[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dental-anxiety\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dental-anxiety":29},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,33,0,25,[9,45,71,94,115,140,169,197,225,255,281,315,339,360,387,414,439,460,486,510,540,565,589,613,638],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100614005","clinical-study-evaluating-the-effect-of-virtual-reality-on-reducing-patients-anxiety-during-wisdom-teeth-extraction-100614005",false,"NCT07273968","Clinical Study Evaluating the Effect of Virtual Reality on Reducing Patients' Anxiety During Wisdom Teeth Extraction","Clinical Study Evaluating the Effect of Virtual Reality on Reducing Anxiety in Patients Undergoing Wisdom Teeth Extraction","SEREIN","Inclusion criteria:\n\n* Age 18-65\n* Indication for extraction of 4 wisdom teeth or ≥2 mandibular wisdom teeth\n* ASA I-II\n* Written informed consent.\n\nExclusion criteria:\n\n* Visual\u002Fhearing impairment\n* Psychiatric disorders or psychotropics (\\\u003C8 weeks)\n* Claustrophobia\n* Heavy smoking \\>10 cig\u002Fday\n* Previous radiotherapy (jaw)\n* ASA III-IV\n* Pregnancy\n* Antithrombotic therapy\n* Chemotherapy\n* Bisphosphonates\n* Uncontrolled diabetes\n* Severe anxiety requiring GA or pharmacological sedation\n* No health insurance affiliation.","ALL","18 Years","65 Years",{"count":22,"type":23},60,"ESTIMATED","INTERVENTIONAL",[26],"NA","Dental anxiety is common during third molar extractions and may exacerbate pain perception. Local anesthesia does not prevent exposure to stress-inducing stimuli. Virtual reality (VR) combined with hypnotic scripts (HypnoVR®) provides immersive multisensory distraction. This study tests whether VR reduces perioperative anxiety and postoperative pain compared to local anesthesia alone.",[29,30,31],"Dental Anxiety","Third Molar Extraction","Oral Surgery","RECRUITING","2026-08-18",{"date":35,"type":36},"2026-08-20","ACTUAL",{"date":38,"type":36},"2026-04-10",{"date":40,"type":23},"2027-09-01",{"name":42,"class":43},"University Hospital, Strasbourg, France","OTHER",1,{"id":46,"slug":47,"hasResults":12,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":18,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":24,"phases":57,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":67,"leadSponsor":69,"locationsCount":44},"100647897","different-local-anesthesia-techniques-for-mandibular-primary-molar-pulpectomy-100647897","NCT07714915","Different Local Anesthesia Techniques for Mandibular Primary Molar Pulpectomy","Comparison of Computer-Controlled and Conventional Local Anesthesia Techniques on Dental Anxiety and Pain During Mandibular Primary Molar Pulpectomy: A Split-Mouth Randomized Clinical Trial","Inclusion Criteria:\n\n* Children aged 6 to 8 years.\n* Requiring bilateral pulpectomy treatment of mandibular primary molars.\n* Frankl Behavior Rating Scale score of 3 or 4.\n* American Society of Anesthesiologists (ASA) Physical Status I.\n* No known allergy to local anesthetic agents.\n* No previous experience with dental local anesthesia.\n* No signs of acute abscess or swelling in the treatment area.\n* Parent or legal guardian able to provide written informed consent and child willing to participate.\n\nExclusion Criteria:\n\n* ASA Physical Status II or higher.\n* Known allergy or contraindication to local anesthetic agents.\n* Frankl Behavior Rating Scale score of 1 or 2.\n* Children receiving psychological or psychiatric treatment.\n* Physical or intellectual disabilities that could interfere with study procedures.\n* Previous experience with dental local anesthesia.\n* Presence of acute abscess, cellulitis, or diffuse swelling in the treatment area.",true,"6 Years","8 Years",{"count":56,"type":23},38,[26],"This study aims to compare the effects of computer-controlled local anesthesia and conventional inferior alveolar nerve block on dental anxiety and pain in children undergoing pulpectomy of mandibular primary molars. Both anesthesia techniques are routinely used in pediatric dental practice and are considered standard methods of care.\n\nChildren aged 6 to 8 years who require bilateral pulpectomy of mandibular primary molars will be included in this split-mouth randomized clinical trial. Each participant will receive both anesthesia techniques during separate treatment sessions. Dental anxiety, pain, and physiological parameters, including heart rate, blood pressure, oxygen saturation, and body temperature, will be assessed before, during, and after treatment using validated pediatric assessment scales and routine clinical measurements.\n\nThe findings of this study may help identify the anesthesia technique that provides greater comfort and reduces anxiety and pain during pediatric dental treatment, thereby improving the overall treatment experience for children.",[29,60,61],"Pain","Pulpal Diseases","NOT_YET_RECRUITING","2026-08-11",{"date":65,"type":36},"2026-08-12",{"date":65,"type":23},{"date":68,"type":23},"2026-10-15",{"name":70,"class":43},"Recep Tayyip Erdogan University Training and Research Hospital",{"id":72,"slug":73,"hasResults":12,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":79,"targetDuration":4,"studyType":24,"phases":81,"briefSummary":82,"conditions":83,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":44},"100651337","virtual-reality-during-periodontal-frenectomy-100651337","NCT07760987","Virtual Reality During Periodontal Frenectomy","Evaluation of the Effects of Virtual Reality Application on Anxiety, Pain, and Physiological Stress Responses During Periodontal Frenectomy","VRFren","Inclusion Criteria:\n\n* Adults aged 18 to 65 years\n* Classified as American Society of Anesthesiologists physical status I or II\n* Presence of a clinical indication for periodontal frenectomy\n* No previous periodontal surgery experience\n* No previous virtual reality experience\n\nExclusion Criteria:\n\n* Pregnancy or breastfeeding\n* Visual or hearing impairment that may prevent the use of the virtual reality headset\n* History of claustrophobia\n* History of vertigo\n* Use of analgesic or sedative medication within the last 24 hours\n* Current substance dependence\n* Presence of active infection in the surgical area\n* Current regular use of antidepressants, anxiolytics, antipsychotics, mood stabilizers, sedatives\u002Fhypnotics, or other psychotropic medications",{"count":80,"type":23},70,[26],"The goal of this clinical trial is to learn whether virtual reality can reduce anxiety, pain, and physiological stress responses during periodontal frenectomy in adults who need this surgical procedure.\n\nThe main questions it aims to answer are:\n\nDoes virtual reality reduce anxiety before and after periodontal frenectomy? Does virtual reality reduce pain during and after the procedure? Does virtual reality have a favorable effect on physiological stress responses such as blood pressure, heart rate, and oxygen saturation? Does virtual reality affect surgical process-related outcomes and early wound healing?\n\nResearchers will compare adults who receive standard periodontal frenectomy with virtual reality-based audiovisual distraction to adults who receive standard periodontal frenectomy without virtual reality.\n\nParticipants will:\n\nComplete anxiety and pain questionnaires before the procedure. Undergo periodontal frenectomy under local anesthesia. Be randomly assigned to either the virtual reality group or the control group. Have blood pressure, heart rate, oxygen saturation, and pain levels recorded at defined time points during the procedure.\n\nRecord daily pain levels and analgesic use for 7 days after surgery. Return for a 7-day follow-up visit for suture removal and early wound healing assessment.",[29,84,85],"Frenectomy","Virtual Reality","2026-08-07",{"date":65,"type":36},{"date":89,"type":23},"2026-09",{"date":91,"type":23},"2027-08",{"name":93,"class":43},"Muhammed Emin Kalender",{"id":95,"slug":96,"hasResults":12,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":4,"eligibilityCriteria":100,"healthyVolunteers":52,"sex":18,"minAge":53,"maxAge":54,"enrollmentInfo":101,"targetDuration":4,"studyType":103,"phases":4,"briefSummary":104,"conditions":105,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":4},"100649289","effects-of-topical-anesthetics-on-pain-and-anxiety-in-children-100649289","NCT07733622","Effects of Topical Anesthetics on Pain and Anxiety in Children","Evaluation of the Effects of Different Topical Anesthetic Agents on Pain and Anxiety in Pediatric Patients","Inclusion Criteria:\n\n* Children aged 6 to 8 years.\n* Frankl Behavior Rating Scale score of 3 or 4.\n* No previous history of local anesthetic injection for dental treatment.\n* Requiring maxillary infiltration anesthesia for treatment of a maxillary second primary molar.\n* Requiring non-emergency, painless dental treatment.\n* Medically healthy children with no chronic systemic disease, mental disability, or physical disability.\n* Written informed consent obtained from a parent or legal guardian.\n\nExclusion Criteria:\n\n* Frankl Behavior Rating Scale score of 1 or 2.\n* Physical or intellectual disability.