[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"endurance-training\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:endurance-training":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,44,69,96],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100646534","progressive-pressure-support-reduction-as-inspiratory-muscle-endurance-training-in-mechanically-ventilated-patients-100646534",false,"NCT07689110","Progressive Pressure Support Reduction as Inspiratory Muscle Endurance Training in Mechanically Ventilated Patients","Progressive Pressure Support Reduction as Inspiratory Muscle Endurance Training in Mechanically Ventilated Critically Ill Patients: Effect on Maximal Inspiratory Pressure, Diaphragm Thickening Fraction, Weaning Success and Extubation (INSPIRA-RCT)","inspira-rct","Inclusion Criteria:\n\n1. Age ≥ 18 years\n2. Admitted to ICU with invasive mechanical ventilation for more than 48 hours at the time of randomization\n3. Expected to remain intubated for at least 24 additional hours, at the discretion of the attending intensivist\n4. Active pressure support ventilation (PSV) mode with PS level ≥ 5 cmH2O\n5. Richmond Agitation-Sedation Scale (RASS) score between -1 and +1\n6. Arterial pH ≥ 7.35 and serum lactate ≤ 2.0 mmol\u002FL\n7. Peripheral oxygen saturation (SpO2) ≥ 90% with current FiO2\n8. Informed consent obtained from patient or legal representative\n\nExclusion Criteria:\n\n1. Neurological condition affecting central respiratory control (high cervical spinal cord injury, ALS, myasthenia gravis, active Guillain-Barré syndrome)\n2. Established tracheostomy at the time of inclusion\n3. Restriction on head-of-bed elevation to ≥ 30 degrees\n4. Decision to limit therapeutic effort (LET) or life expectancy \\\u003C 48 hours\n5. Active hemodynamic instability (requirement for ≥ 2 vasopressors or vasopressor adjustment within the last 6 hours)\n6. Multiple rib fractures or undrained pneumothorax\n7. Simultaneous participation in another interventional clinical trial\n8. Previous inclusion in this study","ALL","18 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"NA","Mechanical ventilation causes rapid diaphragm muscle atrophy, detectable within 18 hours of ventilator support, which is a major contributor to weaning failure and prolonged ICU stay.\n\nThis randomized controlled trial tests whether a physiotherapist-guided inspiratory endurance training program - achieved by progressively reducing pressure support (PS) levels on the ventilator - can preserve or improve inspiratory muscle strength and diaphragm structure in critically ill adults on mechanical ventilation, compared to standard ICU care.\n\nParticipants will be randomly assigned to one of two groups. The intervention group will receive twice-daily training sessions (weekdays only) in which the physiotherapist gradually reduces PS by up to 50% of the baseline level, causing the patient to breathe with greater muscular effort - equivalent to progressive endurance exercise for the diaphragm. The control group will receive standard weaning care as directed by the attending intensivist.\n\nThe primary outcome is maximal inspiratory pressure (PImax) at day 7. Secondary outcomes include diaphragm thickening fraction measured by ultrasound, time to successful extubation, weaning success rate, and mortality.\n\nAll measurements are performed by the ICU physician (blinded to group allocation) using airway occlusion maneuvers recorded on the ventilator and diaphragm ultrasound, following a standardized protocol.",[27,28,29,30],"Respiratory Muscle Weakness","Mechanical Ventilation Weaning","Physiotherapy","Endurance Training","NOT_YET_RECRUITING","2026-07-04",{"date":34,"type":35},"2026-07-08","ACTUAL",{"date":37,"type":21},"2026-10-01",{"date":39,"type":21},"2028-03-30",{"name":41,"class":42},"University of Santiago de Compostela","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":51,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":54,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":43},"100623775","the-effects-of-rosuvastatin-on-running-training-adaptation-and-safety-100623775","NCT07401017","The Effects of Rosuvastatin on Running Training Adaptation and Safety","The Effects of Rosuvastatin on Physiological Adaptation and Safety During Regular Long-Distance Running Training: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Meets clinical criteria for statin therapy, including at least one of the following:\n* Family history of hyperlipidemia.