[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"depression-andor-anxiety-in-the-mild-to-moderate-range\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:depression-andor-anxiety-in-the-mild-to-moderate-range":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,48,81,111,139],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100633889","internet-based-cognitive-behavioural-therapy-icbt-for-anxiety-and-depression-in-singapore-100633889",false,"NCT07532551","Internet-Based Cognitive Behavioural Therapy (iCBT) for Anxiety and Depression in Singapore","Assessing the Clinical and Cost Effectiveness of Internet-Based Cognitive Behavioural Therapy (iCBT) for Anxiety and Depression in Singapore","1. Quantitative Study - Patients\n\n   Inclusion Criteria:\n   * Age ≥21 years\n   * Tier 2 - 3 depression and\u002For anxiety based on PHQ-9 and GAD-7 scores\n\n     * PHQ-9 score of 5 to 19\n     * GAD-7 score of 5 to 14\n   * Able to provide informed consent\n\n   Exclusion Criteria:\n   * Unable to read or understand English (Primary 6 level)\n   * Unable to use the internet (e.g. due to lack of internet access or insufficient digital literacy)\n   * Does not possess a mobile device or is not able to access the iCBT application\n   * Actively experiencing psychosis\n   * Suspected with personality disorder\n   * Primary concern is obsessive compulsive disorder (OCD)\n   * Tier 4 patients with severe depression or anxiety\n\n     * PHQ-9 score of 20 and above\n     * GAD-7 score of 15 and above\n   * Any suicidal risk or ideation\n\n     * PHQ-9 Question 9 score of more than 2\n2. Qualitative Study - Service Providers\n\nInclusion Criteria:\n\n* Are currently or previously have been involved in the delivery, supervision, or implementation of the iCBT programme\n* Have had direct experience supporting patients enrolled in the study\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Have no direct involvement in the iCBT programme; or\n* Have had insufficient exposure to the programme, defined as managing fewer than one referred case or less than one month of involvement at the time of recruitment.\n* Conflict of interest or Supervisory Hierarchy Concerns - Individuals whose participation may create perceived coercion or introduce bias\n* Inability to provide informed consent","ALL","21 Years",{"count":19,"type":20},390,"ESTIMATED","INTERVENTIONAL",[23],"NA","Cognitive-behavioural therapy (CBT) has a robust evidence base for treating anxiety disorders and depression, including transdiagnostic CBT. Internet-based CBT (iCBT) offers a new approach to delivering these therapies. iCBT is a digital adaptation of traditional CBT that leverages digital platforms to deliver similar therapeutic interventions. iCBT encompasses structured programmes that provide users with tools and techniques to manage mental health issues such as depression and anxiety. The digital format ensures timely access to CBT and typically includes interactive modules, videos, self-assessment tools, and virtual therapist support. This study aims to evaluate the effectiveness of iCBT in reducing symptoms of anxiety and depression, as well as its cost-effectiveness and acceptability in local context.\n\nThe main questions it aims to answer are:\n\n1. Do participants receiving iCBT show a reduction in symptoms of anxiety and\u002For depression, and does the effectiveness of iCBT vary based on individual user characteristics?\n2. What are the factors that influence the acceptance, adoption, and engagement rates of iCBT among Singaporeans?\n3. Is iCBT more cost-effective as compared to usual care?\n\nResearchers will compare guided iCBT to usual care (traditional CBT) to assess iCBT's clinical effectiveness, cost-effectiveness, and acceptability in Singapore's primary and community healthcare settings.