\n* History of cardiovascular disease, diabetes mellitus, Graves' disease, epilepsy, hyperthyroidism, active infection, phenylketonuria, cardiovascular shock, otorrhea, or otitis.\n* Known hypersensitivity or allergy to benzocaine, lidocaine, or any component of the topical anesthetic formulations.\n* Emergency dental treatment or presence of dental pain requiring urgent intervention.\n* Chronic liver or kidney disease.\n* History of methemoglobinemia.",{"count":102,"type":23},160,"OBSERVATIONAL","Dental anxiety and pain associated with local anesthetic injections are among the most common barriers to successful dental treatment in children. Topical anesthetic agents are widely used to reduce discomfort during needle insertion; however, evidence regarding the comparative effectiveness of different formulations remains limited.\n\nThis prospective observational study aims to evaluate the effects of four routinely used topical anesthetic applications (benzocaine spray, benzocaine gel, lidocaine spray, and lidocaine gel) on pain and anxiety during local infiltration anesthesia in pediatric dental patients. The study will include 160 healthy children aged 6-8 years who require maxillary infiltration anesthesia for routine dental treatment. The choice of topical anesthetic will be determined by the treating clinician as part of routine clinical practice, and no additional intervention or treatment modification will be performed for research purposes.\n\nDental anxiety will be assessed using the Modified Child Dental Anxiety Scale-faces version (MCDASf), behavioral responses during local anesthetic administration will be evaluated using the Sound, Eye, and Motor (SEM) scale, and self-reported pain will be measured using the Wong-Baker FACES Pain Rating Scale. Physiological parameters, including heart rate, blood pressure, peripheral oxygen saturation (SpO₂), and body temperature, will be recorded before, during, and after local anesthetic administration. The findings are expected to provide evidence regarding the effectiveness of commonly used topical anesthetic formulations in reducing pain and anxiety during pediatric dental treatment and may contribute to optimizing behavior management strategies in clinical practice.",[29,106],"Children","2026-07-24",{"date":109,"type":36},"2026-07-29",{"date":111,"type":23},"2026-07-30",{"date":113,"type":23},"2026-09-10",{"name":70,"class":43},{"id":116,"slug":117,"hasResults":12,"nctId":118,"briefTitle":119,"officialTitle":120,"acronym":121,"eligibilityCriteria":122,"healthyVolunteers":52,"sex":18,"minAge":53,"maxAge":123,"enrollmentInfo":124,"targetDuration":4,"studyType":24,"phases":126,"briefSummary":127,"conditions":128,"keywords":131,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":44},"100626719","turtle-assisted-animal-interaction-on-dental-anxiety-and-physiological-parameters-in-children-100626719","NCT07439289","Turtle-Assisted Animal Interaction on Dental Anxiety and Physiological Parameters in Children","Effects of Turtle-Assisted Animal Interaction on Dental Anxiety and Physiological Parameters in Children: A Randomized Controlled Trial","TAADA","Inclusion Criteria:\n\n* Children aged 6-10 years\n\n  * Children with ASA I-II general health status\n  * Children who have obtained written parental consent + an age-appropriate informed consent form\n  * Children undergoing non-invasive procedures that do not require local anesthesia, such as dental examinations, fissure sealant or fluoride application. • Children who can understand Turkish instructions (for scale application).\n\nExclusion Criteria:\n\n* • Children with animal phobia \u002F intense fear of turtles (as stated by the child or parent). • Children with immunosuppression or a history of severe allergic diseases. • Children with a dental plan requiring sedation\u002FGA within the last month (due to intense anxiety or systemic illness).\n\n  * Children with an active infectious disease \u002F a condition requiring isolation. • Children for whom a physician has deemed contact with animals inadvisable. • Children who have been included in a similar behavioral\u002Fanxiety intervention program during the same period.","10 Years",{"count":125,"type":23},50,[26],"This study aims to measure the effect of a structured AAT session with a turtle present on dental anxiety and behavioral compliance in children during routine procedures that do not require local anesthesia in a pediatric dental clinic.",[129,29,130],"Animal-Human Bonding","Pediatric Disease",[129,29,130],"2026-07-23",{"date":107,"type":36},{"date":135,"type":36},"2026-03-01",{"date":137,"type":23},"2026-09-01",{"name":139,"class":43},"Igdir University",{"id":141,"slug":142,"hasResults":12,"nctId":143,"briefTitle":144,"officialTitle":145,"acronym":4,"eligibilityCriteria":146,"healthyVolunteers":52,"sex":18,"minAge":147,"maxAge":148,"enrollmentInfo":149,"targetDuration":4,"studyType":24,"phases":151,"briefSummary":152,"conditions":153,"keywords":154,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":161,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":44},"100648166","effectiveness-of-brighthearts-biofeedback-relaxation-and-virtual-reality-distraction-during-inferior-alveolar-nerve-block-injection-in-children-100648166","NCT07717229","Effectiveness of BrightHearts Biofeedback Relaxation and Virtual Reality Distraction During Inferior Alveolar Nerve Block Injection in Children","A Comparative Evaluation of the Effectiveness of the BrightHearts Application as a Biofeedback Relaxation Tool Versus Virtual Reality Distraction in Reducing Dental Anxiety and Improving Behavior in Children During Inferior Alveolar Nerve Block Injection: A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Children from 7 to 12 years\n2. Children who have dental procedures that require an inferior alveolar nerve block injection.\n3. Healthy Children.\n4. Children who fall under Frankl's behavioral rating of 2 (negative) or 3 (positive)\n\nExclusion Criteria:\n\n1. Children with special health care needs\n2. Children or parents who are unable or unwilling to cooperate with the study protocol or assessment","7 Years","12 Years",{"count":150,"type":23},39,[26],"The study is designed to compare the effectiveness of \"BrightHearts\" biofeedback relaxation tool versus Virtual Reality distraction and Verbal distraction as a distraction methods in reducing dental anxiety and improving behavior during the inferior alveolar nerve block procedure.",[29],[155,156,157,158,159],"dental anxiety","inferior alveolar nerve block","brighthearts","virtual reality","biofeedback","2026-07-18",{"date":162,"type":36},"2026-07-21",{"date":164,"type":36},"2025-11-15",{"date":166,"type":23},"2026-09-30",{"name":168,"class":43},"October University for Modern Sciences and Arts",{"id":170,"slug":171,"hasResults":12,"nctId":172,"briefTitle":173,"officialTitle":173,"acronym":174,"eligibilityCriteria":175,"healthyVolunteers":12,"sex":18,"minAge":53,"maxAge":176,"enrollmentInfo":177,"targetDuration":4,"studyType":103,"phases":4,"briefSummary":179,"conditions":180,"keywords":182,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":188,"lastUpdatePostDateStruct":189,"startDateStruct":191,"completionDateStruct":193,"leadSponsor":195,"locationsCount":44},"100648367","compare-the-intensity-of-pain-felt-by-children-during-the-local-anesthesia-procedure-to-that-perceived-by-the-accompanying-parent-100648367","NCT07718477","Compare the Intensity of Pain Felt by Children During the Local Anesthesia Procedure to That Perceived by the Accompanying Parent.","ADDenT","Inclusion Criteria:\n\n* Children aged 6 to 15\n* Children requiring dental treatment involving local anaesthetic\n* Children accompanied by at least one parent (or legal guardian)\n* Children and parents who speak French fluently\n\nExclusion Criteria:\n\n* Children under the age of 6 (complex self-assessment)\n* Children over the age of 15 (no longer fall within the scope of paediatric dentistry)\n* Children or accompanying parents who have difficulty understanding due to a limited command of French or any form of intellectual disability\n* Children whose parents have not consented to their participation in the study\n* Children who do not wish to participate in the study\n* Unaccompanied children\n* Children with an intolerance or allergy to local anaesthetics, vasoconstrictors or excipients","15 Years",{"count":178,"type":23},100,"The goal of this observational study is to compare the intensity of pain experienced by children (aged 6 to 15) during local anaesthesia with that perceived by the parent accompanying them. The main question it aims to answer is:\n\nCan a parent help assess their child's pain when the child is unable to assess it themselves? A preliminary study carried out in the dentistry department of Clermont-Ferrand University Hospital in 2019 showed that parents could be effective external assessors in distinguishing between pain and anxiety in their own children, whom they know well, and were better at this than dentists, who are more prone to errors of judgement.13 This pilot study covered several dental procedures, including pulpotomy, extraction of a primary tooth, curettage of a carious lesion and dental anaesthesia. The study yielded interesting results but also contained some biases, so the investigators would like to improve upon it. To do so, the focus here is on a single therapeutic procedure: local anaesthesia, which is one of the procedures most feared by children and, very often, by the parents accompanying them as well.