[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"evaluation-of-mainstreamed-models-of-genetic-service-delivery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:evaluation-of-mainstreamed-models-of-genetic-service-delivery":23},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":26,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":4},"100654491","implementation-effectiveness-trial-of-mainstreaming-of-clinical-genomic-sequencing-for-rare-disease-in-ontario-canada-100654491",false,"NCT07799792","Implementation-effectiveness Trial of Mainstreaming of Clinical Genomic Sequencing for Rare Disease in Ontario, Canada","Mainstreaming of Clinical Genomic Sequencing for Rare Disease in Ontario, Canada: Protocol for a Province-wide Hybrid Type 2 Implementation-effectiveness Trial","For intervention outcomes,\n\n\\- All patients who have received genome-wide sequencing in Ontario are eligible\n\nFor implementation outcomes,\n\n* All non-geneticist clinicians practicing in Ontario who have ordered genome-wide sequencing for their patients are eligible\n* Caregivers of patients who have had genome-wide sequencing through a non-geneticist clinician in Ontario are eligible, caregivers must be over 18 years of age","ALL",{"count":18,"type":19},100,"ESTIMATED","OBSERVATIONAL","Genomic sequencing (GS) is increasingly recommended as a diagnostic test for patients with suspected genetic disorders, but access often remains limited to those referred to medical geneticists. Enabling non-geneticist clinicians to access GS can expedite diagnoses for affected families and reduce burdens on the geneticist-led model of care. Targeted implementation strategies are needed to empower non-geneticist clinicians to access GS, however data to inform these strategies are lacking. To this end, the investigators have set out to carry out a prospective, hybrid implementation-effectiveness trial of mainstreamed clinical GWS in Ontario, Canada. The study team will evaluate the laboratory, clinical, patient and implementation outcomes of the mainstreamed model of care.",[23,24,25],"Evaluation of Mainstreamed Models of Genetic Service Delivery","Genetic Disease","Neurodevelomental Disorders",[27,28,29,30,31,32],"mainstreaming","rare disease","genome-wide sequencing","implementation","genomic sequencing","neurodevelopmental disease","NOT_YET_RECRUITING","2026-08-28",{"date":36,"type":37},"2026-09-02","ACTUAL",{"date":39,"type":19},"2026-09-01",{"date":41,"type":19},"2027-08-31",{"name":43,"class":44},"The Hospital for Sick Children","OTHER"]