[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"eating-disorders\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:eating-disorders":28},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,67,0,25,[9,60,95,132,161,191,211,245,279,313,344,376,397,420,440,462,491,517,544,568,599,630,652,676,699],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":48,"lastUpdatePostDateStruct":49,"startDateStruct":52,"completionDateStruct":54,"leadSponsor":56,"locationsCount":59},"100594275","non-invasive-cranial-electrical-stimulation-for-mealtime-anxiety-in-adults-with-eating-disorders-100594275",false,"NCT07017322","Non-invasive Cranial Electrical Stimulation for Mealtime Anxiety in Adults With Eating Disorders","Investigating Non-invasive Cranial Electrotherapy Stimulation for Acute Anxiety in Inpatients With Eating Disorders","Inclusion Criteria:\n\n1. Age 18-30 years old at the time of enrollment\n2. Enrolled in Rogers Behavioral Health Eating Disorder Recovery Program Inpatient Unit at the Oconomowoc, WI clinic location\n3. Have a primary diagnosis of any DSM-5 eating disorder (anorexia nervosa, bulimia nervosa, binge eating disorder, avoidant\u002Frestrictive food intake disorder, other specified feeding or eating disorder)\n4. Ability to communicate effectively using written and spoken English\n5. Participant is eligible for mealtime anxiety support based on:\n\n   * ≤ 75% meal plan compliance\n   * Visible anxiety\u002Fdistress during program meals\n   * Engagement in compensatory behaviors or self-harm before, during, or after meals, or medical staff judge patient to be at risk of same\n\nExclusion Criteria:\n\n1. Metal in the body of any kind (e.g., braces, pacemakers, metal plates or screws, intracranial electrodes, implanted devices\u002Fdefibrillators, prostheses)\n2. Currently taking medication that reduces seizure threshold (e.g., clomipramine)\n3. Cranial pathologies (e.g., holes, plates)\n4. History of seizure or black-out concussion\n5. Pregnancy\n6. Risk of suicide\u002Fself-harm by self-strangulation with cranial electrotherapy stimulation (CES) device judged by study medical staff\n7. Participant calibrates to a stimulation level below 200 microampere (μA)","ALL","18 Years","30 Years",{"count":21,"type":22},30,"ESTIMATED","INTERVENTIONAL",[25],"NA","The study is to evaluate the feasibility of using a non-invasive brain stimulation device in a sample of inpatients with eating disorders (ED). The study will help researchers evaluate whether their device protocol is practical for eating disorder inpatients as a way to manage eating disorder and anxiety symptoms. A secondary aim of the study is to evaluate preliminary effectiveness of the protocol for reducing pre-meal anxiety during the treatment, and explore effects on eating disorder symptoms over the course of the inpatient admission.",[28,29],"Eating Disorders","Anxiety",[31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46],"electrotherapy stimulation","Alpha-Stim AID","cranial electrotherapy stimulation","CES","meal anxiety","Non-invasive cranial electrotherapy stimulation","Inpatient weight restoration","avoidant restrictive food intake disorder","other specified feeding or eating disorder","anorexia nervosa","bulimia nervosa","purging disorder","binge eating disorder","ARFID","OSFED","procedural anxiety","RECRUITING","2026-08-10",{"date":50,"type":51},"2026-08-12","ACTUAL",{"date":53,"type":51},"2025-06-03",{"date":55,"type":22},"2027-11-01",{"name":57,"class":58},"Rogers Behavioral Health","OTHER",1,{"id":61,"slug":62,"hasResults":12,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":68,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":4,"studyType":23,"phases":74,"briefSummary":75,"conditions":76,"keywords":78,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":59},"100650677","development-implementation-and-evaluation-of-the-hadas-program-for-the-prevention-of-eating-disorders-in-adolescent-female-athletes-coaches-and-families-100650677","NCT07750301","Development, Implementation, and Evaluation of the HADAS Program for the Prevention of Eating Disorders in Adolescent Female Athletes, Coaches, and Families.","A Program for the Prevention of ED in Adolescent Female Athletes, the HADAS: Protocol for a Randomized Controlled Trial Study","The HADAS","Inclusion Criteria:\n\n* Athletes: Female gender; aged between 12 and 16 years old; actively possessing a formal federation license in an aesthetic sport discipline (e.g., rhythmic gymnastics, artistic gymnastics, synchronized swimming, figure skating) within Spain; providing signed informed assent concurrently with written informed consent from parents\u002Flegal representatives; and presenting no active, formal clinical diagnosis of an eating disorder (ED).\n* Coaches: Serving as a primary trainer or technical staff member within the participating sports club; and providing written informed consent.\n* Family Members: Operating as the primary parent, guardian, or legal representative of an included athlete; and providing written informed consent.\n\nExclusion Criteria:\n\n* Athletes: Presenting a current, formal clinical diagnosis of an eating disorder (e.g., Anorexia Nervosa, Bulimia Nervosa, Binge Eating Disorder, or ARFID) at baseline (T0); or refusal to provide informed assent or parental consent.\n* Non-compliance or failure to provide signed informed consent from coaches or primary legal guardians.",true,"FEMALE","12 Years","16 Years",{"count":73,"type":22},236,[25],"Adolescent female athletes in aesthetic sports disciplines (such as rhythmic gymnastics, artistic gymnastics, synchronized swimming, and figure skating) face a complex interaction between general sociocultural beauty pressures and sport-specific aesthetic demands (e.g., the 'slim to win' culture and weight-focused performance expectations). These combined pressures significantly increase their risk of developing body dissatisfaction and eating disorders (EDs). To address these systemic vulnerabilities, the HADAS Program (Habits, Eating, Sports, Adolescents, and Health) was developed as a multi-level, synchronized psychoeducational intervention designed to target the complete \"sports triangle\": adolescent female athletes, their technical coaches, and their immediate family members. The primary objective of this cluster randomized controlled trial (cluster RCT) is to evaluate the efficacy of the HADAS Program in reducing eating disorder risk (EAT-26) and body image dissatisfaction (BSQ-34) among competitive adolescent female athletes aged 12 to 16 years. Sports clubs are randomly assigned to either the Experimental Group (receiving the HADAS intervention) or a Waitlist Control Group (maintaining standard training). The program includes 5 interactive group sessions for athletes, 4 reflective workshops for coaches, and 2 structured sessions for family members, all supported by cohort-specific workbooks. Outcomes are evaluated across four longitudinal time points: Baseline (T0), Immediate Post-intervention (T1), 6-month Follow-up (T2), and 12-month Follow-up (T3).",[28,77],"Body Image Dissatisfaction",[28,79,80,81,82,83,84],"Primary Prevention","Adolescent Health","Aesthetic Sports","Sports Psychology","Family Relations","Health Education","NOT_YET_RECRUITING","2026-08-01",{"date":88,"type":51},"2026-08-06",{"date":90,"type":22},"2026-10",{"date":92,"type":22},"2029-05",{"name":94,"class":58},"Universidad Miguel Hernandez de Elche",{"id":96,"slug":97,"hasResults":12,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":101,"eligibilityCriteria":102,"healthyVolunteers":68,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":103,"targetDuration":4,"studyType":23,"phases":105,"briefSummary":106,"conditions":107,"keywords":112,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":59},"100649722","tirzepatide-impact-assessment-study-100649722","NCT07740291","Tirzepatide Impact Assessment Study","Tirzepatide Impact Assessment: Exploring Health and Wellness Outcomes","TIA","Inclusion Criteria:\n\n* Age 18 years or older\n* BMI of 27.5 kg\u002Fm2 or higher\n* For GLP-1 RA arm: initiating semaglutide or tirzepatide for weight loss as prescribed by their own medical provider\n* For LS comparator arm: not currently taking a GLP-1 receptor agonist or other weight-loss medication, and no use of weight-loss medication within the past 3 months\n\nExclusion Criteria:\n\n* Pregnant\n* Breastfeeding\n* Wears a pacemaker or other internal medical device\n* Chronic kidney disease in the past 2 years\n* Active cancer or cancer treatment within the past 6 months\n* Current diagnosis of any major endocrine, inflammatory, cardiovascular, or neurological disorder\u002Fcondition, including Addison's disease, autism, congestive heart failure, Crohn's disease, Cushing's syndrome, hyperparathyroidism, multiple sclerosis, neuromuscular disorders (Guillain-Barre syndrome or myasthenia gravis), stroke, thyroid gland disorders (hyperthyroidism or hypothyroidism), type 1 diabetes, and ulcerative colitis\n* Insulin therapy for type 2 diabetes\n* For LS comparator arm only: initiating any weight-loss medication (including a GLP-1 receptor agonist) currently or within the past 3 months",{"count":104,"type":22},27,[25],"This study examines how two different weight-loss strategies affect heart and metabolic health, as well as changes at the molecular level in the body. One group includes adults who are starting a GLP-1 receptor agonist medication (i.e., semaglutide or tirzepatide) prescribed by their own doctor for weight loss. The other group includes adults who will participate in a structured lifestyle program combining a reduced-calorie diet with increased physical activity. Both groups complete assessments at the start of the study and again after three months.