\n\nOnce consent has been obtained from both parents (or legal guardians), two questionnaires will be used. The first will consist of simple questions and will be aimed at the children (9 items). The second (20 items) will be for parents and will provide additional information on the child's state of health and on the parents' anxiety regarding their own dental care and that provided to their child. The main aim of both questionnaires will be to assess the intensity of pain perceived by the child during the administration of local anaesthesia, with the child self-reporting their pain and the parent providing an external assessment. These questionnaires will be completed every Wednesday, which allows a child (requiring multiple treatments) to complete the questionnaires several times, thereby enabling us to observe changes in the pain perceived by the child and their accompanying parent over the course of successive anaesthetic procedures.",[181,29],"Dental Pain",[183,184,185,186,187],"pediatric odontology","dental pain assessment","anxiety","children","parents","2026-07-17",{"date":190,"type":36},"2026-07-22",{"date":192,"type":23},"2026-07-01",{"date":194,"type":23},"2028-07-01",{"name":196,"class":43},"University Hospital, Clermont-Ferrand",{"id":198,"slug":199,"hasResults":12,"nctId":200,"briefTitle":201,"officialTitle":202,"acronym":4,"eligibilityCriteria":203,"healthyVolunteers":12,"sex":18,"minAge":204,"maxAge":205,"enrollmentInfo":206,"targetDuration":4,"studyType":24,"phases":207,"briefSummary":208,"conditions":209,"keywords":211,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":216,"lastUpdatePostDateStruct":217,"startDateStruct":219,"completionDateStruct":221,"leadSponsor":223,"locationsCount":4},"100639347","comparasion-of-dental-anxiety-in-first-time-complete-denture-patients-100639347","NCT07597057","Comparasion of Dental Anxiety in First Time Complete Denture Patients","Comparison of Dental Anxiety Level in Edentulous Patients Before and After Seeking Complete Denture Treatment for the First Time: A Quasi-Experimental Study","Inclusion Criteria: Edentulous patients (missing all teeth) requiring first-time complete dentures.\n\nExclusion Criteria: History of previous denture use, severe cognitive impairment, or systemic diseases contraindicating dental procedures.","40 Years","70 Years",{"count":80,"type":23},[26],"This quasi-experimental study compares dental anxiety levels in edentulous patients at two specific clinical points: the primary impression appointment and the denture insertion appointment. The study aims to determine if the process of receiving first-time complete dentures significantly impacts patient anxiety levels. Data will be collected from 70 participants at the Khyber College of Dentistry over a five-week interval between the two appointments",[210,29],"Edentulous Mouth",[212,213,214,215],"complete denture","dental anxiety scale","prosthodontics","edentulism","2026-05-13",{"date":218,"type":36},"2026-05-19",{"date":220,"type":23},"2026-05-01",{"date":222,"type":23},"2026-12-30",{"name":224,"class":43},"Khyber College of dentistry",{"id":226,"slug":227,"hasResults":12,"nctId":228,"briefTitle":229,"officialTitle":230,"acronym":4,"eligibilityCriteria":231,"healthyVolunteers":12,"sex":18,"minAge":53,"maxAge":148,"enrollmentInfo":232,"targetDuration":4,"studyType":24,"phases":233,"briefSummary":234,"conditions":235,"keywords":239,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":246,"lastUpdatePostDateStruct":247,"startDateStruct":249,"completionDateStruct":251,"leadSponsor":253,"locationsCount":4},"100635146","comparison-of-needle-free-injection-and-conventional-syringe-for-tooth-extractions-in-children-100635146","NCT07548892","Comparison of Needle-Free Injection and Conventional Syringe for Tooth Extractions in Children","Comparison of Needle-Free Injection and Conventional Syringe in Tooth Extractions in Children: Effects on Pain, Anxiety, and Vital Signs","Inclusion Criteria:\n\n* Being between 6-12 years of age\n* Having a primary tooth to be extracted with buccal and lingual anesthesia\n* Being in category 2, 3, or 4 according to the Frankl Behavior Scale\n* Being systemically healthy\n* No known history of allergy to local anesthetics\n* No antibiotic use in the last month and no analgesic use in the last 12 hours\n* Not having acute dental pain\n* Having sufficient cognitive ability to understand the anxiety assessment scales\n* Voluntary participation with written parental consent\n\nExclusion Criteria:\n\n* Being under 6 years of age or over 12 years of age\n* Displaying category 1 behavior according to the Frankl scale\n* Presence of severe acute dental infection or a condition requiring emergency intervention\n* Presence of a requirement for surgical extraction in the tooth indicated for extraction\n* Incomplete root development of the underlying permanent tooth\n* History of systemic disease (for example heart disease, uncontrolled asthma, epilepsy, diabetes)\n* Inability to use pain\u002Fanxiety scales due to neurological or developmental disorder\n* History of allergic reaction to local anesthetics or other drugs used\n* Presence of hypersensitivity to odors or inhalation intolerance\n* Refusal of participation by the child or parent",{"count":22,"type":23},[26],"The goal of this clinical trial is to learn whether a needle-free injection system can make tooth extraction less stressful for children than a conventional dental syringe. The study will include healthy children 6 to 12 years old who need a primary tooth extraction with buccal and lingual local anesthesia. The main questions are whether the needle-free method can lower anxiety, lower pain, and reduce changes in vital signs compared with the conventional syringe.\n\nResearchers will randomly assign participants to 1 of 2 groups. One group will receive local anesthesia with a needle-free jet injection system. The other group will receive local anesthesia with a conventional syringe and a 27-gauge dental needle. In both groups, a topical lidocaine spray will be used before the injection, and the same anesthetic solution will be given. All tooth extractions will be performed by the same clinician using standard clinical procedures.\n\nParticipants' anxiety, pain, and vital signs will be checked before the procedure, after anesthesia, and after tooth extraction. Anxiety will be measured with the Face Image Scale (FIS). Pain will be measured with the Face, Legs, Activity, Cry, Consolability (FLACC) scale and the Wong-Baker Faces Pain Rating Scale (WBS). Vital signs will include systolic and diastolic blood pressure, heart rate, and oxygen saturation. No blood, saliva, or tissue samples will be collected, and no audio or video recording will be made.",[236,29,237,238],"Tooth Extraction","Procedural Pain","Anesthesia, Dental",[240,241,236,242,243,29,244,245],"Needle-Free Injection","Conventional Syringe","Pediatric Dentistry","Local Anesthesia","Pain Perception","Vital Signs","2026-04-23",{"date":248,"type":36},"2026-04-29",{"date":250,"type":23},"2026-04-15",{"date":252,"type":23},"2026-12-31",{"name":254,"class":43},"Ondokuz Mayıs University",{"id":256,"slug":257,"hasResults":12,"nctId":258,"briefTitle":259,"officialTitle":260,"acronym":4,"eligibilityCriteria":261,"healthyVolunteers":52,"sex":18,"minAge":53,"maxAge":148,"enrollmentInfo":262,"targetDuration":4,"studyType":24,"phases":264,"briefSummary":265,"conditions":266,"keywords":267,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":274,"startDateStruct":275,"completionDateStruct":277,"leadSponsor":279,"locationsCount":44},"100635029","effectiveness-of-aromatherapy-and-digital-anesthesia-in-managing-dental-anxiety-and-pain-in-children-100635029","NCT07547371","Effectiveness of Aromatherapy and Digital Anesthesia in Managing Dental Anxiety and Pain in Children","Assessing the Effectiveness of Aromatherapy and Digital Anesthesia Techniques for the Management of Tooth-Extraction-Related Dental Anxiety and Pain in Children","Inclusion Criteria:\n\nParticipants will be recruited from the Department of Pediatric Dentistry at Istanbul University Faculty of Dentistry who meet the following criteria:\n\nChildren aged 6-12 years,\n\nIndicated for extraction of a mandibular primary molar without acute infection or abscess,\n\nNo use of analgesic or sedative medications within the previous 24 hours,\n\nAbsence of any systemic disease,\n\nBehavior rated as Category 2, 3, or 4 on the Frankl Behavior Rating Scale,\n\nVoluntary agreement to participate in the study.