[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dental-caries\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dental-caries":28},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,90,0,25,[9,54,86,119,145,176,200,228,254,282,305,328,355,381,412,445,468,491,519,545,572,599,624,649,670],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":4},"100651880","whatsapp-messages-to-improve-mothers-oral-health-knowledge-and-childrens-toothbrushing-100651880",false,"NCT07765654","WhatsApp Messages to Improve Mothers' Oral Health Knowledge and Children's Toothbrushing","Effectiveness of WhatsApp-Based Messages as an Adjunct to Oral Health Education on Maternal Oral Health Knowledge and Child Toothbrushing Behavior: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Mother of at least one child aged 3 to 6 years\n* Aged 18 years or older\n* Able to read and understand Arabic\n* Owns a smartphone with an active WhatsApp account\n* Attending the Pediatric Dentistry Clinics at King Abdulaziz University Hospital at the time of recruitment\n* Willing to participate and provide informed consent\n\nExclusion Criteria:\n\n* Dental professional or dental student\n* Currently participating in another oral health education program targeting child oral health or toothbrushing practices","FEMALE","18 Years",{"count":20,"type":21},106,"ESTIMATED","INTERVENTIONAL",[24],"NA","Tooth decay is one of the most common health problems in young children in Saudi Arabia. Brushing twice a day with fluoride toothpaste is one of the most effective ways to prevent it, but preschool children cannot do this properly on their own and depend on their mothers to brush for them and to supervise them. Mothers usually receive oral health advice only once, during a dental visit, and a single session may not be enough to change daily habits at home.\n\nThis study will test whether short oral health messages sent to mothers on WhatsApp, in addition to the usual face-to-face advice, help mothers know more about toothbrushing and help their children brush better.\n\nMothers of children aged 3 to 6 years attending the Pediatric Dentistry Clinics at King Abdulaziz University Hospital in Jeddah will be invited to take part. All mothers will first answer a short questionnaire about what they know about toothbrushing and how their child currently brushes. All mothers will then receive the same 10 to 15 minute face-to-face oral health education session. After the session, each mother will be placed into one of two groups by chance, like flipping a coin. Mothers in the first group will also receive two WhatsApp messages a week for eight weeks, sixteen messages in total, covering how often to brush, how much fluoride toothpaste to use, correct brushing technique, and how to help and supervise their child. Mothers in the second group will not receive these messages.\n\nAfter eight weeks, all mothers will answer the same questionnaire again, and the answers of the two groups will be compared. Taking part involves no dental treatment or procedures beyond the child's normal care, and mothers may withdraw at any time.",[27,28,29,30,31],"Oral Health","Dental Caries","Health Behavior","Oral Hygiene","Early Childhood Caries (ECC)",[33,34,35,36,37,38,39,40,41],"WhatsApp","mHealth","Mobile Health","Toothbrushing","Preschool Children","Maternal Knowledge","Oral Health Education","Health Promotion","Saudi Arabia","NOT_YET_RECRUITING","2026-08-17",{"date":45,"type":46},"2026-08-18","ACTUAL",{"date":48,"type":21},"2026-08-30",{"date":50,"type":21},"2027-08-30",{"name":52,"class":53},"King Abdulaziz University","OTHER",{"id":55,"slug":56,"hasResults":12,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":4,"eligibilityCriteria":60,"healthyVolunteers":12,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":4,"studyType":22,"phases":66,"briefSummary":67,"conditions":68,"keywords":72,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":4},"100652430","clinical-and-radiographic-success-of-calcium-hydroxide-iodoform-paste-versus-modified-triple-antibiotic-paste-for-necrotic-primary-molars-in-children-100652430","NCT07773805","Clinical and Radiographic Success of Calcium Hydroxide-Iodoform Paste Versus Modified Triple Antibiotic Paste for Necrotic Primary Molars in Children","Assessment of the Clinical and Radiographic Success of Calcium Hydroxide Iodoform Paste Versus Modified Triple Antibiotic Paste for the Treatment of Necrotic Primary Molars Using LSTR Technique: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Pediatric patients aged 4-7 years\n* Positive parental informed consent\n* Restorable necrotic mandibular second primary molars with peri-radicular\u002Ffurcal involvement and\u002For pathologic root resorption (external or internal one-third to two-thirds of the root)\n* Presence of chronic apical abscess or sinus tract or furcation radiolucency\n\nExclusion Criteria:\n\n* Medically compromised patient\n* Children with a known allergy to any of the components being utilized\n* Molars near exfoliation\n* Molars with severely resorbed roots more than two thirds, indicated for extraction\n* Molar with insufficient coronal structure disabling proper coronal seal\n* Presence of a periapical or interradicular radiolucent area which could compromise the permanent tooth bud","ALL","4 Years","7 Years",{"count":65,"type":21},50,[24],"This randomized clinical trial aims to compare the clinical and radiographic success of calcium hydroxide-iodoform paste and modified triple antibiotic paste when used for the treatment of necrotic primary molars in children using the lesion sterilization and tissue repair (LSTR) technique. The study will include children aged 4-7 years with restorable necrotic mandibular second primary molars. Participants will be randomly assigned to receive LSTR treatment with either calcium hydroxide-iodoform paste or modified triple antibiotic paste. Clinical and radiographic findings will be assessed during follow-up over 12 months to determine the success of each treatment. The study hypothesis is that there will be a difference in the clinical and radiographic success between the two treatment materials when used with the LSTR technique",[69,70,28,71],"Dental Pulp Necrosis","Periapical Diseases","Primary Teeth",[73,69,74,75,76],"Lesion Sterilization and Tissue Repair","Calcium Hydroxide-Iodoform Paste","Modified Triple Antibiotic Paste","Necrotic Primary Teeth","2026-08-16",{"date":79,"type":46},"2026-08-19",{"date":81,"type":21},"2027-01",{"date":83,"type":21},"2028-01",{"name":85,"class":53},"Cairo University",{"id":87,"slug":88,"hasResults":12,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":92,"eligibilityCriteria":93,"healthyVolunteers":12,"sex":61,"minAge":94,"maxAge":95,"enrollmentInfo":96,"targetDuration":4,"studyType":22,"phases":98,"briefSummary":99,"conditions":100,"keywords":104,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":118},"100607293","hall-technique-vs-conventional-crown-restoration-in-permanent-molars-split-mouth-trial-in-children-100607293","NCT07186673","Hall Technique vs Conventional Crown Restoration in Permanent Molars: Split-Mouth Trial in Children","The Effectiveness of Using the Hall Technique in Restoring First Permanent Molars","HTCC-SM","Inclusion Criteria (Clinical):\n\n* No signs or symptoms of irreversible pulpitis\n* Molars with carious lesions affecting two or more surfaces\n* Permanent first molars with developmental defects\n\nInclusion Criteria (Radiographic):\n\n* First molars with an intact dentin layer visible radiographically\n* No signs of internal or external resorption\n* No evidence of periradicular bone resorption\n\nExclusion Criteria:\n\n* Patients with known nickel allergy\n* Severely damaged molars not restorable with preformed crowns\n* First molars without opposing teeth\n* Pulp exposure during caries excavation","8 Years","15 Years",{"count":97,"type":21},10,[24],"The aim of this study is to compare the clinical and radiographic success of stainless steel crowns placed using the Hall Technique versus the conventional method in the restoration of permanent first molars in children, and to evaluate their effects on occlusal relationships, crown adaptation, and patient satisfaction.\n\nStudy Outcomes The primary outcome of this study was to evaluate the clinical and radiographic success of stainless steel crowns placed on permanent first molars using the Hall Technique in comparison to the conventional crown placement method. The secondary outcomes included assessment of the marginal fit and adaptation of preformed crowns using both techniques, analysis of changes in occlusal relationships-specifically the vertical dimension of occlusion and overbite-and evaluation of patient satisfaction. Patient satisfaction was measured using a five-point Likert scale at multiple time points: immediately post-treatment, and at one, three, and six months.",[101,28,102,103],"Permanent Molars","Tooth Decay","Permanent First Molar Caries",[105,106,107,28],"Hall Technique","Stainless Steel Crowns","Permanent First Molars","RECRUITING","2026-08-12",{"date":111,"type":46},"2026-08-14",{"date":113,"type":46},"2025-12-01",{"date":115,"type":21},"2026-08-15",{"name":117,"class":53},"Latakia University",3,{"id":120,"slug":121,"hasResults":12,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":4,"eligibilityCriteria":125,"healthyVolunteers":12,"sex":61,"minAge":126,"maxAge":4,"enrollmentInfo":127,"targetDuration":4,"studyType":22,"phases":129,"briefSummary":131,"conditions":132,"keywords":133,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":138,"completionDateStruct":140,"leadSponsor":142,"locationsCount":144},"100650524","phase-2-a-clinical-study-of-kh001-for-pulp-preservation-and-safety-in-deep-dentin-caries-100650524","NCT07751016","A Clinical Study of KH001 for Pulp Preservation and Safety in Deep Dentin Caries","A Randomized, Single-center, Double-blinded, Placebo-controlled, Investigator-initiated Trial to Evaluate the Efficacy and Safety of KH001 in Patients With Deep Dentinal Caries","Inclusion Criteria:\n\n* Is ≥ 19 years old by the time of the screening visit.