\n\nAt each visit, participants have their weight, body composition, blood pressure, and resting metabolic rate measured. A blood draw is collected to evaluate cholesterol, blood sugar, insulin, appetite hormones, and liver and kidney function markers, and to analyze gene activity (RNA sequencing) and metabolites, which are small molecules that reflect how the body is using energy and nutrients. Participants also complete online questionnaires about diet, disordered eating, stress, mental health, and quality of life. Those in the lifestyle group attend three individual nutrition and physical activity counseling sessions over the course of the study.\n\nThe main goals of the study are (1) to determine whether GLP-1 receptor agonist medication or lifestyle changes produce greater improvements in heart and metabolic health markers over three months; (2) to examine if GLP-1 receptor agonist medication or lifestyle changes produce greater improvement in disordered eating, stress, mental health, and quality of life; (3) to investigate if GLP-1 receptor agonist medication or lifestyle changes produce greater improvement in appetite-related hormones (i.e., ghrelin, GLP-1, insulin, leptin, and peptide YY); and (4) to explore whether the two approaches cause different changes in gene expression and metabolic profiles. This is a pilot study conducted at Texas Tech University's Nutrition and Metabolic Health Initiative clinic in Lubbock, Texas.\n\nWho can participate: Adults aged 18 years and older with a BMI of 27.5 or higher who are either starting semaglutide or tirzepatide therapy for weight management or who are seeking weight management without the use of weight-loss medications.\n\nWho cannot participate: Individuals who are pregnant or lactating, have a pacemaker or internal medical device, have certain serious medical conditions (such as active cancer, uncontrolled hypertension, or severe kidney disease), have type 1 diabetes, or use insulin for type 2 diabetes.",[108,109,110,28,111],"Obesity & Overweight","Cardiometabolic Health Indicators","Addiction","Mental Health",[113,114,115,116,117,118,119,120,121,122],"GLP-1 receptor agonists","obesity","Multi-omics profiling","Semaglutide","Tirzepatide","Appetite Regulation","Addictive Behaviors","eating disorders","appetite-related hormones","mental health","2026-07-28",{"date":125,"type":51},"2026-07-31",{"date":127,"type":51},"2025-01-02",{"date":129,"type":22},"2026-12-07",{"name":131,"class":58},"Texas Tech University",{"id":133,"slug":134,"hasResults":12,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":4,"eligibilityCriteria":138,"healthyVolunteers":12,"sex":17,"minAge":139,"maxAge":140,"enrollmentInfo":141,"targetDuration":4,"studyType":23,"phases":143,"briefSummary":144,"conditions":145,"keywords":147,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":59},"100649338","flexed-full-threshold-ed-substudy-100649338","NCT07732829","FlexED: Full Threshold ED Substudy","FlexED: A Digital Gamified Early Intervention for Eating Disorders","Inclusion Criteria:\n\n* Female age 15-25 years\n* Weight Concerns Scale score of \\>=47\n* Meets diagnostic criteria for an eating disorder based on the DSM-5\n\nExclusion Criteria:\n\n* Psychosis, substance use disorder, or current suicidal ideation or self-harm\n* Start or change in psychiatric medications within the past month\n* Non-English speaking","15 Years","25 Years",{"count":142,"type":22},6,[25],"The purpose of this study is to test whether a new digital intervention decreases eating disorder symptoms in young women with eating disorders by changing how they experience thoughts and feelings about their body. The digital intervention is based on Acceptance and Commitment Therapy (ACT). Participants complete up to 7 digital intervention sessions using their mobile phone that include a character, story line and interactive exercises, games and digital rewards.\n\nResearchers will examine the impact of the intervention on participants' ability to respond flexibly to body-image distress or triggers, measuring things like heart rate, eye movements, and reaction time to body-image related words and images, and examine changes in eating disorder symptoms before and after intervention.",[28,146],"Body Image",[148,28,149,150,151],"Body Image Flexibility","Acceptance and Commitment Therapy","Psychological Flexibility","Early Intervention","2026-07-24",{"date":154,"type":51},"2026-07-29",{"date":156,"type":22},"2026-07",{"date":158,"type":22},"2028-07",{"name":160,"class":58},"Duke University",{"id":162,"slug":163,"hasResults":12,"nctId":164,"briefTitle":165,"officialTitle":166,"acronym":4,"eligibilityCriteria":167,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":168,"targetDuration":4,"studyType":23,"phases":170,"briefSummary":172,"conditions":173,"keywords":174,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":183,"startDateStruct":185,"completionDateStruct":187,"leadSponsor":189,"locationsCount":59},"100609724","phase-2-eating-disorder-chatbot-optimization-100609724","NCT07218302","Eating Disorder Chatbot Optimization","Optimizing an Automated Chatbot to Achieve Efficient, Scalable Treatment for Eating Disorders","Inclusion Criteria:\n\n* 18+ years old\n* Owns a smartphone\n* Speaks English\n* US resident\n* Screens for a clinical or subclinical eating disorder\n* Low suicidality\n* Not currently in treatment for an eating disorder\n* Does not have a medical condition or take medications that impact appetite\u002Fweight\n* Not currently pregnant\n\nExclusion Criteria:\n\n* Below 18 years of age\n* Does not own a smartphone\n* Does not speak English\n* Lives outside the US\n* Screens as: at risk for an eating disorder, anorexia nervosa, atypical anorexia nervosa, avoidant\u002Frestrictive food intake disorder, or not at risk for an ED\n* High suicidality\n* In treatment for an eating disorder\n* Has a medical condition or takes medication(s) that impact appetite\u002Fweight\n* Currently pregnant",{"count":169,"type":22},800,[171],"PHASE2","The purpose of this study is to optimize an automated digital chatbot intervention for adults with clinical or subclinical eating disorders.",[28],[175,176,177,178,179,180,181],"Eating Disorder Intervention","Eating Pathology","Eating Disorder Symptoms","Digital Mental Health","Chatbot","Optimization Randomized Control Trial","Multiphase Optimization Strategy","2026-07-20",{"date":184,"type":51},"2026-07-21",{"date":186,"type":51},"2026-07-17",{"date":188,"type":22},"2029-07-31",{"name":190,"class":58},"Washington University School of Medicine",{"id":192,"slug":193,"hasResults":12,"nctId":194,"briefTitle":195,"officialTitle":195,"acronym":4,"eligibilityCriteria":196,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":197,"enrollmentInfo":198,"targetDuration":4,"studyType":23,"phases":200,"briefSummary":201,"conditions":202,"keywords":4,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":204,"startDateStruct":205,"completionDateStruct":207,"leadSponsor":209,"locationsCount":59},"100564634","targeting-transdiagnostic-self-regulatory-factors-and-eating-disorder-pathology-among-adults-with-binge-spectrum-eating-disorders-a-mhealth-interoceptive-exposure-intervention-the-bio-health-study-100564634","NCT06631729","Targeting Transdiagnostic Self-regulatory Factors and Eating Disorder Pathology Among Adults With BInge-spectrum Eating disOrders: A mHEALTH Interoceptive Exposure Intervention (the Bio-HEALTH Study)","Inclusion Criteria:\n\n* ages 18-64;\n* no changes to ED treatment in the past 4-weeks;\n* agree not to access other eating disorder treatments throughout the studies (unless warranted by a worsening of participants' symptoms during the study period; see Monitoring Participant Safety for more information);\n* no bariatric surgery (prior or planned during the study period);\n* no pregnancy or lactation (current or planned during the study);\n* own an Apple or Android-brand iOS smartphone (which is required for compatibility with the apps used in this study;\n* reside in the continental U.S.;\n* meet Diagnostic and Statistical Manual of Mental Disorders-5-TR (DSM-5-TR) criteria for binge eating disorder (BED) or bulimia nervosa (BN), both of which include objective binge eating (i.e., consuming a larger amount of food than most people would eat in a similar period of time under similar circumstances with loss of control over eating during the episode) ≥1x\u002Fweek over the past 3 months (APA, 2022). Single-item questions will determine eligibility via criteria 1-7. Criterion 8 for will be determined via the Eating Disorder Diagnostic Scale for the DSM-5 (EDDS-5; Stice et al., 2000, 2004), which has exhibited good sensitivity (.88), specificity (.98), and positive predictive power (.74) for detecting EDs among community samples (Stice et al., 2000, 2004).