\n* LDL-C ≥ 160 mg\u002FdL.\n* 10-year Atherosclerotic Cardiovascular Disease (ASCVD) risk ≥ 7.5%\n* Diabetes mellitus with LDL-C ≥ 70 mg\u002FdL.\n* Determined by a clinician to require lipid-lowering therapy.\n* Currently using or eligible to initiate rosuvastatin therapy.\n* Performs long-distance running at least 3 times per week and is willing to maintain regular training for 3 months.\n* Able and willing to undergo cardiopulmonary exercise testing (CPET) and to record training data using a sports watch (for TRIMP calculation).\n* No known drug allergies and provides written informed consent after study explanation.\n\nExclusion Criteria:\n\n* Known allergy or intolerance to statins or rosuvastatin.\n* History of severe statin-related adverse events, including rhabdomyolysis or marked creatine kinase (CK) elevation.\n* Liver dysfunction with AST or ALT \\> 3× upper limit of normal.\n* Moderate to severe renal impairment (eGFR \\\u003C 30 mL\u002Fmin\u002F1.73 m²).\n* Current lower-limb pain, tendon injury, or other conditions that prevent running training.\n* Not suitable for maximal cardiopulmonary exercise testing (CPET), such as unstable angina, uncontrolled hypertension, or recent cardiovascular events.\n* Pregnant or breastfeeding.\n* Inability to comply with study procedures, including use of a sports watch, regular follow-up visits, or maintaining running training.",true,{"count":53,"type":21},40,[24],"Statins lower low-density lipoprotein cholesterol (LDL-C) and help prevent atherosclerotic cardiovascular disease, but some users develop statin-associated muscle symptoms (SAMS) such as soreness, stiffness, weakness, or elevated creatine kinase (CK). These symptoms may be more noticeable during exercise. Regular long-distance running improves cardiopulmonary fitness-VO₂max, aerobic threshold (AT), and respiratory compensation point (RCP)-mainly through mitochondrial and metabolic adaptations. Prior studies suggest that lipophilic statins like simvastatin may blunt these adaptations, while hydrophilic statins such as rosuvastatin may have a smaller impact. However, prospective data in habitual endurance runners are limited.\n\nThis randomized controlled trial will examine how rosuvastatin affects cardiopulmonary fitness improvements and muscle tolerance in individuals who run at least three times per week and meet clinical criteria for statin therapy. After informed consent and baseline cardiopulmonary exercise testing (CPET), participants will be randomized to rosuvastatin 10 mg daily or no statin therapy for three months. Both groups will maintain their usual training routines, and training load will be recorded using heart-rate-based TRIMP. CPET will be repeated monthly to assess changes in VO₂max, AT, and RCP, and muscle enzymes and SAMS will be evaluated at each visit.\n\nThe study aims to clarify whether rosuvastatin influences endurance-related physiological adaptations or increases muscle symptoms in regular long-distance runners.",[57,58,30,59],"Dyslipidemia","Long-Distance Running","Statin-Associated Muscle Symptoms","2026-02-05",{"date":62,"type":35},"2026-02-10",{"date":64,"type":21},"2026-03-01",{"date":66,"type":21},"2026-10-31",{"name":68,"class":42},"Taipei Medical University WanFang Hospital",{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":51,"sex":17,"minAge":18,"maxAge":76,"enrollmentInfo":77,"targetDuration":4,"studyType":22,"phases":79,"briefSummary":80,"conditions":81,"keywords":82,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":43},"100621699","evaluation-of-a-training-recommendation-strategy-for-trail-runners-100621699","NCT07374016","Evaluation of a Training Recommendation Strategy for Trail Runners.","TRAILWISE","Inclusion Criteria:\n\n* Have no contraindications to trail running (Fédération Française d'Athlétisme test procedures)\n* Have been trail running competitively for at least 1 year\n* In possession of an ITRA performance index\n* Intends to run at least one ITRA-indexed race in the second half of the follow-up period\n* Own a training watch, and intend to record all training sessions of more than 10 minutes in their shared database\n* Have freely given their written consent.\n\nExclusion Criteria:\n\n* Any person with chronic joint pathologies (e.g. recurrent sprains, patellar or ligament problems) or cardiac pathologies.\n* Any person with chronic or central neurological pathologies.