[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"delirium-prevention\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:delirium-prevention":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,49],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100659656","dexmedetomidine-for-prevention-of-delirium-after-hip-fracture-surgery-100659656",false,"NCT07867899","Dexmedetomidine for Prevention of Delirium After Hip Fracture Surgery","Intraoperative Dexmedetomidine for Prevention of Postoperative Delirium in Patients Undergoing Hip Fracture Surgery: a Pre-post Study","DEXLIR","Inclusion Criteria:\n\n* Patients at least 65 years of age undergoing surgery for hip fracture in general or spinal anesthesia\n* Treated during the defined pre- or post-implementation period\n\nExclusion Criteria:\n\n* Known hypersensitivity to dexmedetomidine\n* Second- or third-degree AV block without pacemaker\n* Acute cerebral conditions with potentially impaired cerebral autoregulation\n* Acute or chronic liver failure","ALL","65 Years",{"count":20,"type":21},242,"ESTIMATED","OBSERVATIONAL","Postoperative delirium is common after hip fracture surgery and is associated with delayed recovery and serious postoperative complications. Patients with hip fracture are often elderly, acutely admitted, in pain, and have multiple comorbidities, all of which increase the risk of delirium.\n\nThis study evaluates whether implementation of intraoperative dexmedetomidine prophylaxis reduces postoperative delirium in patients undergoing hip fracture surgery. The study will compare patients treated before and after implementation of dexmedetomidine prophylaxis.",[25,26,27,28],"Delirium - Postoperative","Delirium Prevention","Dexmedetomidine","Dexmedetomidine Infusion",[30,31,32,27,33,34,35],"Hip fracture","Surgery","Postoperative","Delirium prevention","Pre-post intervention","Geriatric anesthesia","RECRUITING","2026-10-05",{"date":39,"type":40},"2026-10-09","ACTUAL",{"date":42,"type":40},"2026-10-01",{"date":44,"type":21},"2027-04-14",{"name":46,"class":47},"Peter Gaarsdal Uhrbrand","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":67,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":77,"leadSponsor":79,"locationsCount":4},"100653563","evaluation-of-a-hospital-program-to-prevent-postoperative-delirium-in-older-patients-100653563","NCT07787832","Evaluation of a Hospital Program to Prevent Postoperative Delirium in Older Patients","Evaluation of the Quality Management Project 'Prevention of Post-operative Delirium in the Care of Older Patients' at the University Medical Centre Hamburg","EvaDel","Inclusion Criteria:\n\n* Age ≥65 years\n* Scheduled for or undergoing inpatient surgery at the study site\n* Able to provide written informed consent\n* Sufficient language proficiency to understand the study information and complete the study assessments\n\nExclusion Criteria:\n\n* Current schizophrenia\n* Active alcohol dependence or harmful alcohol use\n* Current drug abuse\n* severe intellectual disability\n* Preoperative delirium\n* Inability to understand the nature, significance, and implications of study participation or to provide informed consent",{"count":58,"type":21},720,"INTERVENTIONAL",[61],"NA","Postoperative delirium is a common complication in older adults undergoing surgery. It is characterized by an acute and fluctuating disturbance of attention, awareness, and thinking. Delirium may be associated with prolonged hospital stay, loss of independence, cognitive decline, complications, and increased need for care.\n\nThe University Medical Center Hamburg-Eppendorf has introduced a multicomponent care program to prevent postoperative delirium in patients aged 65 years and older. The program includes preoperative assessment of risk factors such as frailty, cognitive impairment, and malnutrition, as well as information for patients and relatives. Depending on the individual risk profile, preventive measures may include support with orientation, adequate hydration and nutrition, early mobilization, preservation of the sleep-wake cycle, use of glasses and hearing aids, avoidance of unnecessary room changes, and reduction of medications that may contribute to delirium. A specialized delirium team supports patients and clinical staff during the hospital stay.\n\nEvaDel is a prospective study evaluating how patient care and clinical outcomes change while this delirium prevention program is gradually implemented in routine clinical practice. Participants will be followed from before surgery until three months after the operation. The study will assess the occurrence of postoperative delirium, cognitive function, independence in everyday activities, postoperative complications, and the extent to which the preventive measures were successfully implemented.\n\nThe study hypothesis is that a higher degree of implementation of the delirium prevention program will be associated with a lower rate of postoperative delirium and with better cognitive, functional, and clinical outcomes after surgery.",[64,26,65,66],"Postoperative Delirium","Multicomponent Care Program","Older Adults (60 - 85 Years Old)",[68,69,70,71],"delirium","older adults","anesthesia","surgery","NOT_YET_RECRUITING","2026-08-22",{"date":75,"type":40},"2026-08-26",{"date":42,"type":21},{"date":78,"type":21},"2029-06-30",{"name":80,"class":47},"Universitätsklinikum Hamburg-Eppendorf"]