\n\nExclusion Criteria:\n\nChildren with a history of systemic disease or those taking medications on a regular basis,\n\nKnown allergy to local anesthetic agents or essential oils,\n\nUse of analgesic or sedative medications within the previous 24 hours,\n\nChildren with asthma, chronic obstructive pulmonary disease (COPD), upper respiratory tract infections, or any respiratory condition that may increase sensitivity to inhalational therapies,\n\nChildren rated as Category 1 on the Frankl Behavior Rating Scale, indicating an inability to cooperate,\n\nTeeth indicated for extraction due to acute infection or abscess,\n\nPatients with teeth presenting mobility, ankylosis, or root resorption exceeding one-third of the root length.",{"count":263,"type":23},132,[26],"The goal of this clinical study is to learn whether aromatherapy and digital anesthesia are effective in reducing dental anxiety and pain during tooth extraction in children. The study also aims to understand how these methods influence children's comfort and cooperation during treatment.\n\nThe main questions this study aims to answer are:\n\nDo aromatherapy (lavender and orange essential oils) and digital anesthesia reduce dental anxiety and pain during tooth extraction in children?\n\nAre these methods more comfortable and less stressful for pediatric patients compared to traditional anesthesia techniques?\n\nDoes digital anesthesia improve cooperation and ease of management during dental treatment?\n\nResearchers will compare aromatherapy and digital anesthesia with conventional anesthesia methods to determine whether these techniques make the extraction process easier and more comfortable for children.\n\nParticipants will:\n\nReceive either aromatherapy, digital anesthesia, conventional anesthesia, or a combination depending on the study group\n\nUndergo tooth extraction under controlled clinical conditions\n\nBe evaluated before, during, and after treatment using standardized pain and anxiety scales\n\nProvide post-treatment feedback along with their parents regarding comfort and anxiety levels\n\nThis study may help identify gentler and more child-friendly approaches to managing anxiety and pain during pediatric dental procedures.",[60,29,236],[268,269,270,271,272],"Dental anxiety","Dental pain","Primary molar extraction","Aromatherapy","Computer-controlled anesthesia","2026-04-16",{"date":246,"type":36},{"date":276,"type":36},"2025-12-11",{"date":278,"type":23},"2026-07-04",{"name":280,"class":43},"Arzu Pınar Erdem",{"id":282,"slug":283,"hasResults":12,"nctId":284,"briefTitle":285,"officialTitle":286,"acronym":4,"eligibilityCriteria":287,"healthyVolunteers":52,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":288,"targetDuration":4,"studyType":24,"phases":290,"briefSummary":291,"conditions":292,"keywords":295,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":307,"lastUpdatePostDateStruct":308,"startDateStruct":310,"completionDateStruct":311,"leadSponsor":313,"locationsCount":44},"100623612","use-of-augmented-reality-glasses-and-noise-cancelling-headphones-to-reduce-dental-anxiety-in-adult-patients-100623612","NCT07398898","Use of Augmented Reality Glasses and Noise-Cancelling Headphones to Reduce Dental Anxiety in Adult Patients","Use of New Technologies in Dentistry","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Qualified for one of the following dental procedures: supragingival scaling, curettage, tooth extraction, or caries cavity preparation and restoration\n* Provided written informed consent\n* Agreed to random allocation to one of the study groups\n* Able to understand and complete the STAI questionnaire and VAS pain scale\n\nExclusion Criteria:\n\n* Acute dental pain at the time of the procedure\n* Teeth qualified for resection\n* Pregnancy\n* Diagnosis of cerebral palsy\n* Epilepsy with seizures in the past 6 months\n* Use of hearing aids\n* Severe vision impairment\n* Non-cooperative behavior or inability to understand the study questionnaires\n* Absence on the scheduled procedure date",{"count":289,"type":23},250,[26],"This study investigates whether new audiovisual technologies can help reduce anxiety and stress experienced by adult patients during dental procedures. Dental fear and anxiety are common barriers to receiving proper oral care. This randomized controlled trial aims to explore whether the use of specific devices-augmented reality (AR) glasses and noise-cancelling (ANC) headphones-can improve patient comfort and decrease physiological signs of stress during dental treatment.\n\nParticipants in this study will undergo a standard dental procedure. In addition, they will be randomly assigned to one of three groups: a control group (no audiovisual intervention), a group using ANC headphones that play relaxing music during the procedure, or a group using AR glasses that display relaxing visual scenes along with the same music.\n\nBefore the procedure, each participant will complete a psychological questionnaire (STAI) to assess their level of anxiety. During the procedure, physiological stress will be monitored using sensors that track parameters such as skin conductance (GSR) and heart rate. After the treatment, patients will be asked to rate their pain level and describe their experience with or without the audiovisual intervention.\n\nThe goal is to better understand the effectiveness of non-pharmacological methods in reducing anxiety and stress in adult dental patients. Participation in the study is entirely voluntary and will not affect the quality or availability of dental care. Patients may withdraw at any time without consequences. The study also collects basic demographic information and patient feedback to evaluate potential factors that may influence anxiety levels.\n\nBy testing new immersive tools such as AR glasses and ANC headphones in a real clinical setting, this research may contribute to improving patient well-being and enhancing the dental care experience.",[29,293,294],"Music Therapy","Oral Surgical Procedures",[155,296,297,298,299,300,301,302,303,304,305,306],"Music therapy","augmented reality","active noise cancelling","maxillofacial surgery","Dental phobia","audiovisual distraction","dental fear","perioperative anxiety","STAI","galvanic skin response","relaxation techniques","2026-03-25",{"date":309,"type":36},"2026-03-27",{"date":135,"type":36},{"date":312,"type":23},"2026-06-30",{"name":314,"class":43},"Medical University of Warsaw",{"id":316,"slug":317,"hasResults":12,"nctId":318,"briefTitle":319,"officialTitle":320,"acronym":60,"eligibilityCriteria":321,"healthyVolunteers":52,"sex":18,"minAge":147,"maxAge":148,"enrollmentInfo":322,"targetDuration":4,"studyType":24,"phases":324,"briefSummary":325,"conditions":326,"keywords":328,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":330,"lastUpdatePostDateStruct":331,"startDateStruct":333,"completionDateStruct":335,"leadSponsor":337,"locationsCount":44},"100628494","the-effect-of-a-kaleidoscope-and-cartoons-for-dental-treatment-in-children-100628494","NCT07462364","The Effect of a Kaleidoscope and Cartoons for Dental Treatment in Children","The Effect of a Kaleidoscope and Cartoons on Pain and Anxiety Associated With Local Anesthetic Injection for Dental Treatment in Children","Inclusion Criteria:\n\n* Children aged between 7 and 12 years\n* Children requiring local infiltration anesthesia for dental treatment\n* Children who apply to the Pediatric Dentistry Clinic of Dicle University Faculty of Dentistry\n* Children and their parents who voluntarily agree to participate in the study and provide informed consent\n* Children with positive or definitely positive behavior according to the Frankl Behavior Rating Scale\n\nExclusion Criteria:\n\n* Children with chronic diseases\n* Children with a history of hospitalization or surgery\n* Children with neurological or behavioral disorders such as autism, attention deficit hyperactivity disorder (ADHD), or learning disabilities\n* Children with mental retardation, hearing impairment, or speech problems\n* Children with dental abscesses or fistulas",{"count":323,"type":23},126,[26],"Dental fear and anxiety are among the most common challenges encountered in pediatric dental practice and may negatively affect children's cooperation and acceptance of dental treatment. Local anesthesia injections are considered one of the main sources of pain and anxiety during dental procedures in children. Although pharmacological methods can be effective in managing pain and anxiety, they may not always be preferred due to potential side effects, limited applicability, and the possibility of increasing stress in children. Therefore, non-pharmacological behavioral management techniques, particularly distraction methods, are increasingly used in pediatric dentistry to reduce pain perception and anxiety.\n\nThe aim of this randomized controlled trial is to evaluate the effects of kaleidoscope use and cartoon distraction on pain, fear, and anxiety associated with local anesthesia injections in children undergoing dental treatment. The study will be conducted at the Department of Pediatric Dentistry, Faculty of Dentistry, Dicle University. A total of 126 children aged between 7 and 12 years who require local infiltration anesthesia during dental treatment will be included in the study. Participants will be randomly assigned to one of three groups: the Kaleidoscope Group, the Cartoon Distraction Group, or the Control Group. Children in the kaleidoscope group will use a kaleidoscope during the local anesthesia injection, while children in the cartoon group will watch cartoons during the procedure. In the control group, local anesthesia will be administered according to the routine clinical procedure without any distraction technique.