[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"emergency-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:emergency-surgery":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,46,72,93,121,150],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100648223","5-versus-10-mcg-norepinephrine-bolus-in-treatment-of-postinduction-and-early-intraoperative-hypotension-in-emergency-abdominal-surgery-100648223",false,"NCT07719075","5 Versus 10 mcg Norepinephrine Bolus in Treatment of Postinduction and Early Intraoperative Hypotension in Emergency Abdominal Surgery","Comparing 5 mcg and 10 mcg Norepinephrine Bolus in Treatment of Postinduction and Early Intraoperative Hypotension in Emergency Abdominal Surgery: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Adult patients, American Society of anesthesiologists (ASA) I-III undergoing emergency abdominal surgery\n\nExclusion Criteria:\n\n* Severe cardiac morbidities (impaired contractility with ejection fraction \\\u003C 45%, heart block, arrhythmias, tight valvular lesions)\n* Patients on vasopressor infusion,\n* Pregnant or lactating women,\n* Allergy of any of the study drugs","ALL","21 Years","65 Years",{"count":20,"type":21},136,"ESTIMATED","INTERVENTIONAL",[24],"NA","Postinduction hypotension is a frequent intraoperative complication, particularly in emergency abdominal surgery due to factors such as sepsis, hypovolemia, and limited preoperative cardiac assessment. Because it can lead to serious organ injury, prompt prevention and management are essential. Vasopressors, including ephedrine, phenylephrine, and norepinephrine, are commonly used, with NE gaining interest as an intraoperative bolus despite uncertainty about the optimal dose in general surgery population The aim of this study is to compare 5 mcg to 10 mcg norepinephrine bolus for treatment of postinduction hypotension and early intraoperative in emergency abdominal surgery.",[27,28,29],"Hypotension on Induction","Emergency Surgery","Norepinephrine",[31,32,33],"hypotension","norepinephrine","emergency surgery","RECRUITING","2026-08-04",{"date":37,"type":38},"2026-08-05","ACTUAL",{"date":35,"type":38},{"date":41,"type":21},"2026-12",{"name":43,"class":44},"Cairo University","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":4,"enrollmentInfo":53,"targetDuration":55,"studyType":56,"phases":4,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":45},"100514200","china-research-for-severe-spontaneous-intracerebral-hemorrhagecrisih-100514200","NCT05975398","China Research for Severe Spontaneous Intracerebral Hemorrhage（CRISIH）","Inclusion Criteria:\n\n1. Age 18 years or older.\n2. Spontaneous, nontraumatic intracerebral hemorrhage.\n3. Treatment with surgical or conservative management according to clinical indications and routine clinical practice.\n4. Written informed consent provided by the patient or legally authorized representative\u002Ffamily member.\n\nExclusion Criteria:\n\n1. Patients had cerebrovascular diseases associated with hemorrhage, such as intracranial aneurysm, cerebrovascular malformation, or intracranial tumors.\n2. Hemorrhagic transformation of cerebral infarction.\n3. Hemorrhage caused by cerebral venous thrombosis.\n4. Patients with severe coagulation disorder, such as hemophilia.\n5. Patients with coagulation dysfunction caused by malignant tumor, hepatic insufficiency, renal dysfunction, thrombocytopenia, coagulation diseases, or related conditions.\n6. Patients receiving other anticoagulation medications, including vitamin K antagonists or novel oral anticoagulants.\n7. Patients who died before arrival at the hospital, on arrival at the hospital, or within a short period (6 hours) after admission.","18 Years",{"count":54,"type":21},2000,"1 Year","OBSERVATIONAL","Background: Although emergency surgery may reduce mortality in patients with severe spontaneous intracerebral hemorrhage (SSICH), the effectiveness and safety of surgical treatment among SSICH patients receiving long-term oral antiplatelet therapy (LOAPT) remain unclear. The CRISIH registry was originally designed to evaluate the effect and safety of emergency surgery in SSICH patients receiving LOAPT and has subsequently continued as an ongoing multicenter registry of spontaneous intracerebral hemorrhage.\n\nMethods: The CRISIH registry is an ongoing prospective, multicenter cohort registry conducted across participating clinical centers in China. The registry was initiated in November 2019 and is designed as a 10-year registry with continued recruitment and follow-up. Data from the initial five-year enrollment period are used for interim and secondary analyses, while recruitment and follow-up continue during the subsequent registry period. Clinical, radiological, surgical, laboratory, and follow-up information are collected using standardized case report forms. For the originally registered primary outcome, patients are followed until death or 6 months after the occurrence of primary hemorrhage; selected follow-up assessments and secondary analyses may extend beyond this period according to the registry protocol.