[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dyspnea-during-mechanical-ventilation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dyspnea-during-mechanical-ventilation":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100645481","mechanical-ventilator-adjustments-and-patient-dyspnea-100645481",false,"NCT07701850","Mechanical Ventilator Adjustments and Patient Dyspnea","The Influence of Standard Ventilator Setting Adjustments on Dyspnea Experienced in Awake Mechanically-ventilated Patients: A Pilot Study","Inclusion Criteria:\n\n* Admitted to a participating ICU at BIDMC\n* Requiring mechanical ventilation\n* Awake by both of the following criteria\n* RASS -2 to +2\\*\n* CAM-ICU negative‡\n* Able to communicate\u002Fanswer dyspnea questionnaire\n\n  * RASS (Richmond Agitation-Sedation Scale) is a validated scale commonly used in the ICU to assess patient's level of sedation and agitation. It ranges from -5 to +4. While -5 means an unarousable coma, +4 means violent patient with immediate self danger. The scale from -2 to +2 ranges from light sedation to agitated.\n\n    * CAM-ICU (Confusion Assessment Method) is an ICU validated scale used to assess the presence of delirium. A negative CAM-ICU scale has good positive and negative predictive value to diagnose or exclude delirium.\n\nPhysicians and nurses are trained to evaluate patients using both scales\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years old\n* Comfort measures only\n* Hemodynamic instability (MAP \\\u003C 65 mmHg) or increasing requirement of vasopressor\n* PEEP \\> 10 cmH2O\n* FiO2 \\> 0.6\n* Current Prone position\n* Current Pneumothorax\n* Bronchopleural fistula\n* Neuromuscular conditions that impair responding to the dyspnea scale or expression\n* Dementia\n* Prisoners\n* Pregnant women\n* Patients intubated and ventilated for less than 12 hours during the current ventilation episode\n* pH \\\u003C 7.20 or \\> 7.55\n* Presence of chest tube\n* Status post thoracotomy\n* Treating clinician refusal","ALL","18 Years",{"count":19,"type":20},20,"ESTIMATED","INTERVENTIONAL",[23],"NA","In the past 5 years, there are increasing data suggesting that patients treated with mechanical ventilation experience shortness of breath, despite appropriate sedation. This adverse experience is believed to contribute to the finding that up to 25% of patients who survive severe respiratory diseases experience mental health problems including post traumatic distress syndrome (PTSD). The purpose of this study is to evaluate if\u002Fhow sequential changes in the delivery of mechanical ventilation affect shortness of breath sensation in awake patients requiring mechanical ventilation. Improving the knowledge of the impact of the patient-ventilator interaction on shortness of breath sensation may lead to strategies to improve the comfort of non-sedated and sedated ventilated patients, and thereby reduce mental health sequelae in survivors of acute severe respiratory diseases The investigators hypothesize that current ventilator strategies, particularly reduced tidal volume (size of breath given by the ventilator) utilized in managing patients with severe respiratory diseases, contribute to shortness of breath in patients with increased drive to breathe. In this setting, some safe ventilator changes may improve or worsen the shortness of breath sensation in awake patients on mechanical ventilation.",[26,27,28],"Respiratory Failure","Dyspnea During Mechanical Ventilation","Mechanical Ventilation",[30,31,32],"respiratory failure","mechanical ventilation","dyspnea","NOT_YET_RECRUITING","2026-07-08",{"date":36,"type":37},"2026-07-14","ACTUAL",{"date":39,"type":20},"2026-09-01",{"date":41,"type":20},"2027-07-01",{"name":43,"class":44},"Beth Israel Deaconess Medical Center","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":45},"100608776","automatic-detection-of-dyspnea-in-mechanically-ventilated-critically-ill-patients-100608776","NCT07205952","Automatic Detection of Dyspnea in Mechanically Ventilated, Critically Ill Patients","Inclusion criteria:\n\n* Adults of either sex (≥18 years)\n* Endotracheally intubated in the past 24 hours.\n* Expected to require ≥24 hours of mechanical ventilation.\n\nExclusion criteria:\n\n* Continuous neuromuscular blockade.\n* Ventilated on Airway Pressure Release Ventilation mode.",{"count":53,"type":20},60,"OBSERVATIONAL","The investigators will conduct a prospective, observational, two-center ICU study of 60 subjects on mechanical ventilation with respiratory failure of any cause.",[27],"RECRUITING","2025-09-25",{"date":60,"type":37},"2025-10-03",{"date":62,"type":37},"2024-11-22",{"date":64,"type":20},"2025-10",{"name":66,"class":44},"Hospital de Clinicas José de San Martín"]