Deep infiltrating endometriosis","GnRH-a","Triptorelin","Frozen-thawed embryo transfer","Hormone replacement therapy","Clinical pregnancy rate","RECRUITING","2026-07-06",{"date":40,"type":41},"2026-07-10","ACTUAL",{"date":43,"type":41},"2025-08-01",{"date":45,"type":22},"2027-07-31",{"name":47,"class":48},"Li-jun Ding","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":60,"conditions":61,"keywords":70,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":49},"100604083","phase-4-assessing-the-efficacy-of-indocyanine-green-for-ureter-identification-during-robot-assisted-surgery-in-advanced-stage-endometriosis-100604083","NCT07144904","Assessing the Efficacy of Indocyanine Green for Ureter Identification During Robot-Assisted Surgery in Advanced-Stage Endometriosis","A Side-Randomized, Self-Controlled Trial Assessing the Efficacy of Indocyanine Green Fluorescence Imaging for Intraoperative Ureter Identification During Robot-Assisted Single-Site Surgery in Advanced-Stage Endometriosis","Inclusion Criteria:\n\n* Stage III or IV endometriosis (rASRM classification)\n* Planned robotic transabdominal endometriosis excision with or without hysterectomy.\n\nExclusion Criteria:\n\n\\- Subjects who are part of a vulnerable population will be excluded including those who are prisoners, younger than 18 years old, pregnant, individuals with mental disabilities or cognitive impairment.",{"count":58,"type":22},40,[25],"The goal of this side-randomized, self-controlled trial, 1-site study is to explore the efficacy of Indocyanine Green Fluorescence (ICG) for Intraoperative Ureter Identification During Robot-Assisted Single-Site Surgery in Advanced-Stage Endometriosis.\n\nResearchers will perform temporary ureteral stent using indocyanine green fluorescence for intraoperative ureteral identification on either the left or right side of subjects who are undergoing a robotic assisted transumbilical resection of advanced endometriosis.\n\nParticipants will be randomized to receive ICG-assisted ureteral identification on either the left or right side. Randomization will be conducted using a computer-generated block randomization method.\n\nThe primary aim is to determine whether ICG-assisted ureter visualization can reduce operative time for endometriosis resection and ureterolysis, and minimize the risk of ureteral injury.\n\nSecondary objectives are to assess the feasibility and safety of temporary ureteral ICG stenting for intraoperative ureter identification in advanced endometriosis.",[62,63,28,64,65,66,67,68,69],"Indocyanine Green (ICG)","Robotic Surgical Procedure","Endometriosis Pelvic","Endometriosis (Diagnosis)","Endometriosis of the Cul-de-sac","Ureteral Stent Placement","Ureteral Injury","Endometriosis Ovaries",[71,72,73,74,75],"ureteral stent placement","indocyanine green","endometriosis","robotic surgery","ureteral identification","NOT_YET_RECRUITING","2025-08-20",{"date":79,"type":41},"2025-08-28",{"date":81,"type":22},"2025-10-01",{"date":83,"type":22},"2026-03-15",{"name":85,"class":48},"Baylor College of Medicine",{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":90,"acronym":91,"eligibilityCriteria":92,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":93,"enrollmentInfo":94,"targetDuration":4,"studyType":23,"phases":96,"briefSummary":98,"conditions":99,"keywords":103,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":49},"100575765","evaluation-of-rectal-infiltration-depth-and-length-in-bowel-involvement-of-deep-infiltrative-endometriosis-die-using-intraoperative-transrectal-ultrasound-trus-100575765","NCT06776536","Evaluation of Rectal Infiltration Depth and Length in Bowel Involvement of Deep Infiltrative Endometriosis (DIE) Using Intraoperative Transrectal Ultrasound (TRUS)","DIE IO TRUS","Inclusion Criteria:\n\n* The study will include a minimum of 15 female patients aged 18-55 with bowel involvement due to deep infiltrative endometriosis, requiring bowel resection.\n\nExclusion Criteria:\n\nPatients with bowel endometriosis who does not require bowel resection, patients who have other bowel diseases, such as rectal tumors, Crohn's disease, or ulcerative colitis, will be excluded.\n\n\\-","55 Years",{"count":95,"type":22},15,[97],"NA","we aim to evaluate the success of intraoperative transrectal ultrasound in measuring the depth and extent of bowel involvement in patients preoperatively diagnosed with intestinal endometriosis using transvaginal ultrasound and MRI, and who are planned for bowel resection",[28,100,101,102],"Transrectal Ultrasound","Bowel Endometriosis","Bowel Resection",[104,105,106,107],"Deeply infiltrating endometriosis","bowel endometriosis","transrectal ultrasound","bowel resection","2025-01-10",{"date":110,"type":41},"2025-01-15",{"date":112,"type":22},"2025-01-07",{"date":114,"type":22},"2026-04-07",{"name":116,"class":117},"Başakşehir Çam & Sakura City Hospital","OTHER_GOV"]