[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dyssynergia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dyssynergia":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100647274","balloon-inflation-in-biofeedback-100647274",false,"NCT07705542","Balloon Inflation in Biofeedback","Analysing the Impact of Balloon Inflated vs Balloon Deflated Push Manoeuvres in Chronically Constipated Patients During Biofeedback Therapy","Inclusion Criteria:\n\n* dyssynergia, constipation, obstructive defecation\n\nExclusion Criteria:\n\n* Patients with anorectal inflammation due to conditions such as solitary rectal ulcer syndrome\n* Patients with significantly altered anorectal anatomy due to abnormalities such as large rectocele, rectal prolapse or intussusception\n* History of major anorectal surgery\n* Unable to be investigated with HR-ARM due to contraindications such as recent anorectal surgery (\\\u003C6 weeks), active anorectal infections, severe anal pain or fissures(?), thrombosed haemorrhoids, or inability to tolerate anorectal catheters\n* Patients with pre-existing co-morbid inflammatory gastrointestinal conditions, including\n* Coeliac and Crohn's disease","ALL","18 Years",{"count":19,"type":20},10,"ESTIMATED","INTERVENTIONAL",[23],"NA","Chronic constipation, particularly due to dyssynergic defecation, is common and impacts quality of life. Biofeedback therapy (BFT) is the most effective conservative treatment, teaching patients to coordinate abdominal and anal muscles during defecation. In standard practice, the rectal balloon used in high-resolution anorectal manometry (HRAM) and biofeedback is left deflated, though some centres inflate it to simulate a more natural urge to defecate.\n\nHowever, the efficacy of this modification has not been validated. This study aims to determine whether performing BFT with the balloon inflated to a patient's defecatory desire volume enhances physiological coordination and patient understanding compared to the standard deflated approach.",[26,27,28,29],"Constipation","Chronic Constipation","Dyssynergia","Anismus",[31],"biofeedback","RECRUITING","2026-07-13",{"date":35,"type":36},"2026-07-15","ACTUAL",{"date":38,"type":36},"2026-05-13",{"date":40,"type":20},"2026-07",{"name":42,"class":43},"Hull University Teaching Hospitals NHS Trust","OTHER_GOV",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":21,"phases":56,"briefSummary":57,"conditions":58,"keywords":59,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":5},"100501289","fecobionics-in-biofeedback-therapy-in-dyssynergia-patients-100501289","NCT05807321","Fecobionics in Biofeedback Therapy in Dyssynergia Patients","Fecobionics to Monitor and Predict Biofeedback Therapy in Dyssynergia Patients","Inclusion Criteria:\n\n1. Subject must provide written informed consent.\n2. Age between 21-75 years.\n3. Subjects must fulfill the criteria for obstructed defecation\u002Fdyssynergia and enter the BFT at UCSD or Scripps.\n\nExclusion Criteria:\n\n1. Female who is pregnant or lactating.\n2. Prior abdominal or anorectal surgery or bowel resection.\n3. Diagnosis of fecal incontinence, any anorectal symptoms and drug use that affect anorectal function.\n4. Confirmed or suspected COVID-19 infection.\n5. Severe cardiovascular disease.\n6. Subjects not willing to consent and undergo the specified tests in this study.\n7. Other exclusions, that in the opinion of the investigator, the volunteer is not a suitable subject for the study.","21 Years","75 Years",{"count":55,"type":20},24,[23],"Constipation affects 12-19% of Americans. Pelvic floor dyssynergia is considered to play an important role in constipation but the underlying mechanisms are not well understood in individual patients. The investigators have developed a novel device named Fecobionics that provide detailed mapping of physiological parameters during defecation. The aim of the study is to use Fecobionics to assess anorectal function in dyssynergia patients and monitor and predict the outcome of the biofeedback therapy.",[28,26],[60,61,62],"Fecobionics","Biofeedback therapy","Defecation","2025-10-20",{"date":65,"type":36},"2025-10-21",{"date":67,"type":36},"2023-10-03",{"date":69,"type":20},"2027-03-31",{"name":71,"class":72},"The California Medical Innovations Institute, Inc.","OTHER"]