[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"disuse-atrophy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:disuse-atrophy":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":4},"100646498","effect-of-knee-position-on-muscle-loss-during-leg-immobilization-100646498",false,"NCT07690150","Effect of Knee Position on Muscle Loss During Leg Immobilization","A Novel Angle: Manipulating Knee Position to Understand Muscle Deterioration During Leg Immobilization","Inclusion Criteria:\n\n* Healthy males and females\n* Aged from 18-40 years at the time of signing informed consent\n* 18.5 \\\u003C BMI \\\u003C 30 kg·m-2\n* Must be willing and able to communicate and participate in the whole study\n\nExclusion Criteria:\n\n* Smoking\n* Diabetes (Type 1, Type 2, or genetic form of diabetes)\n* Any diagnosed cardiovascular (heart) disease or high blood pressure (≥140 mmHg systolic and\u002For ≥90 mmHg diastolic)\n* Chronic use of any prescribed or over the counter pharmaceuticals that may modulate muscle protein metabolism (excluding oral contraceptives and contraceptive devices).\n* A personal or family history of thrombosis, epilepsy, seizures or schizophrenia.\n* Prone to keloid forming (i.e. hyperplastic growth of scars).\n* Any known disorders in muscle metabolism\n* Regular use of dietary protein and\u002For amino acid supplements (\\>3 times per week)\n* Currently involved in a structured progressive resistance training programme (\\>3 times per week)\n* Known allergy to lidocaine\n* Known severe kidney problems\n* Allergy to one or multiple amino acids\n* Recent (within the last 6 months) or current musculoskeletal injury (e.g. leg fracture)\n* Having received or ingested a stable isotope tracer containing 15N in the past\n* Contra-indications for MRI such as incompatible metal objects in the body and claustrophobia.\n* Currently taking part in other scientific research\n* Pregnant or breastfeeding\n* Unable to give consent",true,"ALL","18 Years","40 Years",{"count":21,"type":22},30,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study looks at what happens to leg muscles when the knee is kept straight or bent during five days of wearing a brace. We want to find out if keeping the knee bent (so the thigh muscle is stretched) helps prevent muscle loss compared to keeping the knee straight. Thirty healthy adults will take part. They will wear a knee brace for five days and have several tests before and after, including scans, blood samples, and small muscle samples. The results may help doctors find better ways to protect muscles when people cannot move, for example after surgery or illness.",[28,29,30],"Muscle Atrophy","Disuse Atrophy","Immobilization",[32,33,34,35,36,37],"Quadriceps","Knee Brace","Muscle Protein Breakdown","Dynamometry","Stable Isotope Tracers","MRI","NOT_YET_RECRUITING","2026-07-01",{"date":41,"type":42},"2026-07-08","ACTUAL",{"date":44,"type":22},"2026-08-01",{"date":46,"type":22},"2028-06-01",{"name":48,"class":49},"Wageningen University","OTHER",{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":23,"phases":61,"briefSummary":62,"conditions":63,"keywords":64,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":77},"100639538","cross-education-of-skill-and-strength-in-healthy-people-subjected-to-an-upper-limb-disuse-model-100639538","NCT07615062","Cross-education of Skill and Strength in Healthy People Subjected to an Upper-limb Disuse Model","Cross-education of Skill and Strength Through Contralateral Manual Dexterity Training in Healthy Young Adults Subjected to an Upper-limb Disuse Model: A Randomized Controlled Trial.","IMMO-CROSS","Inclusion Criteria:\n\n* Individuals will be eligible for inclusion if they are right-handed adults aged 18 to 35 years with a body mass index (BMI) between 18.5 and 30 kg\u002Fm².\n* Individuals must be classified as physically inactive, defined as not meeting the World Health Organization criteria of at least 150 minutes of moderate-intensity physical activity or 75 minutes of vigorous-intensity physical activity per week.\n\nExclusion Criteria:\n\n* Individuals who have engaged in physical training (e.g., any form of strength or aerobic exercise) or specific manual dexterity training within the past 6 months. - Individuals who regularly participate in artistic, occupational, or sporting activities requiring high levels of manual dexterity (e.g., musicians, gamers, craftspeople).\n* Individuals with a history of orthopedic or traumatic injuries affecting either upper extremity. Individuals with pathologies or conditions that preclude safe training (e.g., uncontrolled hypertension, or visual, auditory, or cognitive impairments \\[for example, dyscalculia\\]).\n* Individuals currently using nutritional supplements or medications that interfere with the regulation of skeletal muscle mass and strength (e.g., whey protein, creatine) or the central nervous system (e.g., antidepressants, anxiolytics, hypnotics).","35 Years",{"count":60,"type":22},34,[25],"This randomized controlled trial aims to compare manual dexterity and strength between a group undergoing a contralateral manual dexterity training program and a no-intervention control group in healthy, physically inactive individuals subjected to an induced upper-limb disuse model.",[29,30],[65,30,66,67],"Cross-education","contralateral training","interlimb transfer","2026-05-22",{"date":70,"type":42},"2026-05-29",{"date":72,"type":22},"2026-05-25",{"date":74,"type":22},"2027-01-30",{"name":76,"class":49},"Universidad Catolica de Temuco",1]