[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"diagnostic-errors\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:diagnostic-errors":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100651035","effect-of-pneumatic-tube-system-vs-personnel-transport-on-hemolysis-index-in-emergency-department-blood-samples-a-randomized-within-patient-matched-trial-100651035",false,"NCT07755007","Effect of Pneumatic Tube System vs. Personnel Transport on Hemolysis Index in Emergency Department Blood Samples: A Randomized, Within-Patient Matched Trial","Comparison of the Effect of Pneumatic Tube System and Personnel Transport on Hemolysis Index in Blood Samples From the Emergency Department: A Randomized, Within-Patient Matched, Single-Blind, Prospective Study","PTS-HEMO-ED","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Presenting to the emergency department of Marmara University Pendik Training and Research Hospital\n* Venous blood draw required for routine clinical care needing two or more yellow-cap (serum separator) tubes\n* Written informed consent provided by the participant\n\nExclusion Criteria:\n\n* Known underlying hemolytic disorder (e.g., hemolytic anemia, sickle cell disease, G6PD deficiency, autoimmune hemolytic anemia, or TTP\u002FHUS)\n* Macroscopic hemolysis visible in the sample tube immediately after phlebotomy\n* Age younger than 18 years","ALL","18 Years",{"count":20,"type":21},166,"ESTIMATED","INTERVENTIONAL",[24],"NA","Hemolysis is the most common pre-analytical error in emergency department (ED) laboratory specimens and can lead to false elevation of intracellular analytes (potassium, LDH, AST, hemoglobin), resulting in misdiagnosis and unnecessary testing. Blood samples in the ED are transported to the laboratory either by pneumatic tube systems (PTS) or manually by personnel. Although PTS shortens turnaround time, the forces generated during transport may damage erythrocyte membranes and promote hemolysis. Evidence on whether PTS increases hemolysis compared with personnel transport is inconsistent, partly because existing studies use parallel-group designs that cannot control for between-subject biological variability, and partly because findings differ across PTS brands and configurations. The Sumetzberger Power Control PTS installed at Marmara University Pendik Training and Research Hospital (speed 4-5 m\u002Fs, 120 m, cushioned capsule) has not been prospectively validated for hemolysis risk. This study uses a randomized, within-patient matched, single-blind design in which two simultaneously drawn yellow-cap tubes from the same patient are randomly allocated-one to PTS and one to personnel transport-thereby eliminating between-patient variability. The primary outcome is the Hemolysis Index (HI) category (ordinal scale 0-5 corresponding to free hemoglobin thresholds of \\\u003C50, 50-99, 100-199, 200-299, 300-500, and \\>500 mg\u002FdL). Secondary outcomes include the rate of clinically significant hemolysis (HI ≥ 1 \u002F free Hb ≥ 50 mg\u002FdL) and the correlation between transport time and HI.",[27,28,29],"Hemolysis","Diagnostic Errors","Blood Specimen Collection",[31,32,33,34,35,36],"Pneumatic Tube System","Blood Specimen Transport","Hemolysis Index","Emergency Service, Hospital","Pre-Analytical Variability","Sumetzberger","NOT_YET_RECRUITING","2026-08-05",{"date":40,"type":41},"2026-08-10","ACTUAL",{"date":43,"type":21},"2026-08",{"date":45,"type":21},"2027-01",{"name":47,"class":48},"Marmara University Pendik Training and Research Hospital","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":60,"briefSummary":61,"conditions":62,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":5},"100496708","achieving-diagnostic-excellence-through-prevention-and-teamwork-100496708","NCT05747755","Achieving Diagnostic Excellence Through Prevention and Teamwork","Achieving Diagnostic Excellence Through Prevention and Teamwork (ADEPT)","ADEPT","Inclusion Criteria:\n\n* Adult patients admitted to general medicine services at one of the participating hospitals and who either died during the hospitalization, were transferred to the ICU \\>= 48 hours after admission, or had a rapid response.\n\nExclusion Criteria:\n\n* Admitted for a non-medical reason\n* Patients coded in the field who are moribund on arrival to the hospital",{"count":59,"type":21},7200,[24],"This study seeks to link a group of hospitals to measure and share the rates of diagnostic errors, to understand underlying causes of diagnostic errors, and develop ways that hospitals, clinicians, and patients can work together to avoid diagnostic errors and harms due to those errors. The investigators will test how data sharing and collaboration improve diagnostic processes and develop approaches which can be sustained into the future. The approach represents a novel application of rigorous outcome adjudication to the problem of inpatient diagnostic errors using a learning health system model.",[28],"2023-03-03",{"date":65,"type":41},"2023-03-07",{"date":67,"type":21},"2023-03",{"date":69,"type":21},"2026-09",{"name":71,"class":48},"Brigham and Women's Hospital"]