[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"depressive-and-anxiety-disorders\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:depressive-and-anxiety-disorders":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,74],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":4},"100634573","miles-for-mental-health-100634573",false,"NCT07541443","Miles for Mental Health","Miles for Mental Health: The Impact of Cardiovascular Fitness on Mental Health Outcomes","Inclusion Criteria:\n\n* Age 18+ years\n* Generalized anxiety and\u002For depressive disorder diagnosis\n* Able to exercise without use of ambulatory device\n* Willing and able to attend a minimum of 2 group exercise sessions weekly\n\nExclusion Criteria:\n\n* Myocardial infarction or symptoms of coronary artery disease in the last 2yrs\n* Uncontrolled hypertension within the last 6 months\n* Cancer in the last 2yrs (except non-metastatic basal or squamous cell carcinoma)\n* Significant pain or musculoskeletal disorder that would prohibit participation in an exercise program\n* Possible\u002Fprobably dementia or mild cognitive impairment (MCI) base on adjudication\n* Physician concern regarding safety or completion of the study","ALL","18 Years",{"count":19,"type":20},20,"ESTIMATED","INTERVENTIONAL",[23],"NA","Common mental health disorders, like anxiety and depression, are widespread among the American population. The prevalence of mental health disorders among adults continues has consistently increased from previous decades and is now a major public health challenge. Data shows that 1 in 5 Americans regularly report feeling depressed. Therapy is supported as an effective means of treating mental anxiety and depression, and lessening their severity. But therapy is expensive and not always covered by insurance. It is well known that exercise provides physiological and psychological benefits to those suffering from mental health disorders. However, prescribing and monitoring exercise can be challenging, if not impossible, for mental health practitioners, and individuals often are unsure how to begin an exercise program on their own. Studies that have investigated the impact on exercise on mental health have delivered exercise using a traditional clinical trial exercise structure, where exercise is completed by the client\u002Fpatient under the supervision of a professional. This structure, while beneficial, does not always transfer well to real-world settings. Working one-on-one with an exercise professional poses financial and scheduling barriers for most. Few, if any, studies have used group exercise and group therapy to address mental health concerns. This study aims to combine cardiovascular exercise with group therapy to investigate the impact of cardiovascular fitness on mental health outcomes among Rural dwelling adults living with generalized anxiety and\u002For depressive disorders.",[26,27],"Generalized Anxiety Disorder (GAD)","Depressive and Anxiety Disorders",[29,30,31,32,33],"cardiovascular fitness","mental health","anxiety","depression","group exercise","NOT_YET_RECRUITING","2026-07-17",{"date":37,"type":38},"2026-07-20","ACTUAL",{"date":40,"type":20},"2026-07-27",{"date":42,"type":20},"2026-12-31",{"name":44,"class":45},"Emporia State University","OTHER",{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":57,"briefSummary":58,"conditions":59,"keywords":60,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":73},"100647138","testing-the-effectiveness-of-process-based-therapy-in-routine-patient-care-and-assessing-its-influence-on-therapist-decision-making-100647138","NCT07704138","Testing the Effectiveness of Process Based Therapy in Routine Patient Care and Assessing Its Influence on Therapist Decision Making","Process Based Therapy Applicability, Effectiveness and Compatibility (PBACE). A Within Therapist Randomized Controlled Trial Testing the Effectiveness of Process Based Therapy in Routine Patient Care and Assessing Its Influence on Therapist Decision Making","PBACE","Inclusion Criteria:\n\n* A primary ICD-11 diagnosis of a depressive or anxiety disorder\n* Age 18-65 years\n* Sufficient knowledge of the German language\n* Participating patients are not required to discontinue medication, but to keep medication constant over the treatment period\n\nExclusion Criteria:\n\n* Increased suicidality\n* Substance abuse or dependency\n* diagnosis of a cluster A or B (DSM-5) personality disorder\n* pervasive developmental disorder, psychotic disorder, eating disorder, bipolar disorder, or severe physical illness.","65 Years",{"count":56,"type":20},60,[23],"Background: Process Based Therapy (PBT) is a novel approach for a more personalized psychotherapy by integrating patient's ecological momentary assessment (EMA) data into treatment planning and focusing on empirically measured maladaptive processes. Previous pilot studies have examined the efficacy and feasibility of PBT in different settings. However, the effectiveness of this approach as well as the influence of providing EMA data on therapist's decision-making as well as treatment planning is yet unexplored.\n\nObjective: This study aims to evaluate the effectiveness of PBT in a naturalistic setting as well examine the influence of the provision of EMA data on therapists' decision-making.\n\nMethods: Thiry therapists as well as 60 patients will be recruited. Therapists will each treat two patients which are randomly allocated to either an intervention group receiving PBT or an active control group receiving routine psychotherapy. Treatment outcomes will be measured pre and post treatment as well as a 6-month follow-up. Therapists' decision making will be measured before training in PBT as well as during the treatment process using think aloud protocols (TAP) as well as quantitative measurements for decision making styles and self efficacy in decision making.\n\nDiscussion: This study could add insights into the ongoing research about the efficacy and effectiveness of PBT as well as provide insights into therapists' treatment decisions. While PBT holds theoretical promise for a more personalized and effective treatment, empirical data is still needed to assess its theoretical merit, which this study could provide. Expanding on the thus far scarce literature on decision-making in the therapeutic process, valuable information about processes guiding therapists' treatment decisions could be gained.",[27],[61,62],"Process Based Therapy","effectiveness","RECRUITING","2026-07-09",{"date":66,"type":38},"2026-07-15",{"date":68,"type":20},"2026-06-27",{"date":70,"type":20},"2029-01-01",{"name":72,"class":45},"Goethe University",1,{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":21,"phases":81,"briefSummary":82,"conditions":83,"keywords":86,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":73},"100626493","act-with-cf-self-help-toolkit-100626493","NCT07436351","ACT With CF Self-Help Toolkit","Inclusion Criteria:\n\n* 18 years or older\n* Existing diagnosis of cystic fibrosis\n* PHQ-9 score \\>4 or GAD-7 score \\>4\n\nExclusion Criteria:\n\n* History of suicide attempts or acute suicidal ideation on clinical assessment\n* Presence of psychotic disorder or symptoms\n* Presence of psychiatric disorders that interfere with participation in the study, judged by the study or treating clinician\n* Presence of other medical conditions that interfere with participation in the study, judged by the study or treating clinician",{"count":56,"type":20},[23],"Acceptance and Commitment Therapy (ACT) tailored to meet the needs of adults living with cystic fibrosis (ACT with CF) is a newer form of talk therapy that has been shown to reduce anxiety \\& depression and improve psychological flexibility, and value-based living. The investigators are now trying to find out whether a self-help version of this treatment (ACT with CF - Self Help Toolkit) is also effective in reducing anxiety and depression and improving psychological flexibility and value-based living in adults with CF.\n\nAdults with cystic fibrosis are at increased risk for anxiety and depression. This study examines whether a patient-facing therapy, ACT with CF - Self Help Toolkit can help to reduce anxiety and depression among adults with CF. This treatment can be accessed on the participant's smartphone.",[84,27,85],"Cystic Fibrosis (CF)","Psychological Flexibility",[87,88,89,90],"cystic fibrosis","ACT","CF","chronic illness","2026-02-27",{"date":93,"type":38},"2026-03-03",{"date":95,"type":38},"2026-01-20",{"date":97,"type":20},"2027-04",{"name":99,"class":45},"Thomas Jefferson University"]