\n\nStudy Design: The CRISIH registry was designed as a prospective, multicenter cohort registry of patients with spontaneous intracerebral hemorrhage. One originally registered comparative focus evaluates SSICH patients receiving LOAPT, comparing total mortality and survival outcomes between patients receiving emergency surgical treatment and those receiving conservative treatment. The safety of surgery is assessed by comparing postoperative hemorrhagic complications among operated patients with and without LOAPT. Based on the observed clinical characteristics and outcomes of patients receiving LOAPT, the registry also evaluates ischemic events after discontinuation of LOAPT and explores coagulation function assessment strategies in operated patients receiving LOAPT.\n\nObjective: The CRISIH registry aims to prospectively evaluate clinical outcomes and management strategies in patients with spontaneous intracerebral hemorrhage. An originally registered focus of the registry is to assess the effectiveness and safety of emergency surgery among SSICH patients receiving LOAPT, thereby generating evidence to support future clinical management.\n\nSecondary Analysis Update: The present update describes an interim secondary analysis of the ongoing CRISIH registry based on patients enrolled during the initial five-year period from November 2019 to December 2024. This analysis focuses on postoperative disorders of consciousness after surgery for spontaneous intracerebral hemorrhage, with consciousness status assessed at 30, 90, 180, and 365 days after surgery using the Coma Recovery Scale-Revised. This interim secondary analysis does not alter the ongoing registry design, recruitment status, or originally registered primary outcome.",[59,60,28,61,62],"Severe Spontaneous Intracranial Hemorrhage","Long-term Antiplatelet Treatment","Complications","Disorders of Consciousness","2026-07-08",{"date":65,"type":38},"2026-07-10",{"date":67,"type":38},"2019-11-01",{"date":69,"type":21},"2030-12-31",{"name":71,"class":44},"Beijing Tiantan Hospital",{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":79,"targetDuration":4,"studyType":22,"phases":81,"briefSummary":82,"conditions":83,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":90,"leadSponsor":92,"locationsCount":45},"100628781","hemodynamic-effects-of-intravenous-paracetamol-in-patients-undergoing-emergency-laparotomy-100628781","NCT07466108","Hemodynamic Effects of Intravenous Paracetamol in Patients Undergoing Emergency Laparotomy","Hemodynamic Effects of Intravenous Paracetamol in Patients Undergoing Emergency Laparotomy: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Adult patients, ASA I-III undergoing emergency laparotomy\n\nExclusion Criteria:\n\n* Severe cardiac morbidities (impaired contractility with ejection fraction \\\u003C 40%, heart block, arrhythmias, tight valvular lesions)\n* Hemodynamically unstable patients (defined as patients with MAP \\\u003C 65 mmHg or need vasopressor to maintain MAP\\>65 mmHg).\n* Patients with high shock index (heart rate \u002F systolic blood pressure \\>1)\n* Pregnant or lactating women,\n* Allergy of any of the study drugs",{"count":80,"type":21},90,[24],"Emergency laparotomy is a high-risk procedure often performed in patients with severe physiological derangements due to sepsis, making perioperative management challenging. Although multimodal analgesia is essential, options are often limited by factors such as hemodynamic instability, renal dysfunction, and coagulopathy. Intravenous paracetamol is commonly recommended for perioperative analgesia because of its opioid-sparing effect, but evidence suggests it may cause hypotension through peripheral vasodilation, particularly in critically ill patients. Most data on this effect come from observational studies, and evidence regarding its intraoperative hemodynamic impact remains limited.",[84,85,28],"Paracetamol","Hypotension Drug-Induced","2026-03-18",{"date":88,"type":38},"2026-03-20",{"date":86,"type":38},{"date":91,"type":21},"2026-09",{"name":43,"class":44},{"id":94,"slug":95,"hasResults":11,"nctId":96,"briefTitle":97,"officialTitle":98,"acronym":4,"eligibilityCriteria":99,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":100,"enrollmentInfo":101,"targetDuration":103,"studyType":56,"phases":4,"briefSummary":104,"conditions":105,"keywords":108,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":45},"100582001","preoperative-hemoglobin-and-acute-kidney-injury-in-emergency-surgery-100582001","NCT06857630","Preoperative Hemoglobin and Acute Kidney Injury in Emergency Surgery","The Association Between Preoperative Hemoglobin and Acute Kidney Injury in Emergency Surgery: A Prospective Observational Study","Inclusion Criteria:\n\n* Patients undergoing emergency non-cardiac surgery\n\nExclusion Criteria:\n\n* Known renal failure\n* Need for reoperation within 48 hours postoperatively\n* Exit status within 48 hours postoperatively\n* Known hematological disease\n* Known kidney transplantation\n* Urgent surgery planned due to urinary system related diseases\n* Patients who did not accept to participate in the study","80 Years",{"count":102,"type":21},420,"2 Years","Optimization of hemoglobin levels for organ perfusion is essential, especially in critically ill patients. Although anemia is associated with severe organ failure, especially in coronary artery disease, the effects of blood transfusion or various interventions to increase hemoglobin levels on outcomes continue to be debated. The effects of hemoglobin levels in emergency surgery patients on the development of postoperative AKI have been investigated in a small number of studies in the literature, and clear results have not yet been