[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"diabetes-prevention\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:diabetes-prevention":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,46,79,111],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100651674","couple-coordinated-lifestyle-intervention-for-women-with-a-history-of-gestational-diabetes-mellitus-100651674",false,"NCT07762625","Couple-Coordinated Lifestyle Intervention for Women With a History of Gestational Diabetes Mellitus","Effectiveness of a Couple-Coordinated Lifestyle Intervention Among Women With a History of Gestational Diabetes Mellitus","Inclusion Criteria:\n\n1. For women:\n\n   * 20 to 40 years of age.\n   * Diagnosed with gestational diabetes mellitus during the most recent pregnancy.\n   * Have basic literacy and sufficient cognitive and physical ability to participate in the study.\n   * Living with their spouse.\n   * Able to use a smartphone.\n   * Willing to participate in the study.\n2. For spouses:\n\n   * Living with an eligible woman with a history of gestational diabetes mellitus.\n   * Have basic literacy and sufficient cognitive and physical ability to participate in the study.\n   * Able to use a smartphone.\n   * Willing to participate in the study.\n\nExclusion Criteria:\n\n1. For women:\n\n   * Diabetes diagnosed before pregnancy or after delivery.\n   * Pregnant at the time of screening.\n   * Currently using medications that affect glucose metabolism or medications for weight loss.\n   * Cognitive impairment or a serious psychiatric disorder.\n   * A contraindication to postpartum exercise.\n   * Current participation in another lifestyle intervention program.\n2. For spouses:\n\n   * A diagnosed major chronic disease, such as coronary heart disease or diabetes, or another serious physical illness.\n   * Cognitive impairment or a serious psychiatric disorder.\n   * Current participation in another lifestyle intervention program.\n\nWomen with a history of gestational diabetes mellitus and their spouses will be recruited during postpartum follow-up visits at the participating hospitals. Both members of the couple must meet their respective eligibility criteria.",true,"ALL","20 Years","40 Years",{"count":21,"type":22},362,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to evaluate the effects of a couple-based collaborative lifestyle intervention among women with a history of gestational diabetes. The main questions it aims to answer are:\n\nDoes the intervention improve body mass index and 2-hour plasma glucose after an oral glucose tolerance test? Does the intervention improve health behaviors, psychological well-being, self-efficacy, couple functioning, and life satisfaction?\n\nResearchers will compare a couple-based collaborative lifestyle intervention with a woman-only lifestyle intervention to determine whether adding spousal collaboration and support leads to greater improvements.\n\nParticipants will:\n\nReceive healthy lifestyle education posts for 3 months. In the couple-based group, also receive instant messages on behavioral promotion and couple collaboration and support videos.",[28,29,30,31,32],"Diabetes Prevention","GDM","Lifestyle Intervention","Couples","Postpartum","NOT_YET_RECRUITING","2026-08-08",{"date":36,"type":37},"2026-08-13","ACTUAL",{"date":39,"type":22},"2026-08-15",{"date":41,"type":22},"2028-08-30",{"name":43,"class":44},"The Third Xiangya Hospital of Central South University","OTHER",3,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":16,"sex":17,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":78},"100589860","paths-up-health-behavior-self-monitoring-mobile-app-for-adolescents-100589860","NCT06959901","PATHS-UP Health Behavior Self-monitoring Mobile App for Adolescents","Investigating the Efficacy of Mobile Health Monitoring and Self-care to Improve Obesity Outcomes in Hispanic Adolescence Populations","PATHS-UP","Inclusion Criteria:\n\n* self-identify as Hispanic or Latino\n* 12-18 years\n* BMI% in the 85th-95th range,\n* Owns their own iphone\n\nExclusion Criteria:\n\n* Currently enrolled in a health program\n* Diagnosed with T2D\n* Present with a disease or condition that would prevent one from engaging in activity","12 Years","18 Years",{"count":57,"type":22},30,[25],"Hispanic adolescents in the U.S. are disproportionately burdened by type 2 diabetes (T2D) compared to non-Hispanic white youth (0.079% vs. 0.017%) contributing to higher rates of T2D-related vascular complications, cardiovascular disease, and mortality, among this population. Disparities in T2D are driven in part by independent, modifiable risk factors including low levels of physical activity, sleep, and poor diet. Lifestyle interventions are the cornerstone for maintaining glucose control and managing T2D. However, few studies have developed and tested lifestyle interventions for Hispanic youth with T2D. Digital health interventions that promote healthy lifestyle behaviors like physical activity, sleep, and diet, have demonstrated effectiveness among adults. Studies that use health-based smartphone applications have demonstrated preliminary efficacy for improving health-related lifestyle behaviors as these digital tools leverage behavior change techniques (e.g. self-monitoring, goal-setting, feedback) that have proven effective. Use of digital technology allows for the continuous delivery of intervention content into the home environment extending the reach of clinical care while engaging youth in a format that is age-appropriate given that today's