\n* Has signed written informed consent in the study.\n* Subjects who can comply with oral hygiene during the study period.\n\nExclusion Criteria:\n\n* Is allergic to the active ingredient or other ingredients used in the investigational product.\n* Have participated in another clinical study within 30 days from screening visit and have a history of administration of investigational product.\n* Is judged by the investigator as ineligible for participation for other reasons.","19 Years",{"count":128,"type":21},36,[130],"PHASE2","The Purpose of this Study is to Evaluate Pulp Preservation and Safety of KH001 in the Administration of Deep Dentin Caries.",[28],[134],"caries","2026-08-03",{"date":137,"type":46},"2026-08-06",{"date":139,"type":21},"2026-09-30",{"date":141,"type":21},"2028-06-30",{"name":143,"class":53},"Seoul National University Dental Hospital",1,{"id":146,"slug":147,"hasResults":12,"nctId":148,"briefTitle":149,"officialTitle":150,"acronym":4,"eligibilityCriteria":151,"healthyVolunteers":152,"sex":61,"minAge":18,"maxAge":4,"enrollmentInfo":153,"targetDuration":62,"studyType":155,"phases":4,"briefSummary":156,"conditions":157,"keywords":160,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":168,"startDateStruct":170,"completionDateStruct":172,"leadSponsor":174,"locationsCount":144},"100650201","discovery-and-validation-of-biomarkers-for-periodontitis-dental-caries-and-oral-squamous-cell-carcinoma-100650201","NCT07745803","Discovery and Validation of Biomarkers for Periodontitis, Dental Caries and Oral Squamous Cell Carcinoma","Discovery and Validation of Biomarkers for Periodontitis, Dental Caries and Oral Squamous Cell Carcinoma: A Multi-Disease Cohort Study","Inclusion Criteria:\n\nParticipants must meet all of the following criteria:\n\n1. Adults aged 18 years or older.\n2. Able to understand the study information and provide written informed consent.\n3. Meet the criteria for one of the study groups based on clinical evaluation and disease assessment, including:\n\nOral squamous cell carcinoma (OSCC); Periodontal disease; Dental caries; Oral health without the corresponding diseases (healthy controls).\n\nExclusion Criteria:\n\nParticipants will be excluded if they meet any of the following criteria:\n\n1. Edentulous individuals.\n2. History of radiotherapy to the head and neck region.\n3. Presence of immunodeficiency conditions (for example, human immunodeficiency virus infection).\n4. Pregnancy.",true,{"count":154,"type":21},4000,"OBSERVATIONAL","The goal of this observational study is to develop better ways to detect and predict major oral diseases, including oral cancer, gum disease, and tooth decay. This study will collect detailed oral health information and biological samples from adults with different oral health conditions and healthy participants to identify markers that may help doctors detect diseases earlier and predict how diseases may change over time. The main questions this study aims to answer are whether biological markers from saliva, mouth rinse samples, blood, or oral tissue samples can help identify people with oral diseases, whether these markers can predict future disease changes such as worsening gum disease, new or progressing tooth decay, or recurrence and spread of oral cancer, and whether combining clinical information with biological markers can improve disease detection and risk prediction. Participants will receive a standard oral health examination, provide information about their health history and oral health behaviors, provide biological samples when appropriate, and be followed over time through clinical visits, questionnaires, and health information collection. Researchers will compare findings among people with different oral health conditions and healthy participants to better understand disease-related changes and develop tools for earlier detection and prediction of oral disease outcomes.",[158,159,28],"Oral Squamous Cell Carcinoma (OSCC)","Periodontal Disease",[161,162,163,164,165,166,167],"Oral disease","Oral squamous cell carcinoma","Periodontal disease","Dental caries","Biomarkers","Early detection","Prognostic prediction",{"date":169,"type":46},"2026-08-04",{"date":171,"type":21},"2026-08-25",{"date":173,"type":21},"2031-12-30",{"name":175,"class":53},"Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University",{"id":177,"slug":178,"hasResults":12,"nctId":179,"briefTitle":180,"officialTitle":181,"acronym":4,"eligibilityCriteria":182,"healthyVolunteers":152,"sex":61,"minAge":183,"maxAge":184,"enrollmentInfo":185,"targetDuration":4,"studyType":22,"phases":187,"briefSummary":189,"conditions":190,"keywords":191,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":194,"lastUpdatePostDateStruct":195,"startDateStruct":196,"completionDateStruct":197,"leadSponsor":198,"locationsCount":144},"100649974","phase-3-povidone-iodine-for-caries-prevention-100649974","NCT07741409","Povidone Iodine for Caries Prevention","Povidone Iodine to Prevent Early Childhood Caries","Inclusion Criteria\n\n* 1 to 3 years of age\n* No plans to relocate in the next 12 months\n\nExclusion Criteria\n\n* Thyroid condition\n* Antibiotic usage in the prior 3 months","1 Year","3 Years",{"count":186,"type":21},174,[188],"PHASE3","The goal of this clinical trial is to learn if Povidone Iodine works to prevent tooth decay and suppress the mouth germs responsible for tooth decay. The main questions it aims to answer are:\n\n1. How will home use of Povidone Iodine, as an adjunct treatment to standard dental care, reduce the incidence of tooth decay?\n2. How will home use of Povidone Iodine reduce the mouth germs responsible for tooth decay?\n3. If Povidone Iodine use is accompanied by probiotic use, will its effectiveness be even better than Povidone Iodine alone?\n\nParticipants will:\n\n1. Provide a plaque sample at the beginning of the study.\n2. Swab their children's teeth once a week for one month and then monthly thereafter. Some participants may be asked to use probiotic drops nightly after brushing their teeth.\n3. Keep a record of compliance.\n4. Return every 6 months for a dental exam and to provide a plaque sample. Keep a diary of their symptoms and the number of times they use a rescue inhaler",[28],[28,192,193],"Povidone Iodine","Probiotics","2026-07-29",{"date":135,"type":46},{"date":135,"type":21},{"date":141,"type":21},{"name":199,"class":53},"Jeffrey A. Banas",{"id":201,"slug":202,"hasResults":12,"nctId":203,"briefTitle":204,"officialTitle":205,"acronym":4,"eligibilityCriteria":206,"healthyVolunteers":152,"sex":61,"minAge":207,"maxAge":208,"enrollmentInfo":209,"targetDuration":4,"studyType":22,"phases":211,"briefSummary":212,"conditions":213,"keywords":215,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":219,"lastUpdatePostDateStruct":220,"startDateStruct":222,"completionDateStruct":224,"leadSponsor":226,"locationsCount":144},"100648789","clinical-evaluation-of-the-retention-of-fissure-sealants-applied-following-guided-biofilm-therapy-and-conventional-polishing-100648789","NCT07725133","Clinical Evaluation of the Retention of Fissure Sealants Applied Following Guided Biofilm Therapy and Conventional Polishing","Clinical Evaluation of the Retention of Fissure Sealants Applied Following Guided Biofilm Therapy and Conventional Polishing: A Split-Mouth Randomized Clinical Trial","Inclusion Criteria:\n\n* Children aged 6-10 years presenting to the Department of Pediatric Dentistry, Marmara University Faculty of Dentistry, for routine dental treatment.\n* Systemically healthy individuals classified as ASA I.\n* Children who are cooperative and able to maintain communication throughout the clinical procedure.\n* Presence of at least two comparable permanent first molars with unrestored occlusal surfaces that are either caries-free or have initial lesions limited to the pit and fissure level.\n\nExclusion Criteria:\n\n* Individuals with systemic diseases (e.g., diabetes, epilepsy, cardiovascular diseases), classified as ASA II or higher.\n\nIndividuals who have used antibiotics, anti-inflammatory drugs, or immunosuppressive medications within the past 3 months.\n\n* Children who are unable to communicate due to emotional, psychological, or developmental disorders.\n* Individuals with previously placed pit and fissure sealants on their permanent first molars.\n* Presence of deep carious lesions, restorations, or structural defects such as molar-incisor hypomineralization (MIH) in the teeth planned for inclusion in the study.","6 Years","10 Years",{"count":210,"type":21},80,[24],"This randomized split-mouth clinical trial will compare two methods of occlusal surface cleaning before pit and fissure sealant placement in children aged 6-10 years.\n\nIn each participant, eligible permanent first molars will receive either erythritol-based Guided Biofilm Therapy or conventional rotary-brush polishing before phosphoric acid etching and placement of the same resin-based sealant. Each child will receive both interventions on opposite sides of the mouth.