\n\nPain, fear, and anxiety levels will be assessed using the Wong-Baker FACES Pain Rating Scale, the Children's Fear Scale, and the Children's Anxiety Scale-State. Behavioral responses will also be evaluated using the Frankl Behavior Rating Scale. The findings of this study are expected to provide evidence regarding the effectiveness of simple and non-pharmacological distraction techniques in reducing pain and anxiety associated with local anesthesia injections in pediatric dental patients.",[29,327,60],"Dental Fear",[329],"Dental anxiety, dental fear, pain, local anesthesia, children","2026-03-11",{"date":332,"type":36},"2026-03-13",{"date":334,"type":36},"2026-03-10",{"date":336,"type":23},"2026-05-10",{"name":338,"class":43},"Dicle University",{"id":340,"slug":341,"hasResults":12,"nctId":342,"briefTitle":343,"officialTitle":344,"acronym":4,"eligibilityCriteria":345,"healthyVolunteers":12,"sex":18,"minAge":53,"maxAge":54,"enrollmentInfo":346,"targetDuration":4,"studyType":24,"phases":348,"briefSummary":349,"conditions":350,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":351,"lastUpdatePostDateStruct":352,"startDateStruct":354,"completionDateStruct":356,"leadSponsor":358,"locationsCount":4},"100628880","evaluation-of-augmented-reality-on-dental-pain-and-anxiety-during-primary-molars-extraction-100628880","NCT07467395","Evaluation of Augmented Reality on Dental Pain and Anxiety During Primary Molars' Extraction","Evaluation of Augmented Reality on Dental Pain and Anxiety During Primary Molars' Extraction: Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Medically free children without visual or auditory impairment (ASA I).\n* Children aged 6-8 years.\n* Children with Frankl behaviour rating score 3 or 4.\n* Children requiring extraction in one of their primary molars.\n* Parents who will accept to give their consent and participate in the study\n\nExclusion Criteria:\n\n* Children require emergency dental treatment.\n* Children with a history of epilepsy and anxiety disorder.\n* Children with previous bad dental experience.\n* Allergy to local anaesthetic drugs.",{"count":347,"type":23},30,[26],"The aim of this study is to evaluate the impact of using virtual reality glasses compared to augmented reality glasses as distraction methods to reduce the dental anxiety and pain in children during extraction of primary molars.",[29],"2026-03-09",{"date":353,"type":36},"2026-03-12",{"date":355,"type":23},"2026-04",{"date":357,"type":23},"2026-07",{"name":359,"class":43},"Sara Hazem Mohamed Rabie",{"id":361,"slug":362,"hasResults":12,"nctId":363,"briefTitle":364,"officialTitle":365,"acronym":4,"eligibilityCriteria":366,"healthyVolunteers":52,"sex":18,"minAge":20,"maxAge":4,"enrollmentInfo":367,"targetDuration":4,"studyType":24,"phases":369,"briefSummary":370,"conditions":371,"keywords":372,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":379,"lastUpdatePostDateStruct":380,"startDateStruct":381,"completionDateStruct":383,"leadSponsor":385,"locationsCount":44},"100628193","effect-of-nature-sounds-during-dental-filling-on-anxiety-in-older-adults-100628193","NCT07458451","Effect of Nature Sounds During Dental Filling on Anxiety in Older Adults","The Effect of Listening to Nature Sounds During Dental Filling Procedures on Anxiety, Fear, and Patient Satisfaction in Older Adults","Inclusion Criteria:\n\n* Age 65 years or older\n* Patients scheduled to undergo dental filling treatment\n* Mini-Mental State Examination (MMSE) score ≥ 24\n* Ability to communicate and understand study procedures\n* No hearing impairment that would prevent listening to audio through headphones\n* Willingness to participate and provide informed consent\n\nExclusion Criteria:\n\n* Use of antidepressant medications\n* Presence of severe cognitive impairment (MMSE \\\u003C 24)\n* Hearing impairment preventing participation in the auditory intervention\n* Communication problems that may interfere with questionnaire completion\n* Refusal or inability to provide informed consent",{"count":368,"type":23},78,[26],"Dental anxiety is common among older adults and may lead to delayed or avoided dental treatment, which can negatively affect oral health. Non-pharmacological approaches such as auditory interventions have been suggested as simple methods to reduce anxiety during dental procedures.\n\nThe aim of this randomized controlled study is to evaluate the effect of listening to nature sounds during dental filling procedures on anxiety, fear, and patient satisfaction in older adults. The study will be conducted at Artvin Oral and Dental Health Center with individuals aged 65 years and older who require dental filling treatment.\n\nParticipants will be randomly assigned to one of three groups: a nature sound group, a white noise (placebo) group, and a control group. Individuals in the nature sound group will listen to recorded natural sounds, including ocean waves, bird songs, and light rain, through wireless headphones for 15 minutes during the dental filling procedure. Participants in the placebo group will listen to white noise for the same duration, while the control group will receive routine dental treatment without any auditory intervention.\n\nAnxiety, fear, and patient satisfaction will be measured before and after the dental procedure using standardized assessment tools, including the State-Trait Anxiety Inventory and visual analog scales. The results of this study may provide evidence on whether natural sound exposure can be an effective, simple, and non-invasive method to reduce anxiety and improve patient comfort during dental procedures in older adults.",[29],[373,29,374,375,376,377,378],"Nature Sounds","Dental Filling","Older Adults","White Noise","Patient Satisfaction","Randomized Controlled Trial","2026-03-04",{"date":351,"type":36},{"date":382,"type":23},"2026-03-15",{"date":384,"type":23},"2027-03-20",{"name":386,"class":43},"EMRE ERKAL",{"id":388,"slug":389,"hasResults":12,"nctId":390,"briefTitle":391,"officialTitle":392,"acronym":393,"eligibilityCriteria":394,"healthyVolunteers":52,"sex":18,"minAge":53,"maxAge":123,"enrollmentInfo":395,"targetDuration":4,"studyType":24,"phases":397,"briefSummary":398,"conditions":399,"keywords":401,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":405,"lastUpdatePostDateStruct":406,"startDateStruct":408,"completionDateStruct":410,"leadSponsor":412,"locationsCount":4},"100627204","effect-of-play-dough-slime-and-plush-toys-on-dental-anxiety-and-pain-in-children-during-dental-treatment-100627204","NCT07445594","Effect of Play Dough, Slime, and Plush Toys on Dental Anxiety and Pain in Children During Dental Treatment","Evaluation of the Effectiveness of Play Dough, Slime, and Plush Toys on Dental Anxiety, Pain Perception, and Salivary Cortisol Levels in Children During Dental Treatment","PLAY-DENT","Inclusion Criteria:\n\n1. Children aged 6-10 years requiring restorative dental treatment.\n2. Indication for dental treatment under local anesthesia.\n3. Ability to understand and respond to dental anxiety and pain assessment scales (CFSS-DS and Wong-Baker Faces Scale).\n4. Children classified as ASA I or ASA II.\n5. No prior exposure to the distraction materials used in the study during dental treatment.\n6. Written informed consent obtained from parents or legal guardians.\n\nExclusion Criteria:\n\n1. Presence of systemic diseases or medical conditions affecting stress response or contraindicating routine dental treatment\n2. History of psychiatric, neurological, or developmental disorders that may impair cooperation or communication\n3. Use of medications influencing anxiety, pain perception, heart rate, or cortisol levels\n4. Requirement for sedation or general anesthesia for dental treatment\n5. Acute dental infection or emergency treatment requiring immediate intervention\n6. Refusal of participation by the child or parent\u002Flegal guardian",{"count":396,"type":23},90,[26],"This study aims to evaluate the effectiveness of tactile distraction materials, including play dough, slime, and plush toys, on dental anxiety, pain perception, and physiological stress responses in children undergoing dental treatment. Ninety children aged 6-10 years receiving restorative dental treatment under local anesthesia were randomly assigned to one of four groups: play dough, slime, plush toy, or control group without distraction. Dental anxiety and pain levels were assessed using validated psychometric scales, while physiological stress responses were evaluated through heart rate monitoring and salivary cortisol measurements. The study seeks to determine whether simple non-pharmacological distraction techniques can improve behavioral cooperation and reduce anxiety and pain perception during pediatric dental procedures. Findings may contribute to the development of child-friendly dental management strategies and enhance the quality of pediatric dental care.",[29,181,400],"Behavioral Management",[29,402,181,403,404],"Distraction Techniques","Behavior Management","Salivary Cortisol","2026-02-27",{"date":407,"type":36},"2026-03-03",{"date":409,"type":23},"2026-02-17",{"date":411,"type":23},"2026-06-01",{"name":413,"class":43},"Afyonkarahisar Health Sciences University",{"id":415,"slug":416,"hasResults":12,"nctId":417,"briefTitle":418,"officialTitle":419,"acronym":4,"eligibilityCriteria":420,"healthyVolunteers":12,"sex":18,"minAge":53,"maxAge":148,"enrollmentInfo":421,"targetDuration":4,"studyType":24,"phases":423,"briefSummary":424,"conditions":425,"keywords":426,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":431,"lastUpdatePostDateStruct":432,"startDateStruct":434,"completionDateStruct":436,"leadSponsor":438,"locationsCount":44},"100621205","lavender-vs-bitter-orange-aromatherapy-to-reduce-anxiety-and-pain-in-pediatric-local-anesthesia-100621205","NCT07367594","Lavender vs Bitter Orange Aromatherapy to Reduce Anxiety and Pain in Pediatric Local Anesthesia","Comparative Evaluation of the Effect of Lavender Versus Bitter Orange Essential Oils Aromatherapy on Decreasing Dental Anxiety and Pain of Children During Administration of Local Anesthetic: (A Randomized Clinical Trial)","Inclusion Criteria:\n\n* Children with the age range of 6-12 years\n* Any dental procedure that requires injection of local anesthesia.