[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"diaphragm-dysfunction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:diaphragm-dysfunction":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,47,68,93,122],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100650790","diaphragmatic-ultrasonography-in-difficult-weaning-100650790",false,"NCT07751237","Diaphragmatic Ultrasonography in Difficult Weaning","The Role of Diaphragmatic Ultrasonography in Difficult Weaning From Mechanical Ventilation: A Randomized Clinical Trial","DUS-WEAN","Inclusion Criteria:\n\n* Adults patients receiving invasive mechanical ventilation who are classified as having difficult weaning, defined as failure of the first spontaneous breathing trial.\n* Richmond Agitation-Sedation Scale (RASS) score between -2 and +1.\n* Clinical stability, defined as:\n* No vasopressor support or only low-dose, stable vasopressor therapy.\n* Absence of significant cardiac arrhythmias or ongoing myocardial ischemia.\n* Adequate oxygenation (SpO₂ \\>90% or PaO₂ \\>60 mmHg).\n* Respiratory rate \\\u003C35 breaths\u002Fmin.\n\nExclusion Criteria:\n\n* Inability to obtain informed consent.\n* Pre-existing neuromuscular disease.\n* Pregnancy.\n* Inability to perform the ultrasound examination because of chest drains, surgical wounds, or skin lesions at the assessment sites.","ALL","18 Years",{"count":20,"type":21},220,"ESTIMATED","INTERVENTIONAL",[24],"NA","Weaning from mechanical ventilation (MV) is a gradual process that includes several steps until the complete withdrawal of ventilatory support. Difficult weaning is defined as weaning completed only after the first attempt to withdraw the patient from ventilatory support, that is, a patient who failed the first spontaneous breathing trial (SBT). The use of ultrasound (US) to assess diaphragmatic and extradiaphragmatic muscles, such as the parasternal muscles, has been employed to determine diaphragmatic dysfunction and ventilatory effort, contributing to the decision-making process regarding weaning. Among the tools used for bedside monitoring and evaluation of patients are ventilatory variables that indicate an adequate level of ventilatory assistance in spontaneous modes through ventilatory drive, such as P0.1 (occlusion pressure in the first 100 ms) and assessment of ventilatory effort-inspiratory muscle pressure (Pmus)-which have also contributed to the downscaling of ventilatory support. However, there is still no consensus in the literature regarding predicted values or the effective role of these tools as predictors of weaning during the spontaneous breathing trial (SBT). The available studies investigating the relationship between diaphragmatic US, through measurements of diaphragmatic excursion and thickening fraction, and weaning failure from mechanical ventilation are mostly observational, which limits the strength of the current evidence. Therefore, it is essential to conduct randomized clinical trials, which are still unprecedented on this topic, to more robustly assess the efficacy of this technique as a decision-support tool during the weaning process, thereby contributing to more precise clinical practice. OBJECTIVES: The primary objective of this study is to evaluate the effect of diaphragmatic US use on ventilator-free days in patients with difficult weaning. The secondary objective is to analyze the relationship between the ventilatory variables P0.1 and Pmus, diaphragmatic US, and parasternal muscle recruitment during the SBT. METHODS: This is a randomized clinical trial, following CONSORT recommendations, which will be prospectively registered on the ClinicalTrials platform. Patients will be included after failing the first SBT. Subsequently, they will be randomized into two groups: In the shared US group, the results of diaphragmatic assessment via US will be shared with the attending team for decision-making regarding extubation. In the second group, the non-shared US group, the attending team will not have access to the diaphragmatic assessment for decision-making. EXPECTED RESULTS: It is expected that the shared US group of patients will have a shorter duration of MV and a lower number of extubation failures.",[27,28,29],"Weaning Mechanical Ventilation","ICU Ill Patients","Diaphragm Dysfunction",[31,32,33],"ultrasound Diaphragm","complicated weaning","Critical Illness","RECRUITING","2026-08-03",{"date":37,"type":38},"2026-08-07","ACTUAL",{"date":40,"type":21},"2026-08",{"date":42,"type":21},"2029-09",{"name":44,"class":45},"Hospital de Clinicas de Porto Alegre","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":46},"100634316","respiratory-physiotherapy-and-diaphragm-thickness-in-ventilated-icu-patients-100634316","NCT07538102","Respiratory