\n\nParticipants in the intervention group will:\n\n1. Undergo guided iCBT intervention consisting of 8 weeks of online modules covering core CBT techniques\n2. Counsellors will schedule 3 regular check-ins\n3. Questionnaires will be administered at 5 timepoints\n4. Selected participants will be invited for a semi-structured interview to assess their experiences with iCBT\n\nParticipants in the control group will:\n\n1. Continue usual care\n2. Questionnaires will be administered at 5 timepoints\n\nA parallel qualitative study involving service providers is required to contextualise trial findings, identify implementation barriers and enablers and inform national scale-up and policy decisions. It aims to explore service providers' experiences, perceptions and contextual factors influencing the implementation of iCBT within routine primary-care and community mental-health services participating in this trial.",[26,27],"Depression and\u002For Anxiety in the Mild-to-moderate Range","Cognitive Behavioral Therapy",[29,30,31,32,33,34],"internet-delivered cognitive behavioural therapy","cognitive behavioural therapy","CBT","iCBT","anxiety","depression","RECRUITING","2026-08-02",{"date":38,"type":39},"2026-08-05","ACTUAL",{"date":41,"type":39},"2026-07-02",{"date":43,"type":20},"2028-03",{"name":45,"class":46},"National University of Singapore","OTHER",3,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":21,"phases":60,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":80},"100647127","effect-of-a-programme-including-an-ai-enhanced-mobile-application-on-the-mental-well--being-of-young-adolescents-in-hong-kong-100647127","NCT07704996","Effect of a Programme Including an AI-enhanced Mobile Application on the Mental Well- Being of Young Adolescents in Hong Kong","Effect of a Programme Including an AI-enhanced Mobile Application on the Mental Well-being of Young Adolescents in Hong Kong - A Cluster RCT Study","AI-eCAMP_RCT","Inclusion Criteria:\n\n* The inclusion criteria will be students at participating schools who can read Chinese and are aged 11-15 (P5 to F2), with parental consent.\n\nExclusion Criteria:\n\n* Students with known physical (musculoskeletal) or cognitive\u002Fmental problems that would compromise physical exercise or our intervention or outcomes will be excluded.","11 Years","15 Years",{"count":59,"type":20},300,[23],"Study Aim and Methods (≈250 words) It aims to evaluate the effectiveness, user perceptions, and applicability of the e-CAMP intervention in improving mental well-being and reducing depressive symptoms among adolescents aged 11-15 years. The primary research question is whether e-CAMP can significantly reduce depressive symptoms, measured by the Patient Health Questionnaire-9 (PHQ-9).\n\nSecondary objectives are to examine whether e-CAMP : improves mental health literacy using the Chinese-version Universal Mental Health Literacy Scale for Adolescents (UMHL), promotes healthier smart device use as measured by the Smartphone Addiction Scale (SAS), increases physical activity assessed through the Global Adolescent and Child Physical Activity Questionnaire (GAC-PAQ) , and to evaluate participants' perceptions of the intervention's applicability, acceptability through survey.\n\nA prospective two-arm cluster randomized controlled trial (RCT) following CONSORT 2010 guidelines will be conducted in eight eligible Hong Kong schools, which will be randomly assigned to either the intervention or usual-care group. A process evaluation will also be undertaken.\n\n320 students will be recruited with inclusion criteria : Chinese students aged 11-15 years (Primary 5 to Secondary 2) with parental consent. Students with physical, cognitive, or mental conditions that may affect participation will be excluded.\n\nStudents in the intervention group will receive usual school care and access to the e-CAMP mobile app, which they will be encouraged to use at least three times weekly for eight weeks (10-15 minutes per session). Students in the control group will receive usual school care, including a 45-minute nurse-led health talk and PowerPoint handouts.",[63,26],"Mental Health",[65,34,66,67,68,69],"mental health","adolescents","programme","AI","mobile application","NOT_YET_RECRUITING","2026-07-15",{"date":73,"type":39},"2026-07-16",{"date":75,"type":20},"2026-08-03",{"date":77,"type":20},"2028-12-31",{"name":79,"class":46},"Tung Wah College",1,{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":89,"sex":16,"minAge":90,"maxAge":4,"enrollmentInfo":91,"targetDuration":4,"studyType":21,"phases":93,"briefSummary":94,"conditions":95,"keywords":98,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":80},"100647092","sanamente-a-peer-led-program-to-reduce-health-disparities-in-rural-latinoa-communities-100647092","NCT07705776","SanaMente: A Peer-Led Program to Reduce Health Disparities in Rural Latino\u002Fa Communities","SanaMente: A Peer-Led, Evidence-Based Mental Health and Lifestyle Program to Reduce Health Disparities in Rural Latino\u002Fa Communities","SanaMente","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Identify as Hispanic\u002FLatino\u002Fa.