[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dual-use-of-cigarettes-and-e-cigarettes\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dual-use-of-cigarettes-and-e-cigarettes":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100651083","dose-up-dose-optimization-for-smoking-and-e-cigarette-use-pharmacotherapy-100651083",false,"NCT07754578","DOSE-UP: Dose Optimization for Smoking and E-Cigarette Use Pharmacotherapy","High-Dose Nicotine Replacement Therapy for Quitting Cigarettes and E-cigarettes","Inclusion Criteria:\n\n* age 18+;\n* report nicotine-containing e-cigarette use 5+ times per day, \\>5 days per week, for \\> 6 months;\n* smoking \\>1 cigarette per day, \\>5 days per week, for \\>6 months;\n* interest in quitting cigarettes and e-cigarettes within the next month (\\>6 on 10-point scale);\n* willing to try nicotine replacement therapy;\n* access to text\u002Finternet\u002Femail.\n\nExclusion Criteria:\n\n* report use of other tobacco or nicotine products (i.e., pouches, smokeless tobacco, hookah) \\>1 time per week in the past 3 months;\n* have medical contraindications for nicotine replacement therapy use (patch and lozenge; e.g., recent myocardial infarction, arrhythmias, angina, vascular disease, or medical conditions in which consumption of phenylalanine is contraindicated such as PKU);\n* report current use of smoking cessation medications (varenicline, bupropion, other nicotine replacement therapies);\n* endorse symptoms of Cannabis Use Disorder (using the CUDIT assessment);\n* unable to consent (e.g., cognitive deficit, non-English speaking);\n* live outside the US.","ALL","18 Years",{"count":19,"type":20},321,"ESTIMATED","INTERVENTIONAL",[23],"PHASE2","This randomized clinical trial evaluates the effectiveness of augmented-dose combination nicotine replacement therapy (NRT) versus standard-dose NRT and no-NRT control for cessation of dual combustible cigarette (CC) and electronic cigarette (EC) use. Adults who currently engage in dual use and are motivated to quit both products will be assigned to one of three 12-week interventions: (1) no pharmacotherapy (behavioral support only), (2) standard-dose NRT (21 mg nicotine patch + 4 mg lozenges, 5-20\u002Fday), or (3) augmented-dose NRT (21 mg + 14 mg patches + 4 mg lozenges, 5-30\u002Fday). All groups receive evidence-based behavioral support through the EX Program. Primary outcomes include biochemically confirmed dual abstinence and CC-only abstinence at 12 and 24 weeks. A subset of participants will provide blood and saliva samples to assess DNA damage biomarkers associated with tobacco use and cessation.",[26],"Dual Use of Cigarettes and E-cigarettes",[28,29,30,31,32],"tobacco","smoking","cigarette","e-cigarette","dual use","NOT_YET_RECRUITING","2026-08-07",{"date":36,"type":37},"2026-08-11","ACTUAL",{"date":39,"type":20},"2026-10-10",{"date":41,"type":20},"2031-07-10",{"name":43,"class":44},"Medical University of South Carolina","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":52,"minAge":17,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":21,"phases":55,"briefSummary":57,"conditions":58,"keywords":61,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":45},"100602529","cessation-of-dual-use-of-cigarettes-and-e-cigarettes-during-pregnancy-100602529","NCT07124702","Cessation of Dual Use of Cigarettes and E-cigarettes During Pregnancy","Inclusion Criteria:\n\n* Less than 21 weeks pregnant to ensure adequate time for intervention;\n* 18 years or older;\n* Actively using both cigarettes and electronic cigarettes (e-cigarettes);\n* Willing to receive cessation information;\n* Able to read, understand, and speak English;\n* Having a low household income defined as ≤185% of the federal poverty level.\n\nExclusion Criteria:\n\n* Teen pregnancy (\\\u003C18 y);\n* Unstable housing;\n* Uncontrolled mental health disorders;\n* Non-English speakers.","FEMALE",{"count":54,"type":20},45,[56],"NA","We propose a randomized controlled trial to develop and evaluate a cessation program with two different strategies for dual users during pregnancy. We plan to enroll 45 pregnant mothers (≤20 gestational weeks) with low household incomes from the Western NY region. To be eligible, they must be currently dual using CCs and nicotine-containing ECs. These mothers will be randomized into one of three groups: 1) simultaneous cessation intervention group (N=15), 2) stepwise cessation intervention group (N=15), and 3) control group (N=15). We hypothesize that nicotine abstinence rates at 8 weeks after randomization will be higher in the intervention groups than in the control group.",[26,59,60],"Gestational Weight Gain","Birth-weight-for-gestational-age z Score",[62,63,64,65,66],"Randomized Controlled Trial","Tobacco use","Electronic cigarette","Pregnancy","Intervention","RECRUITING","2025-11-11",{"date":70,"type":37},"2025-11-13",{"date":72,"type":37},"2025-10-01",{"date":74,"type":20},"2027-03-31",{"name":76,"class":44},"State University of New York at Buffalo"]