Physiotherapy and Diaphragm Thickness in Ventilated ICU Patients","Effect of Respiratory Physiotherapy on Diaphragmatic Thickness in Mechanically Ventilated Patients in Intensive Care Unit: A Prospective Observational Controlled Trial","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Mechanically ventilated for at least 5 days\n* Hemodynamically stable\n* Unconscious (Glasgow Coma Scale indicating impaired consciousness)\n* Informed consent obtained from legal representatives\n\nExclusion Criteria:\n\n* Neuromuscular disease\n* Traumatic diaphragm injury\n* Thoracic deformity causing mechanical impairment of respiration\n* Terminal-stage patients\n* Patients in whom respiratory physiotherapy is contraindicated\n* Presence of a cardiac pacemaker or implantable cardioverter-defibrillator (ICD)",{"count":55,"type":21},66,"OBSERVATIONAL","This study aims to evaluate the effect of respiratory physiotherapy on diaphragm thickness in patients receiving mechanical ventilation support in the intensive care unit. Thinning and dysfunction of the diaphragm muscle observed during mechanical ventilation complicate the extubation process and increase the risk of respiratory failure in patients. Diaphragm dysfunction prolongs ventilator use and increases ICU mortality. The main objective of this research is to determine whether respiratory physiotherapy has protective or ameliorative effects on diaphragm muscle structure and function, to optimize the ventilator weaning process, and to provide scientific contributions to the field of respiratory rehabilitation. Changes in diaphragm thickness will be objectively evaluated using ultrasonography, and the aim is to obtain evidence-based data on the effectiveness of respiratory physiotherapy.",[29],"2026-05-07",{"date":61,"type":38},"2026-05-08",{"date":63,"type":38},"2025-08-01",{"date":65,"type":21},"2026-10-01",{"name":67,"class":45},"Hitit University",{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":4,"eligibilityCriteria":74,"healthyVolunteers":11,"sex":17,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":4,"studyType":22,"phases":79,"briefSummary":80,"conditions":81,"keywords":4,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":4},"100634460","effect-of-inspiratory-muscle-training-on-diaphragm-function-in-copd-patients-100634460","NCT07539974","Effect of Inspiratory Muscle Training on Diaphragm Function in COPD Patients","Effect of Threshold Inspiratory Muscle Training on Diaphragm Thickness and Diaphragm Excursion Value in Chronic Obstructive Pulmonary Disease Patients","Inclusion Criteria:\n\n* Patients with a COPD GOLD stage 2\n* Age 40-59 years\n* Maximal Inspiratory Pressure (MIP) value of less than 70 cmH₂O or below the lower limit of normal for their age and gender\n* Clinically stable for at least 4 weeks prior to the study\n* Ready to participate in research and sign informed consent\n\nExclusion Criteria:\n\n* Patients with contraindications to Inspiratory Muscle Training or spirometry (e.g., recent thoracic or abdominal surgery, pneumothorax, or history of spontaneous pneumothorax).\n* Patients participating in other structured respiratory muscle training or pulmonary rehabilitation programs concurrently that could confound the results\n* Patients undergoing other therapies that may affect diaphragmatic muscle measurement results, such as electrical diaphragmatic stimulation","40 Years","59 Years",{"count":78,"type":21},15,[24],"This study investigates the effect of threshold inspiratory muscle training on diaphragm thickness and diaphragm excursion, measured using ultrasonography, in patients with stable chronic obstructive pulmonary disease (COPD).",[82,29],"Chronic Obstructive Pulmonary Disease (COPD)","NOT_YET_RECRUITING","2026-04-20",{"date":86,"type":38},"2026-04-23",{"date":88,"type":21},"2026-04-01",{"date":90,"type":21},"2026-09-01",{"name":92,"class":45},"Universitas Padjadjaran",{"id":94,"slug":95,"hasResults":11,"nctId":96,"briefTitle":97,"officialTitle":97,"acronym":98,"eligibilityCriteria":99,"healthyVolunteers":100,"sex":17,"minAge":18,"maxAge":101,"enrollmentInfo":102,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":104,"conditions":105,"keywords":108,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":46},"100612430","correlation-of-diaphragm-shear-wave-elastography-with-transdiaphragmatic-pressure-in-healthy-adults-a-feasibility-study-100612430","NCT07253480","Correlation of Diaphragm Shear-Wave Elastography With Transdiaphragmatic Pressure in Healthy Adults: a Feasibility Study","PLEASSURE 1","Inclusion Criteria:\n\n* 18-60 years, BMI 18-30 kg\u002Fm²\n* No known respiratory, neuromuscular, or cardiothoracic disease\n* Able to perform inspiratory maneuvers and consent.