\n\nExclusion Criteria:\n\n* not between the ages of 18 and 64;\n* had changes to ED treatment in the past 4 weeks;\n* plan to access other eating disorder treatments throughout the study;\n* received or are planning to undergo bariatric surgery during the study period;\n* currently pregnant or lactating, or planning to become pregnant or lactate during the study period;\n* no Apple or Android-brand iOS smartphone;\n* do not live in the continental U.S.;\n* do not currently experience BN or BED.","64 Years",{"count":199,"type":22},144,[25],"The present study will be fully remote (virtual) and include observational design features (assessments) plus a clinical trial. All assessments will be completed using HIPAA-approved platforms (e.g., Qualtrics, MindLogger EMA platform). After screening via Qualtrics to determine eligibility (described below), participants will complete a cross-sectional survey via Qualtrics, followed by a baseline EMA period. During the baseline EMA period, participants will receive brief (3-5 minutes) surveys on their mobile devices 6 times per day for 7-days via the MindLogger app. During the baseline EMA period, participants will also be asked to wear non-invasive chest-worn Holter monitors (Polar H10 Holter monitors) that will capture their heartrate variability data.\n\nThey will then complete the 4-week intervention (HRV bio or ED-JITAI treatment arms; see below), followed by a post-intervention 7-day EMA assessment period while they also wear the Holter monitors. Recruitment is expected to last for 1.5 years. In HRV-bio, participants will also complete a HRV biofeedback task via the Elite HRV app. In this intervention, participants will learn how to use their HRV data that they will see in real-time via the Elite HRV app to improve their HRV by engaging in an app-guided diaphragmatic breathing exercise. They will complete this exercise twice daily (morning, night). In ED-JITAI, participants will be prompted to complete focused, guided body scan tasks that will be sent to them via the MindLogger app. These guided tasks will be sent to them in the form of 1 of 3 brief (3-5 minute) videos via the MindLogger app. The body scans will be designed to promote participants' connection with, vs.\n\ndistancing\u002Fdistraction from, feared ED sensations (e.g., hunger, satiety, bloating).\n\nParticipants will receive prompts to complete the body scans at times when they report via EMA that they are experiencing worse interoception than usual. \"Worse interoception than usual\" will be defined as participants' EMA-reported interoception scores during the intervention period that fall 1 SD or more above their baseline EMA-reported interoception levels.",[28],"2026-07-16",{"date":186,"type":51},{"date":206,"type":51},"2025-01-15",{"date":208,"type":22},"2026-12-31",{"name":210,"class":58},"University of Minnesota",{"id":212,"slug":213,"hasResults":12,"nctId":214,"briefTitle":215,"officialTitle":216,"acronym":217,"eligibilityCriteria":218,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":219,"enrollmentInfo":220,"targetDuration":4,"studyType":23,"phases":222,"briefSummary":223,"conditions":224,"keywords":229,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":237,"lastUpdatePostDateStruct":238,"startDateStruct":239,"completionDateStruct":241,"leadSponsor":243,"locationsCount":59},"100639845","eating-disorder-dynamic-intervention-100639845","NCT07600671","Eating Disorder Dynamic Intervention","Rapid Innovation of Precision Psychiatry Interventions Using Dynamic Systems Modeling and Ecological Quasi-Experiments","EDDI","Inclusion Criteria:\n\n1. Age 18-70\n2. At least 12 ED behaviors from the same behavioral category in the past 12 weeks (i.e., at least 12 binge eating episodes, at least 12 compensatory behaviors, and\u002For at least 12 instances of dietary restriction)\n3. Ownership of a smartphone\n4. Willingness to complete ecological momentary assessment (EMA) and sensor data collection\n5. Live in the United States\n6. Has a primary care provider or is willing to establish a primary care provider\n\nExclusion Criteria:\n\n1. Inability to fluently speak, read, and write in English\n2. Body mass index \\\u003C 17.5 kg\u002Fm2\n3. Medical complications of ED symptoms requiring immediate treatment\n4. Current ED-focused therapy\n5. Severe psychopathology (i.e., active suicidal ideation, psychosis, bipolar disorder, or substance use disorder) or intellectual disability inhibiting engagement in study protocols","70 Years",{"count":221,"type":22},170,[25],"The goal of this study is to develop and test a digital program to help people with eating disorders in their everyday lives. The program uses brief surveys and sensor data collected by smartphones to understand when someone may be at higher risk for behaviors like restricting food, binge eating, or using unhealthy weight control behaviors.",[28,225,226,227,228],"Anorexia Nervosa","Bulimia Nervosa","Binge Eating Disorder","Other Specified Feeding or Eating Disorder",[230,231,232,233,234,235,236],"binge eating","eating problem","eating disorder","purging","restriction","weight control behavior","dieting","2026-07-15",{"date":203,"type":51},{"date":240,"type":51},"2026-07-08",{"date":242,"type":22},"2030-07-31",{"name":244,"class":58},"Trustees of Dartmouth College",{"id":246,"slug":247,"hasResults":12,"nctId":248,"briefTitle":249,"officialTitle":249,"acronym":250,"eligibilityCriteria":251,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":252,"enrollmentInfo":253,"targetDuration":4,"studyType":23,"phases":255,"briefSummary":256,"conditions":257,"keywords":265,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":270,"lastUpdatePostDateStruct":271,"startDateStruct":273,"completionDateStruct":275,"leadSponsor":277,"locationsCount":59},"100645833","halo-trial-high-medium-and-low-intensity-psychotherapy-for-binge-eating-disorder-100645833","NCT07698132","HALO-TRIAL: High, Medium And LOw Intensity Psychotherapy for Binge Eating Disorder","HALO","Inclusion Criteria:\n\n* Binge Eating Disorder according to DSM-5 criteria\n* 18-65 years of age\n* Fluent Danish speaker\n\nExclusion Criteria:\n\n* Concurrent psychotherapeutic treatment\n* Use of weight loss medications within the last month (i.e., GLP-1 receptor antagonists)\n* Suicidal ideation or suicidality\n* Psychosis or psychotic disorders\n* Mania or bipolar disorder\n* Drug misuse disorder\n* Alcohol misuse disorder\n* Cluster B personality disorders in the severe range (diagnosed)\n* Dosage of Antidepressants, Antipsychotics and Stimulants must be stable for at least 6 months","65 Years",{"count":254,"type":22},256,[25],"The HALO trial is designed as a four-armed, assessor-blinded, fidelity-monitored randomized clinical trial. The goal of this randomized controlled study is to investigate the effectiveness of four different psychotherapy programs and to determine which one is most effective in reducing the number of binge-eating episodes in people with the eating disorder Binge Eating Disorder (BED), by directly comparing three intensities of Cognitive Behavioral Therapy-Enhanced against a manualized treatment as usual.\n\nParticipants will be asked to complete a 21-weeks randomized intervention and participate in follow up assesments.",[227,258,259,260,261,262,263,264,28],"Binge Eating Episodes","Binge Eating\u002FLoss of Control Eating","Binge Eating Disorders","Binge Eating","Binge Eating Behaviour","Binge Eating Disorder Associated With Obesity","Eating Disorder Binge",[227,28,266,267,268,269],"Cognitive Behavioral Therapy","Psychotherapy","Randomized Controlled Trial","Evidence-based Psychiatry","2026-07-07",{"date":272,"type":51},"2026-07-13",{"date":274,"type":51},"2024-06-10",{"date":276,"type":22},"2032-12",{"name":278,"class":58},"Herlev and Gentofte Hospital",{"id":280,"slug":281,"hasResults":12,"nctId":282,"briefTitle":283,"officialTitle":284,"acronym":4,"eligibilityCriteria":285,"healthyVolunteers":68,"sex":69,"minAge":286,"maxAge":287,"enrollmentInfo":288,"targetDuration":4,"studyType":23,"phases":290,"briefSummary":291,"conditions":292,"keywords":296,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":305,"lastUpdatePostDateStruct":306,"startDateStruct":307,"completionDateStruct":309,"leadSponsor":311,"locationsCount":59},"100645213","overvaluation-of-weight-and-shape-intervention-vs-the-body-project-100645213","NCT07678554","Overvaluation of Weight and Shape Intervention vs The Body Project","Pilot Testing Overvaluation of Weight and Shape Intervention vs The Body Project","Inclusion Criteria:\n\n* Female-identifying\n* High School\n* College Adolescents\n* Ages 14-22\n\nExclusion Criteria:\n\n* Non-female identifying\n* Outside of the United States","14 Years","22 Years",{"count":289,"type":22},90,[25],"Priorities aims to reduce body image concerns, prevent eating disorders, bolster self-esteem, and promote mental and emotional health by helping participants identify and nurture alternative sources of self-worth. Priorities would