\n* Any person deprived of their liberty or under legal protection (guardianship, curatorship, safeguard of justice, family habilitation).","65 Years",{"count":78,"type":21},1209,[24],"Finding the optimal training, i.e. the training that enables the athlete to achieve the best performance while preserving their physical and psychological integrity, is a multi-factorial issue.\n\nEach individual's background and training capacity are very different, hence the need for personalised training. The availability of data combined with advances in Artificial Intelligence (data modelling and analysis sciences, big data, machine learning, deep learning, etc.) offer the opportunity to refine our understanding of training and adapt recommendations according to the runner's profile for a given objective (achieving a time over a distance, completing an event, etc.). The strategy that the investigators wish to evaluate as part of this trial could make it possible to recommend an optimal training load, as well as the distribution of intensities (as a percentage of the aerobic threshold, anaerobic threshold, VVO2max, etc). The two features are (i) the personalisation will be based on training history, the level of the runner, age and gender, and the runner can focus on training, and (ii) the strategy will be adaptive, i.e. the algorithm will update the training load in real time based on contextual data about the athlete (level of fatigue via heart rate variability, feedback on recent training sessions, feelings of stress).",[30],[83,84,85,86],"Trail running","Performance","Training recommendations","Artificial intelligence","2026-01-21",{"date":89,"type":35},"2026-01-28",{"date":91,"type":21},"2026-03",{"date":93,"type":21},"2027-12",{"name":95,"class":42},"Centre Hospitalier Universitaire de Saint Etienne",{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":4,"eligibilityCriteria":102,"healthyVolunteers":51,"sex":103,"minAge":18,"maxAge":104,"enrollmentInfo":105,"targetDuration":4,"studyType":22,"phases":107,"briefSummary":108,"conditions":109,"keywords":112,"overallStatus":116,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":43},"100555252","combined-effects-of-plyometric-and-endurance-training-among-female-hockey-players-100555252","NCT06509672","Combined Effects of Plyometric and Endurance Training Among Female Hockey Players","Combined Effects of Plyometric and Endurance Training on Speed, Agility and Strength Among Female Hockey Players","Inclusion Criteria:\n\n* Only female hockey players\n\n  * Age 18-24 years\n  * Athletes with at least one year experience in hockey\n  * Athletes must be without previous experience in intense strength\u002Fendurance training\n  * Only players who will participate in at all training sessions will be included in the statistical analysis\n\nExclusion Criteria:\n\n* Participants having injuries resulting in loss of one or more hockey matches\u002F training sessions in the preceding three months prior to the initiation of the study\n* Participants with the history of systemic disease\n* Participants with history of lower extremity and lumber spine pathology\n* Participants with prior surgery history","FEMALE","24 Years",{"count":106,"type":21},30,[24],"Athletes need plyometric training as well as endurance training to enhance their speed, strength and agility in the field. Plyometric exercise involves stretching the muscle immediately before making a rapid concentric contraction. The combined action is commonly called a stretch-shortening cycle (SSC). Similar gains of maximal strength have been reported with traditional strength and plyometric training, but the latter approach appears to induce greater gains in muscle power. The combination of balance and muscle strength\u002Fpower exercises seems to be an appropriate possibility, since both modalities induced adaptation on the neuromuscular level. A blocked combination of balance and muscle strength exercises effectively improve physical performance, and improvements in performance are more pronounced if balance exercises are followed by strength exercises than vice versa.",[110,30,111],"Plyometric Exercise","Hockey",[113,114,115],"Plyometric training","Endurance training","Hockey players","RECRUITING","2024-07-15",{"date":119,"type":35},"2024-07-19",{"date":121,"type":35},"2024-06-14",{"date":123,"type":21},"2024-09-14",{"name":125,"class":42},"Riphah International University"]