\n* Patients of La Clínica del Pueblo in Carbondale, Colorado.\n* Spanish-speaking (bilingual Spanish-English speakers are eligible).\n* Interest in improving your physical and emotional well-being.\n* Are currently managing or are at risk for chronic medical or metabolic conditions (e.g., diabetes, cardiovascular disease, liver, or kidney conditions), but a diagnosis is not required.\n* Experiencing or at risk for stress, low mood, or anxiety (formal diagnosis not required)\n* Willingness and ability to participate in the SanaMente program.\n* Willing to provide a release of information authorizing study staff to communicate with La Clínica del Pueblo in the event that a participant endorses suicidality or if it becomes necessary to share relevant medical information to ensure participant safety and appropriate care.\n\nExclusion Criteria:\n\n* Individuals who are unable to provide informed consent.\n* Individuals who are unwilling or unable to participate in the group-based or one-to-one SanaMente sessions.",true,"18 Years",{"count":92,"type":20},40,[23],"The goal of this clinical trial is to evaluate the feasibility, acceptability, and preliminary effectiveness of the SanaMente peer-led mental health and lifestyle program for rural Latino\u002Fa adults with chronic medical conditions and mental health concerns. The main questions it aims to answer are:\n\n* Is the SanaMente program feasible and acceptable for rural Latino\u002Fa adults with chronic medical conditions and mental health concerns?\n* Does participation in the SanaMente program improve mental health outcomes (depression, anxiety, and stress), healthy lifestyle behaviors (sleep, physical activity, and nutrition), and overall well-being?\n\nThis is a single-arm pilot study without comparison group.\n\nParticipants will:\n\n* Participate in the 6-8 week SanaMente peer-led group program.\n* Complete surveys at baseline, mid-program, and post-program assessing mental health, lifestyle behaviors, overall well-being, and program satisfaction.\n* Complete an exit survey and have the option to participate in a focus group to provide feedback on the program's usability, acceptability, perceived impact, and suggestions for improvement.",[26,96,97],"Stress (Psychology)","Chronic Medical Illness",[99,100,101,102],"rural","Peer-led intervention","Chronic disease","Latino\u002Fa mental health","2026-07-10",{"date":71,"type":39},{"date":106,"type":39},"2026-03-06",{"date":108,"type":20},"2026-12-10",{"name":110,"class":46},"University of Colorado, Boulder",{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":115,"acronym":4,"eligibilityCriteria":116,"healthyVolunteers":11,"sex":16,"minAge":117,"maxAge":4,"enrollmentInfo":118,"targetDuration":4,"studyType":21,"phases":120,"briefSummary":121,"conditions":122,"keywords":125,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":137,"locationsCount":80},"100644029","social-prescribing-for-a-mindful-lifestyle-100644029","NCT07669805","Social Prescribing for a Mindful Lifestyle","Inclusion Criteria:\n\n* People aged 55 years or older.\n* People with a Geriatric Depression Scale (GDS-15) score of 7-10 or a UCLA Loneliness Scale Version 3 score of 35-64.\n* People can understand the research process, meet the requirements of the research, and can sign the informed consent and participate in the project.\n\nExclusion Criteria:\n\n* People that are unable to cooperate with the project or follow-up.\n* According to the PI's judgment, people with severe or poorly controlled conditions include ongoing acute diseases, severe infections, severe abnormal laboratory tests, or serious medical conditions with the following systems: cardiovascular, pulmonary, hepatic, nervous, mental, metabolic, renal, musculoskeletal, gastrointestinal, etc.\n* People with severe depression, risk of self-harm, severe cognitive impairment (dementia), visual or hearing impairment, and disabilities that prevent the completion of the project and assessment.