[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"endocrine-disorder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:endocrine-disorder":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,52],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":33,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100652310","bao-yuan-tang-extract-and-galactooligosaccharides-for-sleep-regulation-100652310",false,"NCT07774897","Bao Yuan Tang Extract and Galactooligosaccharides for Sleep Regulation","Sleep-Promoting Effects of Bao Yuan Tang Whole-Component Extract Combined With Galactooligosaccharides: A Prospective, Multicenter, Triple-blind, Randomized Controlled Trial","Inclusion Criteria:\n\n* Female registered nurses aged 25-45 years.\n* Participants must meet at least one of the following criteria, self-reported presence of at least one target symptom of the trial, including insomnia, daytime fatigue, or difficulty initiating sleep or Pittsburgh Sleep Quality Index (PSQI) score \\>7.\n* Engagement in shift work for at least one month before enrollment, with either ≥ 4 night shifts or ≥32 hours of night-shift work during the preceding month.\n\nExclusion Criteria:\n\n* Diagnosed with type 1 or type 2 diabetes mellitus and currently receiving pharmacological treatment.\n* Diagnosed with clinically thyroid dysfunction, including hyperthyroidism or hypothyroidism, and currently receiving pharmacological treatment.\n* Diagnosed with Cushing's syndrome, pituitary dysfunction, or other clearly defined endocrine disorders.\n* Diagnosed with polycystic ovary syndrome (PCOS) and currently receiving pharmacological treatment.\n* Use of medications that may affect study outcomes, including oral contraceptives, glucose-lowering agents, hormonal medications, hypnotics, lipid-regulating agents, or thyroid hormone preparations, within the past 3 months.\n* Pregnancy, lactation, or planned pregnancy during the study period.\n* Confirmed severe organic diseases, such as hepatic or renal insufficiency, cardiovascular disease, or malignancy.\n* Known allergy to any component of the investigational product.\n* Use of probiotics, prebiotics, or related traditional Chinese medicine preparations within the past 1 month.\n* Participation in another clinical trial within the past 3 months.\n* Planned engagement in vigorous exercise or a weight-management program during the study period.\n* A previous diagnosis of psychiatric disorders, such as anxiety or depression.\n* Any condition judged by the investigator to involve communication difficulties, poor compliance, or potential interference with adherence to the study protocol.",true,"FEMALE","25 Years","45 Years",{"count":21,"type":22},400,"ESTIMATED","INTERVENTIONAL",[25],"NA","Certain classical formulas in traditional Chinese medicine and dietary prebiotics have demonstrated beneficial effects on various aspects of suboptimal health status in previous studies. This research aims to evaluate the effects of Bao Yuan Tang full-component extract combined with galactooligosaccharides on improving health-related outcomes in female registered nurse with suboptimal health status, including sleep disturbances, fatigue, endocrine dysregulation, and glucose and lipid metabolic abnormalities.",[28,29,30,31,32],"Sleep Disturbance","Fatigue Syndrome, Chronic","Endocrine Disorder","Glucose Metabolism Disorder","Lipid Metabolism Disorders",[34,35,36,37,38],"Bao Yuan Tang full-component extract","Galactooligosaccharides","Sleep quality","Prebiotic","Metabolic health","NOT_YET_RECRUITING","2026-08-16",{"date":42,"type":43},"2026-08-19","ACTUAL",{"date":45,"type":22},"2026-09-30",{"date":47,"type":22},"2027-09-30",{"name":49,"class":50},"Hepatopancreatobiliary Surgery Institute of Gansu Province","OTHER",6,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":16,"sex":60,"minAge":4,"maxAge":61,"enrollmentInfo":62,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":65,"conditions":66,"keywords":73,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":85},"100342698","offspring-born-to-mothers-with-polycystic-ovary-syndrome-in-guangzhou-cohort-study-100342698","NCT03742011","Offspring Born to Mothers With Polycystic Ovary Syndrome in Guangzhou Cohort Study","Health of Offspring Born to Mothers With Polycystic Ovary Syndrome in Guangzhou Cohort Study","PCOS-BIG","Inclusion Criteria:\n\n* Offspring born to women diagnosed with PCOS\n* Offspring born to women with \\\u003C20 weeks of gestation, intended to eventually deliver in Guangzhou Women and Children's Medical Center\n* Permanent residents or families intended to remain in Guangzhou for ≥3 years\n\nExclusion Criteria:\n\n* None","ALL","18 Years",{"count":63,"type":22},2000,"OBSERVATIONAL","The Offspring Born to Mothers with Polycystic Ovary Syndrome in Guangzhou Cohort study (PCOS-BIG) was established to investigate the short- and long-term effects of intrauterine exposure to maternal PCOS on the health of offspring in Guangzhou, China. Data are collected regarding maternal PCOS subtypes, nursing, diet and education as well as health outcomes in their later life. Biological samples including blood and tissue samples are also collected from participants.",[67,68,69,70,71,30,72],"PCOS","Offspring, Adult","Hyperandrogenism","Epigenetics","Insulin Resistance","Metabolic Disturbance",[67,69,70,74],"Glucolipid metabolism disorder","RECRUITING","2024-02-22",{"date":78,"type":43},"2024-02-26",{"date":80,"type":43},"2012-02-01",{"date":82,"type":22},"2038-12-31",{"name":84,"class":50},"Guangzhou Women and Children's Medical Center",1]