\n\nExclusion Criteria:\n\n* Pregnancy\n* History of smoking (\\> 10 pack years)\n* Impaired swallowing, as well as esophageal diseases, or disorders at the level of the gastroesophageal sphincter",true,"60 Years",{"count":103,"type":21},12,"Changes in intrapleural pressure after lung volume reduction in Chronic Obstructive Pulmonary disease (COPD) patients can lead to complications, including an increased risk of pneumothorax. This procedure, intended to improve lung function, may disturb the pressure balance within the pleural space, potentially precipitating pneumothorax. Careful monitoring of intrapleural pressure could help predict patients at risk. However, intrapleural pressure can currently only be measured invasively. Diaphragm shear-wave elastography (SWE) has been shown to reflect transdiaphragmatic pressure during isovolumetric inspiratory efforts and ventilation against inspiratory loading, and therefore may serve as a non-invasive surrogate for intrapleural pressure. This project outlines a stepwise study plan to evaluate SWE as a tool for intrapleural pressure monitoring (Figure 1). The project only moves to the next phase is the study previous phase was achieved successfully. The current protocol involves the first phase: to validate diaphragm SWE against transdiaphragmatic pressure and assess measurement reliability for local ultrasound systems in healthy adults.This prospective, single-centre, observational validation study will include twelve healthy adult volunteers. During a single study session, participants will perform standardized inspiratory efforts while simultaneous measurements of diaphragm SWE, transdiaphragmatic pressure (via esophageal and gastric balloon catheters), and mouth pressures are obtained. These methods are routinely applied in physiological research and carry minimal risk. Apart from brief nasal or throat discomfort during catheter placement, no significant adverse effects are expected. By establishing the relationship between diaphragm SWE, transdiaphragmatic pressure, and mouth pressures, this study aims to provide the essential validation step for future clinical research in COPD patients following lung volume reduction.",[106,29,107],"Diaphragm Ultrasound","Health Adult Subjects",[109,110,111,112],"diaphragm","ultrasound","diaphragmatic pressure","shear-wave elastography","2025-11-29",{"date":115,"type":38},"2025-12-05",{"date":117,"type":21},"2026-04",{"date":119,"type":21},"2026-09",{"name":121,"class":45},"Isala",{"id":123,"slug":124,"hasResults":11,"nctId":125,"briefTitle":126,"officialTitle":126,"acronym":127,"eligibilityCriteria":128,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":129,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":131,"conditions":132,"keywords":133,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":46},"100548438","incidence-and-impact-of-icu-acquired-diaphragm-weakness-100548438","NCT06420999","Incidence and Impact of ICU-acquired Diaphragm Weakness","PRODIGY","Inclusion Criteria:\n\n1. Age ≥ 18 years\n2. Invasive or non-invasive respiratory support (ventilation, high-flow oxygen therapy, whatever the reason) for at least 48 hours.\n3. Weaning from respiratory support (invasive or not) within the last 24 hours.\n4. Patient (or trusted person\u002Frelative) informed and not opposed to the study.\n\nExclusion Criteria:\n\n1. Known pre-existing diaphragmatic dysfunction (phrenic lesion, neuromuscular disease, etc.)\n2. Patients with tracheostomy\n3. Non-communicating patients\n4. Patients deprived of liberty by court or administrative order, or under legal protection (guardianship, curators).",{"count":130,"type":21},194,"ICU survivors are at an increased risk of hospital and ICU readmission. Among the complications of ICU stay, diaphragmatic dysfunction is common, with a prevalence of 60 to 80%, and is associated with increased mortality and prolonged hospital stays. Furthermore, several studies have reported that the observation of impaired respiratory muscle function upon ICU discharge is associated with a poor long-term prognosis. However, the incidence and prognostic impact of persistent diaphragmatic dysfunction at ICU discharge have never been evaluated. The measurement of dyspnea, a composite evaluation of respiratory muscle function, has not been assessed for predicting prognosis upon ICU discharge.\n\nThe hypothesis of the project is that the presence of ICU-acquired diaphragmatic dysfunction at ICU discharge is associated with a poorer prognosis within 90 days.",[29],[134,135,136],"ICU","diaphragmatic activity","Respiratory support","2025-05-26",{"date":139,"type":38},"2025-05-28",{"date":141,"type":38},"2024-07-29",{"date":143,"type":21},"2028-01-29",{"name":145,"class":45},"Assistance Publique - Hôpitaux de Paris"]