use group discussions, role-plays \\& behavioral challenges, homework assignments \\& letter-writing, and self-worth activism to achieve this. The Priorities intervention will be compared to The Body Project (an existing and successful harm reduction and eating disorder prevention program) for its effectiveness of reducing body image concerns and eating disorder outcomes. This study aims to evaluate whether there is a more effective eating disorder prevention program than The Body Project.",[146,293,28,294,295],"Mental Health Outcomes","Body Dysmorphic Disorders","Self-esteem",[297,298,299,300,301,302,303,304],"Eating disorder","Female","Body project","Priorities","self-esteem","adolescent mental health","Body dysmorphia","Disordered eating","2026-07-03",{"date":270,"type":51},{"date":308,"type":22},"2026-07-01",{"date":310,"type":22},"2027-06-01",{"name":312,"class":58},"Stanford University",{"id":314,"slug":315,"hasResults":12,"nctId":316,"briefTitle":317,"officialTitle":318,"acronym":4,"eligibilityCriteria":319,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":320,"targetDuration":4,"studyType":23,"phases":322,"briefSummary":323,"conditions":324,"keywords":327,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":308,"lastUpdatePostDateStruct":337,"startDateStruct":339,"completionDateStruct":341,"leadSponsor":342,"locationsCount":59},"100646879","dramatherapy-for-psychological-and-social-well-being-in-obesity-and-bariatric-care-100646879","NCT07685483","Dramatherapy for Psychological and Social Well-Being in Obesity and Bariatric Care","Effect of Dramatherapy Combined With Adapted Physical Activity on Psychological and Social Well-Being in Patients With Obesity and Eating Disorders in Medical and Bariatric Care: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 18 years or older.\n* Body mass index (BMI) ≥ 40 kg\u002Fm², or BMI ≥ 35 kg\u002Fm² with obesity-related comorbidities, or BMI ≥ 30 kg\u002Fm² with associated eating disorders or problematic eating behaviors.\n* Enrollment in a medical or bariatric care pathway at the Institut de l'Obésité, Clinique ELSAN Saint-Omer, including a therapeutic education program with adapted physical activity.\n* Availability and willingness to complete the planned study procedures and follow-up assessments.\n* Written informed consent provided after complete information about the study.\n* Affiliation to a social security system.\n\nExclusion Criteria:\n\n* Major medical contraindications to adapted physical activity or group sessions, including unstable cardiovascular disease or severe non-compensable locomotor limitations.\n* Severe psychiatric disorders or severe unstable eating disorders contraindicating bariatric surgery or preventing adequate participation in group sessions.\n* Major cognitive impairment or neuropsychological disorders preventing understanding of instructions or completion of assessments.\n* Unstable medical treatment or recent therapeutic modification likely to significantly affect body weight, fatigability, or mental health.\n* Inability to complete the full study protocol, including prolonged unavailability or planned relocation outside the region.\n* Refusal or inability to provide informed consent.\n* Major logistical barriers preventing access to the intervention site without feasible alternative arrangements.\n* Participation in a structured adapted physical activity program within the 3 months preceding inclusion.",{"count":321,"type":22},250,[25],"Obesity is currently a major public health challenge in France, particularly in the Hauts-de-France region, where prevalence exceeds 20% of the adult population. Bariatric surgery has considerably increased over the last two decades and is now recognized as an effective therapeutic option within a multidisciplinary care pathway. However, many patients continue to experience difficulties related to body image, emotional regulation, problematic eating behaviors, and long-term adherence to adapted physical activity (APA), which may limit the sustainability of treatment benefits. International literature highlights the importance of integrating psychological and psychosocial support alongside medical, nutritional, and physical interventions.\n\nThis monocentric randomized controlled trial aims to evaluate the effects of adding dramatherapy (DT) to a standardized APA program in adult patients with obesity enrolled in medical or bariatric care pathways at the Institut de l'Obésité of Clinique ELSAN Saint-Omer (France). Participants will be randomized to receive either standard APA alone or APA combined with DT. The intervention is designed to improve emotional expression, body perception, self-confidence, psychosocial well-being, and long-term adherence to care. Dramatherapy sessions will include theatrical expression, role play, improvisation, relaxation, and body-oriented creative exercises adapted to patients with obesity.\n\nThe primary objective is to evaluate the effect of DT on quality of life at the end of care, compared with APA alone, using the French version of the EQVOD questionnaire. Secondary objectives include the evaluation of eating behaviors and problematic eating regulation (TFEQ-R18, SCOFF), body image and body-related quality of life (BIQLI), self-efficacy (GSES), anxiety and depressive symptoms (BDI-II), adherence to APA programs, and anthropometric parameters such as body mass index, abdominal circumference, and body composition. Assessments will be conducted at baseline, at the end of the intervention, and at 6- and 12-month follow-up.\n\nThe study also includes a complementary qualitative component based on semi-structured interviews, ethnographic observation, body mapping, and identity boxes in order to explore patients' subjective experiences, psychosocial trajectories, and perceived impact of the intervention. Quantitative and qualitative data will be analyzed using a mixed-methods approach. A total of 250 participants are expected to be included. This study seeks to provide evidence regarding the potential added value of integrating dramatherapy into obesity and bariatric care pathways.",[325,108,28,326],"Obesity (Disorder)","Bariatric Surgery",[328,28,326,329,330,331,332,333,334,335,336],"Obesity","Dramatherapy","Art Therapy","Adapted Physical Activity","Body image","Quality of life","Psychosocial Well-Being","Psychosocial intervention","Body Mapping",{"date":338,"type":51},"2026-07-06",{"date":340,"type":51},"2026-06-30",{"date":92,"type":22},{"name":343,"class":58},"Universite du Littoral Cote d'Opale",{"id":345,"slug":346,"hasResults":12,"nctId":347,"briefTitle":348,"officialTitle":348,"acronym":349,"eligibilityCriteria":350,"healthyVolunteers":68,"sex":17,"minAge":351,"maxAge":352,"enrollmentInfo":353,"targetDuration":4,"studyType":23,"phases":355,"briefSummary":356,"conditions":357,"keywords":359,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":367,"lastUpdatePostDateStruct":368,"startDateStruct":370,"completionDateStruct":372,"leadSponsor":374,"locationsCount":59},"100636395","preved-mr-improving-emotion-dysregulation-through-mixed-reality-based-dialectical-behavioral-therapy-in-adolescents-and-young-adults-at-risk-of-developing-eating-disorders-100636395","NCT07565129","PrevED MR. Improving Emotion Dysregulation Through Mixed Reality Based Dialectical Behavioral Therapy in Adolescents and Young Adults at Risk of Developing Eating Disorders.","PrevED MR","Inclusion Criteria:\n\n* Adolescents and young adults aged 13 to 35 years.\n* Spanish-speaking participants who are able to understand the study procedures and complete the assessment instruments.\n* Students recruited from participating schools, universities, or related recruitment settings.\n* Participants at mid-to-high risk of developing eating disorders, as assessed by the Eating Attitudes Test-26 (EAT-26) and selected subscales of the Eating Disorder Inventory-3 (EDI-3).\n* Participants who provide informed consent. For minors, informed consent from a parent or legal guardian will also be required, together with the minor's assent when applicable.\n\nExclusion Criteria:\n\n* Current or past self-reported diagnosis of an eating disorder.\n* Current severe psychiatric symptoms or diagnosis that could interfere with participation, including suicidal, manic, or psychotic symptoms.\n* Severe neurodevelopmental disorder, intellectual disability, or other cognitive impairment that could interfere with understanding or completing the study procedures.\n* Physical, motor, or sensory impairment that could interfere with the assessment procedures or the use of the mixed\u002Fvirtual reality intervention.\n* Current psychological or pharmacological treatment for a mental health disorder delivered on a weekly or biweekly basis.\n* Inability to understand Spanish.\n* Failure to provide informed consent. For minors, lack of parent or legal guardian consent will also be an exclusion criterion.","13 Years","35 Years",{"count":354,"type":22},72,[25],"The aim of this study is to evaluate the feasibility and preliminary effects of PrevED MR, a group-based preventive intervention for adolescents and young adults at risk of developing eating disorders. PrevED MR is based on dialectical behavior therapy skills and uses mixed reality and virtual reality activities to support emotion regulation, mindfulness, distress tolerance, and body-related acceptance.