\n\nThe sealants will be followed for up to 36 months to determine whether the surface-cleaning method influences sealant retention and clinical performance. Procedure-related discomfort will also be compared between the two methods.",[214,28],"Pit and Fissure Sealant Retention",[216,217,218],"guided biofilm therapy","airflowing","fissure sealant","2026-07-21",{"date":221,"type":46},"2026-07-24",{"date":223,"type":21},"2026-07-20",{"date":225,"type":21},"2029-10-20",{"name":227,"class":53},"Marmara University",{"id":229,"slug":230,"hasResults":12,"nctId":231,"briefTitle":232,"officialTitle":233,"acronym":4,"eligibilityCriteria":234,"healthyVolunteers":152,"sex":61,"minAge":207,"maxAge":63,"enrollmentInfo":235,"targetDuration":237,"studyType":155,"phases":4,"briefSummary":238,"conditions":239,"keywords":240,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":219,"lastUpdatePostDateStruct":247,"startDateStruct":248,"completionDateStruct":250,"leadSponsor":252,"locationsCount":4},"100648741","caries-of-first-permanent-molars-and-association-with-dietary-and-oral-habits-among-a-group-of-egyptian-children-100648741","NCT07725757","Caries of First Permanent Molars and Association With Dietary and Oral Habits Among a Group of Egyptian Children","Caries Status of First Permanent Molars and Their Association With Dietary and Oral Hygiene Habits Among a Group of Egyptian Children Aged 6-7 Years : A Cross Sectional Study.","Inclusion Criteria:\n\n* Age: 6 to 7 years old children\n* Children with written informed consent from their parents or guardians were included\n* Healthy child\n\nExclusion Criteria:\n\n* Previous history\u002Fcurrent radiotherapy and\u002For chemotherapy.\n* Presence of retained primary teeth or congenital or developmental anomalies affecting the permanent dentition.\n* Missing teeth due to causes other than dental caries.\n* Subjects undergoing orthodontic therapy, which might preclude normal tooth brushing.\n* Subjects who, in the opinion of the Investigator, may be non-compliant with study procedures.",{"count":236,"type":21},272,"1 Day","This cross-sectional study aims to assess the prevalence of dental caries in the first permanent molars of Egyptian children aged 6 to 7 years, and to examine how this caries status relates to the children's dietary habits and oral hygiene practices. A total of 272 children will undergo a clinical oral examination, and their parents or guardians will complete a structured questionnaire covering diet, tooth-brushing habits, and socio-demographic background. The findings are intended to help identify risk factors associated with early caries in these key teeth, supporting better-targeted preventive dental care for this age group.",[28],[164,241,242,243,244,245,246],"First Permanent Molars","Prevalence","Cross sectional","dietary habits","Oral hygiene habits","Egyptian children",{"date":221,"type":46},{"date":249,"type":21},"2026-09-01",{"date":251,"type":21},"2026-11-01",{"name":253,"class":53},"October University for Modern Sciences and Arts",{"id":255,"slug":256,"hasResults":12,"nctId":257,"briefTitle":258,"officialTitle":259,"acronym":4,"eligibilityCriteria":260,"healthyVolunteers":152,"sex":61,"minAge":18,"maxAge":261,"enrollmentInfo":262,"targetDuration":4,"studyType":155,"phases":4,"briefSummary":264,"conditions":265,"keywords":267,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":276,"lastUpdatePostDateStruct":277,"startDateStruct":278,"completionDateStruct":280,"leadSponsor":281,"locationsCount":144},"100648170","validation-of-a-digital-caries-risk-assessment-questionnaire-against-the-cambra-protocol-in-an-egyptian-adult-population-100648170","NCT07716254","Validation of a Digital Caries Risk Assessment Questionnaire Against the CAMBRA Protocol in an Egyptian Adult Population","Validation of a Digital Caries Risk Assessment Questionnaire Against the CAMBRA Protocol in an Egyptian Adult Population: A Cross-Sectional Diagnostic Agreement Study","* Inclusion Criteria\n\n  1. Adults aged 18 to 65 years.\n  2. Egyptian nationals or individuals who have resided in Egypt for at least 5 years.\n  3. Able to read and understand Arabic or English.\n  4. Presence of at least 10 natural teeth.\n  5. Presenting for routine dental examination, preventive care, or treatment planning.\n  6. Able and willing to provide written informed consent.\n* Exclusion Criteria\n\n  1. Presence of acute dental pain or a dental emergency requiring immediate treatment at the time of enrollment.\n  2. Severe cognitive impairment or psychiatric disorder that would interfere with completion of the questionnaire or informed consent.\n  3. Currently participating in another oral health research study.\n  4. Complete edentulism or extensive fixed prosthetic rehabilitation that precludes assessment of the Decayed, Missing, and Filled Teeth (DMFT) index.","65 Years",{"count":263,"type":21},384,"This study is designed as a cross-sectional diagnostic agreement study conducted in accordance with the Standards for Reporting Diagnostic Accuracy Studies (STARD 2015) and the Guidelines for Reporting Agreement and Precision of Patient-reported Assessments (GRAPPA). The study evaluates the diagnostic agreement between the Digital Caries Risk Questionnaire (DCRQ), a novel patient self-administered digital instrument, and the Caries Management by Risk Assessment (CAMBRA) protocol as the primary clinical comparator. The Decayed, Missing, and Filled Teeth (DMFT) index is used as the reference standard for cumulative caries experience, with a threshold of DMFT ≥ 4 to identify individuals with high caries experience. Although the DMFT index reflects previous disease experience rather than future disease risk, it provides an objective clinical outcome for assessing construct validity. Accordingly, CAMBRA serves as the primary comparator for risk classification, whereas the DMFT index supports validation by evaluating the relationship between questionnaire-derived risk categories and cumulative clinical disease burden.\n\nThe methodological rationale for this study is based on the current evidence supporting contemporary caries risk assessment models. CAMBRA is recognized as one of the most extensively validated and widely implemented caries risk assessment systems and has demonstrated diagnostic performance comparable to other internationally accepted risk assessment models. Systematic evidence has shown that these validated models provide acceptable discriminatory ability and calibration for identifying individuals at increased risk of developing dental caries. Furthermore, recent evidence synthesizing longitudinal cohort studies has identified a consistent set of adult caries risk factors, including smoking, systemic diseases, water fluoridation exposure, educational level, fluoride toothpaste use, dietary sugar intake, bacterial plaque accumulation, and previous caries experience. These established determinants are comprehensively represented within the nine domains of the DCRQ, supporting its content validity. In addition, previous validation studies of simplified questionnaire-based caries risk assessment instruments have demonstrated acceptable internal consistency, good test-retest reliability, and significant associations between increasing risk categories and objective clinical indicators such as DMFT scores, plaque accumulation, white spot lesions, and active cavitated lesions. Collectively, these findings support the use of a cross-sectional diagnostic agreement design in which questionnaire-derived risk classification is evaluated against an established clinical risk assessment protocol and validated using objective measures of cumulative caries experience.",[28,266],"Caries Risk",[268,269,270,271,272,273,274,275],"CAMBRA","caries risk assessment","digital health","oral health questionnaire","diagnostic agreement","Egypt","MENA","preventive dentistry","2026-07-15",{"date":219,"type":46},{"date":279,"type":46},"2026-06-05",{"date":251,"type":21},{"name":253,"class":53},{"id":283,"slug":284,"hasResults":12,"nctId":285,"briefTitle":286,"officialTitle":287,"acronym":288,"eligibilityCriteria":289,"healthyVolunteers":12,"sex":61,"minAge":94,"maxAge":208,"enrollmentInfo":290,"targetDuration":4,"studyType":22,"phases":292,"briefSummary":293,"conditions":294,"keywords":295,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":297,"lastUpdatePostDateStruct":298,"startDateStruct":299,"completionDateStruct":301,"leadSponsor":303,"locationsCount":144},"100645642","clinical-and-radiographic-assessment-of-first-permanent-molars-with-cention-n-100645642","NCT07703176","Clinical and Radiographic Assessment of First Permanent Molars With Cention-N","Assessment of Clinical, Radiographic, and Oral Health-Related Quality of Life Following Restoration of First Permanent Molars With Cention-N: A 12-Month Split-Mouth Randomized Controlled Trial","Cention-N","Inclusion Criteria:\n\nClinical:\n\n1. Children aged 8-10 years.\n2. Children classified as ASA physical status I or II.\n3. Children demonstrate positive or definitely positive behavior (scores 3 or 4 on the Frankl Behavior Rating Scale).\n4. Children who are available for regular recall visits throughout the study period.\n5. Presence of bilateral carious lesions in permanent first molars, with a clear description of lesion depth whenever possible.