youth are digital frontrunners. Unfortunately, while the use of digital health interventions have increased, few studies have focused on adolescents with overweight and obesity who are at high risk for T2D. The purpose of this study is to 1) develop a mobile health platform for remote and continuous monitoring of activity, sleep, and nutrition and 2) conduct a pilot study (30 days) to evaluate the efficacy of a novel digital health platform in improving obesity-related health outcomes outcomes in Hispanic adolescents (12-18 years; N=30) population.",[61,28],"Obesity and Diabetes Mellitus, Type 2",[63,64,65,66,67],"mHealth","Digital health","teen health","lifestyle intervention","mobile phone app","RECRUITING","2026-07-03",{"date":71,"type":37},"2026-07-07",{"date":73,"type":37},"2025-04-30",{"date":75,"type":22},"2026-08-01",{"name":77,"class":44},"Baylor College of Medicine",1,{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":87,"targetDuration":4,"studyType":23,"phases":89,"briefSummary":90,"conditions":91,"keywords":95,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":78},"100608225","randomized-double-blind-crossover-trial-comparing-low-gi-functional-vs-standard-wholegrain-carbohydrates-on-glycolipid-metabolism-and-vascular-stress-markers-in-adults-with-suboptimal-triglyceridemia-100608225","NCT07198789","Randomized, Double-blind Crossover Trial Comparing Low-GI Functional vs. Standard Wholegrain Carbohydrates on Glycolipid Metabolism and Vascular Stress Markers in Adults With Suboptimal Triglyceridemia","Randomized, Double-Blind, Placebo-Controlled Crossover Clinical Trial to Evaluate the Effect of a Functional Low-Glycemic Index Carbohydrates Versus Standard Wholegrain Carbohydrates on Glycolipid Metabolism and Vascular Stress Markers in Subjects With Suboptimal Triglyceridemia","GLOW","Inclusion Criteria:\n\n* Male or female aged ≥ 18 years\n* TG\\>150 mg\u002FdL\n* Subjects who have the capability to communicate and to comply with the study's requirements.\n* Subjects agree to participate in the study and having dated and signed the informed consent form.\n\nExclusion Criteria:\n\n* Gluten hypersensitivity\u002FCoeliac disease diagnosis\n* BMI\\>30 kg\u002Fm2\n* Any preventive treatments (i.e. lipid-lowering drugs, antihypertensives) not stabilized in type and dose for at least 3 months\n* Any medical or surgical condition that would limit the patient adhesion to the study protocol.",{"count":88,"type":22},40,[25],"Low-glycemic index (GI) carbohydrates help prevent type 2 diabetes and cardiovascular disease by reducing postprandial glucose, insulin spikes, inflammation, and triglyceride synthesis. They improve weight, lipid profiles, and vascular health. Our study will compare functional low-GI vs. standard wholegrain carbs in a Mediterranean diet to assess their effect on the Triglycerides-Glucose Index, a marker of metabolic and cardiovascular risk, in subjects with suboptimal triglyceride levels.",[92,28,93,94],"Cardiovascular Prevention","Inflammation","Nutrition",[96,97,98,99,100,101],"Low glycemic index","Low-GI diet","Triglycerides-Glucose Index","Low-glycemic index carbohydrates","Wholegrain carbohydrates","Altograno®","2026-04-27",{"date":104,"type":37},"2026-05-01",{"date":106,"type":37},"2026-02-02",{"date":108,"type":22},"2026-09-29",{"name":110,"class":44},"University of Bologna",{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":4,"eligibilityCriteria":117,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":118,"targetDuration":4,"studyType":23,"phases":120,"briefSummary":121,"conditions":122,"keywords":125,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":4},"100624690","optimizing-implementation-of-the-intensive-diabetes-prevention-program-100624690","NCT07412912","Optimizing Implementation of the Intensive Diabetes Prevention Program","Optimizing Implementation of the Intensive Diabetes Prevention Program in District Health Centres: A Hybrid Type 3 Study to Enhance Recruitment and Retention for Prediabetes Management","Inclusion Criteria:\n\n* Being 18 years of age or above\n* Having a baseline HbA1c within the prediabetes range (6.0%-6.4%)\n* Holding a scheduled appointment at a DHC\n\nExclusion Criteria:\n\n* Having a diagnosis of diabetes mellitus\n* Currently using of oral hypoglycaemic agents or medications known to induce significant weight changes\n* Having medical conditions that would limit participation, such as active cancer or cognitive impairment",{"count":119,"type":22},170,[25],"The goal of this clinical trial is to explore the effectiveness and implementation outcomes of the optimized Intensive Diabetes Prevention Program (IDPP) in District Health Centres. The main questions it aims to answer are:\n\n* Do the implementation strategies - patient engagement system, structured training, and reminder systems - work better than usual approaches in terms of acceptability, adoption, appropriateness, feasibility, sustainability, and implementation cost?\n* Do patient health outcomes - HbA1c levels, BMI, lipid profile, quality of life, perception of empowerment, and health service utilization - stay the same or get better when these improved strategies are used compared to usual approaches?",[123,28,124],"Prediabetes","Implementation Science",[126,127,128],"Intensive Diabetes Prevention Program","Behavioural determinants","Prediabetes management","2026-02-09",{"date":131,"type":37},"2026-02-17",{"date":133,"type":22},"2026-06-01",{"date":135,"type":22},"2027-12-31",{"name":137,"class":44},"The Hong Kong Polytechnic University"]