\n\nParticipants will be randomly assigned to either the PrevED MR intervention group or a waiting-list control group. The intervention will be delivered over 6 weeks, with two sessions per week, for a total of 12 sessions. Assessments will be conducted at baseline and after the intervention to examine changes in eating disorder symptoms, body image acceptance, emotion regulation strategies, rumination, usability, sense of presence, cybersickness, satisfaction, and adherence.",[28,358],"Emotion Dysregulation",[360,361,362,363,364,365,366,332],"Eating disorders","Eating disorder prevention","Emotion regulation","Dialectical behavior therapy","Mixed reality","Adolescents","Young adults","2026-06-22",{"date":369,"type":51},"2026-06-25",{"date":371,"type":51},"2026-04-28",{"date":373,"type":22},"2027-09",{"name":375,"class":58},"Universitat Internacional de Catalunya",{"id":377,"slug":378,"hasResults":12,"nctId":379,"briefTitle":380,"officialTitle":381,"acronym":4,"eligibilityCriteria":382,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":197,"enrollmentInfo":383,"targetDuration":4,"studyType":385,"phases":4,"briefSummary":386,"conditions":387,"keywords":4,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":388,"lastUpdatePostDateStruct":389,"startDateStruct":391,"completionDateStruct":393,"leadSponsor":395,"locationsCount":4},"100619907","inpatient-care-of-patients-with-difficult-to-treat-anorexia-nervosa---factors-affecting-treatment-outcome-100619907","NCT07350720","Inpatient Care of Patients With Difficult to Treat Anorexia Nervosa - Factors Affecting Treatment Outcome.","Inpatient Care of Patients With Difficult to Treat Eating Disorders - What Affects Treatment Outcome?","Inclusion Criteria:\n\n* Anorexia Nervosa diagnosis (ICD F50.0)\n* Admitted to inpatient care at department 5 at Region Skåne Eating Disorders Center\n\nExclusion Criteria:\n\n* Confidential identity\n* Inability to read or write in Swedish or English\n* Condition or treatment that, according to the study team, makes participation in the study inappropriate",{"count":384,"type":22},100,"OBSERVATIONAL","The overall aim of the project is to investigate factors that may influence treatment outcomes in people with difficult-to-treat anorexia nervosa who are enrolled in inpatient care at the Region Skåne Eating Disorders Centre in Lund. Treatment expectations, sense of autonomy, and patient participation, will be investigated, as well as caregivers' attitudes towards, and experiences of working with, autonomy and patient participation in the inpatient setting. The research project is expected to contribute to increased knowledge about the treatment of difficult-to-treat anorexia nervosa, and what part patient participation and autonomy may play when treating severe eating disorders. The overall objectives of the research program are:\n\n1. To contribute to increased knowledge about factors that influence the treatment of people with difficult-to-treat anorexia nervosa\n2. To highlight the role of autonomy and patient participation in inpatient care of severe eating disorders\n3. To use the research results for clinical improvement work at Region Skåne Eating Disorders Center",[28,225],"2026-06-15",{"date":390,"type":51},"2026-06-16",{"date":392,"type":22},"2026-09",{"date":394,"type":22},"2029-12",{"name":396,"class":58},"Region Skane",{"id":398,"slug":399,"hasResults":12,"nctId":400,"briefTitle":401,"officialTitle":402,"acronym":403,"eligibilityCriteria":404,"healthyVolunteers":12,"sex":17,"minAge":70,"maxAge":287,"enrollmentInfo":405,"targetDuration":4,"studyType":23,"phases":407,"briefSummary":408,"conditions":409,"keywords":4,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":412,"lastUpdatePostDateStruct":413,"startDateStruct":414,"completionDateStruct":416,"leadSponsor":418,"locationsCount":4},"100642332","evaluation-of-a-day-hospital-program-for-adolescents-and-young-adults-with-eating-disorders-100642332","NCT07648108","Evaluation of a Day Hospital Program for Adolescents and Young Adults With Eating Disorders","Evaluation of the Contribution of a Specialized Day Hospital for Adolescents and Young Adults With Eating Disorders: Long-Term Clinical Outcomes and Cross-Reported Experiences","UDJ-TCA","Inclusion Criteria:\n\n* Adolescents and young adults aged 12 to 22 years\n* Diagnosed with an eating disorder\n* Referred for admission to the day hospital program between October 2019 and December 2023\n* Provided informed consent (and parental consent for minors)\n\nExclusion Criteria:\n\n* Refusal to participate\n* Age below 12 years or above 22 years",{"count":406,"type":22},307,[25],"This study aims to evaluate the clinical, psychological, and functional outcomes of adolescents with anorexia nervosa receiving multidisciplinary care in hospital settings. Participants are treated either in a day hospitalization program or in a full-time inpatient program, in accordance with the French national guidelines (Haute Autorité de Santé, HAS) for the management of anorexia nervosa.\n\nThe study seeks to better understand the evolution of patients' health status over time, including nutritional, psychological, and social dimensions, and to identify factors associated with treatment response. Data will be collected as part of routine clinical care without modification of the standard therapeutic management.\n\nThe results of this study may help improve clinical practices and optimize care pathways for adolescents with anorexia nervosa.",[28,410,411],"Nervosa Adolescent","Adolescent Eating Disorders","2026-06-12",{"date":388,"type":51},{"date":415,"type":22},"2026-05-25",{"date":417,"type":22},"2027-02-24",{"name":419,"class":58},"Fondation Santé des Étudiants de France",{"id":421,"slug":422,"hasResults":12,"nctId":423,"briefTitle":424,"officialTitle":425,"acronym":4,"eligibilityCriteria":426,"healthyVolunteers":12,"sex":17,"minAge":139,"maxAge":140,"enrollmentInfo":427,"targetDuration":4,"studyType":23,"phases":429,"briefSummary":430,"conditions":431,"keywords":432,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":433,"lastUpdatePostDateStruct":434,"startDateStruct":436,"completionDateStruct":437,"leadSponsor":439,"locationsCount":59},"100643268","a-study-testing-a-digital-gamified-early-intervention-for-eating-disorders-flexed-100643268","NCT07632248","A Study Testing a Digital, Gamified Early Intervention for Eating Disorders (\"FlexED\")","A Randomized Controlled Trial Testing Mechanism Engagement and Clinical Impact of FlexED: A Digital, Gamified Early Intervention for Eating Disorders","Inclusion Criteria:\n\n* Female between the age of 15-25 years old.\n* Weight Concerns Scale score of \\>=47.\n* Endorses one or more eating disorder behaviors (e.g., extreme dieting or exercise, subjective or objective binge eating, purging behaviors).\n\nExclusion Criteria:\n\n* Currently meets the DSM-5 diagnostic criteria for full threshold anorexia nervosa, bulimia nervosa or binge eating disorder, or for an eating or feeding disorder that does not include body-image or weight related distress and is not the focus of study (e.g., ARFID, PICA) or a past diagnosis of one of these disorders.\n* Change in psychotropic medications in the past month.\n* Active suicidal ideation, current substance use disorder or diagnosed psychotic disorder.\n* Bipolar disorder not being treated with medication.\n* Currently in treatment for an eating disorder.\n* Non-English speaking.",{"count":428,"type":22},128,[25],"The goal of this clinical trial is to test whether a new digital intervention decreases eating disorder symptoms in young women and girls at risk by changing how they experience thoughts and feelings about their body.\n\nThe digital intervention is based on Acceptance and Commitment Therapy (ACT). Participants will be randomly assigned (like a coin toss) to either the new digital intervention or education modules completed online.\n\nThe main questions are:\n\nDoes the digital intervention change how participants experience thoughts and feelings about their body or how they react to eating disorder triggers (e.g., images of idealized bodies)? Do these changes lead to decreases in eating disorder symptoms? Is the intervention acceptable and at the right dose?\n\nParticipants will:\n\nComplete seven brief digital sessions over about 8 weeks. Complete interviews, surveys and lab assessments of reaction to body-related words and images.