\n6. Asymptomatic vital permanent first molars showing no clinical or radiographic signs of pathology.\n\nRadiographic:\n\n1. Normal lamina dura and periodontal ligament space.\n2. No apical radiolucency.\n\nExclusion Criteria:\n\nClinical:\n\n1. Children with behavioral difficulties or without signed parental consent.\n2. Children are classified as ASA physical status class III or higher.\n3. Teeth presenting clinical signs of pulpitis or necrosis (e.g., nocturnal pain, fistula, abscess, pulp exposure, or pathological mobility).\n\nRadiographic:\n\n1. Evidence of abnormal radiolucency involving the pulp chamber or root apex.\n2. Detection of furcal bone radiolucency or abnormal root resorption.",{"count":291,"type":21},100,[24],": Assessment of Clinical, Radiographic, and Oral Health-Related Quality of Life Following Restoration of First Permanent Molars with Cention N: A 12-Month Split-Mouth Randomized Controlled Trial\n\nIntroduction\n\nDental caries is one of the most common chronic diseases affecting children. First permanent molars (FPMs) are particularly susceptible to caries because of their early eruption and complex occlusal anatomy. Restorative treatment aims to preserve tooth function and prevent disease progression. Composite resin is widely used because of its esthetics and mechanical properties; however, polymerization shrinkage may compromise marginal integrity. Cention N is a newer alkasite restorative material that releases fluoride, calcium, and hydroxide ions, promoting remineralization and enhancing caries resistance. Since treatment success should include both clinical outcomes and patient-centered outcomes, oral health-related quality of life (OHRQoL) will also be assessed.\n\nAim\n\nTo compare the clinical and radiographic performance of Cention N and bioactive injectable resin composite in restoring first permanent molars over 12 months. A secondary objective is to evaluate changes in children's oral health-related quality of life.\n\nMaterials and Methods\n\nThis will be a split-mouth randomized controlled clinical trial involving 100 children aged 8-10 years.\n\nInclusion criteria:\n\nHealthy children (ASA I or II). Positive\u002Fdefinitely positive behavior (Frankl 3 or 4). Bilateral carious first permanent molars. Vital, asymptomatic teeth without radiographic pathology.\n\nExclusion criteria:\n\nLack of parental consent. ASA III or higher. Teeth with signs of irreversible pulp disease or radiographic pathology.\n\nEthical approval will be obtained from the Research Ethics Committee, Faculty of Dentistry, Minia University, and written informed consent will be obtained from parents.\n\nClinical Procedure\n\nFollowing clinical and radiographic examination, local anesthesia and rubber dam isolation will be performed. Caries will be removed conservatively, followed by acid etching and adhesive application.\n\nOne molar will be restored with bioactive injectable resin composite according to the manufacturer's instructions.\n\nThe contralateral molar will be restored with Cention N, mixed and placed according to the manufacturer's instructions, with optional light curing.\n\nAll restorations will be finished and polished using standardized procedures.\n\nOutcome Assessment\n\nPrimary outcome\n\nClinical and radiographic evaluation at 3, 6, and 12 months using the modified USPHS criteria, including:\n\nColor match Marginal adaptation Marginal discoloration Anatomic form Secondary caries Restoration integrity\n\nSecondary outcome Assessment of oral health-related quality of life using the Child Perceptions Questionnaire (CPQ8-10), which evaluates oral symptoms, functional limitations, emotional well-being, and social well-being.\n\nStatistical Analysis\n\nCollected data will be tabulated and analyzed using appropriate statistical methods to compare the performance of both restorative materials over the follow-up period.",[28],[296],"Cention N Clinical Trial","2026-07-13",{"date":276,"type":46},{"date":300,"type":46},"2026-03-09",{"date":302,"type":21},"2027-09-09",{"name":304,"class":53},"Minia University",{"id":306,"slug":307,"hasResults":12,"nctId":308,"briefTitle":309,"officialTitle":310,"acronym":4,"eligibilityCriteria":311,"healthyVolunteers":152,"sex":61,"minAge":312,"maxAge":313,"enrollmentInfo":314,"targetDuration":4,"studyType":155,"phases":4,"briefSummary":315,"conditions":316,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":319,"lastUpdatePostDateStruct":320,"startDateStruct":322,"completionDateStruct":324,"leadSponsor":326,"locationsCount":4},"100647354","salivary-cytokines-mmp-8-and-dental-caries-in-osteoporosis-patients-100647354","NCT07709247","Salivary Cytokines, MMP-8 and Dental Caries in Osteoporosis Patients","Osteoporoz Hastalarında Tükürük Sitokin, Matrix Metalloproteinase 8 ve Diş Çürüğünün Değerlendirilmesi","Inclusion Criteria:\n\n* Willing to give voluntary consent For Group 1, having been diagnosed with osteoporosis For Group 2, being systemically healthy and not having a diagnosis of osteoporosis\u002Fosteopenia\n\nExclusion Criteria:\n\n* Having a chronic inflammatory or autoimmune disease Using glucocorticoids, anti-anxiety medications, antidepressants, or antiepileptic drugs Having been diagnosed with any malignancy Having any endocrine disease Having undergone periodontal treatment within the last 6 months","45 Years","75 Years",{"count":65,"type":21},"This study examines saliva samples from patients with osteoporosis. The levels of cytokines and Matrix Metalloproteinase-8 (MMP-8) enzyme in saliva will be measured. Additionally, the dental caries status of participants will be evaluated. The aim of this study is to understand the relationship between osteoporosis and oral health. Only saliva samples will be collected from participants; no treatment or medication will be administered.",[317,28,165,318],"Osteoporosis","Matrix Metalloproteinase 8","2026-07-12",{"date":321,"type":46},"2026-07-16",{"date":323,"type":21},"2026-07-10",{"date":325,"type":21},"2027-07-10",{"name":327,"class":53},"Afyonkarahisar Health Sciences University",{"id":329,"slug":330,"hasResults":12,"nctId":331,"briefTitle":332,"officialTitle":333,"acronym":4,"eligibilityCriteria":334,"healthyVolunteers":152,"sex":61,"minAge":18,"maxAge":4,"enrollmentInfo":335,"targetDuration":4,"studyType":22,"phases":336,"briefSummary":337,"conditions":338,"keywords":340,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":347,"lastUpdatePostDateStruct":348,"startDateStruct":349,"completionDateStruct":351,"leadSponsor":352,"locationsCount":354},"100602516","phase-3-effectiveness-of-toothpaste-tablets-on-plaque-gingival-health-and-caries-experiences-100602516","NCT07124533","Effectiveness of Toothpaste Tablets on Plaque, Gingival Health and Caries Experiences","Effectiveness of Toothpaste Tablets on Plaque, Gingival Health and Caries Experiences: A 6-week Randomized Controlled Trial","Inclusion Criteria:\n\n1. Subjects are 18 years or older;\n2. Subjects who will comply with study protocol;\n3. Subjects who can read and understand the consent form;\n4. Subjects available during the study period;\n5. Subjects have more than 20 teeth.\n\nExclusion Criteria:\n\n1\\. Subjects under the age of 18.",{"count":65,"type":21},[188],"Objectives: To evaluate the effectiveness of toothpaste tablets when compared to conventional dentifrices in removing plaque.\n\nMethods: 50 participants are randomized into two groups: Denttabs toothpaste tablets (T) and Colgate's Cavity Protection toothpaste (P). Both groups utilize their assigned dentifrice for 6 weeks. A pre and post-assessment measures the Gingival Index (GI) and Plaque Index (PI) and Decayed, Missing and Filled Teeth (DMFT). A questionnaire on the use of the product is distributed at the end of the study.",[339,28],"Gingival Inflammation",[341,342,343,344,345,346],"Gingival Index","Plaque Index","Dentifrice","Toothpaste Tablets","Caries Experiences","Consumer Satisfaction","2026-07-08",{"date":323,"type":46},{"date":350,"type":21},"2026-12",{"date":350,"type":21},{"name":353,"class":53},"Loma Linda University",2,{"id":356,"slug":357,"hasResults":12,"nctId":358,"briefTitle":359,"officialTitle":360,"acronym":4,"eligibilityCriteria":361,"healthyVolunteers":152,"sex":61,"minAge":362,"maxAge":363,"enrollmentInfo":364,"targetDuration":4,"studyType":155,"phases":4,"briefSummary":366,"conditions":367,"keywords":368,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":372,"lastUpdatePostDateStruct":373,"startDateStruct":375,"completionDateStruct":376,"leadSponsor":378,"locationsCount":4},"100646836","sequential-pvp-i-and-fv-100646836","NCT07683910","Sequential PVP-I and FV","Sequential Application of PVP-I and Fluoride Varnish: A Prospective Cohort Study","Inclusion Criteria:\n\n* Children 6-24 months of age at enrollment. To be eligible a child will have at least 1 erupted tooth that is either sound or has only a d1 (white spot) lesion.\n\nExclusion Criteria:\n\n1. Previous treatment with fluoride varnish\n2. Known allergy to iodine\n3. Diagnosis of thyroid disease\n4. Chronic, prophylactic use of antibiotics\n5. Treatment with another investigational drug or other intervention within 30 days preceding the Baseline Visit.