\n* Cooperative patients.(according to Frankl's classification class 1 and 2)\n* Parents or guardians willing to participate in the study.\n* Healthy child\n\nExclusion Criteria:\n\n* Children with complicated systemic disease.\n* Uncooperative patients. .(according to Frankl's classification class 3 and 4)\n* Children with severe cognitive impairment or developmental disorders\n* Children with respiratory tract infections.\n* Children experiencing dental pain such as (acute pain or hyperemia).",{"count":422,"type":23},26,[26],"This randomized controlled clinical trial aims to evaluate and compare the effectiveness of lavender essential oil and bitter orange essential oil aromatherapy in reducing dental anxiety and pain in children during the administration of local anesthesia. Children aged 6-12 years undergoing dental procedures requiring local anesthetic infiltration will be randomly assigned to lavender aromatherapy, bitter orange aromatherapy, or placebo (empty inhaler). Dental anxiety will be assessed using pulse rate and blood pressure measurements, while pain will be evaluated using the FLACC behavioral pain scale. The findings are expected to provide evidence on the role of aromatherapy as a non-pharmacological, safe, and cost-effective behavior guidance method in pediatric dentistry.",[29,243],[427,428,429,430,155],"aromatherapy","local anesthesia injection","lavender essential oil","bitter orange essential oil","2026-01-26",{"date":433,"type":36},"2026-01-28",{"date":435,"type":23},"2026-02",{"date":437,"type":23},"2026-04-01",{"name":168,"class":43},{"id":440,"slug":441,"hasResults":12,"nctId":442,"briefTitle":443,"officialTitle":444,"acronym":4,"eligibilityCriteria":445,"healthyVolunteers":12,"sex":18,"minAge":53,"maxAge":446,"enrollmentInfo":447,"targetDuration":4,"studyType":24,"phases":449,"briefSummary":450,"conditions":451,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":452,"lastUpdatePostDateStruct":453,"startDateStruct":455,"completionDateStruct":456,"leadSponsor":458,"locationsCount":44},"100620036","inhaled-lavender-oil-rosemary-oil-and-their-combination-in-reducing-dental-anxiety-and-pain-in-pediatric-dental-patients-100620036","NCT07352397","Inhaled Lavender Oil, Rosemary Oil, and Their Combination in Reducing Dental Anxiety and Pain in Pediatric Dental Patients","The Effect of Inhaled Lavender Oil, Rosemary Oil, and Their Combination in Reducing Dental Anxiety and Pain in Pediatric Dental Patients (A Randomized Controlled Clinical Trial)","Inclusion Criteria:\n\n* Frankl behavioural rating score 2 or 3 during preoperative assessment.\n* Healthy children ASAI.\n* Children without a previous dental history.\n* Children presenting with at least one mandibular molar indicated for extraction. (43)\n* Completion of the written informed consent form by parents\u002Fguardian.\n\nExclusion Criteria:\n\n* Children with colds, asthma, and any other respiratory diseases.\n* Children who took NSAIDs or analgesic drugs in the last 8 hours before treatment.","9 Years",{"count":448,"type":23},80,[26],"Background: Dental anxiety and pain are common concerns in pediatric dentistry. These issues can lead to negative experiences for children and can make it difficult for them to cooperate during treatment. While medications can help manage these symptoms, it can also have side effects. This highlights the need for safe and effective complementary treatments. Aromatherapy, particularly with lavender and rosemary oils, has demonstrated anxiolytic and analgesic properties in different fields. However, their effect in helping children cope with dental anxiety and pain during procedures requiring local anesthesia has not yet been thoroughly studied.\n\nPurpose: This study aims to investigate the efficacy of inhaled lavender oil, rosemary oil, and their combination in reducing dental anxiety and pain in children receiving local anesthesia for extraction of lower primary molar",[29],"2026-01-12",{"date":454,"type":36},"2026-01-20",{"date":454,"type":23},{"date":457,"type":23},"2026-02-25",{"name":459,"class":43},"Alexandria University",{"id":461,"slug":462,"hasResults":12,"nctId":463,"briefTitle":464,"officialTitle":465,"acronym":4,"eligibilityCriteria":466,"healthyVolunteers":52,"sex":18,"minAge":147,"maxAge":148,"enrollmentInfo":467,"targetDuration":4,"studyType":24,"phases":468,"briefSummary":469,"conditions":470,"keywords":473,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":477,"lastUpdatePostDateStruct":478,"startDateStruct":480,"completionDateStruct":482,"leadSponsor":484,"locationsCount":44},"100603238","effect-of-ai-supported-child-friendly-communication-on-dental-anxiety-in-pediatric-patients-100603238","NCT07133919","Effect of AI-Supported Child-Friendly Communication on Dental Anxiety in Pediatric Patients","Evaluation of the Effect of Traditional Behavior Management Techniques and AI-Assisted Child-Friendly Communication on Dental Anxiety in Pediatric Dental Anesthesia Applications","Inclusion Criteria:\n\n* Children volunteers and their parents\u002Flegal guardians who have read and signed the informed consent form and agreed to participate in the study\n* Systemically healthy children aged 6-12 years in the mixed dentition period\n* Children requiring restorative dental procedures (including pulpotomy, pulp capping, or composite restorations) on mandibular teeth under inferior alveolar nerve block local anesthesia\n* Children who are attending their first dental visit and demonstrate behavior rated as 2 (negative) or 3 (positive) according to the Frankl Behavior Rating Scale (Categories: 1 - definitely negative; 2 - negative; 3 - positive; 4 - definitely positive) Behaviors will be categorized as positive (+) or negative (-) based on the Frankl Behavior Rating Scale (Wright's modification)\n* Children receiving local anesthesia for the first time\n\nExclusion Criteria:\n\n* Children volunteers and their parents\u002Flegal guardians who read the informed consent form but declined to participate in the study\n* Children with systemic diseases requiring continuous medication\n* Children with mental or cognitive impairments, as well as those with visual or hearing disabilities\n* Children who, after oral prophylaxis at the first visit, exhibit \"definitely negative\" (Frankl 1) or \"definitely positive\" (Frankl 4) behavior according to the Frankl Behavior Rating Scale\n* Children with previous experience of local anesthesia",{"count":22,"type":23},[26],"This study compares the effects of traditional behavior management techniques and AI-assisted child-friendly communication on dental anxiety, physiological stress, and pain perception during local anesthesia in healthy children aged 6-12. The aim is to evaluate the effectiveness of AI-supported communication tools in reducing anxiety and improving comfort in pediatric dental treatments, potentially enhancing clinical outcomes and advancing technology use in pediatric dentistry.",[471,243,472,29],"Caries, Dental","Inferior Alveolar Nerve Block",[474,155,475,476,156],"dental anesthesia","pediatric dentistry","pediatric patients","2025-12-22",{"date":479,"type":36},"2025-12-24",{"date":481,"type":36},"2025-10-15",{"date":483,"type":23},"2026-01",{"name":485,"class":43},"Çanakkale Onsekiz Mart University",{"id":487,"slug":488,"hasResults":12,"nctId":489,"briefTitle":490,"officialTitle":491,"acronym":4,"eligibilityCriteria":492,"healthyVolunteers":52,"sex":18,"minAge":19,"maxAge":204,"enrollmentInfo":493,"targetDuration":4,"studyType":24,"phases":495,"briefSummary":496,"conditions":497,"keywords":498,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":501,"lastUpdatePostDateStruct":502,"startDateStruct":504,"completionDateStruct":506,"leadSponsor":508,"locationsCount":44},"100606279","music-therapy-in-restorative-dentistry-100606279","NCT07173491","Music Therapy in Restorative Dentistry","Effectiveness of Music-Based Interventions in Reducing Dental Anxiety During Restorative Dental Treatment","Inclusion Criteria:\n\n* Systemically healthy adults aged 18-40 years.