[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"drug-induced-crystalline-nephropathy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:drug-induced-crystalline-nephropathy":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":5},"100652468","drug-induced-crystalluria-in-sulfamethoxazole-high-dose-ciprofloxacin-and-high-dose-amoxicillin-100652468",false,"NCT07772752","Drug-induced Crystalluria in Sulfamethoxazole, High Dose Ciprofloxacin and High Dose Amoxicillin","Drug-induced Crystalluria in Sulfamethoxazole, High Dose Ciprofloxacin and High Dose Amoxicillin Treatment: a Prospective Study","CRYSTALLINE","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Able to give informed consent without the intervention of a legal representative\n* Treatment with\n* sulfamethoxazole\u002Ftrimethoprim, with minimum dose of\n* ≥ 800\u002F160 mg q12h oral administration (PO) or intravenous administration (IV) for eGFR ≥ 30 ml\u002Fmin\n* ≥ 400\u002F80 mg q12h OR or IV for eGFR \\\u003C 30 ml\u002Fmin OR\n* high dose ciprofloxacin, defined as\n* ≥ 750 mg q12h PO or ≥ 400 mg q8h IV for eGFR ≥ 60 ml\u002Fmin\n* ≥ 750 mg q24h PO or ≥ 400 mg q12h IV for eGFR 15-59 m\u002Fmin\n* ≥ 750 mg q24h PO OR ≥ 400 mg q24h IV for eGFR \\\u003C 15 ml\u002Fmin\n\nOR\n\n* high dose amoxicillin, defined as\n* ≥ 2g q6h IV for eGFR ≥ 30 ml\u002Fmin\n* ≥ 2g q8h IV for eGFR 15-29 ml\u002Fmin\n* ≥ 2g q12h IV for eGFR \\\u003C 15 ml\u002Fmin\n* Treatment for min 24 hours and sufficiently long to perform one crystalluria investigation as defined in the protocol\n* Baseline renal function up to 72 hours prior to the start of antibiotic treatment available (evaluated by serum creatinine and eGFR (CKD-EPI)) for all study groups and additional serum urea for the sulfamethoxazole group).\n\nExclusion Criteria:\n\n* Unable to give informed consent without the intervention of a legal representative\n* No baseline renal function up to 72 hours prior to the start of antibiotic treatment available, evaluated by serum creatinine and eGFR (CKD-EPI)) for all study groups and additional serum urea for the sulfamethoxazole group.\n* Treatment duration \\\u003C 24 hours or insufficiently long to perform one crystalluria inves-tigation as defined in the protocol\n* Patients treated with hemodialysis or peritoneal dialysis, anuric patients before start of antibiotic treatment\n* Patients with urinary diversions","ALL","18 Years",{"count":20,"type":21},290,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study examines in hospitalized patients, treated with sulfamethoxazole, high dose ciprofloxacin or high dose iv amoxicillin, the incidence of drug-induced urinary crystal formation and its association with acute kidney injury development.",[27,28,29],"Drug-induced Crystalline Nephropathy","Drug-induced Crystalluria","Infections Treated With Sulfamethoxazole, High Dose Ciprofloxacin or High Dose iv Amoxicillin",[31,32,33,34,35,36],"crystalluria","drug-induced acute kidney injury","drug-induced crystalline nephropathy","amoxicillin","sulfamethoxazole","ciprofloxacin","RECRUITING","2026-08-13",{"date":40,"type":41},"2026-08-19","ACTUAL",{"date":43,"type":41},"2025-12-08",{"date":45,"type":21},"2026-12-31",{"name":47,"class":48},"Universitair Ziekenhuis Brussel","OTHER"]