[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"exercise-training\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:exercise-training":30},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,39,0,25,[9,53,82,114,141,167,202,236,263,294,337,363,391,423,460,488,504,532,557,590,614,645,668,702,730],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":21,"enrollmentInfo":22,"targetDuration":4,"studyType":25,"phases":26,"briefSummary":28,"conditions":29,"keywords":35,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100617408","adaptive-self-efficacy-based-ai-coaching-for-cycling-100617408",false,"NCT07318233","Adaptive Self-Efficacy-Based AI Coaching for Cycling","Adaptive Self-Efficacy-Based AI Coaching for Enhanced Indoor Cycling Performance: A Personalized Machine Learning Approach","AI","Inclusion Criteria:\n\n* Age 18-40 years\n\n  * Recreationally active\n  * Familiar with stationary cycling\n  * Able to complete 20 minutes of vigorous cycling\n\nExclusion Criteria:\n\n* Cardiovascular, metabolic, or respiratory conditions\n\n  * Medications affecting heart rate response\n  * Lower extremity injury within past 3 months\n  * Competitive cyclists (\\>10 hours cycling\u002Fweek)\n  * Pregnancy",true,"ALL","18 Years","40 Years",{"count":23,"type":24},120,"ESTIMATED","INTERVENTIONAL",[27],"NA","The primary objective of this study is to evaluate whether adaptive, AI-delivered personalized self-efficacy-based AI coaching based on real-time physiological and performance feedback enhance indoor cycling power output during a 20-minute time trial compared to static affirmations and exercise-only control conditions.",[30,31,32,33,34],"Exercise Training","Exercise Behavior","Exercise Adherence Challenges","Motivation for Physical Activity","Motivational Enhancement",[36,37,38,39],"Physical Activity","AI affirmations","just-in-time adaptive intervention","cycling","RECRUITING","2026-08-13",{"date":43,"type":44},"2026-08-17","ACTUAL",{"date":46,"type":44},"2026-05-15",{"date":48,"type":24},"2028-12-28",{"name":50,"class":51},"University of Miami","OTHER",1,{"id":54,"slug":55,"hasResults":12,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":25,"phases":63,"briefSummary":64,"conditions":65,"keywords":68,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":52},"100592108","effects-of-orthosis--exercise-on-spondylolisthesis-100592108","NCT06989138","Effects of Orthosis & Exercise on Spondylolisthesis","The Effect of Orthosis and Exercise Training on Pain, Physical Function and Quality of Life in Patients With Spondylolisthesis","Inclusion Criteria:\n\n* Individuals aged 18-65\n* Individuals without indication for surgery\n* Individuals diagnosed with grade 1-2 spondylolysis\n* Individuals without neurological deficits\n* Individuals diagnosed with radicular pain or non-specific chronic low back pain for more than 3 months\n\nExclusion Criteria:\n\n* Surgery recommended after diagnosis\n* History of lumbar surgery\n* Presence of rheumatic inflammatory diseases or diabetic polyneuropathy\n* Individuals with symptoms of cauda equina or ischemic heart disease\n* Presence of back pain with non-mechanical causes or non-radicular neuropathic pain\n* Having received this type of exercise therapy before","65 Years",{"count":62,"type":24},48,[27],"In the treatment of spondylolisthesis, conservative methods are initially preferred unless severe neurological symptoms are present; surgical treatment is only performed in refractory cases lasting at least 3-6 months. Conservative treatment consists of orthotic use, activity restriction, pain control, physiotherapy and exercise. Orthotics may promote healing by restricting movement; however, there are not enough studies on this subject. Exercise is the intervention with the highest level of evidence in chronic low back pain. The efficacy of stabilisation exercises in providing positive and long-lasting effects on pain and functional disability in patients with spondylolisthesis has been demonstrated. However, studies evaluating the effect of exercise on spinal stability and radiological findings are limited. Therefore, this study aims to compare the effects of stabilization and conventional exercises with orthosis on radiographic findings, pain, physical function and quality of life.",[66,67,30],"Spondylolisthesis","Orthosis",[66,67,69,70,71,72],"Exercise","Stabilization","Physical function","Kinesiophobia","2026-07-31",{"date":75,"type":44},"2026-08-03",{"date":77,"type":44},"2025-07-26",{"date":79,"type":24},"2027-02",{"name":81,"class":51},"Medipol University",{"id":83,"slug":84,"hasResults":12,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":88,"eligibilityCriteria":89,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":90,"targetDuration":4,"studyType":25,"phases":92,"briefSummary":93,"conditions":94,"keywords":99,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":52},"100648998","exercise-based-cardiac-rehabilitation-for-patients-with-heart-failure-with-preserved-ejection-fraction-empower-hfpef-100648998","NCT07727096","Exercise-Based Cardiac Rehabilitation for Patients With Heart Failure With Preserved Ejection Fraction (EMPOWER-HFpEF)","Effects of a Supervised Exercise Training Program on Clinical Outcomes, Functional Capacity, and Quality of Life in Patients With Heart Failure With Preserved Ejection Fraction (EMPOWER-HFpEF)","EMPOWER-HFpEF","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Diagnosis of heart failure with preserved ejection fraction (HFpEF) according to current clinical guidelines, defined by: a) signs and\u002For symptoms of heart failure; b) left ventricular ejection fraction ≥50%; c) elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP) (≥220 pg\u002FmL); and, d) objective evidence of structural and\u002For functional cardiac abnormalities consistent with HFpEF.