\n* Presence of D2 dentin caries confirmed by clinical and radiographic examination, characterized by radiolucency limited to the outer half of the dentin without pulpal or periapical pathology,\n* Indication for single-session restorative treatment,\n* Individuals with moderate-to-high dental anxiety according to the Modified Dental Anxiety Scale (MDAS), defined as a total score ≥10 (moderate: 10-18; high: ≥19).\n* Ability and willingness to complete questionnaires and comply with study procedures.\n\nExclusion Criteria:\n\n* deep dentin or pulpal involvement lesions, secondary caries, cracks, or fractured teeth,\n* Acute or spontaneous dental pain, percussion sensitivity, or periapical pathology,\n* Individuals with an MDAS total score ≤ 9 (no\u002Flow dental anxiety) were excluded.\n* Hearing impairment or contraindications for music therapy,\n* Psychiatric medication use or a diagnosed psychiatric disorder affecting anxiety response,\n* Pregnant or breastfeeding individuals.",{"count":494,"type":23},75,[26],"After administering a questionnaire to collect demographic data (including gender, age, education level, and frequency of dental visits) and MDAS scores, patients with an MDAS score of 10 or higher, indicating moderate to high dental anxiety, will be randomly allocated into three groups (n = 25 per group). Standard restorative treatment will be performed on the selected patients under music therapy.",[29],[499,155,500],"restorative treatment","music therapy","2025-09-24",{"date":503,"type":36},"2025-09-29",{"date":505,"type":36},"2025-01-20",{"date":507,"type":23},"2025-11-20",{"name":509,"class":43},"Ataturk University",{"id":511,"slug":512,"hasResults":12,"nctId":513,"briefTitle":514,"officialTitle":515,"acronym":516,"eligibilityCriteria":517,"healthyVolunteers":12,"sex":18,"minAge":518,"maxAge":519,"enrollmentInfo":520,"targetDuration":4,"studyType":24,"phases":522,"briefSummary":523,"conditions":524,"keywords":527,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":533,"lastUpdatePostDateStruct":534,"startDateStruct":536,"completionDateStruct":537,"leadSponsor":538,"locationsCount":4},"100604967","sleeperone-vs-conventional-infiltration-pain-perception-in-mandibular-primary-molar-extraction-100604967","NCT07156396","SleeperOne vs. Conventional Infiltration: Pain Perception in Mandibular Primary Molar Extraction","Comparative Evaluation of A Novel Anesthetic Device vs. Conventional Infiltration in Pain Perception Among A Group of Pediatric Patients Undergoing Extraction Of Mandibular Primary Molars: A Randomized Clinical Trial","SOTIMAN","Inclusion criteria:\n\n* Children Aged between 3 to 5 years.\n* Medically fit children classified as ASA physical status I and II\n* Parents acceptance to participate in the study (informed consent)\n* Children with teeth diagnostically confirmed to require extraction\n\nExclusion criteria:\n\n* Patients with an allergy to local anesthesia.\n* Uncooperative children\n* Children requiring general anesthesia","3 Years","5 Years",{"count":521,"type":23},28,[26],"This clinical trial is being conducted in the Department of Pediatric Dentistry, Faculty of Dentistry, Cairo University. The purpose of the study is to compare the pain perception and comfort of children during tooth extraction when using a computer-controlled local anesthetic device (SleeperOne® 5) versus the conventional syringe infiltration technique.\n\nChildren between 3 and 5 years of age who require extraction of a maxillary primary molar will be invited to participate. Before starting, a topical anesthetic gel (benzocaine) will be applied. Then, local anesthesia will be given using either the SleeperOne® device or the traditional syringe, depending on the group assigned.\n\nPain during injection and extraction will be assessed using both child-friendly rating scales and independent evaluation by the dentist. Patient anxiety, heart rate, and blood pressure will also be recorded.\n\nThis study aims to provide evidence on whether computer-controlled anesthesia can reduce children's pain and anxiety compared with the conventional method, leading to a more comfortable dental experience.\n\nThe study is a randomized clinical trial and will be conducted in a single visit at the Pediatric Dentistry Outpatient Clinic, Faculty of Dentistry, Cairo University. The results may help improve pain management and patient comfort during dental treatment for children.",[29,60,525,526],"Pain Management","Extraction, Tooth",[528,529,530,531,532,244],"Pediatric dentistry","Tooth extraction","conventional infiltration","sleeperOne 5","Computer-Controlled anesthesia","2025-09-02",{"date":535,"type":36},"2025-09-05",{"date":533,"type":23},{"date":533,"type":23},{"name":539,"class":43},"Ameera Alaa Eldin Abdalazim Khalifa",{"id":541,"slug":542,"hasResults":12,"nctId":543,"briefTitle":544,"officialTitle":545,"acronym":4,"eligibilityCriteria":546,"healthyVolunteers":52,"sex":18,"minAge":147,"maxAge":123,"enrollmentInfo":547,"targetDuration":4,"studyType":24,"phases":549,"briefSummary":550,"conditions":551,"keywords":555,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":558,"lastUpdatePostDateStruct":559,"startDateStruct":560,"completionDateStruct":562,"leadSponsor":564,"locationsCount":44},"100604974","pain-and-anxiety-in-pediatric-dentistry-computer-controlled-vs-traditional-anesthesia-100604974","NCT07156487","Pain and Anxiety in Pediatric Dentistry: Computer-Controlled vs. Traditional Anesthesia","The Evaluation of the Effects of Computer-controlled Electronic Anesthesia Systems and Traditional Local Anesthesia Techniques, Along With Different Anesthetic Agents, on Pain and Anxiety Levels During Dental Treatments in Pediatric Patients: A Randomized Controlled Clinical Study","Inclusion Criteria:\n\n* Patients classified as ASA I in general systemic health\n\n  * Children between 7 and 10 years of age\n  * Absence of any syndromic condition\n  * No physical or mental disability\n  * No prior dental treatment experience\n  * Frankl Behavior Rating Scale Class III or IV\n  * Presence of carious lesions limited to less than one-third of the buccolingual distance between cusp tips on the occlusal surfaces of primary or permanent molars on both sides\n  * Radiographic evidence of caries involving up to half of the dentin thickness with intact dentin at the pulp-dentin border in primary or permanent molars on both sides\n  * Teeth on both sides responding positively to pulp vitality tests, with no periradicular pathology or significant widening of the lamina dura on periapical radiographs\n\nExclusion Criteria:\n\n* Patients with mild or severe systemic diseases or those undergoing medical treatment\n\n  * Patients younger than 7 or older than 10 years of age\n  * Uncooperative or noncompliant patients classified as Class I or Class II according to the Frankl Behavior Rating Scale\n  * Patients requiring urgent dental treatment\n  * Patients with wide carious lesions extending beyond one-third of the buccolingual distance between cusp tips on the occlusal surfaces\n  * Patients with carious lesions limited to less than one-third of the buccolingual width only on one side of the jaw\n  * Teeth with carious lesions not reaching half of the dentin thickness on radiographic evaluation or lacking intact dentin at the pulp border\n  * Teeth that do not respond positively to pulp vitality tests, or that show periradicular lesions or marked widening of the lamina dura on periapical radiographs",{"count":548,"type":23},84,[26],"The purpose of this clinical study is to evaluate how different local anesthesia techniques affect pain and anxiety levels in children undergoing dental treatment. Specifically, the study compares traditional syringe-based anesthesia with a computer-controlled local anesthesia system.\n\nThe study seeks to answer the following question: Which combination of anesthesia technique is most effective in reducing pain and anxiety in pediatric dental patients?\n\nBy understanding the impact of these variables, the study aims to help dental professionals choose the most appropriate anesthesia approach to improve the comfort and emotional well-being of children during dental procedures.",[552,553,29,554],"Traditional Local Anesthesia","Computer-controlled Electronic Anesthesia","Anxiety in Children",[242,556,557],"Injections, Intraosseous","Dental Instruments","2025-09-01",{"date":535,"type":36},{"date":561,"type":23},"2025-10",{"date":563,"type":23},"2026-03",{"name":338,"class":43},{"id":566,"slug":567,"hasResults":12,"nctId":568,"briefTitle":569,"officialTitle":570,"acronym":4,"eligibilityCriteria":571,"healthyVolunteers":52,"sex":18,"minAge":519,"maxAge":54,"enrollmentInfo":572,"targetDuration":4,"studyType":24,"phases":573,"briefSummary":576,"conditions":577,"keywords":578,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":580,"lastUpdatePostDateStruct":581,"startDateStruct":583,"completionDateStruct":585,"leadSponsor":587,"locationsCount":44},"100603582","phase-2-chamomile-gummies-and-pediatric-dental-anxiety-100603582","NCT07138391","Chamomile Gummies and Pediatric Dental Anxiety","The Efficacy of Chamomile Gummies on Dental Anxiety in Children A Randomized Clinical Trial","Inclusion Criteria:\n\n* Patients exhibiting Frankl's behavior rating grade III or IV.