\n* People are currently or expected to join any other physical training courses or nutrition intervention plans during the project period.\n* Others are based on the judgment of the PI that participating in this project may adversely affect the safety of the subjects, hinder the progress of the experiment, or interfere with the evaluation of the outcomes of the project.","55 Years",{"count":119,"type":20},50,[23],"The goal of this clinical trial is to evaluate the effectiveness of an 8-week mindfulness lifestyle social prescribing program in community-dwelling older adults aged 55 and older. The main questions it aims to answer are:\n\nTo establish a mindfulness lifestyle social prescribing model applied to the psychological and social health promotion of middle-aged and older populations.\n\nTo evaluate the effectiveness of the intervention on improving depressive symptoms, loneliness, and quality of life in this population.\n\nParticipants will receive an 8-week group intervention program, with each weekly session lasting approximately 3 hours. The structured curriculum integrates mindfulness awareness, body scanning, mindfulness stretching, breathing training, healthy dietary education, and art practices (such as herbal therapy and leaf printing). Researchers will collect and evaluate data from pre- and post-intervention assessments to measure changes in depressive symptoms, loneliness risk, and overall quality of life.",[26,123,124],"Loneliness","Social Isolation",[126,127,128,129,130],"Mindfulness","Older Adults","Lifestyle Medicine","Quality of Life","Social Prescribing","2026-06-21",{"date":133,"type":39},"2026-06-25",{"date":135,"type":20},"2026-07-01",{"date":77,"type":20},{"name":138,"class":46},"Buddhist Tzu Chi General Hospital",{"id":140,"slug":141,"hasResults":11,"nctId":142,"briefTitle":143,"officialTitle":144,"acronym":4,"eligibilityCriteria":145,"healthyVolunteers":89,"sex":16,"minAge":90,"maxAge":4,"enrollmentInfo":146,"targetDuration":4,"studyType":21,"phases":147,"briefSummary":148,"conditions":149,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":156,"leadSponsor":158,"locationsCount":80},"100607431","testing-adapted-self-help-plus-sh-for-stress-and-well-being-in-international-students-at-a-us-university-100607431","NCT07188467","Testing Adapted Self-Help Plus (SH+) for Stress and Well-Being in International Students at a U.S. University","Implementing a Scalable Mental Health Intervention for International Students: A Pilot Study of Digitized Self-Help Plus","Inclusion Criteria:\n\n* Enrolled as an international student at The New School\n* Age 18 years or older\n* Willing to provide informed consent and complete study assessments\n* Score of ≥3 on the PHQ-4, indicating at least mild distress\n* Sufficient English proficiency to comprehend intervention materials\n\nExclusion Criteria:\n\n* Severe psychiatric conditions requiring immediate intervention (e.g., active psychosis, severe mood disorders)\n* Visual, hearing, or neurocognitive impairments that prevent engagement with the intervention\n* Having an advanced degree in psychology or mental health-related fields (to prevent prior knowledge bias)\n* Score of 2 or higher on PHQ-4 Item 3 or Item 4 (frequent thoughts of self-harm or severe distress)",{"count":119,"type":20},[23],"The goal of this clinical trial is to learn if an adapted version of Self-Help Plus (SH+), a stress management program developed by the World Health Organization, can reduce stress and improve well-being in international students at a U.S. university. The main questions it aims to answer are:\n\nDoes SH+ reduce perceived stress, anxiety, and depressive symptoms in international students? Does SH+ improve feelings of social support, self-efficacy, and adjustment in a new cultural environment?\n\nParticipants will:\n\nAttend a two-day in-person workshop that includes animated videos, interactive activities, and group discussions.\n\nComplete three surveys (before the workshop, right after, and six weeks later) about stress, mood, and well-being.\n\nOptionally, take part in a short interview to share feedback about their experience.",[150,26,123,151],"Stress, Psychological","Adjustment, Psychological","2025-10-07",{"date":154,"type":39},"2025-10-09",{"date":152,"type":39},{"date":157,"type":20},"2026-01",{"name":159,"class":46},"The New School"]