\n* High-risk clinical profile, defined by at least one of the following: a) hospitalization for acute or worsening heart failure within the previous 120 days; b) outpatient worsening heart failure within the previous 120 days requiring emergency department evaluation or intensification of oral or intravenous diuretic therapy in a specialized heart failure clinic; c) recent diagnosis of symptomatic HFpEF (≤120 days) with New York Heart Association (NYHA) functional class II-III; or d) stable symptomatic HFpEF (NYHA class II-III) with at least two of the following comorbidities: hypertension, diabetes mellitus, obesity (body mass index ≥30 kg\u002Fm²), chronic kidney disease, dyslipidemia, obstructive sleep apnea, or stable coronary artery disease, together with elevated NT-proBNP (≥220 pg\u002FmL in patients in sinus rhythm or ≥600 pg\u002FmL in patients with atrial fibrillation).\n* Clinically stable at the time of enrollment, with no requirement for intravenous therapy or major changes in heart failure treatment during the previous 2 weeks.\n* Considered by the investigator to be able to participate in a structured exercise-based cardiac rehabilitation program safely.\n* Able and willing to provide written informed consent before any study-specific procedures.\n\nExclusion Criteria:\n\n* Inability to safely participate in a structured exercise-based cardiac rehabilitation program because of severe neurological or musculoskeletal disorders, significant cognitive impairment, or severe psychiatric illness that, in the opinion of the investigator, would interfere with study participation.\n* Clinically unstable heart failure at the time of enrollment, defined by the need for intravenous therapy, recent major changes in heart failure treatment, or ongoing heart failure decompensation.\n* Severe valvular heart disease considered to be the primary cause of the patient's symptoms.\n* Acute coronary syndrome, unstable angina, or coronary revascularization within the previous 2 weeks.\n* Uncontrolled hypertension, defined as resting systolic blood pressure ≥160 mmHg or diastolic blood pressure ≥100 mmHg, or resting heart rate ≥110 beats\u002Fmin despite guideline-directed medical therapy.\n* Severe primary pulmonary disease predominantly limiting functional capacity, including significant pulmonary hypertension, chronic thromboembolic pulmonary disease, or severe chronic obstructive pulmonary disease.\n* Primary cardiomyopathy or known infiltrative heart disease.\n* Severe non-cardiac comorbidity associated with an estimated life expectancy of less than 1 year, in the opinion of the investigator.\n* Inability to provide written informed consent or to comply with study procedures and follow-up requirements.",{"count":91,"type":24},390,[27],"Heart failure with preserved ejection fraction (HFpEF) is a common condition among older adults. It is associated with frequent hospitalizations, impaired functional capacity, reduced quality of life, and high healthcare utilization. Despite recent advances in pharmacological therapy, many patients continue to experience recurrent clinical deterioration and functional decline. Exercise-based cardiac rehabilitation has demonstrated benefits in improving physical performance and quality of life. Still, its effect on long-term clinical outcomes in patients with high-risk HFpEF has not been established.\n\nThe EMPOWER-HFpEF study is a multicenter, randomized, controlled trial designed to evaluate whether an early, individualized, multimodal exercise-based cardiac rehabilitation program improves clinical outcomes compared with usual care in patients with HFpEF. Eligible participants will be randomly assigned in a 1:1 ratio to receive either usual care alone or usual care plus a structured 12-month exercise-based cardiac rehabilitation program. The intervention includes an initial 6-month supervised phase, followed by a 6-month hybrid phase combining supervised sessions with structured home- or community-based exercise to promote long-term adherence and maintenance of physical activity.