reported. This study was designed to evaluate the effect of hemoglobin levels on the development of AKI after adjustment for known predictive factors.",[28,106,107],"Acute Kidney Injury","Hemoglobin",[109,110,111,107],"Acute kidney injury","Emergency surgery","Risk factor","2026-03-13",{"date":114,"type":38},"2026-03-17",{"date":116,"type":38},"2025-01-01",{"date":118,"type":21},"2027-05-01",{"name":120,"class":44},"Samsun University",{"id":122,"slug":123,"hasResults":11,"nctId":124,"briefTitle":125,"officialTitle":125,"acronym":126,"eligibilityCriteria":127,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":4,"enrollmentInfo":128,"targetDuration":4,"studyType":22,"phases":130,"briefSummary":131,"conditions":132,"keywords":138,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":45},"100558744","acute-preoperative-pain-and-chronic-post-surgical-pain-in-emergency-surgery-100558744","NCT06555107","Acute Preoperative Pain and Chronic Post-surgical Pain in Emergency Surgery","POCSE","Inclusion Criteria:\n\n* Age ≥18 years old.\n* Emergency orthopaedic and\u002For abdominal surgery.\n* Informed consent.\n* Affiliation to a social security scheme\n\nExclusion Criteria:\n\n* Intraoperative complications that are life-threatening or require the surgical procedure to be discontinued.\n* Post-operative intensive care unit admission.\n* Ambulatory surgery.\n* Endoscopic surgery.\n* Repeat surgery at the same site in less that 3months.\n* Pregnant or breast-feeding patients.\n* Patients under guardianship or deprived of liberty.\n* Patients suffering from psychiatric pathologies.\n* Patients suffering from neurodegenerative pathologies.\n* Patients for whom self-assessment of pain using a numerical scale (0-10) cannot be carried out (non-communicative patients, non-French-speaking patients, and so on).",{"count":129,"type":21},693,[24],"Studies evaluating postoperative pain as a risk factor for CPSP are almost exclusively carried out in the context of scheduled surgery. As a result, the preoperative pain studied as a risk factor for chronicity is essentially a state of pain that has persisted for several weeks or even several months.\n\nIn emergency surgeries, patients are subject to acute preoperative pain of varying intensity and the duration of which may vary by a few days. A few studies have highlighted the intensity of acute preoperative pain as a factor favouring moderate to severe postoperative pain. At this point, no study has addressed the long-term consequences of this intense preoperative pain the emergency context.\n\nAn evaluation in the field of emergency surgery, where the preoperative pain is often intense and limited in time, would enable us to identify more precisely the impact of acute pain on the incidence of CPSP.\n\nThe investigators are hypothesising that the occurrence of CPSP at 3 months in patients undergoing emergency orthopaedic or abdominal surgery is associated with acute preoperative pain.",[133,134,28,135,136,137],"Chronic Postsurgical Pain","Acute Pain","Opioid","Postoperative Pain","Risk Factors",[139,133,134,33,140,136],"risk factors","opioid","2026-01-15",{"date":143,"type":38},"2026-01-16",{"date":145,"type":38},"2024-08-29",{"date":147,"type":21},"2027-04",{"name":149,"class":44},"Centre Hospitalier Universitaire, Amiens",{"id":151,"slug":152,"hasResults":11,"nctId":153,"briefTitle":154,"officialTitle":155,"acronym":156,"eligibilityCriteria":157,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":4,"enrollmentInfo":158,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":160,"conditions":161,"keywords":169,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":178,"completionDateStruct":180,"leadSponsor":182,"locationsCount":45},"100594226","prognosis-of-veno-venous-extracorporeal-membrane-oxygenation-in-emergency-thoracic-surgery-100594226","NCT07016685","Prognosis of Veno-Venous Extracorporeal Membrane Oxygenation in Emergency Thoracic Surgery","Prognostic Factors for 90-day Mortality in Patients Undergoing Veno-venous Extracorporeal Membrane Oxygenation for Emergency Thoracic Surgery","PECUR","Inclusion Criteria:\n\n* Adults ≥ 18 years\n* VV-ECMO initiated during or after emergency thoracic surgery\n* No opposition to data use\n\nExclusion Criteria:\n\n* Pregnant women\n* Veno-Arterial ECMO patients\n* Patients under legal protection",{"count":159,"type":21},380,"Veno-vneous extracorporeal membrane oxygenation (VV-ECMO) is an established support strategy for acute respiratory failure, but its role in the perioperative management of emergency thoracic surgery remains poorly defined. This retrospective, multicenter, observational study aims to assess the clinical outcomes and prognostic factors in this high-risk population. Patients undergoing emergency thoracic procedures requiring VV-ECMO will be compared to a control cohort of patients treated with VV-ECMO for medical respiratory failure. Data will be collected from two French academic centers (CHU Amiens-Picardie and CHU Dijon).",[162,163,28,164,165,166,167,168],"VV-ECMO","Thoracic Surgery","ARDS","Retrospective Cohort","Propensity Score Matching","Mortality","ECMO Outcomes",[170,162,33,164,171,172,173,174],"thoracic surgery","retrospective cohort","propensity score matching","mortality","ECMO outcomes","2025-06-12",{"date":177,"type":38},"2025-06-13",{"date":179,"type":38},"2025-06-01",{"date":181,"type":21},"2026-04",{"name":149,"class":44}]