\n\nParticipants are followed for about 1 year.",[28,146],[28,148,149,150,151],"2026-06-01",{"date":435,"type":51},"2026-06-08",{"date":433,"type":22},{"date":438,"type":22},"2028-07-31",{"name":160,"class":58},{"id":441,"slug":442,"hasResults":12,"nctId":443,"briefTitle":444,"officialTitle":445,"acronym":4,"eligibilityCriteria":446,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":252,"enrollmentInfo":447,"targetDuration":4,"studyType":23,"phases":449,"briefSummary":450,"conditions":451,"keywords":4,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":454,"lastUpdatePostDateStruct":455,"startDateStruct":457,"completionDateStruct":458,"leadSponsor":460,"locationsCount":59},"100637872","safety-behavior-fading-versus-progressive-muscle-relaxation-for-appearance-concerns-100637872","NCT07589621","Safety Behavior Fading Versus Progressive Muscle Relaxation for Appearance Concerns","Safety Behavior Fading Versus Progressive Muscle Relaxation for Appearance Concerns: A Randomized Clinical Trial of Digital Interventions","Inclusion Criteria:\n\n* being between the ages of 18 and 65 years old\n* having an internet-capable smart-phone\n* scoring at or above the empirical cutoff for appearance concerns measured by the Social Appearance Anxiety Scale (i.e., 52)\n\nExclusion Criteria:\n\n* changes in psychotropic medication in the last 4 weeks\n* failing attention checks in baseline data collection",{"count":448,"type":22},300,[25],"The current study aims to explore the efficacy of a text message based safety behavior fading intervention compared to a progressive muscle relaxation intervention for appearance concerns.",[452,28,453],"Body Dysmorphic Disorder","Social Anxiety Disorder","2026-05-29",{"date":456,"type":51},"2026-06-02",{"date":454,"type":51},{"date":459,"type":22},"2026-12",{"name":461,"class":58},"Florida State University",{"id":463,"slug":464,"hasResults":12,"nctId":465,"briefTitle":466,"officialTitle":466,"acronym":4,"eligibilityCriteria":467,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":468,"targetDuration":4,"studyType":23,"phases":470,"briefSummary":471,"conditions":472,"keywords":478,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":483,"lastUpdatePostDateStruct":484,"startDateStruct":486,"completionDateStruct":488,"leadSponsor":489,"locationsCount":59},"100489298","a-precision-medicine-approach-to-target-engagement-for-emotion-regulation-100489298","NCT05651295","A Precision Medicine Approach to Target Engagement for Emotion Regulation","Inclusion Criteria:\n\n* Elevated emotion dysregulation\n\nExclusion Criteria:\n\n* Lack of proficiency in English\n* No access to smartphone\n* Conditions requiring greater than outpatient care",{"count":469,"type":22},390,[25],"The proposed study is designed to first test whether teaching people personalized or standardized emotion regulation skills leads to greater decreases in daily negative emotion intensity. Second, using data from an initial sample, the investigators will prospectively assign an independent sample of participants to receive their predicted optimal or non-optimal skills to determine if it is feasible and efficacious to match participants to the most appropriate training condition. Results of these studies may identify the mechanisms by which emotion regulation interventions impact emotional functioning and allow for the development of personalized, evidence-based, and scalable emotion regulation interventions.",[473,474,29,475,476,477,28],"Emotional Regulation","Depression","Borderline Personality Disorder","Obsessive-Compulsive Disorder","Posttraumatic Stress Disorder",[479,480,481,482],"cognitive-behavior therapy","mechanism","ecological momentary assessment","personalization","2026-05-07",{"date":485,"type":51},"2026-05-11",{"date":487,"type":51},"2023-09-29",{"date":208,"type":22},{"name":490,"class":58},"Matthew Southward, PhD",{"id":492,"slug":493,"hasResults":12,"nctId":494,"briefTitle":495,"officialTitle":496,"acronym":497,"eligibilityCriteria":498,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":499,"targetDuration":4,"studyType":23,"phases":501,"briefSummary":502,"conditions":503,"keywords":504,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":508,"lastUpdatePostDateStruct":509,"startDateStruct":511,"completionDateStruct":513,"leadSponsor":514,"locationsCount":516},"100577661","impact-of-a-mobile-app-based-waitlist-intervention-on-readiness-for-eating-disorder-treatment-100577661","NCT06801197","Impact of a Mobile App-Based Waitlist Intervention on Readiness for Eating Disorder Treatment","Impact of a Mobile App-Based Waitlist Intervention (MI-Coach: ED) on Readiness for Eating Disorder Treatment: A Randomized Controlled Trial","MI-Coach: ED","Inclusion Criteria:\n\n* Must self-identify as a woman, including cisgender or transgender individuals.\n* Must be at least 18 years old at the time of enrollment.\n* Currently on a waitlist to receive treatment for an eating disorder at provincially funded eating disorder programs in British Columbia.\n* Meets criteria for a threshold or subthreshold eating disorder, including anorexia nervosa (restricting or binge\u002Fpurge subtype), bulimia nervosa, binge eating disorder, or other specified feeding or eating disorder (OSFED).\n* Able to read and understand English fluently.\n* Owns or has regular access to a smartphone or mobile device capable of running the MI-Coach: ED app.\n\nExclusion Criteria:\n\n* Does not identify as a woman, regardless of sex assigned at birth.\n* Currently receiving active treatment for an eating disorder, such as outpatient therapy, inpatient care, or day programs.\n* Diagnosed with a schizophrenia-spectrum disorder or other psychotic disorder.\n* Presence of a cognitive impairment or sensory deficit (e.g., severe visual or hearing impairment) that would interfere with the ability to use the app or complete study assessments.\n* History of a recent traumatic brain injury or neurological condition that might impact participation.\n* Any condition that, in the opinion of the investigators, would interfere with the participant's ability to comply with the study protocol or complete the intervention.",{"count":500,"type":22},74,[25],"The goal of this randomized controlled trial is to evaluate whether a mobile app-based motivational interviewing intervention (MI-Coach: ED) can improve motivation and readiness for treatment in adults with eating disorders who are currently on waitlists for provincially funded eating disorder services in British Columbia. The main questions it aims to answer are:\n\n* Does the use of MI-Coach: ED improve overall motivation, confidence, and readiness for treatment compared to treatment-as-usual (waitlist with no intervention)?\n* Does the app help mitigate declines in motivation over time among waitlisted individuals?\n\nResearchers will compare participants using the MI-Coach: ED app to a delayed treatment control group to assess differences in motivation, readiness for treatment, and associated clinical outcomes.\n\nParticipants will:\n\n* Treatment group: Use the MI-Coach: ED app for four weeks, completing interactive modules focused on motivation and readiness for change, while also completing weekly brief assessments of motivation.\n* Delayed treatment group: Remain on the waitlist with no intervention for four weeks while completing weekly brief assessments of motivation. After this period, they will receive access to the MI-Coach: ED app and be integrated into the treatment group.\n* Complete pre-test and post-test questionnaires at 0, 4, 8, and 12 weeks assessing motivation, eating pathology, anxiety, and depressive symptoms.\n\nThis study aims to inform evidence-based practices for reducing the adverse effects of long waitlist durations on individuals with eating disorders.",[28],[120,505,506,507],"digital interventions","motivational interviewing","treatment barriers","2026-05-05",{"date":510,"type":51},"2026-05-08",{"date":512,"type":51},"2025-10-21",{"date":373,"type":22},{"name":515,"class":58},"University of British Columbia",3,{"id":518,"slug":519,"hasResults":12,"nctId":520,"briefTitle":521,"officialTitle":522,"acronym":523,"eligibilityCriteria":524,"healthyVolunteers":12,"sex":17,"minAge":70,"maxAge":525,"enrollmentInfo":526,"targetDuration":4,"studyType":23,"phases":527,"briefSummary":528,"conditions":529,"keywords":530,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":537,"lastUpdatePostDateStruct":538,"startDateStruct":539,"completionDateStruct":540,"leadSponsor":542,"locationsCount":59},"100581512","guided-self-help-for-eating-disorders-implementation-study-100581512","NCT06851273","Guided Self Help for Eating Disorders Implementation Study","National Implementation of Highly Efficient Evidence-Informed Treatment for Youth With Eating Disorders","GSHimplement","Inclusion Criteria:\n\n* Family including an adolescent with a confirmed diagnosis of Anorexia nervosa according to DSM-5-TR criteria.