\n\nThe primary objective is to determine whether this rehabilitation strategy reduces adverse clinical outcomes, including all-cause mortality, heart failure hospitalizations, all-cause hospitalizations, and outpatient heart failure decompensation, while improving functional capacity and health-related quality of life over 12 months. The results of this study will provide evidence on the effectiveness of a long-term multimodal exercise-based cardiac rehabilitation program as part of the comprehensive management of patients with HFpEF.",[95,96,97,30,98],"HF - Heart Failure","HFpEF - Heart Failure With Preserved Ejection Fraction","Readmission Rates","Cardiac Rehab",[100,101,102,103],"Heart Failure with Preserved Ejection Fraction","Cardiac Rehabilitation","Quality of Life","Readmission","NOT_YET_RECRUITING","2026-07-22",{"date":107,"type":44},"2026-07-27",{"date":109,"type":24},"2026-09-01",{"date":111,"type":24},"2031-09-01",{"name":113,"class":51},"Fundación para la Investigación del Hospital Clínico de Valencia",{"id":115,"slug":116,"hasResults":12,"nctId":117,"briefTitle":118,"officialTitle":118,"acronym":119,"eligibilityCriteria":120,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":121,"enrollmentInfo":122,"targetDuration":4,"studyType":25,"phases":124,"briefSummary":125,"conditions":126,"keywords":130,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":135,"startDateStruct":136,"completionDateStruct":137,"leadSponsor":139,"locationsCount":52},"100648930","the-effect-of-olive-leaf-extract-supplementation-on-training-induced-skeletal-muscle-functional-and-molecular-adaptations-in-healthy-volunteers-100648930","NCT07729072","The Effect of Olive Leaf Extract Supplementation on Training-induced Skeletal Muscle Functional and Molecular Adaptations in Healthy Volunteers","OLE_Training_1","Inclusion Criteria:\n\n1. Being between 18 and 45 years old\n2. Being healthy (assessed through the PAR-Q questionnaire).\n3. Being physically active, but not involved in any structured training program\n4. Being available for the study period.\n\nExclusion Criteria:\n\n1. If a participant answers positively to any YES\u002FNO question in the PAR-Q health questionnaire. For questions requiring a precision, any positive answer will be reviewed by a medical doctor, who will determine the inclusion\u002Fexclusion of the participant.\n2. Having allergy to xylocaine\n3. Being pregnant.","45 Years",{"count":123,"type":24},60,[27],"The goal of this study is to investigate the effect of combining olive leaf extract supplementation with endurance training (moderate intensity continuous training or sprint interval training). We hypothesize that OLE supplementation during training, as compared to training alone with placebo, will translate into better performance outcomes. More specifically, we hypothesize that the additional benefits of OLE supplementation on performance will be mediated by improved mitochondrial characteristics in skeletal muscle and increased neural activation.",[127,30,128,129],"Healthy Adult Participants","Neuromuscular Adaptations","Nutritional Intervention",[131,132,133,134],"exercise","mitochondria","knee extensors","performance",{"date":107,"type":44},{"date":109,"type":24},{"date":138,"type":24},"2029-12-31",{"name":140,"class":51},"University of Lausanne",{"id":142,"slug":143,"hasResults":12,"nctId":144,"briefTitle":145,"officialTitle":146,"acronym":147,"eligibilityCriteria":148,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":60,"enrollmentInfo":149,"targetDuration":4,"studyType":25,"phases":151,"briefSummary":152,"conditions":153,"keywords":156,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":52},"100648073","home-based-high-intensity-interval-training-in-systemic-lupus-erythematosus-100648073","NCT07716462","Home-Based High-Intensity Interval Training in Systemic Lupus Erythematosus","Exercise and Muscle Biology in Systemic Lupus Erythematosus","MIGHT-SLE","Inclusion Criteria:\n\n* Age 18 to 65 years.\n* Diagnosis of systemic lupus erythematosus according to the 2019 European Alliance of Associations for Rheumatology\u002FAmerican College of Rheumatology classification criteria.\n* Stable, non-organ-threatening systemic lupus erythematosus, defined as a Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) score of 6 or less at screening, with no active renal or central nervous system involvement.\n* Stable background lupus therapy, defined as no initiation of a new disease-modifying antirheumatic drug or biologic therapy and no change in the dose of immunosuppressive therapy within 8 weeks before enrollment.\n* Persistent fatigue and\u002For muscle pain, with a PROMIS Fatigue T-score of 55 or greater.\n* Stable prednisone dose, or equivalent glucocorticoid dose, of 5 mg per day or less for at least 12 weeks before enrollment.\n* Able to safely participate in a moderate-intensity exercise program.\n* Able and willing to provide informed consent.\n* Able and willing to comply with the home-based exercise protocol and study procedures.\n\nExclusion Criteria:\n\n* Prednisone dose greater than 5 mg per day, or receipt of a glucocorticoid burst within 8 weeks before enrollment.\n* Pregnancy.\n* Severe anemia, defined as hemoglobin less than 10 g\u002FdL.\n* Uncontrolled hypothyroidism.\n* Severe systemic lupus erythematosus disease activity, defined as a SLEDAI-2K score greater than 8.\n* End-stage kidney disease requiring renal replacement therapy or estimated glomerular filtration rate less than 30 mL\u002Fmin\u002F1.73 m².\n* Uncontrolled hypertension, defined as blood pressure greater than 160\u002F100 mmHg.\n* Decompensated heart failure.