\n* Children requiring invasive dental treatment in their primary teeth\n\nExclusion Criteria:\n\n1. Patients with severe dental symptoms (e.g. spontaneous pain, pain not relieved by analgesics).\n2. History of allergy to local anesthesia\n3. Children who currently use any medication",{"count":368,"type":23},[574,575],"PHASE2","PHASE3","The aim of this study is to evaluate the effect of oral chamomile on reducing dental anxiety in children. Anxiety assessments will be done by recording the pulse rate and blood pressure and by using modified child dental anxiety scale.",[29],[155,579,186],"chamomile","2025-08-21",{"date":582,"type":36},"2025-08-22",{"date":584,"type":23},"2025-08",{"date":586,"type":23},"2025-11",{"name":588,"class":43},"Ain Shams University",{"id":590,"slug":591,"hasResults":12,"nctId":592,"briefTitle":593,"officialTitle":594,"acronym":4,"eligibilityCriteria":595,"healthyVolunteers":52,"sex":18,"minAge":53,"maxAge":596,"enrollmentInfo":597,"targetDuration":4,"studyType":24,"phases":599,"briefSummary":600,"conditions":601,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":605,"lastUpdatePostDateStruct":606,"startDateStruct":608,"completionDateStruct":610,"leadSponsor":611,"locationsCount":44},"100530106","virtual-reality-distraction-for-dental-anxiety-rct-100530106","NCT06182462","Virtual Reality Distraction for Dental Anxiety (RCT)","The Effects of A Virtual Reality Game on Anxiety During Dental Procedures in Children (VR-TOOTH): A Randomized, Controlled Trial Protocol","Inclusion Criteria:\n\n1. Aged 6 to 17 years;\n2. Received the dentist's recommendation to participate;\n3. Required to undergo any dental procedure;\n4. Accompanied by a parent or a legal guardian who can understand, read, and write in either French or English.\n\nExclusion Criteria:\n\n1. Suffer from epilepsy,\n2. Paralysis or paresis of the hand\n3. Has any diagnosed eye disease\u002Fproblem,\n4. Any other conditions preventing them from using virtual reality (VR) (e.g., epidermolysis bullosa).","17 Years",{"count":598,"type":23},88,[26],"The aim of this randomized clinical trial is to verify the efficacy of VR immersion over a muted cartoon on a wall-mounted TV to decrease dental fear and anxiety of children undergoing dental procedures. The study also aims to gain insight on the satisfaction of parents and healthcare providers on the use of VR during dental appointments.\n\nMain research question: Does VR immersion compare to a cartoon on a wall-mounted TV is more efficacious to decrease dental fear and anxiety of children requiring dental procedures?\n\nParticipants will be playing through a VR immersive game wearing a eye-tracking VR headset that requires no movement of the head to play, facilitating the dental procedure.\n\nThe investigators will take measures of the stress levels of participants and their parents using a validated stress scale and also by taking salivary samples to verify the levels of a stress biomarker (alpha-amylase).",[29,602,603,604],"Dental Phobia","Dental Trauma","Dental Diseases","2025-08-18",{"date":607,"type":36},"2025-08-24",{"date":609,"type":36},"2023-11-01",{"date":563,"type":23},{"name":612,"class":43},"St. Justine's Hospital",{"id":614,"slug":615,"hasResults":12,"nctId":616,"briefTitle":617,"officialTitle":618,"acronym":4,"eligibilityCriteria":619,"healthyVolunteers":52,"sex":18,"minAge":53,"maxAge":54,"enrollmentInfo":620,"targetDuration":4,"studyType":24,"phases":622,"briefSummary":623,"conditions":624,"keywords":625,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":629,"lastUpdatePostDateStruct":630,"startDateStruct":632,"completionDateStruct":634,"leadSponsor":636,"locationsCount":44},"100596412","electronic-vs-conventional-syringes-impact-on-pediatric-pain-and-anxiety-100596412","NCT07045116","Electronic vs. Conventional Syringes: Impact on Pediatric Pain and Anxiety","Effectiveness of Electronic Anesthesia Delivery Syringe Versus Conventional Syringe on Pain and Anxiety Perception During Local Anesthetic Injection in Children Randomized Clinical Trial","Inclusion Criteria:\n\n* 6-8-year-old children.\n* Medically free (ASA class I).\n* Children attending their first dental visit.\n* The patient should have at least one vital primary molar with deep carious lesion on each side.\n\nExclusion Criteria:\n\n* Patient has any allergy to local anesthesia.\n* Patients take any medications that affect the salivary flow.\n* Patient taken corticosteroid.\n* Children whose parents or legal guardians refuse to sign the informed consent.",{"count":621,"type":23},40,[26],"Study Overview Purpose: To compare pain and anxiety levels in children aged 6-8 during local anesthesia administration using electronic vs. conventional syringes.\n\nDesign: Split-mouth randomized controlled trial (RCT) involving 40 children receiving both types of anesthesia during pulp therapy of bilateral maxillary primary molars.\n\nObjectives Primary Outcome: Pain level measured via Visual Analogue Scale (VAS).\n\nSecondary Outcomes:\n\nPhysiological markers: heart rate and oxygen saturation via pulse oximetry.\n\nSalivary amylase levels (anxiety biomarker) assessed using ELISA.\n\nMethodology Children are randomly assigned to receive electronic anesthesia on one side and conventional on the other in two separate visits.\n\nSaliva samples are collected before and after each injection.\n\nDouble-blind setup: children blinded using sunglasses; statistician also blinded.\n\nSame operator administers all injections for consistency.\n\nEthical Considerations Written informed consent and assent obtained.\n\nRisks (e.g., systemic toxicity, allergic reactions) minimized via dosage limits and patient monitoring.\n\nPrivacy and data security measures in place.\n\nStatistical Analysis Data analyzed using SPSS; significance set at p ≤ 0.05.\n\nSample size calculated for adequate power (n = 33 minimum; 40 enrolled).\n\nFunding Self-funded.\n\nClinical Relevance Electronic anesthesia may offer a less painful and anxiety-inducing alternative for pediatric dental patients, potentially improving children's long-term attitude toward dental care.",[29,525],[155,626,627,628],"salivary amylase","dental syringes","electronic anesthesia","2025-07-29",{"date":631,"type":36},"2025-07-31",{"date":633,"type":36},"2024-12-01",{"date":635,"type":23},"2025-08-30",{"name":637,"class":43},"Randa Omer Ahmed Bashir",{"id":639,"slug":640,"hasResults":12,"nctId":641,"briefTitle":642,"officialTitle":643,"acronym":644,"eligibilityCriteria":645,"healthyVolunteers":52,"sex":18,"minAge":53,"maxAge":54,"enrollmentInfo":646,"targetDuration":4,"studyType":24,"phases":648,"briefSummary":649,"conditions":650,"keywords":653,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":659,"lastUpdatePostDateStruct":660,"startDateStruct":662,"completionDateStruct":664,"leadSponsor":666,"locationsCount":44},"100597254","study-of-pain-perception-using-computer-controlled-versus-conventional-local-anaesthesia-in-children-undergoing-molar-extraction-100597254","NCT07056101","\"Study of Pain Perception Using Computer-Controlled Versus Conventional Local Anaesthesia in Children Undergoing Molar Extraction","Evaluation of Pain Perception Using Computer-Controlled Local Anaesthesia Delivery With Different Injection Speeds Versus Conventional Anaesthesia for Maxillary Primary Molars: A Randomized Controlled Trial","CCLAD-Pain","Inclusion Criteria:\n\n* Children aged from 6 to 8 years old\n* Both sexes\n* Healthy children classified as ASA I\n* Children with maxillary primary molars indicated for extraction\n* No previous dental experience\n* Mentally capable of communication and following instructions\n* No acute dental pain\n\nExclusion Criteria:\n\n* Uncooperative children or those with a behavioral management problem (Frankl rating 1 or 2)\n* Children with known allergies to the local anesthetic or dental materials used in the study\n* Children taking medications (e.g., antibiotics, analgesics) in the previous 48 hours that may alter pain perception\n* Children whose parents or legal guardians refuse to sign the informed consent form\n* Children experiencing acute dental pain",{"count":647,"type":23},76,[26],"This clinical trial aims to compare pain perception in children during dental procedures when using a computer-controlled local anesthesia device versus a traditional syringe. Children aged 6 to 8 years who need maxillary primary molar extraction will be randomly assigned to one of four groups: three groups using different speeds of the GENI computer-controlled device, and one group using a conventional syringe. The study will assess pain using facial expression scales and physiological measures such as heart rate. The goal is to find a more comfortable method for delivering anesthesia to pediatric dental patients.",[602,29,651,652],"Dental Anesthesia","Dental Anesthesia Efficacy",[654,244,655,656,657,658],"GENI Device","Local Anesthesia Technique","Articaine","Computer-Controlled Local Anesthesia","Dental Injections","2025-07-10",{"date":661,"type":36},"2025-07-14",{"date":663,"type":23},"2025-07-01",{"date":665,"type":23},"2025-10-31",{"name":667,"class":43},"Tarek MHD kher al saka amini"]