\n6. Visible cavities (d2-4) in the erupted primary teeth\n7. Presence of intraoral soft tissue pathology (gum boil)\n8. Parent anticipates the child will move from current city during the next 24 months.","6 Months","24 Months",{"count":365,"type":21},393,"This prospective cohort study in children will determine if: topical povidone iodine 10% followed by topical fluoride varnish is superior to placebo iodine followed two different varnishes alone to prevent tooth decay (dental caries).",[28],[369,370,371],"Early Childhood Caries","Fluoride Varnish","Povidone-Iodine","2026-06-28",{"date":374,"type":46},"2026-07-06",{"date":249,"type":21},{"date":377,"type":21},"2029-03-01",{"name":379,"class":380},"Advantage Silver Dental Arrest, LLC","INDUSTRY",{"id":382,"slug":383,"hasResults":12,"nctId":384,"briefTitle":385,"officialTitle":386,"acronym":387,"eligibilityCriteria":388,"healthyVolunteers":12,"sex":61,"minAge":207,"maxAge":389,"enrollmentInfo":390,"targetDuration":4,"studyType":22,"phases":391,"briefSummary":392,"conditions":393,"keywords":395,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":403,"lastUpdatePostDateStruct":404,"startDateStruct":406,"completionDateStruct":408,"leadSponsor":410,"locationsCount":144},"100644631","effect-of-ozone-therapy-on-remineralization-of-initial-caries-lesions-in-children-100644631","NCT07671651","Effect of Ozone Therapy on Remineralization of Initial Caries Lesions in Children","Effect of Ozone Therapy on the Remineralization of Initial Caries Lesions in Children: A Randomized Controlled Clinical Trial","OZONE-CARIES","Inclusion Criteria Children aged 6-12 years. Presence of at least one initial non-cavitated caries lesion. Systemically healthy children. Frankl Behavior Rating Scale score of 3 or 4. Written informed consent obtained from the parent or legal guardian. Exclusion Criteria Cavitated caries lesions requiring restorative treatment. History of allergy to any study material. Systemic diseases affecting oral health or salivary flow. Respiratory diseases (e.g., asthma) contraindicating ozone therapy. Use of medications affecting salivary flow or enamel remineralization. Uncooperative children (Frankl score 1 or 2). Parent or guardian unwilling to participate or unable to attend follow-up visits.","14 Years",{"count":210,"type":21},[24],"Initial caries lesions can be managed using non-invasive treatment approaches that promote remineralization and prevent lesion progression. Ozone therapy has been suggested as an adjunctive treatment because of its antimicrobial properties and its potential to enhance remineralization.\n\nThis randomized controlled clinical trial aims to evaluate the effect of ozone therapy on the remineralization of initial caries lesions in children. Participants will be randomly assigned to receive either ozone therapy followed by application of a remineralizing gel or application of the remineralizing gel alone.\n\nChanges in lesion status will be assessed over time using clinical and optical evaluation methods. The results of this study may contribute to the development of evidence-based minimally invasive approaches for the management of early caries lesions in pediatric patients.",[28,394],"Early Caries Lesion",[396,397,398,399,400,401,402],"Ozone Therapy","Remineralization","Non-cavitated Caries Lesions","Pediatric Dentistry","Children","ROCS Medical Minerals","Early Caries Lesions","2026-06-26",{"date":405,"type":46},"2026-06-30",{"date":407,"type":46},"2026-06-01",{"date":409,"type":21},"2027-04-20",{"name":411,"class":53},"Neslihan Atmaca",{"id":413,"slug":414,"hasResults":12,"nctId":415,"briefTitle":416,"officialTitle":416,"acronym":4,"eligibilityCriteria":417,"healthyVolunteers":152,"sex":61,"minAge":418,"maxAge":418,"enrollmentInfo":419,"targetDuration":4,"studyType":22,"phases":421,"briefSummary":422,"conditions":423,"keywords":427,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":439,"lastUpdatePostDateStruct":440,"startDateStruct":441,"completionDateStruct":442,"leadSponsor":443,"locationsCount":144},"100644993","breaking-the-cycle-real-time-family-oral-microbial-transmission-patterns-as-intervention-targets-100644993","NCT07674888","Breaking the Cycle: Real-Time Family Oral Microbial Transmission Patterns as Intervention Targets","Inclusion Criteria:\n\n* Families with at least two children aged 5-12 years living in the same household.\n* least one parent or guardian diagnosed with Stage II or III periodontitis requiring non-surgical periodontal therapy.\n* At least one child who has undergone caries treatment and is considered at high risk for disease recurrence.\n* Willingness of all participating household members to provide oral samples and participate in study procedures.\n* Ability of participants or their legal guardians to provide informed consent, and assent from children where applicable.\n\nExclusion Criteria:\n\n* Children living in multiple households or shared-custody arrangements during the study period.\n* Households unable to complete study visits or follow-up procedures.\n* Individuals unwilling or unable to comply with study procedures.\n* Individuals who do not provide informed consent or assent, where applicable.\n* Medical or behavioral conditions that, in the opinion of the investigators, would preclude safe participation in the study.","5 Years",{"count":420,"type":21},225,[24],"This study aims to understand how oral bacteria that cause tooth decay and gum disease spread among family members and whether treating multiple family members can reduce the return of these bacteria after dental treatment.\n\nFamilies with children aged 5-12 years will be recruited from university dental clinics. Participants will be assigned to one of three treatment groups: treatment for the child only, treatment for the child and parents, or treatment for all family members. Researchers will collect oral bacterial samples from family members before and after treatment and will monitor close-contact interactions within the household using wearable proximity-tracking devices.\n\nThe study will also collect information about oral health habits, family interactions, and environmental factors that may influence bacterial transmission. By combining bacterial DNA analysis with information about family contact patterns, researchers hope to better understand how oral bacteria are shared within households and whether family-based treatment approaches can reduce bacterial recolonization after dental therapy.\n\nThe results of this study may help improve strategies for preventing childhood tooth decay and gum disease by addressing family-level sources of bacterial transmission.",[28,424,425,426],"Periodontitis","Oral Microbiome","Bacterial Transmission",[428,429,430,431,432,433,434,435,436,163,437,438,27],"family microbial transmission","Oral microbiome","Plaque recolonization","Pediatric oral health","Real-time proximity tracking","Ultrawide Band (UWB)","Oral bacterial transmission","Intergenerational pathogen transfer","Biofilm disruption","Family-based intervention","Microbial source tracking","2026-06-25",{"date":405,"type":46},{"date":139,"type":21},{"date":141,"type":21},{"name":444,"class":53},"University of Alberta",{"id":446,"slug":447,"hasResults":12,"nctId":448,"briefTitle":449,"officialTitle":450,"acronym":4,"eligibilityCriteria":451,"healthyVolunteers":152,"sex":61,"minAge":452,"maxAge":418,"enrollmentInfo":453,"targetDuration":4,"studyType":22,"phases":454,"briefSummary":455,"conditions":456,"keywords":457,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":459,"lastUpdatePostDateStruct":460,"startDateStruct":462,"completionDateStruct":464,"leadSponsor":466,"locationsCount":144},"100570906","comparing-stainless-steel-crowns-with-prefabricated-resin-crowns-in-primary-molar-teeth-100570906","NCT06713330","Comparing Stainless Steel Crowns With Prefabricated Resin Crowns in Primary Molar Teeth","A 36-Month Prospective Randomized Clinical Pilot Trial Comparing Stainless Steel Crowns With Prefabricated Resin Crowns in Primary Molar Teeth","Inclusion Criteria:\n\n* CCHMC pediatric dental patients between the ages of 2 years to 5 years and 11 months, at the time of recruitment, who present to any CCHMC dental clinic location and then are found to need full mouth dental rehabilitation.\n* Patients who speak the most common languages at CCHMC will be able to be recruited for the study.\n\n  o English, Spanish, Arabic, Uzbek, Nepali, Chinese Mandarin, Russian, French.\n* These patients must qualify for treatment at the CCHMC dental in-office general anesthesia (IOGA) area or the Procedure Center (PC). IOGA and the PC will be selected as a venue of treatment to control behavioral factors. This is not specific to the study and would occur due to their treatment needs.\n* Participants will have at least one pair of contralateral primary molars with the need for a full coverage restoration in the same arch.\n\n  * For example, tooth A \\& J, B \\& I, S \\& L, or T \\& K\n  * For each participant, a minimum of one SSC or one PRC will be randomly assigned via a split mouth design to be placed as part of the study.\n* Need for Full coverage and high caries risk will be defined by AAPD Best Practice Guidelines 2,16\n\n  o Teeth With\n  1. Extensive caries\n  2. Cervical decalcification\n  3. Developmental defects (e.g., hypoplasia, hypocalcification)\n  4. When failure of other available restorative materials is likely (e.g., interproximal caries extending beyond line angles, patients with bruxism)\n  5. Following pulpotomy or pulpectomy\n  6. For definitive restorative treatment for high caries-risk children as defined by the AAPD\n  7. For patients who exhibit high caries risk and whose treatment is performed under sedation or general anesthesia. This would be normal and not specific to the study.