\n* Unstable pulmonary disease.\n* Neurologic condition that limits exercise performance.\n* Uncontrolled diabetes mellitus.\n* Severe osteoarthritis that limits safe participation in the exercise intervention.\n* Overlap autoimmune disease, including inflammatory myopathy, mixed connective tissue disease, or systemic sclerosis.\n* History of solid-organ or bone marrow transplantation.\n* Any contraindication to magnetic resonance imaging.\n* Inability to fit safely on the magnetic resonance imaging scanner bed.\n* Myocardial infarction or cerebrovascular event within the previous 3 months.\n* Serious hemorrhage, including cerebral hemorrhage, within the previous 12 months.\n* Acute infectious illness within 1 month before enrollment.\n* Inability to provide informed consent.\n* Inability to adhere to the home-based exercise protocol.\n* Current participation in a structured exercise program.",{"count":150,"type":24},20,[27],"Systemic lupus erythematosus, or SLE, is a chronic autoimmune disease that can cause persistent fatigue, muscle pain, reduced physical function, and impaired quality of life, even when the disease is otherwise clinically stable. The biological mechanisms contributing to these symptoms are not fully understood. Abnormal energy production within skeletal muscle and increased fat accumulation within the muscle may contribute to fatigue and reduced physical performance in people with SLE.\n\nThis pilot study will evaluate the effects of a 16-week personalized, home-based exercise program in 20 adults with stable SLE and clinically significant fatigue. The program will include three exercise sessions per week: bodyweight high-intensity interval training, strength training, and walking-based interval training. Sessions will be adapted to each participant's fitness, mobility, symptoms, and exercise tolerance. Some sessions will be supervised remotely by video, while others will be completed independently using personalized recorded instructions.\n\nParticipants will undergo assessments before and after the 16-week program. These assessments will examine skeletal muscle mitochondrial function, fat accumulation within the thigh muscles, physical performance, fatigue, quality of life, and blood-based markers of mitochondrial function and inflammation.\n\nThe study will help determine whether a personalized home-based exercise program can improve muscle health and physical function in people with SLE and will provide information needed to design larger future studies.",[154,155,30],"Systemic Lupus Erthematosus","Fatigue",[157,155,69],"SLE","2026-07-16",{"date":160,"type":44},"2026-07-21",{"date":162,"type":24},"2026-10-01",{"date":164,"type":24},"2027-12",{"name":166,"class":51},"University of Alabama at Birmingham",{"id":168,"slug":169,"hasResults":12,"nctId":170,"briefTitle":171,"officialTitle":172,"acronym":4,"eligibilityCriteria":173,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":174,"enrollmentInfo":175,"targetDuration":4,"studyType":25,"phases":177,"briefSummary":178,"conditions":179,"keywords":185,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":194,"lastUpdatePostDateStruct":195,"startDateStruct":196,"completionDateStruct":198,"leadSponsor":200,"locationsCount":52},"100648165","comparison-between-eccentric-hamstring-training-and-sprint-specific-training-100648165","NCT07716319","Comparison Between Eccentric Hamstring Training and Sprint-Specific Training","Comparison Between Eccentric Hamstring Strength Training and Sprint-Specific Training on Muscle Hypertrophy, Strength, Power, and Sprint Performance in Club Sport Collegiate Athletes","Inclusion Criteria:\n\n* Age 18-25 years\n* Actively participating in a club team\n* \\>6 months experience with resistance training\n* Minimum of 1 year experience at the high school level in organized team sport\n* No history of hamstring injury within the last 6 months\n* No history of major lower extremity surgery (including back)\n* No acute musculoskeletal injury to the lower extremity\n* Not currently pregnant\n\nExclusion Criteria:\n\n* Unable to refrain from resistance training outside the study\n* Unable to make at least 80% of the training sessions\n* Hamstring injury in the last 6 months\n* History of major lower extremity surgery (including back)\n* Acute musculoskeletal injury to the lower extremity\n* Currently pregnant","25 Years",{"count":176,"type":24},90,[27],"The purpose of this study is to compare the effects of an intensity-, volume-, and time under tension-matched eccentric hamstring exercise intervention with the Romanian deadlift (RDL) and the Nordic hamstring exercise (NHE) to a sprint-specific training program on hamstring muscle architecture, volume, sprint performance, strength, and power.