[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"eldery-people\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:eldery-people":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":5},"100587800","optimizing-cns-dha-delivery-in-elderly-adults-at-risk-for-dementia-100587800",false,"NCT06933095","Optimizing CNS DHA Delivery in Elderly Adults at Risk for Dementia","Inclusion Criteria:\n\n1. men and women 55 to 82 years old;\n2. presence of subjective cognitive decline or mild cognitive decline using the SCD questionnaire, DEX, EMQ, MoCA; and mCDR;\n3. No contraindication to a lumbar puncture (LP) unless opting to not have the LP (e.g., thrombocytopenia, coagulopathy, concomitant use of anticoagulant medications, etc.);\n4. fluency in English;\n5. ability to comprehend and comply with the research protocol; and\n6. provision of written informed consent.\n\nExclusion Criteria:\n\n1. diagnosis of dementia due to AD, Parkinson's disease, frontotemporal dementia, multi-infarct dementia, head trauma with loss of consciousness lasting more than 5 minutes and resulting in persisting functional decline within the three years prior to enrollment, epilepsy, leukoencephalopathy, other neurological conditions that would interfere the study objectives, mMIST \\\u003C8 or MoCA-MI score \\\u003C7;\n2. self-reported history of any psychotic disorder or bipolar disorder;\n3. diagnosis of atrial fibrillation, pancreatic, liver, kidney or hematological coagulation disorder;\n4. allergy to shellfish or seafood;\n5. current substance use causing physiological dependence or persisting change in functional capability;\n6. concomitant, regular use of medications that might affect primary outcome measures or adversely interact with the study product including anticoagulant medications;\n7. weekly fish consumption more than 1 x 3 oz servings and\u002For use of DHA-containing supplements within 3 months prior to screening.","ALL","55 Years","82 Years",{"count":19,"type":20},153,"ESTIMATED","INTERVENTIONAL",[23],"NA","The purpose of this placebo-controlled trial is to compare the effects of 24-weeks supplementation with LPC-DHA and TAG-DHA on cerebrospinal fluid and blood DHA levels, as well as biomarkers of central neurodegenerative and neurotrophic activity, in elderly adults experiencing early signs of cognitive\u002Fmemory decline including those with mild cognitive impairment (MCI). Extant evidence supports our overarching hypothesis that LPC-DHA supplementation will be more effective than TAG-DHA for increasing central (CSF) DHA levels and improving biomarker profiles in elderly adults. To assess this hypothesis, the following aims are proposed:\n\nSPECIFIC AIM 1: To compare the effects of LPC-DHA and TAG-DHA supplementation on peripheral and CSF DHA levels in elderly adults experiencing early signs of cognitive\u002Fmemory decline.\n\nSPECIFIC AIM 2: To compare the effects of LPC-DHA and TAG-DHA supplementation on neurotrophic and neurodegenerative biomarkers.\n\nSecondary Aim: To investigate whether changes in CSF DHA levels correlate with changes in objective measures of executive functioning and episodic memory performance.",[26,27,28,29],"Eldery People","Cognitive Decline","Memory Decline","DHA CNS Delivery","RECRUITING","2026-08-17",{"date":33,"type":34},"2026-08-19","ACTUAL",{"date":36,"type":34},"2024-09-15",{"date":38,"type":20},"2029-09-15",{"name":40,"class":41},"University of Cincinnati","OTHER"]