\n* Participants who consent to the study, and who can be available for follow-up recall appointments.\n* All participants will be ASA I or ASA II as defined by the American Society of Anesthesiologists.15\n\nExclusion Criteria:\n\n* Participants who do not meet inclusion criteria will be excluded.\n\n  * Participants whose teeth do not meet the inclusion criteria.\n  * Participants who do not wish to participate in the study.\n  * Patients who do not wish to or cannot reliably return for follow-up visits.\n  * Red dye allergy as patient will not be able to be plaque disclosed during follow-up visits.\n  * Participants who do not speak English, Spanish, Arabic, Uzbek, Nepali, Chinese Mandarin, Russian, French.","2 Years",{"count":65,"type":21},[24],"The main reason for this research study is to learn more about a new flexible white dental crown (BioFLX) by comparing it to an existing flexible metal crown (Stainless Steel Crown). It is of interest to see if this new white crown is clinically equivalent to the existing silver crown that is mainly used in pediatric dentistry. A potential participant for this study would have cavities that require a crown, a type of filling that covers the entire tooth, and recommended dental work be done under general anesthesia.",[28],[458],"Pediatric dentistry","2026-06-24",{"date":461,"type":46},"2026-06-29",{"date":463,"type":46},"2024-05-17",{"date":465,"type":21},"2027-12-29",{"name":467,"class":53},"Children's Hospital Medical Center, Cincinnati",{"id":469,"slug":470,"hasResults":12,"nctId":471,"briefTitle":472,"officialTitle":472,"acronym":473,"eligibilityCriteria":474,"healthyVolunteers":152,"sex":61,"minAge":63,"maxAge":475,"enrollmentInfo":476,"targetDuration":4,"studyType":155,"phases":4,"briefSummary":478,"conditions":479,"keywords":481,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":483,"lastUpdatePostDateStruct":484,"startDateStruct":486,"completionDateStruct":487,"leadSponsor":489,"locationsCount":144},"100642311","dental-caries-and-oral-hygiene-status-in-children-with-specific-learning-disabilities-100642311","NCT07611981","Dental Caries and Oral Hygiene Status in Children With Specific Learning Disabilities","SLD-OH","Inclusion Criteria:\n\n* Children aged 7-12 years\n* For the study group: diagnosis of specific learning disorder (SLD) confirmed by a psychiatrist\n* For the control group: confirmed healthy with no psychiatric diagnosis by a psychiatrist\n* Written informed consent obtained from the parent or guardian\n\nExclusion Criteria:\n\n* Children with additional psychiatric diagnoses (e.g., autism spectrum disorder, attention-deficit\u002Fhyperactivity disorder, intellectual disability)\n* Children with systemic disease or physical disability that may prevent participation in the study","12 Years",{"count":477,"type":21},70,"This study aims to evaluate dental caries and oral hygiene status in children aged 7-12 years with specific learning disabilities (SLD) and to compare the findings with healthy children. Clinical oral examinations, including dmft\u002FDMFT, ICDAS II, Plaque Index, and Gingival Index assessments, will be performed. In addition, questionnaire-based evaluations of oral hygiene habits, dietary habits, and parental supervision during toothbrushing will be conducted.",[480,28,30],"Specific Learning Disabilities",[480,28,27,482,399,342,341],"dmft\u002FDMFT","2026-06-15",{"date":485,"type":46},"2026-06-16",{"date":483,"type":46},{"date":488,"type":21},"2026-10",{"name":490,"class":53},"Alanya Alaaddin Keykubat University",{"id":492,"slug":493,"hasResults":12,"nctId":494,"briefTitle":495,"officialTitle":496,"acronym":4,"eligibilityCriteria":497,"healthyVolunteers":12,"sex":61,"minAge":498,"maxAge":499,"enrollmentInfo":500,"targetDuration":4,"studyType":22,"phases":501,"briefSummary":502,"conditions":503,"keywords":506,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":512,"lastUpdatePostDateStruct":513,"startDateStruct":514,"completionDateStruct":516,"leadSponsor":518,"locationsCount":4},"100642802","clinical-performance-of-cadcam-hard-hybrid-ceramic-inlays-versus-resin-composite-inlays-in-vital-molars-with-extensive-occluso-proximal-cavities-100642802","NCT07648485","Clinical Performance of CAD\u002FCAM Hard Hybrid Ceramic Inlays Versus Resin Composite Inlays in Vital Molars With Extensive Occluso-Proximal Cavities","Clinical Performance of CAD\u002FCAM Hard Hybrid Ceramic Inlays Versus Resin Composite Inlays in Vital Molars With Extensive Occluso-Proximal Cavities: Two-Year Randomized Clinical Trial","Inclusion Criteria:\n\n* Systematically healthy male or female subjects aged 16 to 50 years.\n* Patients with good oral hygiene.\n* Presence of a single vital molar with coronal destruction due to caries, defined as radiographic evidence of caries involving more than 50% of the total dentin thickness with loss of at least one proximal wall.\n* Cavitary preparation involving loss of at least one proximal walls (mesial and\u002For distal), with intact buccal and lingual walls, and all cavosurface margins located in enamel.\n* Presence of functional opposing teeth in stable occlusion\n\nExclusion Criteria:\n\n* Presence of systemic diseases (e.g., uncontrolled diabetes, immune disorders).\n* Current pregnancy or lactation.\n* Documented allergy to resin-based composites or adhesive systems.\n* Evidence of pulpal necrosis or previous endodontic treatment in the target tooth.\n* Presence of cracks or fractures involving the tooth structure.\n* Active localized or generalized periodontal disease.\n* Evidence of parafunctional habits, including bruxism or clenching.\n* High caries risk.","16 Years","50 Years",{"count":65,"type":21},[24],"this study aims to compare the clinical performance of hard hybrid ceramics and composite resin indirect restorations fabricated by CAD\u002FCAM technology for the vital teeth with occluso-proximal cavities. the clinical performance assessed include marginal adaptation primarily and in addition to Color match, marginal discoloration, aesthetic anatomic form, recurrent caries and restoration fracture and post-operative hypersensitivity. the clinical performance will be assessed after the restoration cementation, after 6, 12, 18 and 24 months.",[28,504,505],"Cavity, Dental","Proximal Dental Caries",[507,508,509,510,511],"indirect restoration","CAD\u002FCAM","clinical performance","inlay","hybrid ceramics","2026-06-13",{"date":485,"type":46},{"date":515,"type":21},"2026-08",{"date":517,"type":21},"2028-11",{"name":85,"class":53},{"id":520,"slug":521,"hasResults":12,"nctId":522,"briefTitle":523,"officialTitle":524,"acronym":525,"eligibilityCriteria":526,"healthyVolunteers":12,"sex":61,"minAge":62,"maxAge":94,"enrollmentInfo":527,"targetDuration":4,"studyType":22,"phases":529,"briefSummary":530,"conditions":531,"keywords":532,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":538,"lastUpdatePostDateStruct":539,"startDateStruct":540,"completionDateStruct":542,"leadSponsor":544,"locationsCount":144},"100642397","3d-printed-resin-crowns-vs-stainless-steel-crowns-in-pulpotomized-primary-molars-100642397","NCT07648979","3D-Printed Resin Crowns vs Stainless Steel Crowns in Pulpotomized Primary Molars.","Clinical Evaluation of 3D Printed Resin Based Crowns Versus Stainless Steel Crowns in Pulpotomized Primary Mandibular Molars : A Randomized Controlled Clinical Trial","3DRSCVSSSC","Inclusion Criteria:\n\nChildren aged 4 to 8 years. Cooperative children who are able to accept dental treatment. Teeth diagnosed with reversible pulpitis. Children in good general health with no systemic conditions affecting oral health.\n\nParents\u002Fguardians willing to provide written informed consent and attend follow-up visits.\n\nExclusion Criteria:\n\nTeeth deemed non-restorable (e.g., gross carious destruction or fractures beyond restoration).\n\nParents\u002Fguardians unwilling to participate in the study or provide informed consent.",{"count":528,"type":21},26,[24],"The goal of this clinical trial is to learn whether 3D-printed resin-based crowns are an effective alternative to stainless steel crowns for restoring pulpotomized primary mandibular molars in children. The main questions it aims to answer are:\n\nDo 3D-printed resin-based crowns provide better gingival health than stainless steel crowns? Are there differences in plaque accumulation, crown retention, and child and parent satisfaction between the two crown types?\n\nParticipants will:\n\nReceive either a 3D-printed resin-based crown or a stainless steel crown after pulpotomy.