\n\nParticipants will be assigned to complete one of the 3 hamstring interventions for 10 weeks.",[180,181,30,182,183,184],"Healthy Adult","Athlete","Sport","Running","Ultrasound Imaging",[186,187,188,189,190,191,192,193],"strength","agility","sprint","hypertrophy","countermovement jump","fascicle length","hamstring","range of motion","2026-07-15",{"date":160,"type":44},{"date":197,"type":24},"2026-09",{"date":199,"type":24},"2027-09",{"name":201,"class":51},"University of Wisconsin, Madison",{"id":203,"slug":204,"hasResults":12,"nctId":205,"briefTitle":206,"officialTitle":207,"acronym":4,"eligibilityCriteria":208,"healthyVolunteers":12,"sex":19,"minAge":174,"maxAge":209,"enrollmentInfo":210,"targetDuration":4,"studyType":25,"phases":211,"briefSummary":212,"conditions":213,"keywords":218,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":194,"lastUpdatePostDateStruct":228,"startDateStruct":230,"completionDateStruct":232,"leadSponsor":234,"locationsCount":52},"100647585","effects-of-policosanol-and-exercise-on-fitness-and-lipids-in-people-with-elevated-blood-lipids-100647585","NCT07710261","Effects of Policosanol and Exercise on Fitness and Lipids in People With Elevated Blood Lipids","Effect of Policosanol Supplementation Combined With Concurrent Exercise Training on Physical Fitness and Lipid Profiles in Healthy Volunteers With Elevated Blood Lipid But Not Required Medical Treatment","Inclusion Criteria:\n\n* Men and women aged 25 to 59 years.\n* BMI between 18.5 and 29.9 kg\u002Fm².\n* Diagnosed with or presenting with dyslipidemia within the past 3 months, based on laboratory assessment at baseline or a standard laboratory report issued within the past 3 months, according to the National Cholesterol Education Program Adult Treatment Panel III criteria, defined by at least one of the following:\n* Total cholesterol ≥ 200 mg\u002FdL;\n* Low-density lipoprotein cholesterol ≥ 130 mg\u002FdL and \\\u003C 190 mg\u002FdL;\n* High-density lipoprotein cholesterol \\\u003C 40 mg\u002FdL in men;\n* High-density lipoprotein cholesterol \\\u003C 50 mg\u002FdL in women;\n* Triglycerides ≥ 150 mg\u002FdL.\n* Free from chronic or comorbid conditions that contraindicate participation in aerobic or resistance exercise.\n* Cleared for physical activity based on the Physical Activity Readiness Questionnaire for Everyone.\n* Not regularly physically active during the preceding 3 months, defined as fewer than 3 exercise sessions per week or less than 150 minutes of exercise per week.\n* Able and willing to participate in the study procedures and provide written informed consent.\n\nExclusion Criteria:\n\n* Current or recent use within the past 3 months of lipid-lowering medications or dietary supplements known to influence lipid metabolism, including statins, fibrates, niacin, omega-3 fatty acids, red yeast rice, or policosanol.\n* Known allergy or hypersensitivity to policosanol, sugarcane derivatives, capsule components, or any excipients in the supplement formulation.\n* Presence of chronic or comorbid conditions that may make exercise participation unsafe, including but not limited to cardiovascular disease, chronic obstructive pulmonary disease, severe arthritis, osteoporosis, uncontrolled diabetes, gastrointestinal disorders, or neurological impairments affecting movement control.\n* High-risk lifestyle factors, including heavy smoking, excessive alcohol consumption, or use of recreational drugs.\n\nInability to comply with the study protocol, including inability to participate in the exercise program when assigned or inability to attend scheduled follow-up assessments.\n\n\\- Refusal or inability to provide written informed consent independently.","59 Years",{"count":23,"type":24},[27],"This study will evaluate the effects of policosanol supplementation, concurrent exercise training, and their combination on physical fitness, muscle recovery, inflammatory markers, and blood lipid profiles in adults with elevated blood lipids who are not currently indicated for lipid-lowering medication.\n\nParticipants will be randomly assigned to one of four groups for 12 weeks: policosanol plus exercise training, policosanol alone, placebo plus exercise training, or placebo without structured exercise training. Participants assigned to the supplementation groups will take policosanol 5 mg per day, while those assigned to the placebo groups will take a matching placebo. Participants assigned to the exercise groups will complete a standardized concurrent exercise training program combining aerobic and resistance exercise.\n\nThe study will compare changes in physical fitness, lipid profiles, and selected blood biomarkers before and after the intervention. The findings may help determine whether low-dose policosanol, alone or combined with exercise training, can support cardiometabolic health and physical fitness in adults with dyslipidemia.",[214,215,216,30,217],"Dyslipidemia","Elevated Blood Lipids","Physical Fitness","Muscle Function, Handgrip Strength Test",[219,220,221,222,223,224,225,226,216,214,227],"Policosanol","Octacosanol","Dietary Supplement","Concurrent Exercise Training","Aerobic Exercise","Resistance Exercise","Blood Lipid Profile","Muscle Function","Nutraceutical",{"date":229,"type":44},"2026-07-17",{"date":231,"type":24},"2026-06-22",{"date":233,"type":24},"2027-01-29",{"name":235,"class":51},"Mahidol