\n* Access to computer and internet connection\n* Have the capacity to speak, write, and understand English or French\n* Therapist\u002Fcoaches are licensed mental health clinician with experience in eating disorder treatment\n\nExclusion Criteria:\n\n* Adolescent has a current physical or mental disorder that requires hospitalization and\u002For prohibits the use of psychotherapy\n* Adolescent has a current dependence on drugs or alcohol\n* Adolescent has a current physical condition known to influence weight or eating (pregnancy, diabetes mellitus)\n* Adolescent has expected body weight of less than 75%\n* Adolescent\u002Ffamily has undergone four or more sessions of FBT for anorexia nervosa at any time\n* Does not have the capacity to speak, write, and understand English or French\n* Does not have access to computer and internet connection\n* Professionals are not licensed mental health professionals with experience in eating disorder treatment.","100 Years",{"count":289,"type":22},[25],"Eating disorders are amongst the most understudied illnesses affecting young women in Canada. Further, mortality rates are amongst the highest of all psychiatric illnesses. Despite their high prevalence and mortality rates, research into adolescent eating disorders is underfunded in Canada. In addition to the problem of research underfunding, healthcare system underfunding exists - creating long waiting lists and fragmented care for children and youth with eating disorders. More efficient treatments are urgently needed to reduce wait times and provide expedited care to adolescents on eating disorder waitlists. The current study aims to assess whether implementing a virtual parent-lead therapy, Guided Self Help Family-Based Therapy (GSH FBT) might alleviate wait times for eating disorder services and also reduce eating disorder symptomatology in young people with anorexia nervosa. This study also aims to determine the experiences of both families and medical teams of GSH FBT implementation as an intervention.",[28],[531,532,533,534,535,536],"Anorexia nervosa","Mental disorders","Adolescent eating disorders","Psychotherapy intervention","Guided self help therapy","Family-based treatment","2026-05-01",{"date":483,"type":51},{"date":371,"type":51},{"date":541,"type":22},"2027-12-30",{"name":543,"class":58},"McMaster University",{"id":545,"slug":546,"hasResults":12,"nctId":547,"briefTitle":548,"officialTitle":549,"acronym":550,"eligibilityCriteria":551,"healthyVolunteers":12,"sex":17,"minAge":552,"maxAge":553,"enrollmentInfo":554,"targetDuration":4,"studyType":23,"phases":556,"briefSummary":557,"conditions":558,"keywords":559,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":560,"lastUpdatePostDateStruct":561,"startDateStruct":562,"completionDateStruct":564,"leadSponsor":566,"locationsCount":59},"100570787","treatment-of-adolescent-anorexia-nervosa-100570787","NCT06711783","Treatment of Adolescent Anorexia Nervosa","VISAN - vårdkedja i Samverkan för Unga Patienter Med Anorexia Nervosa (Collaborative Chain of Care in Adolescnt Anorexia Nervosa Treatment)","VISAN","Inclusion Criteria:\n\n* Having been diagnosed with f500 or f501 and being planned for family based therapy at the unit.\n\nExclusion Criteria:\n\n* being subjected to care by the social welfare system","11 Years","17 Years",{"count":555,"type":22},60,[25],"VISAN is a naturalistic study of family based treatment of Anorexia nervosa in adolescnet girls.",[28],[40],"2026-04-30",{"date":537,"type":51},{"date":563,"type":51},"2024-08-01",{"date":565,"type":22},"2029-12-31",{"name":567,"class":58},"Region Örebro County",{"id":569,"slug":570,"hasResults":12,"nctId":571,"briefTitle":572,"officialTitle":573,"acronym":574,"eligibilityCriteria":575,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":576,"targetDuration":4,"studyType":23,"phases":577,"briefSummary":578,"conditions":579,"keywords":583,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":371,"lastUpdatePostDateStruct":592,"startDateStruct":593,"completionDateStruct":595,"leadSponsor":597,"locationsCount":59},"100531301","targeting-social-function-in-anxiety-and-eating-disorders-100531301","NCT06198023","Targeting Social Function in Anxiety and Eating Disorders","Targeting Social Function to Improve Outcomes in Anxiety and Eating Disorders","SF","Inclusion Criteria:\n\n* In the past 12 months, has met DSM-5 criteria met for an eating disorder (Anorexia Nervosa, Atypical Anorexia Nervosa, Bulimia Nervosa, Avoidant-Restrictive Food Intake Disorder, or Other Specified Feeding or Eating Disorder) and\u002For an anxiety disorder (Generalized Anxiety Disorder, Social Anxiety Disorder)\n* Between the ages of 18-30\n\nExclusion Criteria:\n\n* Current inpatient or residential treatment\n* Medical instability or safety\u002Fsuicide risk as determined by the PI",{"count":555,"type":22},[25],"Social processing and cognition are often altered in patients with eating disorders. The goal of this clinical trial is to assess two different social therapeutic interventions -- one educational, one interactive -- for their effectiveness in improving clinical outcomes in patients with eating disorders. Patients in both interventions will receive education about social function in eating disorders, but those in the interactive treatment group will complete an additional collaborative art task.\n\nParticipants will:\n\n* attend a baseline study visit to complete clinical interviews, cognitive testing, and behavioral tasks\n* complete a pre-intervention assessment with questionnaires\n* attend eight sessions of their assigned treatment group over the course of 12 weeks\n* complete three virtual follow-up assessments 4, 8, and 12 months from their baseline\n* attend a final study visit to repeat some clinical interviews, cognitive testing, and behavioral tasks\n\nResearchers will compare changes in eating disorder, mood, and anxiety symptoms as well as test results from baseline and final study visits for each group to see if\n\n* patients can be treated effectively with education alone or if an interactive group component produces additional benefits\n* cognitive and behavioral task performance are associated with recovery or illness state.",[28,225,226,580,581,228,453,582],"Atypical Anorexia Nervosa","Purging (Eating Disorders)","Generalized Anxiety Disorder (GAD)",[584,585,586,587,588,589,590,591],"social function","social cognition","social processing","psychoeducation","group therapy","group intervention","art therapy","social anxiety",{"date":508,"type":51},{"date":594,"type":51},"2024-02-28",{"date":596,"type":22},"2028-09",{"name":598,"class":58},"University of Texas Southwestern Medical Center",{"id":600,"slug":601,"hasResults":12,"nctId":602,"briefTitle":603,"officialTitle":604,"acronym":4,"eligibilityCriteria":605,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":252,"enrollmentInfo":606,"targetDuration":4,"studyType":23,"phases":608,"briefSummary":609,"conditions":610,"keywords":615,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":621,"lastUpdatePostDateStruct":622,"startDateStruct":624,"completionDateStruct":626,"leadSponsor":628,"locationsCount":59},"100628166","the-step-mied-trial-digital-stepped-care-for-emotional-disorders-100628166","NCT07458100","The STEP-MIED Trial: Digital Stepped-Care for Emotional Disorders","Effectiveness and Cost-effectiveness of a Digital Stepped-care Mindfulness Intervention for Recovery From Emotional Disorders: a Multicentre Pragmatic Randomized Controlled Trial","Inclusion Criteria:\n\n1. Age: 18-65 years.\n2. Diagnosed with an emotional disorder by a outpatient psychiatrist, including depressive disorders, anxiety disorders (e.g., generalized anxiety disorder, panic disorder, agoraphobia, social anxiety disorder), obsessive-compulsive disorder, post-traumatic stress disorder, and eating disorders (e.g., anorexia nervosa, bulimia nervosa).\n3. Symptom severity meeting the threshold: PHQ-9 score ≥10 or GAD-7 score ≥8.\n\nExclusion Criteria:\n\n1. Current diagnosis of psychotic disorders or bipolar disorder.\n2. Current organic mental disorders, pervasive developmental disorders, severe cognitive impairment, or substance use disorders.\n3. Current suicide risk (PHQ-9 item 9 score \\>2).\n4. Antisocial personality disorder.\n5. Severe medical illnesses that may affect intervention participation or require recent hospitalization.\n6. Previous participation in a systematic 8-week mindfulness course.\n7. Inability to access the internet.",{"count":607,"type":22},464,[25],"The goal of this clinical trial is to evaluate the effectiveness and cost-effectiveness of a digital mindfulness-based intervention in adults (aged 18-65) diagnosed with emotional disorders like depression or anxiety. The main questions it aims to answer are:\n\n* Does adding a digital mindfulness intervention to usual care help people recover from emotional disorders faster and more sustainably over two years?\n* Is this combined approach more cost-effective than usual care alone? Researchers will compare the group receiving the digital mindfulness intervention plus their usual treatment to the group receiving only their usual treatment to see if the intervention leads to better long-term recovery and represents good value for money.\n\nParticipants in the intervention group will:\n\n* Attend eight weekly 2-hour online group mindfulness sessions.\n* Use a WeChat mini-program for 49 days of guided mindfulness exercises and daily tasks.\n* Patients who have not achieved reliable recovery after group retraining voluntarily participate in individual UP\\&MIED counseling.\n* Complete regular questionnaires and interviews over two years to track their progress.