\n\nAttend follow-up visits for clinical evaluation over 12 months.",[28],[164,533,534,535,106,536,537],"3D-Printed Resin Crowns","Primary Molars","Pulpotomy","crown retention","Gingival Health","2026-06-11",{"date":483,"type":46},{"date":541,"type":21},"2026-07",{"date":543,"type":21},"2027-08",{"name":85,"class":53},{"id":546,"slug":547,"hasResults":12,"nctId":548,"briefTitle":549,"officialTitle":550,"acronym":551,"eligibilityCriteria":552,"healthyVolunteers":152,"sex":61,"minAge":18,"maxAge":4,"enrollmentInfo":553,"targetDuration":4,"studyType":22,"phases":555,"briefSummary":556,"conditions":557,"keywords":560,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":538,"lastUpdatePostDateStruct":564,"startDateStruct":566,"completionDateStruct":568,"leadSponsor":570,"locationsCount":144},"100516585","intraoral-scanners-as-periodontal-and-dental-pathologies-diagnosis-tools-100516585","NCT06006429","Intraoral Scanners as Periodontal and Dental Pathologies Diagnosis Tools","Digital Extraction and Scientific Visualization of Clinical Characteristics From 3D Data From Intraoral Scanners for Dental and Periodontal Pathologies Research : Computer Formalization and Feasibility Study","Odonto3D","Inclusion Criteria:\n\n* adultes\n* consulting the Dental Care Service of the university hospital of Reims\n* presenting at least one gingival recession\n* presenting at least 10 pairs of opposing teeth\n* speaking French\n* who signed the informed consent form\n* affiliated to the French Social Security system\n\nExclusion Criteria:\n\nPatients presenting :\n\n* pregnancy or breastfeeding\n* orthodontic treatments\n* patients under legal protection, trusteeship or guardianship\n* unable to understand auto-questionnary",{"count":554,"type":21},30,[24],"Periodontal diseases and dental pathologies are highly prevalent oral diseases. Thirty-three to fifty percent of adult population presented at least one untreated caries and more than 50% of French population are affected by severe periodontitis. These diseases affect dental organ or periodontal attached system but could have negative impact on general health, quality of life, word and individual well-being. Association between chronic diseases as diabetes, rheumatoid arthritis, cardiovascular diseases, and oral health have been well investigated. Dental and periodontal diagnosis is dependent of various clinical parameters time consuming and dependent operator. It represents a public health challenge. Informatic analysis detecting diseases could be a time gain and a more precise diagnosis tool. Today, any software or algorithm allow automatized detection, clinical qualitative or quantitative indices recording while these informations are present in numeric models",[424,558,28,559],"Gingivitis","Diagnosis",[561,164,562,563],"Periodontal diseases","intra-oral camera","diagnosis",{"date":565,"type":46},"2026-06-12",{"date":567,"type":46},"2022-05-11",{"date":569,"type":21},"2027-12-11",{"name":571,"class":53},"CHU de Reims",{"id":573,"slug":574,"hasResults":12,"nctId":575,"briefTitle":576,"officialTitle":576,"acronym":4,"eligibilityCriteria":577,"healthyVolunteers":152,"sex":61,"minAge":62,"maxAge":4,"enrollmentInfo":578,"targetDuration":4,"studyType":22,"phases":580,"briefSummary":581,"conditions":582,"keywords":584,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":590,"lastUpdatePostDateStruct":591,"startDateStruct":593,"completionDateStruct":595,"leadSponsor":597,"locationsCount":144},"100571029","advancing-water-security-a-community-participatory-school-based-hydration-intervention-100571029","NCT06714929","Advancing Water Security: A Community Participatory School-Based Hydration Intervention","Inclusion Criteria:\n\n* Lunchroom observations: All students (K-5th \\[Pre-Kindergarten if applicable\\]) who eat lunch in the cafeteria on assessment days are eligible\n* BMI and dental caries assessments: 1) student enrolls in study while in 3rd grade (followed through 5th g)\n* Student surveys: Students in 4th-5th grade are eligible to complete surveys assessing beverage intake and perceptions of hydration practices within their school district.\n* Staff surveys: All staff in the target schools will be eligible to complete the Personnel Survey.\n\nExclusion Criteria:\n\n* Lunchroom observations: None.\n* BMI and dental caries assessments: Students are ineligible if they are unable to complete assessments due to developmental or physical reasons, 2) planning to move in the study duration\n* Student surveys: None.\n* Staff surveys: None.",{"count":579,"type":21},7200,[24],"The goal of this study is to determine the effectiveness and sustainability of a community-participatory hydration intervention over 3 years within a district that has newly installed hydration stations and is operating under a policy designed to enhance heathy hydration practices and promote equitable access to drinking water.",[28,583],"Obesity Prevention",[585,586,587,588,589],"hydration","water","sugar-sweetened beverages","dental caries","overweight and obesity","2026-06-08",{"date":592,"type":46},"2026-06-10",{"date":594,"type":46},"2024-08-14",{"date":596,"type":21},"2028-05-31",{"name":598,"class":53},"Virginia Commonwealth University",{"id":600,"slug":601,"hasResults":12,"nctId":602,"briefTitle":603,"officialTitle":604,"acronym":4,"eligibilityCriteria":605,"healthyVolunteers":152,"sex":61,"minAge":63,"maxAge":208,"enrollmentInfo":606,"targetDuration":4,"studyType":22,"phases":608,"briefSummary":609,"conditions":610,"keywords":611,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":616,"lastUpdatePostDateStruct":617,"startDateStruct":618,"completionDateStruct":620,"leadSponsor":622,"locationsCount":144},"100611474","oral-spray-bacillus-spore-probiotic-in-preventing-and-supporting-treatment-of-dental-caries-in-children-100611474","NCT07241052","Oral-Spray Bacillus Spore Probiotic in Preventing and Supporting Treatment of Dental Caries in Children","Evaluating Safety and Efficacy of Oral-Spray Bacillus Probiotic (LiveSpo® Smile CARE) in the Prevention and Adjunctive Treatment of Dental Caries in Children","Inclusion Criteria:\n\n* Children (male or female) aged 7-10 years, currently enrolled in primary school (grades 2-4).\n* At least one decayed tooth (any stage) at the time of screening.\n* Commitment to comply with study requirements, including refraining from using any other probiotic products for the ear, nose, and throat that could affect study outcomes.\n* Written informed consent obtained from a parent or legal guardian.\n\nExclusion Criteria:\n\nParticipant-level exclusion:\n\n* Presence of severe chronic disease, allergy, or use of antibiotics within 1 month prior to study initiation.\n* Use of oral or throat probiotic sprays\u002Flozenges within the past 30 days (excluding gastrointestinal probiotics).\n* Participation in another clinical study within the past 30 days.\n* Acute oral conditions (e.g., abscess, severe gingivitis) interfering with examination or intervention.\n* Currently receiving dental treatment at specialized dental\u002Foral health facilities.\n* History of congenital immunodeficiency or infectious disease.\n* Psychiatric disorders or sleep disturbances.\n* Known sensitivity or allergy to components of the investigational product.\n\nTooth-level exclusion:\n\n* Hard tissue lesions not caused by dental caries.\n* Supernumerary teeth or teeth not part of the functional dental arch.\n* Carious teeth with pain lasting \\>10 seconds during examination.\n* Carious teeth with visible pulp hyperemia (high risk of pulp complications).\n* Teeth showing signs of pulp disease, pulp necrosis, or periapical pathology.\n* Teeth previously treated with endodontic therapy or permanently restored with crowns.\n* Primary teeth with mobility grade ≥2 (due to disease or natural exfoliation).",{"count":607,"type":21},130,[24],"Despite advances in oral health care, cavities remain highly prevalent worldwide, especially among children. Conventional treatment methods focus on removing damaged tooth tissue but fail to completely eliminate or control pathogenic bacteria in the oral cavity, leading to a high risk of caries recurrence in the same or adjacent teeth. Probiotics are a promising biological therapy that can help restore balance in the oral microbiome.\n\nAmong probiotics, Bacillus species are unique because they form spores that make them stable under harsh conditions, such as heat and storage. They can also produce enzymes and natural compounds with antibacterial, anti-inflammatory, and protective effects. These features make Bacillus probiotics strong candidates for oral health applications.\n\nThis study is designed to evaluate the safety and efficacy of an oral-spray probiotic containing Bacillus subtilis ANA48 and Bacillus clausii ANA39 (LiveSpo® Smile CARE) in preventing and supporting the treatment of tooth decay in children. We hypothesize that this probiotic spray, when used regularly, will be safe and well-tolerated, while effectively reducing harmful bacteria in the mouth, preventing the progression of cavities, and improving overall oral health.\n\nStudy Design:\n\n* Sample Size: 130 participants\n* Study Location: a primary school in Hanoi, Vietnam Intervention Description: A total of 130 eligible participants will be randomly assigned to two groups (n = 65 per group).\n\nPlacebo Group will receive a 0.9% NaCl physiological saline, spray twice daily (morning and afternoon). Each application consists of two sprays at three sites (both dental arches and the front teeth), for a total of six sprays per use, continued for three consecutive months.\n\nSmile Care Group will receive an oral-spray probiotics containing ≥ 1 billion CFU\u002FmL × 20 mL of Bacillus subtilis and Bacillus clausii (LiveSpo Smile CARE). The dosage, frequency, and duration of use will be the same as in the placebo group.\n\nAll participants will receive the same standard dental care throughout the study, including the use of identical toothpaste, supervised weekly fluoride rinsing with 0.2% sodium fluoride (NaF), and scheduled follow-up visits. The probiotic and placebo sprays will be packaged in blinded bottles and administered according to the study protocol to maintain objectivity.