University",{"id":237,"slug":238,"hasResults":12,"nctId":239,"briefTitle":240,"officialTitle":241,"acronym":242,"eligibilityCriteria":243,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":244,"targetDuration":4,"studyType":25,"phases":246,"briefSummary":247,"conditions":248,"keywords":250,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":255,"lastUpdatePostDateStruct":256,"startDateStruct":257,"completionDateStruct":259,"leadSponsor":261,"locationsCount":4},"100647069","a-behavioral-digital-intervention-for-parkinsons-disease-100647069","NCT07705620","A Behavioral Digital Intervention For Parkinson's Disease","A Behavioral Digital Intervention For Parkinson's Disease: Protocol For A Quasi-Experimental Study Examining Feasibility, Physical Activity, And Exploratory Patient-Reported Outcomes","MOVE ON UP","Inclusion Criteria:\n\n* Diagnosis of idiopathic Parkinson's disease (self-reported; verification requested from treating physician or neurologist when possible)\n* Hoehn and Yahr stages I-IV (mild to moderate disease severity; ambulatory with or without assistance)\n* Age 18 years or older\n* Access to a computer, tablet, or smartphone with reliable internet connection\n* Basic digital literacy to navigate the study website (caregiver assistance permitted if needed)\n* Ability to communicate with study personnel in the local language (Portuguese, Greek, Croatian, or Italian) to understand instructions and provide informed consent\n* Willingness and ability to provide written informed consent electronically prior to enrolment\n* For those completing remote assessments, willingness to complete self-assessments with or without caregiver assistance following provided video instructions\n\nExclusion Criteria:\n\n* Self-reported severe cognitive impairment that would preclude understanding and following exercise instructions, based on clinical judgment of referring provider or study coordinator following screening conversation\n* Significant active psychiatric problems (e.g., untreated major depression, psychosis, substance abuse) that would interfere with participation or adherence\n* Medical conditions contraindicating moderate-intensity exercise, including:\n\nUnstable cardiovascular disease (uncontrolled hypertension, recent myocardial infarction, unstable angina) Severe orthopedic limitations (acute fractures, severe osteoarthritis limiting mobility) Other systemic conditions that would make participation unsafe as determined by the participant's physician or study coordinator during screening\n\n* Pregnancy\n* Anticipated inability to complete the 8-week intervention period due to planned surgery, extended travel, or other commitments\n\nParticipants with a caregiver willing to assist with technology, assessments, or exercise supervision are not excluded; caregiver involvement will be documented and considered in exploratory analyses where appropriate.",{"count":245,"type":24},68,[27],"The goal of this interventional, quasi-experimental study is to evaluate whether a digital dual-task exercise and behavioral program can improve physical activity and influence patient-reported outcomes in people with Parkinson's disease.\n\nThe main questions it aims to answer are:\n\n1. Is the MOVE ON UP digital intervention feasible and acceptable, based on recruitment, retention, adherence, and safety?\n2. Does participation in the program lead to increased physical activity levels?\n3. Does the intervention produce exploratory improvements in patient-reported outcomes such as motor symptoms, balance confidence, and quality of life?\n\nBecause the study includes a comparison group, researchers will compare participants receiving the MOVE ON UP digital intervention with participants receiving usual care to determine whether the digital program produces measurable behavioral and functional changes.\n\nParticipants will:\n\n1. Complete baseline and post-intervention assessments of physical activity and patient-reported outcomes.\n2. Engage in an 8-week digital dual-task exercise program, including:\n\n   2.1 Structured dual-task exercise sessions delivered digitally. 2.2 Educational content related to Parkinson's disease and physical activity. 2.3 Behavioral support elements informed by the COM-B model.\n3. Use the digital platform to follow the program and complete follow-up questionnaires.",[249,30],"Parkinson Disease",[251,252,253,69,254],"Parkinson's Disease","Dual-Task Training","Digital Health","Behavioral Intervention","2026-07-14",{"date":158,"type":44},{"date":258,"type":24},"2026-11-02",{"date":260,"type":24},"2027-07-30",{"name":262,"class":51},"Egas Moniz - Cooperativa de Ensino Superior, CRL",{"id":264,"slug":265,"hasResults":12,"nctId":266,"briefTitle":267,"officialTitle":268,"acronym":4,"eligibilityCriteria":269,"healthyVolunteers":12,"sex":19,"minAge":121,"maxAge":60,"enrollmentInfo":270,"targetDuration":4,"studyType":25,"phases":272,"briefSummary":273,"conditions":274,"keywords":279,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":285,"lastUpdatePostDateStruct":286,"startDateStruct":288,"completionDateStruct":290,"leadSponsor":292,"locationsCount":52},"100627161","effects-of-mobilization-using-a-powered-lower-limb-exoskeleton-with-prolonged-mechanical-ventilation-100627161","NCT07445035","Effects of Mobilization Using a Powered Lower-limb Exoskeleton With Prolonged Mechanical Ventilation","Physiological and Functional Adaptations Associated With Robot-assisted Lower-limb Activity in Ventilator-dependent Hospitalized Patients","Inclusion Criteria:\n\n* Able to maintain a seated position for at least 1 minute.