[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"degenerative-spine-disease\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:degenerative-spine-disease":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":5},"100652667","vr-cognitive-behavioral-therapy-prehabilitation-for-spinal-deformity-surgery-100652667",false,"NCT07777679","VR-Cognitive Behavioral Therapy Prehabilitation for Spinal Deformity Surgery","A Randomized Controlled Pilot Trial Evaluating Virtual Reality-Based Cognitive Behavioral Therapy (VR-CBT) as a Prehabilitation Intervention for Adult Spinal Deformity Surgery","VR-CBT","Inclusion Criteria:\n\n* Adults between 18 and 75 years old.\n\nDiagnosis of thoracolumbar adult spinal deformity (ASD), including but not limited to adult scoliosis, kyphosis, or spondylolisthesis, confirmed radiographically using SRS-Schwab classification criteria.\n\nScheduled for elective spinal surgery involving fusion of more than four spinal levels.\n\nModerate to severe chronic pain, assessed using the Visual Analog Scale (VAS) or Numeric Rating Scale (NRS).\n\nAbility to participate in an 8-week preoperative prehabilitation program.\n\nAdequate cognitive functioning and English language skills to engage in CBT or VR-CBT treatments.\n\nAbility to provide written informed consent and adhere to study procedures and follow-up visits.\n\nExclusion Criteria:\n\n* Neurological conditions that significantly impact cognition or mobility.\n\nActive spinal infection, malignancy, or significant spinal trauma.\n\nUnmanaged medical conditions that could affect participation in the study.\n\nPregnancy or plans to become pregnant during the study period.\n\nSevere visual impairment, claustrophobia, or other conditions that prevent safe use of VR technology.\n\nCognitive impairment preventing adherence to study procedures.\n\nHistory of non-compliance with medical treatment or failure to adhere to study visits and follow-up.","ALL","18 Years","75 Years",{"count":21,"type":22},80,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to learn whether a virtual reality-based cognitive behavioral therapy (VR-CBT) prehabilitation program can improve recovery and quality of life for adults undergoing elective spine surgery. The main questions it aims to answer are:\n\nDoes participating in an 8-week VR-CBT prehabilitation program before surgery improve physical function and pain-related outcomes at 12 months after surgery?\n\nDoes VR-CBT prehabilitation reduce postoperative anxiety, depression, and pain interference compared with usual preoperative care?\n\nResearchers will compare participants who receive the VR-CBT prehabilitation program plus usual care to participants who receive usual preoperative care alone to see if the VR-CBT program leads to better recovery and patient-reported outcomes.\n\nParticipants will:\n\nUse a VR headset at home to complete structured CBT-based prehabilitation sessions over 8 weeks before surgery.\n\nAttend routine clinic visits and complete questionnaires about pain, function, mood, and quality of life before surgery and through 12 months after surgery.\n\nAllow the research team to review their medical records for information about surgery, complications, and postoperative recovery.",[28,29],"Degenerative Spine Disease","Spinal Stenosis Lumbar",[31,32,33],"Virtual reality-based cognitive behavioral therapy","Patient-reported outcomes","Spine surgery prehabilitation","NOT_YET_RECRUITING","2026-08-17",{"date":37,"type":38},"2026-08-20","ACTUAL",{"date":40,"type":22},"2026-09-01",{"date":42,"type":22},"2028-11-28",{"name":44,"class":45},"University of California, Irvine","OTHER",{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":23,"phases":55,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":69},"100597482","fibergraft-aeridyan-posterolateral-fusion-study-100597482","NCT07059065","FIBERGRAFT Aeridyan Posterolateral Fusion Study","A Post-market, Prospective, Controlled, Multicenter Clinical Study to Evaluate Radiographic Fusion of FIBERGRAFT™ Aeridyan Matrix Bone Graft Substitute in Subjects Who Undergo a Lumbar Posterolateral Fusion Surgery","INCLUSION CRITERIA\n\n1. Subjects who require a 1-3 level instrumented PLF fusion in the lumbar spine in conjunction with a 1 to 2 consecutive level posterior lumbar interbody fusion procedure between L1-S1.\n2. Skeletally mature subjects at least 18 years of age at the time of consenting.\n3. Willing to provide voluntary written informed consent prior to participation in the clinical study.\n\nEXCLUSION CRITERIA\n\n1. Subjects who had previous fusion surgery at the index level(s).\n2. Requiring a Posterolateral Fusion in the lumbar spine at more than three levels and\u002For an interbody fusion at more than two levels\n3. Subjects who have demonstrated allergy or foreign body sensitivity to the implant or graft material.\n4. Pregnant subjects or planning to become pregnant within the next 24 months.\n5. Subjects diagnosed with severe osteoporosis which may prevent adequate fixation and thus preclude the use of these or any other orthopedic implant.\n6. Subjects diagnosed with severe instabilities, vertebral fractures, spinal tumors.\n7. Subjects who have an uncontrolled systemic or metabolic disease which, in the Investigator's opinion, would compromise their health, safety, or ability to participate or follow-up in this clinical study.\n8. Subjects requiring use of an implantable bone graft stimulator or external bone graft stimulator.\n9. Subjects that have infection or osteomyelitis at the graft site. Any medical or surgical condition that precludes the potential benefit of spinal surgery, in the opinion of the Investigator.\n10. Any medical or surgical condition that precludes the potential benefit of spinal surgery, in the opinion of the Investigator.\n11. Dependency on pharmaceutical drugs, drug abuse, or alcoholism resulting in a lack of subject cooperation.\n12. Subjects unable to comply, and\u002For in the Investigator's opinion unable to comply, with the requirements of participation in the clinical study.\n13. Enhanced Demineralized Bone Matrix product for the grafting control used within the posterolateral spine\n14. Use of Bone Morphogenetic Protein (BMP) grafting material within the interbody cage(s).\n15. Body Mass Index (BMI) ≥ 45\n16. Unilateral posterior instrumentation\n17. Subject is currently involved in a workers' compensation claim.\n18. Subject has participated in an interventional clinical trial within the last 6 months or plans to participate in an interventional clinical trial within the next 24 months.",{"count":54,"type":22},316,[25],"This is a post-market, prospective, controlled, multicenter clinical study to evaluate radiographic fusion and clinical outcomes of FIBERGRAFT™ Aeridyan Matrix bone graft substitute in subjects who undergo a 1-3 level instrumented lumbar posterolateral fusion surgery. This clinical study will be conducted at up to 10 clinical sites within the United States.",[28],"RECRUITING","2026-07-02",{"date":61,"type":38},"2026-07-06",{"date":63,"type":38},"2025-08-15",{"date":65,"type":22},"2029-07-31",{"name":67,"class":68},"DePuy Synthes Products, Inc.","INDUSTRY",8]