[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dermatochalasis-of-upper-eyelid\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dermatochalasis-of-upper-eyelid":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,53],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100649396","phase-3-perioperative-haemostasis-procedure-related-pain-after-physiological-or-pharmacological-modifications-of-local-anaesthesia-around-the-eyes-100649396",false,"NCT07734740","Perioperative Haemostasis, Procedure-Related Pain After Physiological or Pharmacological Modifications of Local Anaesthesia Around the Eyes","Perioperative Haemostasis, Procedure-Related Pain After Physiological or Pharmacological Modifications of Local Anaesthesia Around the Eyes (P4LE) - a Double-Masked, Split-Face, Active-Controlled, Pilot Randomised Clinical Trial","P4LE","Inclusion Criteria:\n\n* Patients undergoing bilateral upper eyelid blepharoplasty requiring subcutaneous anaesthesia at Prince of Wales Hospital, Alice Ho Miu Ling Nethersole Hospital and CUHK Medical Centre; and\n* Adult patients aged 18 or above.\n\nExclusion Criteria:\n\n* Patients aged less than 18;\n* Pregnancy;\n* Allergy to local anaesthetic agents;\n* History of previous eyelid surgery; and\n* Patients on antiplatelets or anticoagulants.","ALL","18 Years",{"count":20,"type":21},80,"ESTIMATED","INTERVENTIONAL",[24],"PHASE3","The goal of this clinical trial is to determine whether buffering, warming, or addition of hyaluronidase or tranexamic acid to lignocaine during eyelid injection of local anaesthesia reduce injection pain and procedure-related pain and improve perioperative haemostasis.",[27,28],"Dermatochalasis of Upper Eyelid","Blepharoplasty",[30,28,31,32,33,34,35,36,37,38,39],"Dermatochalasis","Local anaesthesia","Lignocaine","Sodium bicarbonate","Hyaluronidase","Tranexamic acid","Buffered","Warmed","Pain","Haemostasis","NOT_YET_RECRUITING","2026-07-30",{"date":43,"type":44},"2026-08-03","ACTUAL",{"date":46,"type":21},"2026-08",{"date":48,"type":21},"2028-07",{"name":50,"class":51},"Prince of Wales Hospital, Shatin, Hong Kong","OTHER",3,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":22,"phases":62,"briefSummary":64,"conditions":65,"keywords":67,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":82},"100612173","comparative-study-of-ziplyft-treatment-vs-traditional-blepharoplasty-for-upper-eyelid-rejuvenation-100612173","NCT07250139","Comparative Study of Ziplyft Treatment vs. Traditional Blepharoplasty for Upper Eyelid Rejuvenation","Inclusion Criteria:\n\n1. Provide signed written consent prior to participation in any study-related procedures.\n2. Ability, comprehension, and willingness to follow study instructions, and likely to complete all study visits.\n3. Male or female adults, ≥ 35 years old at the Preoperative Visit willing to return for required follow-up visits.\n4. Subjects with excess eyelid skin are eligible to undergo the procedure in the opinion of the investigator.\n5. Female subjects must be 1-year postmenopausal, surgically sterilized, or, if of childbearing potential, have a negative urine pregnancy test at the Preoperative Visit. Women of childbearing potential must use an acceptable form of contraception throughout the study. Acceptable methods include at least one of the following: intrauterine (intrauterine device), hormonal (oral, injection, patch, implant, ring), barrier with spermicide (condom, diaphragm), or abstinence.\n\nExclusion Criteria:\n\n1. Subjects with a current Ptosis diagnosis\n2. Subjects with a history of Graves' Disease\n3. Subjects with Myasthenia Gravis\n4. Subjects that in the opinion of the investigator are anatomically not conducive to using devices (e.g., heavy brow, severe hollowing of the upper eyelid, history of ocular or orbital trauma).\n5. Subjects that have had any previous surgery eyelid or eyebrow region.\n6. Use of anticoagulation therapy, including, but not limited to Aspirin, NSAIDS, Ibuprofen within 7 days and Xarelto, Warfarin, Enoxaparin, Plavix within 3 days prior to planned study procedure.\n7. Active or recent (within 3 months) tobacco user\n8. Allergy to adhesive glue\n9. Participation in any study of an investigational, interventional product within 30 days prior to the Preoperative Visit or at any time during the study period.\n10. Pregnant or nursing females.","35 Years",{"count":61,"type":21},50,[63],"NA","This study will compare two surgery techniques used for upper eyelid (eyelift) surgery: traditional surgery and a newer method called Ziplyft (a non-powered, hand-held clamp). This study will use a \"split-face\" design, meaning one eyelid will be treated with the traditional surgery method and the other with Ziplyft, allowing a direct side-by-side comparison.\n\nThe objectives of the study are to compare Ziplyft treatment vs. traditional surgery by evaluating bruising, wound closure and incision, surgery case time, and subject\u002Fsurgeon surveys.",[27,66,28],"Ptosis, Eyelid",[68,69,70],"Dermatochalasis of upper eyelid, Ptosis of upper eyelid, blepharoplasty,","Ziplyft","upper eyelid surgery","RECRUITING","2025-11-18",{"date":74,"type":44},"2025-11-26",{"date":76,"type":21},"2025-12-08",{"date":78,"type":21},"2026-09-30",{"name":80,"class":81},"Osheru Inc.","INDUSTRY",1]