[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dihydrotestosterone\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dihydrotestosterone":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":4},"100649079","phase-4-finasteride-and-cutibacterium-100649079",false,"NCT07731802","Finasteride and Cutibacterium","Inclusion We will include the group most impacted by PJI\n\n* Adult males\n* Age between 18 and 65 Exclusion\n* History of cryptorchidism, hypospadias, or other congenital abnormality of male reproductive tract\n* Female sex\n* Age younger than 18 or older than 65\n* Current use of Finasteride or other 5-alpha reductase inhibitors\n* Current use of hormone replacement medications such as testosterone\n* Recent antibiotic use within 3 months\n* Have had a negative reaction to oral Finasteride before\n* Recent use of acne treatment within 3 months\n* Self-report very sensitive skin\n* Allergic to chlorhexidine or isopropyl alcohol\n* Have open wounds on both shoulders",true,"MALE","18 Years","65 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","High levels of Testosterone causes high amounts of skin bacteria (Cutibacterium Acnes) which can go into the skin during a shoulder replacement surgery and cause a terrible infection.\n\nThe goal of this experiment is to have participants take Finasteride, a medication that blocks testosterone production, for 2 weeks and evaluate the following:\n\n* Blood levels of testosterone\n* Amount of bacteria on the skin.\n\nParticipants will:\n\n* Be assigned to take Finasteride, or a placebo (a look-alike pill with no active medicine) once daily, for 2 weeks\n* Have a small sample of their blood collected and their skin swabbed with a Q-tip to determine Testosterone levels and bacteria on the skin\n* Blood draw and skin testing will take place before starting Finasteride or the placebo (day 0) and at the end of the experiment (day 14).",[27,28,29],"Dihydrotestosterone","Periprosthetic Joint Infection (PJI)","Cutibacterium Acnes",[31,32,33],"placebo","blood draw","skin culture","NOT_YET_RECRUITING","2026-07-23",{"date":37,"type":38},"2026-07-28","ACTUAL",{"date":40,"type":21},"2026-08-31",{"date":42,"type":21},"2027-08-31",{"name":44,"class":45},"University of Washington","OTHER"]