[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"digital-eye-strain-des\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:digital-eye-strain-des":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100649678","lactic-acid-bacteria-for-reducing-blue-light-induced-eye-fatigue-100649678",false,"NCT07737938","Lactic Acid Bacteria for Reducing Blue Light-Induced Eye Fatigue","The Application of Lactic Acid Bacteria on Reducing Blue Light-Induced Eye Fatigue in Middle-Aged Adults","Inclusion Criteria:\n\n* Men and women aged 20-65 years\n* Daily digital screen use \\>6 hours for at least 1 year\n* Mild to severe digital eye strain (CVS-Q score ≥ 6)\n* Mild to moderate dry eye symptoms (OSDI ≥ 13)\n\nExclusion Criteria:\n\n* Amblyopia or strabismus\n* Severe eye diseases (e.g., glaucoma , cataract , retinal disorders, severe corneal disease)\n* Ocular surgery within the past 12 months\n* Chronic systemic diseases (e.g., uncontrolled diabetes, autoimmune disease, severe liver\u002Fkidney impairment, cancer)\n* Recent use (\\\u003C1 months) of steroids, antibiotics, immunosuppressants, probiotics, prebiotics, or eye-health supplements\n* Pregnant or breastfeeding\n* Allergy to probiotics or study product ingredients\n* Eating disorders, psychiatric illness, or cognitive impairment affecting compliance\n* Any condition judged unsuitable by the investigator",true,"ALL","20 Years","65 Years",{"count":21,"type":22},150,"ESTIMATED","INTERVENTIONAL",[25],"NA","With the widespread use of digital devices and prolonged screen exposure, digital eye strain (DES), also known as computer vision syndrome, has become a global public health concern. Emerging evidence suggests that the gut-eye axis may play an important role in ocular health, as gut microbiota imbalance is associated with systemic inflammation and oxidative stress. Specific probiotics may help alleviate eye discomfort through modulation of immune responses and enhancement of antioxidant defense mechanisms. This randomized, double-blind, placebo-controlled study aims to evaluate the efficacy of supplementation with specific probiotics, Bifidobacterium longum BL531 and Lactobacillus reuteri LR1349, in improving digital eye strain symptoms in adults.",[28],"Digital Eye Strain (DES)",[30,31,32,33],"Eye Fatigue","Probiotics","Digital Eye Strain","Blue Light","NOT_YET_RECRUITING","2026-07-27",{"date":37,"type":38},"2026-07-30","ACTUAL",{"date":40,"type":22},"2026-09-01",{"date":42,"type":22},"2027-12-31",{"name":44,"class":45},"Synbio Tech Inc.","INDUSTRY",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":60,"conditions":61,"keywords":62,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":5},"100561358","efficacy-of-investigator-product-for-the-amelioration-of-digital-eye-strain-in-children-100561358","NCT06589128","Efficacy of Investigator Product for the Amelioration of Digital Eye Strain in Children","Efficacy of Investigator Product for the Amelioration of Digital Eye Strain in Children: a Randomized, Double-blind, Placebo-controlled Human Clinical Trial","DES","Inclusion Criteria:\n\n* Children with DES (CVS-Q score 6-18)\n\nExclusion Criteria:\n\n* Children with CVS-Q score ≥ 19\n* Children who wear contact lenses\n* Children with any diagnosed ocular motility disorder or accommodative\u002Fbinocular vision issues\n* Participants who are colour-blind\n* Participant on any retinols and carotenoid supplements\n* Participants who have immunosuppressive disorders or are taking immunosuppressive medication\n* Atopy, allergic disorders\n* Anaemia\n* Ophthalmic laser treatment (less than 3 months)\n* Systemic disease associated with dry eye\n* Blepharitis\n* Having liver (chronic liver failure, cirrhosis, all types of hepatitis), kidney (chronic kidney disease, haemodialysis) or haematological (anaemia, thalassemia, haemophilia) disorders\n* Psychiatric disease\u002Fmental retardation (bipolar disorder, depression, schizophrenia)\n* Cancer (all types), and endocrine disorders (Cushing's disease, gigantism and hyperthyroidism)\n* Use of steroids, chemotherapy or radiotherapy\n* Currently under another supplementary program","10 Years","11 Years",{"count":58,"type":22},70,[25],"Computer vision syndrome (CVS), also referred to as Digital eye strain (DES), is a group of eye and vision problems caused by prolonged use of electronic devices. The American Optometric Association (APA) defines DES as a group of eye and vision-related problems caused by prolonged computer, tablet, e-reader, and cell phone use. Currently, for more than 20 years, DES has been recognised as a public health issue, and the terms DES are also used to describe the condition, attributed to the wide range of digital devices associated with potential problems.",[28],[63,32,64],"Children","Astaxanthin","RECRUITING","2026-04-27",{"date":68,"type":38},"2026-04-29",{"date":70,"type":38},"2024-10-01",{"date":72,"type":22},"2026-06-30",{"name":74,"class":75},"Universiti Sains Malaysia","OTHER"]