[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"diaphragmatic-paralysis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:diaphragmatic-paralysis":39},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,53,86],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100557458","clinical-utility-of-portable-dynamic-chest-x-ray-ddr-in-the-icu-100557458",false,"NCT06538376","Clinical Utility of Portable Dynamic Chest X Ray (DDR) in the ICU","Clinical Utility of Portable Dynamic Chest X-Ray (DDR) in the ICU: Clinical Trial to Demonstrate the Feasibility of Deploying DDR Technology in the ICU - A Study to Prove Its Increased Diagnostic Value","Inclusion Criteria: Participants must meet all the following inclusion criteria to participate in this study:\n\n* Adults (at least 18 years of age) including both intubated\u002Fventilated and non-intubated patients\n* Likely to have pathology related to either, abnormal diaphragmatic excursion and lung aeration, pulmonary perfusion, increased lung water content or all the above, as well as for cricopharyngeal dysfunction\u002Fswallowing difficulties at risk for aspiration.\n* The subject or a legally authorized representative has provided written informed consent.\n\nExclusion Criteria: Candidates meeting any of the exclusion criteria at baseline will be excluded from study participation. These criteria are:\n\n* Special populations, including women with known pregnancy, prisoners, or institutionalized individuals\n* Patients where additional radiation is clinically contraindicated\n* Care team does not provide assent for approaching patient\u002Fsurrogate\n* For women of child-bearing potential, defined as premenopausal women, a pregnancy test will be administered to determine pregnancy status and confirm eligibility for the study. A pregnancy test will NOT be administered to women who are post-menopausal or have documentation of surgical sterilization.","ALL","18 Years",{"count":19,"type":20},230,"ESTIMATED","INTERVENTIONAL",[23],"NA","Dynamic digital radiography (DDR) is a new advanced version of chest radiography that captures dynamic images at a rate of 15 frames per second. It is coupled with an analytical software that allows it to provide more advanced measures of lung motion, ventilation, and perfusion compared to traditional chest radiography. While implementation of DDR fixed machines are beginning elsewhere in the US, this trial involves the first applications of an FDA-approved portable DDR machine, for use at the bedside in the ICU.\n\nThe goal of this clinical trial is to determine the feasibility and safety of portable DDR technology in the ICU, as well as to evaluate the improved clinical diagnostic value of the portable DDR system over current standards of care.\n\nParticipants will receive one to three sets of DDR images, which will then be compared to their clinical gold standard exams (such as chest x-rays, CTs, or VQ scans) to assess and improve the precision and accuracy of measurements such as diaphragmatic motion, lung movement, and perfusion.",[26,27,28,29,30,31,32,33,34,35,36,37,38,39],"Pulmonary Edema","Pneumonia","Atelectasis","Pleural Effusion","Acute Rejection of Lung Transplant (Disorder)","Airway Obstruction","Rib Fractures","Acute Copd Exacerbation","Asthma COPD","Pulmonary Embolism","Hemothorax","Pneumothorax","Mesothelioma","Diaphragmatic Paralysis","RECRUITING","2025-10-28",{"date":43,"type":44},"2025-10-29","ACTUAL",{"date":46,"type":44},"2023-12-12",{"date":48,"type":20},"2027-11",{"name":50,"class":51},"Brigham and Women's Hospital","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":61,"enrollmentInfo":62,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":65,"conditions":66,"keywords":69,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":52},"100586731","short--and-long-term-effects-of-robot-assisted-plication-in-diaphragmatic-paralysis-100586731","NCT06919185","Short- and Long-term Effects of Robot-assisted Plication in Diaphragmatic Paralysis","Short- and Long-term Effects of Robot-assisted Plication in Diaphragmatic Paralysis - the Prospective RAPIDLY-study","RAPIDLY","Inclusion Criteria:\n\n* Patients with symptomatic unilateral diaphragmatic paralysis persisting for ≥1 year\n* Patients are scheduled for RATS at thoracic surgery clinics in five Swedish university hospitals (Gothenburg, Linköping, Lund, Umeå, and Uppsala).\n\nExclusion Criteria:\n\n* Inability to complete forms in Swedish\n* Neuromuscular disease as the cause of diaphragmatic paralysis\n* Other significant causes of dyspnea\n* Impaired physical capacity from other causes than diaphragmatic paralysis.","85 Years",{"count":63,"type":20},50,"OBSERVATIONAL","Diaphragmatic paralysis may lead to severe symptoms such as breathlessness and reduced physical capacity.\n\nDiaphragmatic plication using Robotic-Assisted Thoracic Surgery (RATS) is a minimally invasive surgical technique developed to improve lung function by correcting diaphragmatic elevation.\n\nWhile its benefits have been reported in retrospective reports, prospective studies are lacking.\n\nThis prospective observational cohort study aimsto evaluate the short- and long-term effects of robot-assisted diaphragmatic plication on subjective breathlessness, physical performance, lung function, blood gases, and imaging findings at five Swedish university hospitals: Gothenburg, Linköping, Lund, Umeå, and Uppsala.\n\nPatients will be assessed preoperatively and postoperatively after one to three months and after one and three years.",[67,39,68],"Diaphragmatic Plication","Diaphragmatic Eventration",[70,71,72,73,74],"RATS","robot-assisted thoracic surgery","plication","dyspnea","thoracotomy","NOT_YET_RECRUITING","2025-04-08",{"date":78,"type":44},"2025-04-11",{"date":80,"type":20},"2025-05",{"date":82,"type":20},"2031-12",{"name":84,"class":85},"Uppsala County Council, Sweden","OTHER_GOV",{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":4,"eligibilityCriteria":92,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":93,"enrollmentInfo":94,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":96,"conditions":97,"keywords":100,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":114},"100534814","phrenic-nerve-reconstruction-for-the-treatment-of-diaphragmatic-paralysis-patient-experiences-and-reported-outcomes-100534814","NCT06243718","Phrenic Nerve Reconstruction for the Treatment of Diaphragmatic Paralysis: Patient Experiences and Reported Outcomes.","A Grounded Theory of Phrenic Nerve Reconstruction for the Treatment of Diaphragmatic Paralysis - A Biopsychosocial Approach to Surgical Evaluation and Outcomes.","Inclusion Criteria:\n\n* Individuals with a confirmed diagnosis of Diaphragmatic Paralysis.\n* Individuals who are scheduled to undergo phrenic nerve reconstructive surgery for the treatment of Diaphragmatic Paralysis.\n\nExclusion Criteria:\n\n\\- Individuals who do not comprehend the English language.","70 Years",{"count":95,"type":20},45,"This study utilizes a grounded theory methodology to explore patient experiences of phrenic nerve reconstructive surgery as a treatment for diaphragmatic paralysis.",[39,98,99],"Pain, Chest","Breath Shortness",[101,39,102,103,104],"Grounded Theory","Diaphragm","Respiratory System","Pain","2024-02-05",{"date":107,"type":44},"2024-02-06",{"date":109,"type":44},"2023-10-10",{"date":111,"type":20},"2026-10-10",{"name":113,"class":85},"Advanced Reconstructive Surgery Alliance",2]