\n\nStudy Duration: 12-18 months",[28],[164,400,612,613,614,615],"probiotics","Oral health","Oral-spray","Bacillus spores","2026-06-04",{"date":279,"type":46},{"date":619,"type":46},"2026-03-05",{"date":621,"type":21},"2027-05-01",{"name":623,"class":380},"Anabio R&D",{"id":625,"slug":626,"hasResults":12,"nctId":627,"briefTitle":628,"officialTitle":628,"acronym":629,"eligibilityCriteria":630,"healthyVolunteers":152,"sex":61,"minAge":207,"maxAge":94,"enrollmentInfo":631,"targetDuration":4,"studyType":22,"phases":632,"briefSummary":633,"conditions":634,"keywords":636,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":407,"lastUpdatePostDateStruct":641,"startDateStruct":643,"completionDateStruct":645,"leadSponsor":647,"locationsCount":144},"100640997","the-effects-of-sodium-fluoride-and-chlorhexidine-use-on-salivary-il-6-and-matrix-metalloproteinase-levels-in-children-with-active-caries-100640997","NCT07609797","The Effects of Sodium Fluoride and Chlorhexidine Use on Salivary IL-6 and Matrix Metalloproteinase Levels in Children With Active Caries","DentalCaries","Inclusion Criteria:\n\n* Children aged 6-8 years with all first permanent molars erupted\n* For active caries groups (Groups A, B, C): participants must meet at least one of the following criteria: dmft ≥ 6, or presence of at least one active caries lesion with an ICDAS code ≥ 3, or clinical evidence of active caries on ≥ 10 surfaces\n* For the dmft = 0 reference group (Group D): all surfaces caries-free and non-high-risk individuals (ICDAS II = 0); only baseline (T0) saliva sampling will be performed\n* No professional topical fluoride application or continuous CHX use within the past 3 months\n* No systemic chronic disease, immunodeficiency, or severe neuromotor disorder\n* No gingival redness, swelling, or bleeding\n* Written parental informed consent obtained\n\nExclusion Criteria:\n\n* Known allergy to fluoride compounds or varnish components\n* Behavioral problems that would prevent safe cooperation during application\n* Regular antibiotic use within the past 1 month\n* Individuals with infectious diseases\n* Those at high risk of endocarditis\n* History of substance dependence\n* Epilepsy\n* Renal failure or immunosuppression",{"count":210,"type":21},[24],"This study aims to compare salivary IL-6, MMP-8, MMP-9, and TIMP-1 levels between healthy children and caries-active children, and to evaluate the effects of 5% sodium fluoride (NaF) varnish and 2% chlorhexidine (CHX) used in caries prevention on these biomarkers.\n\nThe study will be conducted at Alanya Alaaddin Keykubat University, Faculty of Dentistry, Department of Pediatric Dentistry. Informed consent will be obtained from children and their parents\u002Fguardians. Investigator calibration will be performed using Cohen's kappa method prior to data collection. Sample size was calculated assuming 80% power (1-β = 0.80), α = 0.05, and Cohen's d ≈ 0.8, resulting in 20 participants per group using G\\*Power 3.1 software.\n\nStudy groups: Group A: 5% NaF varnish. Group B: 2% CHX + 5% NaF varnish. Group C: Standard oral hygiene education (negative control). Group D: Caries-free children (biological reference; baseline saliva sampling only).\n\nSaliva samples will be collected at T0 (baseline), T1 (30 minutes post-application), and T2 (1 month). Unstimulated whole saliva will be collected, centrifuged at 5,000 g for 10 minutes at 4°C, and stored at -80°C. IL-6, MMP-8, MMP-9, and TIMP-1 levels will be measured using CE-marked\u002FFDA-approved human saliva ELISA kits.",[28,635],"Dental Caries in Children",[164,637,638,639,640],"Matrix metalloproteinase","Interleukin-6","Sodium fluoride","Chlorhexidine",{"date":642,"type":46},"2026-06-02",{"date":644,"type":46},"2026-05-15",{"date":646,"type":21},"2027-06-30",{"name":648,"class":53},"Gül Keskin",{"id":650,"slug":651,"hasResults":12,"nctId":652,"briefTitle":653,"officialTitle":654,"acronym":4,"eligibilityCriteria":655,"healthyVolunteers":152,"sex":61,"minAge":656,"maxAge":657,"enrollmentInfo":658,"targetDuration":4,"studyType":22,"phases":660,"briefSummary":661,"conditions":662,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":663,"lastUpdatePostDateStruct":664,"startDateStruct":666,"completionDateStruct":667,"leadSponsor":669,"locationsCount":118},"100638627","retention-and-caries-prevention-of-giomer-sealant-with-or-without-diode-laser-pre-treatment-a-randomized-controlled-trial-100638627","NCT07612540","Retention and Caries Prevention of Giomer Sealant With or Without Diode Laser Pre-treatment: A Randomized Controlled Trial","Retention Rate and Caries Prevention of Giomer Based Sealant With and Without Diode Laser Pre-treatment in Young Adults: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Young adult Patients Aged 17-22.\n\n  * Good oral hygiene (plaque index score 0 or 1).\n  * Absence of abnormal occlusion habits (e.g. bruxism, nail biting, tooth clenching and mouth breathing).\n  * Patients approving to participate in the study.\n\nExclusion Criteria:\n\n* •Patients with known allergic or adverse reaction to the tested materials.\n\n  * Systematic disease that may affect participation.\n  * Xerostomic patients.","17 Years","22 Years",{"count":659,"type":21},111,[24],"This randomized controlled trial evaluates the effect of diode laser pre-treatment on the retention and caries prevention of giomer-based fissure sealants in young adults aged 17-22 years. The study compares sealant application with and without diode laser conditioning on molars with ICDAS 0-2 fissures over a 12-month follow-up period. Primary outcome is sealant retention using Simonsen's criteria, while secondary outcome is caries prevention using modified USPHS criteria. The study hypothesizes that diode laser pre-treatment may improve sealant retention and enhance caries prevention by modifying enamel surface characteristics and improving sealant penetration.",[28],"2026-05-21",{"date":665,"type":46},"2026-05-28",{"date":407,"type":21},{"date":668,"type":21},"2027-06-01",{"name":85,"class":53},{"id":671,"slug":672,"hasResults":12,"nctId":673,"briefTitle":674,"officialTitle":675,"acronym":4,"eligibilityCriteria":676,"healthyVolunteers":152,"sex":61,"minAge":452,"maxAge":63,"enrollmentInfo":677,"targetDuration":4,"studyType":22,"phases":679,"briefSummary":680,"conditions":681,"keywords":684,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":663,"lastUpdatePostDateStruct":691,"startDateStruct":692,"completionDateStruct":694,"leadSponsor":696,"locationsCount":144},"100638379","luting-cements-for-prefabricated-zirconia-crown-retention-in-primary-anterior-teeth-in-children-100638379","NCT07611734","Luting Cements for Prefabricated Zirconia Crown Retention in Primary Anterior Teeth in Children","Comparison of Self-Adhesive Resin, Conventional Glass Ionomer, and Bioactive Resin-Modified Glass Ionomer Cements for Prefabricated Zirconia Crown Retention in Primary Anterior Teeth: A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Healthy children aged 2 to 7 years\n2. One or more primary maxillary or mandibular incisors requiring full-coverage restoration due to caries or trauma\n3. Adequate remaining tooth structure following preparation, defined as greater than 50% of the clinical crown\n4. Parent or legal guardian able and willing to provide written informed consent and to commit to the 36-month follow-up schedule\n\nExclusion Criteria:\n\n1. Active periodontal disease at the index tooth, defined as a Löe Gingival Index score of 2 or higher\n2. Parafunctional habits such as bruxism, severe thumb-sucking, or tongue-thrust documented at screening\n3. Known allergy or hypersensitivity to zirconia, resin, glass ionomer, or any component of the assigned cement\n4. Inconsistent oral hygiene, defined as less than twice-daily toothbrushing per parental report\n5. Systemic disease affecting bone metabolism, tooth development, or wound healing\n6. Current participation in another interventional dental clinical trial",{"count":678,"type":21},120,[24],"The goal of this clinical trial is to compare the long-term clinical performance of three different luting cements used to bond prefabricated zirconia crowns (PZCs) on primary front teeth in young children. The trial will determine whether any single cement offers superior retention, gum health, or marginal sealing compared to the others over a 3-year period.\n\nMain Questions:\n\nThe study aims to answer the following:\n\nAre conventional glass ionomer cement (GIC), bioactive resin-modified glass ionomer cement (BioCem™), and self-adhesive resin cement (SARC) equivalent in retaining prefabricated zirconia crowns on primary incisors over 36 months? Do these cements differ in their effect on gingival health, plaque accumulation, or marginal discoloration around the cemented crown?\n\nComparison:\n\nResearchers will compare three parallel groups of children whose primary incisors are restored with identical prefabricated zirconia crowns but cemented with one of the three different luting cements.\n\nParticipants will: Receive a clinical and radiographic dental examination at screening. Undergo placement of one or more prefabricated zirconia crowns on primary anterior teeth using their randomly assigned cement. Return to the clinic for blinded follow-up evaluations at 12, 24, and 36 months for assessment of crown retention, gingival health, plaque, and marginal staining.",[28,682,683],"Tooth Injuries","Primary Tooth Restoration",[685,686,687,688,689,690],"Prefabricated Zirconia Crown","Luting Cement","Glass Ionomer Cement","Bioactive Cement","Self-Adhesive Resin Cement","Crown Retention",{"date":665,"type":46},{"date":693,"type":21},"2026-05",{"date":695,"type":21},"2029-07",{"name":697,"class":53},"Murad Alrashidi"]