\n\nAll participants will continue to receive their usual medical care from their doctors throughout the study.",[611,612,613,476,614,28],"Emotional Disorders","Depressive Disorder","Anxiety Disorders","Post-Traumatic Stress Disorder, PTSD",[616,617,618,619,620,611],"Cost-effectiveness","Mindfulness","Recovery","randomized controlled trial","stepped-care","2026-04-18",{"date":623,"type":51},"2026-04-21",{"date":625,"type":51},"2026-03-23",{"date":627,"type":22},"2028-05",{"name":629,"class":58},"Peking University",{"id":631,"slug":632,"hasResults":12,"nctId":633,"briefTitle":634,"officialTitle":635,"acronym":4,"eligibilityCriteria":636,"healthyVolunteers":12,"sex":17,"minAge":70,"maxAge":637,"enrollmentInfo":638,"targetDuration":4,"studyType":23,"phases":640,"briefSummary":641,"conditions":642,"keywords":4,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":644,"lastUpdatePostDateStruct":645,"startDateStruct":647,"completionDateStruct":648,"leadSponsor":650,"locationsCount":59},"100611209","developing-an-artificial-intelligence-ai-chatbot-for-adolescents-and-young-adults-with-eating-disorders-100611209","NCT07237607","Developing an Artificial Intelligence (AI) Chatbot for Adolescents and Young Adults With Eating Disorders","Developing an Artificial Intelligence (AI)-Powered Exposure Therapy Chatbot for Adolescents and Young Adults With Eating Disorders","Inclusion Criteria:\n\n* Age is between or equal to 12-26 years\n* Admitted to the Penn State Health Eating Disorder Partial Hospital Program (PHP) or Intensive Outpatient Program (IOP)\n* Have a personal smartphone\n* Have a diagnosis of anorexia nervosa (AN), bulimia nervosa (BN), binge-eating disorder (BED), or other specified feeding or eating disorder (OSFED)\n* Be English speaking\n\nExclusion Criteria:\n\n* Diagnosis of avoidant\u002Frestrictive food intake disorder (ARFID)\n* Have acute suicidality\n* Diagnosis of an intellectual disability","26 Years",{"count":639,"type":22},20,[25],"The goal of this study is to develop and refine an artificial intelligence (AI)-powered Exposure Therapy for Eating Disorders chatbot web-app that effectively engages adolescents and young adults and decreases anxiety about weight gain. Participants will use the web-app as a supplemental therapeutic tool during their first six weeks of treatment in a Partial Hospitalization Program. Participants will complete assessments every two weeks, including: (1) semi-structured interviews about their experience with the chatbot web-app; (2) implementation outcome measures (e.g., feasibility, usability, acceptability); and (3) anxiety about weight gain.",[28,225,226,643],"Binge-Eating Disorder","2026-04-14",{"date":646,"type":51},"2026-04-15",{"date":625,"type":51},{"date":649,"type":22},"2027-06-30",{"name":651,"class":58},"Milton S. Hershey Medical Center",{"id":653,"slug":654,"hasResults":12,"nctId":655,"briefTitle":656,"officialTitle":656,"acronym":4,"eligibilityCriteria":657,"healthyVolunteers":12,"sex":17,"minAge":4,"maxAge":18,"enrollmentInfo":658,"targetDuration":4,"studyType":385,"phases":4,"briefSummary":659,"conditions":660,"keywords":664,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":667,"lastUpdatePostDateStruct":668,"startDateStruct":670,"completionDateStruct":672,"leadSponsor":674,"locationsCount":142},"100582952","psychotropic-drug-induced-qt-prolongation-and-ecg-monitoring-in-the-pediatric-population-100582952","NCT06870006","Psychotropic-Drug-induced QT Prolongation and ECG Monitoring in the Pediatric Population","Inclusion Criteria:\n\n* Admitted to psychiatry ward\n* Starting a psychotropic drug acting on QT interval\n\nExclusion Criteria:\n\n* Age \\>18aa\n* History of administration of drug acting on QT interval in the 3 months prior",{"count":384,"type":22},"Electrocardiogram (ECG) Q-T prolongation is a cardiac electrophysiological disorder associated with the occurrence of arrhythmias potentially fatal. Several psychotropic drugs are associated with an increased risk of QT prolongation, which is why in clinical practice a baseline ECG is performed before a psychotropic drug is prescribed. However, there are no validated protocols establishing when to repeat this examination or describing clinical events when this examination should be repeated in clinical follow-up.\n\nThe study aims to investigate the incidence of QTc prolongation events as a side effect of chronic psychotropic drug administration. For this purpose, ECGs will be recorded and confounding factors of patients at the beginning of psychotropic therapy and after 3, 6 and 12 months will be analyzed.",[28,661,662,663],"Mood Disorders in Children and Adolescents","Psychotic Disorder","QTc Intervals Changes",[665,666],"QTc interval","psychotropic drugs","2026-03-17",{"date":669,"type":51},"2026-03-18",{"date":671,"type":51},"2024-01-01",{"date":673,"type":22},"2027-01",{"name":675,"class":58},"Meyer Children's Hospital IRCCS",{"id":677,"slug":678,"hasResults":12,"nctId":679,"briefTitle":680,"officialTitle":681,"acronym":4,"eligibilityCriteria":682,"healthyVolunteers":12,"sex":69,"minAge":18,"maxAge":683,"enrollmentInfo":684,"targetDuration":4,"studyType":23,"phases":686,"briefSummary":687,"conditions":688,"keywords":4,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":690,"lastUpdatePostDateStruct":691,"startDateStruct":693,"completionDateStruct":695,"leadSponsor":697,"locationsCount":59},"100628941","diabetes-body-project-2-100628941","NCT07468188","Diabetes Body Project 2","Development of a T2D-Specific, Virtually-Delivered Disordered Eating Prevention Intervention - Diabetes Body Project 2","Inclusion Criteria:\n\n* 1.) Female sex 2) self-reported gender identity of \"woman\"; 3) age 18-40 years old; 4) diagnosed with T2D for at least 6 months; 5) experiencing at least one body image concern.\n\nExclusion Criteria:\n\n* Recent hospitalization for eating disorder within the last 12 months\n* Eating disorder related diabetic ketoacidosis within the last 12 months\n* unwillingness to be video-recorded,\n* restricted English proficiency\n* developmental, cognitive, or psychiatric limitations that compromise participation in the intervention sessions and study.","40 Years",{"count":685,"type":22},42,[25],"The purpose of this study is to test the feasibility and effectiveness of an eating disorder prevention program specifically targeted for women with type 2 diabetes (T2D) called the Diabetes Body Project 2 (DBP2).\n\nThe Diabetes Body Project 2 (DBP2) will be adapted from the Diabetes Body Project, which is an eating disorder prevention program developed to improve satisfaction with body image and diabetes management for young women with type 1 diabetes (DBP).\n\nThe study is looking to see if the DBP is effective in improving body image concerns, reducing disordered eating behaviors and improving glycemic control in women with T2D.",[28,689],"Type 2 Diabetes","2026-03-11",{"date":692,"type":51},"2026-03-12",{"date":694,"type":51},"2025-01-24",{"date":696,"type":22},"2027-05-31",{"name":698,"class":58},"Joslin Diabetes Center",{"id":700,"slug":701,"hasResults":12,"nctId":702,"briefTitle":703,"officialTitle":704,"acronym":4,"eligibilityCriteria":705,"healthyVolunteers":12,"sex":17,"minAge":706,"maxAge":286,"enrollmentInfo":707,"targetDuration":4,"studyType":23,"phases":709,"briefSummary":710,"conditions":711,"keywords":714,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":719,"lastUpdatePostDateStruct":720,"startDateStruct":721,"completionDateStruct":723,"leadSponsor":724,"locationsCount":59},"100628778","lifestyle-intervention-for-obesity-and-eating-disorder-prevention-in-transgender-adolescents-100628778","NCT07466069","Lifestyle Intervention for Obesity and Eating Disorder Prevention in Transgender Adolescents","Lifestyle Intervention to Prevent Obesity and Eating Disorders in Transgender and Gender-Diverse Adolescents: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged 10-14 years\n* Self-identified as transgender or gender-diverse\n\nExclusion Criteria:\n\n* Current diagnosis of eating disorder requiring specialized treatment\n* Severe psychiatric instability\n* Cognitive impairment limiting participation","10 Years",{"count":708,"type":22},24,[25],"Transgender and gender-diverse adolescents are at increased risk for obesity, disordered eating behaviors, body dissatisfaction, and reduced quality of life due to minority stress and structural inequities. However, no structured lifestyle interventions specifically tailored to this population have been developed.\n\nThis randomized controlled trial aims to evaluate the effectiveness of a 6-month interdisciplinary lifestyle intervention designed to prevent obesity and eating disorders in transgender and gender-diverse adolescents aged 10-14 years. Participants will be randomized (1:1) to either an intervention group receiving monthly group sessions (for adolescents and caregivers separately) and weekly supportive messages, or a control group receiving standard outpatient care and general health recommendations.\n\nThe primary outcome is quality of life measured by the WHOQOL-BREF. Secondary outcomes include eating disorder symptoms, body image, diet quality, physical activity levels, sedentary behavior, body composition, and anthropometric measures.",[108,28,712,713],"Body Image Disturbance","Gender Diverse Populations",[715,716,717,718,360,328],"Transgender","Adolescent","Gender-diverse","Lifestyle","2026-03-06",{"date":692,"type":51},{"date":722,"type":22},"2026-03",{"date":459,"type":22},{"name":725,"class":58},"University of Sao Paulo"]