\n* The participant or their legal representative is able to sign the informed consent form.\n\nExclusion Criteria:\n\n* Inability to follow instructions.\n* Intubation\u002Ftracheostomy prior to current admission.\n* Diagnosis of severe left heart failure.\n* Diagnosis of neuromuscular disorders.\n* Unable to stand.\n* Complete paralysis of the lower extremities.\n* Presence of unhealed ulcers in the lower extremities.\n* Deep vein thrombosis of the lower extremities.\n* Lower-limb amputation.\n* Severe hypertension\n* Severe cardiac conditions\n* Severe bilateral joint disorders\n* Severe pain while standing\n* Severe osteoporosis\n* Lower-limb fracture\n* Ongoing epileptic seizure",{"count":271,"type":24},30,[27],"This study aims to evaluate the effects of powered lower-limb exoskeleton-assisted training on lower limb strength, respiratory parameters, 28-day ventilator-free days, and length of hospital stay in patients with prolonged mechanical ventilation admitted to a Respiratory Care Center. The goal is to provide clinical evidence for integrating rehabilitation and respiratory care in this patient population.",[275,276,277,278,30],"Prolonged Mechanical Ventilation","Ventilator Weaning","Ventilator Dependent","Exoskeleton Device",[280,281,282,283,284],"prolonged mechanical ventilation","ventilator weaning","lower limb muscle strengthening","exoskeleton robot","exercise training","2026-06-29",{"date":287,"type":44},"2026-07-01",{"date":289,"type":44},"2026-06-26",{"date":291,"type":24},"2026-12-31",{"name":293,"class":51},"Fu Jen Catholic University",{"id":295,"slug":296,"hasResults":12,"nctId":297,"briefTitle":298,"officialTitle":299,"acronym":4,"eligibilityCriteria":300,"healthyVolunteers":18,"sex":19,"minAge":301,"maxAge":4,"enrollmentInfo":302,"targetDuration":4,"studyType":25,"phases":304,"briefSummary":305,"conditions":306,"keywords":319,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":326,"lastUpdatePostDateStruct":327,"startDateStruct":329,"completionDateStruct":331,"leadSponsor":333,"locationsCount":336},"100644951","the-impact-of-enhanced-music--natural-visuals-on-emotional-health-100644951","NCT07676110","The Impact of Enhanced Music & Natural Visuals on Emotional Health","Impacts of Music, Audio Enhancements, Audio Guidance, and Visuals on Physical and Emotional Well-being. (Emotional Health - Longitudinal 1 Randomized, Controlled Multi-center Study)","Inclusion Criteria:\n\n* You are 13 years of age or older\n* You can read, write, and speak English at a 5th-grade level or higher\n* You are legally capable of providing informed consent (adult participants) or capable of providing assent (child participants)\n* To the best of your knowledge, you are willing and able to commit to the session(s) and activities of this study\n* You are willing and able to use the sound-delivery and data-collection apparatus of this study\n* You are willing to use your own personal equipment. Depending on the study, you may need to have your own ear buds\u002Fheadphones and\u002For a \"smart\" device with internet and\u002For Bluetooth access (e.g., smartphone, iPad).\n* You have normal hearing in both ears.\n* You never experience ringing noises or buzzing sensations in your ears (tinnitus)\n* You do not use a heart\u002Fcardiac pacemaker and do not have any history of cardiac rhythm disturbances, such as cardiac conduction delays or blocks\n* You have no known history of fainting, fainting, spells or seizures, spinning sensations, or trouble with balance (medical terms include epilepsy, seizures, syncope, vertigo, nystagmus)\n* You do not use of any of the following medications: Beta blockers, steroids, ephedrine, acute anti-anxiety medication (e.g., benzodiazepines such as diazepam\u002FValium, lorazepam\u002FAtivan or clonazepam\u002FKlonopin), or acute or chronic pain medications (including narcotics and codeine)\n* For any study session, you will not be under the influence of any substances that could prevent safe participation and will not have consumed e.g., alcohol, THC, Psilocybin, or other mood-altering drugs in the 12 hours preceding the session.\n\nExclusion Criteria:\n\n\\-","13 Years",{"count":303,"type":24},200,[27],"The investigators are conducting research on factors related to the self-regulation of mood and arousal states across a range of everyday activities as well as different levels of stress. Behavioral interventions-such as meditation, listening to music, or visualizing art or nature-offer important alternatives and\u002For adjunctive strategies to pharmaceutical tools or other mechanisms supporting physical and emotional well-being. This research will expand on the knowledge base regarding the impact of biophysical stimulation and\u002For frame of mind on an individual's self-directed management of physical and emotional health. Motivation, confidence, and composure are critical aspects of self-efficacy, framing a person's mindset to make healthy choices across daily activities.