[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"enamel-breakdown\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:enamel-breakdown":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":5},"100648903","correlation-between-colour-of-defect-and-enamel-breakdown-in-first-permanent-molars-with-molar-incisor-hypomineralisation-mih-100648903",false,"NCT07727200","Correlation Between Colour of Defect and Enamel Breakdown in First Permanent Molars With Molar Incisor Hypomineralisation (MIH)","Molar-Incisor Hypomineralisation (MIH): Correlation Between Colour of Defect and Enamel Breakdown","MIH","MIH Study Group\n\nInclusion Criteria:\n\n* Children between 5 to 8 years with MIH molars with or without hypersensitivity according to the MIH-TN Index (Bekes et al 2016)\n* Children with first molars in occlusion\n* Children fit and healthy\n\nExclusion Criteria:\n\n* MIH first permanent molars that have already received any kind of dental treatment\n* Children diagnosed with HSPM (hypomineralised second primary molars)\n* Children older than 8 years - Children younger than 5 years\n* Children with any cranio-facial and\u002For other developmental dental defects\n* Children diagnosed with parafunctions (attrition\u002F erosion)\n* Children and\u002For parents who did not consent to the study\n* Children with MIH teeth that show clinically visible enamel loss during the eruption\n* Children without the first molars in occlusion\n\nNon- MIH Control Group\n\nInclusion Criteria:\n\n* Children between 5 to 8 years with no clinically affected molars- Page 4 of 5\n* Children fit and healthy\n\nExclusion Criteria:\n\n* Children who have already received any kind of dental treatment on their permanent or primary teeth\n* Children diagnosed with MIH or any other disease of the teeth\n* Children older than 8 years\n* Children younger than 5 years\n* Children with any cranio-facial and\u002For other developmental dental defects\n* Children diagnosed with parafunctions (attrition\u002F erosion)\n* Children and\u002For parents who did not consent to the study",true,"ALL","5 Years","8 Years",{"count":22,"type":23},45,"ESTIMATED","OBSERVATIONAL","Cheese molars (MIH) can be recognized not only by their colour abnormalities but also by the enamel breakdown. Clinical management of those teeth may become challenging by the chronic hypersensitivity, that makes various steps during treatment, such as pain control or light curing of any type of composite restorations, difficult or even impossible, despite profound local anaesthesia. The aim of this study is to determine the relationship between colour of the defect and loss of ename in the affected teeth. A correlation between colour of the defect and risk of enamel breakdown could enable early prognosis leading to preventive measures in order to delay or even avoid completely any breakdown of the enamel. Children diagnosed with MIH on their first permanent molars of different severity are matched to children with sound molars. They are identified by the annual school dental check-up and are invited to take part in the study. The children will be invited to the university dental clinic via letter for the first appointment. Upon parental consent, the teeth will be photographed and scanned on the first appointment. Three follo-up appointments will be organised in order to take pictures and scan again the teeth. The baselne scan of the tetth will be compared to the scans of the subsequent appointments in order to measure the level of enamel breakdown and correlate it to the colour of the defect.",[27,28,29],"Molar Incisor Hypomineralisation","Enamel Breakdown","Colour of Defect",[15,29,28],"RECRUITING","2026-07-21",{"date":34,"type":35},"2026-07-27","ACTUAL",{"date":37,"type":35},"2026-01-09",{"date":39,"type":23},"2027-03-31",{"name":41,"class":42},"University of Basel","OTHER"]