[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"depressive-disorders-with-high-anhedonia-symptoms\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:depressive-disorders-with-high-anhedonia-symptoms":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":5},"100629576","tvns-and-approach-avoidance-behavior-in-anhedonia-and-anxiety-100629576",false,"NCT07476469","tVNS and Approach-Avoidance Behavior in Anhedonia and Anxiety","Vagus Nerve Stimulation and Approach-Avoidance Behavior in Anhedonia and Anxiety","Inclusion Criteria:\n\n* BMI between 18,5 and 30,0 kg\u002Fm2,\n* between 18 and 40 years of age, and\n* be able and willing to provide informed consent.\n\nExclusion Criteria:\n\n* have a high risk of suicide,\n* have a lifetime diagnosis of severe neurological disorder (incl. ADHD), schizophrenia, bipolar disorder, or severe substance abuse, posttraumatic stress disorder, obsessive-compulsive disorder, diabetes, epilepsy, or coronary heart disease\n* have fulfilled criteria for an eating disorder or somatic symptom disorder within the last 12-months,\n* take medication (except psychopharmacological medication for MDD or anxiety), patients have to be on stable psychopharmacological medication for at least two months before study participation (minimizing confounding effects)\n* contraindications for MRI (metal implants or claustrophobia)\n* for female individuals if they are pregnant or nursing at the time,\n* impaired movement ability or hearing\n* impaired, uncorrected vision (need contact lenses)\n* contraindications for tVNS hearing aids or diseased skin on the right ear.",true,"ALL","18 Years","40 Years",{"count":21,"type":22},104,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study investigates if anhedonia and anxiety symptoms are associated with alterations in reinforcement learning, effort trade-offs for wins vs. punishments, and foraging behavior under threat. Moreover, it will investigate whether these processes can be influenced by a metabolic load and\u002For transcutaneous vagus nerve stimulation (tVNS). The project consists of (a) an online reinforcement learning study, used to characterize learning, reward sensitivity, and meta-cognition, and (b) a laboratory study in which participants first undergo fMRI while completing an effort-based decision-making task. Second, participants will complete two sessions in VR with randomized active or sham tVNS during a foraging task before and after a caloric load with concurrent physiological recordings.",[28,29,30,31],"Healthy Participants","Anxiety Disorders (With High Anxiety Symptoms)","Depressive Disorders (With High Anhedonia Symptoms)","Comorbid Depression and Anxiety Disorder (With High Anhedonia and High Anxiety Symptoms)",[33,34,35,36,37,38,39],"Depression","Anhedonia","Anxiety","Vagusnerv-Stimulation","tVNS","Virtual Reality","fMRI","RECRUITING","2026-04-20",{"date":43,"type":44},"2026-04-23","ACTUAL",{"date":46,"type":44},"2026-03-23",{"date":48,"type":22},"2028-12-31",{"name":50,"class":51},"Dr. Nils B. Kroemer","OTHER"]