\n\nThe research in this protocol is carried out across multiple sites and studies by means of digital tools and a consistent participant experience workflow. Together, these resources are intended to support individuals across multiple self-directed experiences utilized in the maintenance of their basic health. Before, during, and after session experiences, the participant provides objective (physiological) responses and\u002For subjective (self-report) responses and reflections; some studies also include interviews or focus groups. The combined set of responses can be summarized, connected to other measures, and input to machine learning models to improve personalization of stimuli. By studying the effects of soundBrilliance experiences across a variety of contexts and participant samples, the investigators can better refine each element of the stimulus to improve satisfaction, tolerance, and targeted outcomes.",[307,308,309,310,311,30,312,313,314,315,316,317,318],"Emotion Management Skills","Lifestyle, Healthy","Lifestyle Intervention","Recovery","Exercise and Recovery","Anxiety and Mood Disorders","Sleep","Motivation","Comfort","Pain Management","Rehabilitation","Creativity and Mindfulness",[320,321,322,323,324,325],"Music","Visuals","Visual Imagery","Biophysical Stimuli","Emotional Health","Emotional Management","2026-06-23",{"date":328,"type":44},"2026-06-30",{"date":330,"type":44},"2026-05-25",{"date":332,"type":24},"2027-06",{"name":334,"class":335},"soundBrilliance LLC","INDUSTRY",3,{"id":338,"slug":339,"hasResults":12,"nctId":340,"briefTitle":341,"officialTitle":342,"acronym":4,"eligibilityCriteria":343,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":344,"enrollmentInfo":345,"targetDuration":4,"studyType":25,"phases":347,"briefSummary":348,"conditions":349,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":354,"lastUpdatePostDateStruct":355,"startDateStruct":357,"completionDateStruct":359,"leadSponsor":361,"locationsCount":52},"100642769","acute-effects-of-visual-feedback-assisted-inspiratory-muscle-training-after-lobectomy-100642769","NCT07646288","Acute Effects of Visual Feedback-Assisted Inspiratory Muscle Training After Lobectomy","Evaluation of the Acute Effects of Respiratory Muscle Strength Training With Visual Feedback in Lung Cancer Patients Undergoing Lobectomy","Inclusion Criteria:\n\n* Volunteering to participate in the study,\n* Being clinically stable,\n* Being a lung cancer patient scheduled for lobectomy,\n* Being between 18 and 75 years of age,\n* Being able to cooperate with the tests to be performed.\n\nExclusion Criteria:\n\n* Presence of any orthopedic or neurological problem that prevents walking,\n* History of any surgery involving the thoracic wall,\n* Having diseases that may affect respiratory parameters, such as severe heart failure or severe chronic obstructive pulmonary disease (COPD).","75 Years",{"count":346,"type":24},40,[27],"This study aims to evaluate the acute effects of inspiratory muscle training performed with and without a mobile application providing visual feedback on exercise motivation, patient adherence, dyspnea perception, usability, and patient satisfaction in lung cancer patients undergoing lobectomy via video-assisted thoracic surgery. Participants will perform conventional inspiratory muscle training without visual feedback in the morning on postoperative day 1 after transfer to the ward. After at least two hours of rest, the same exercise protocol will be repeated with a smart adaptor connected to a mobile application to provide visual feedback. Inspiratory muscle training will be performed using a threshold-loading device at 40% of maximal inspiratory pressure, with three sets of ten breaths. Outcomes will be assessed before and\u002For after each session as appropriate.",[350,351,30,352,353],"VATS","Respiratory Muscles","Lung Cancer (NSCLC)","Lobectomy","2026-06-11",{"date":356,"type":44},"2026-06-15",{"date":358,"type":44},"2025-12-01",{"date":360,"type":24},"2027-03-01",{"name":362,"class":51},"Hacettepe University",{"id":364,"slug":365,"hasResults":12,"nctId":366,"briefTitle":367,"officialTitle":367,"acronym":368,"eligibilityCriteria":369,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":344,"enrollmentInfo":370,"targetDuration":4,"studyType":25,"phases":372,"briefSummary":373,"conditions":374,"keywords":378,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":382,"lastUpdatePostDateStruct":383,"startDateStruct":385,"completionDateStruct":387,"leadSponsor":389,"locationsCount":52},"100613469","exercise-and-the-immune-response-in-lung-cancer-100613469","NCT07267000","EXERCISE AND THE IMMUNE RESPONSE IN LUNG CANCER","ImmuEX","Inclusion Criteria:\n\n* Patients suffering from non-small cell or small-cell lung cancer of any histologic subtype, irrespective of routine treatment regimen\n* ECOG 0 or 1\n\nExclusion Criteria:\n\n* Kachexia (BMI\\\u003C18.5)\n* instable bone metastases\n* orthopedic condition rendering the patient unable to ride a stationary bike\n* any medical contraindication for exercise and training\n* a living will against basic or advanced life support",{"count":371,"type":24},50,[27],"This project is about the effect of a 12-week training therapy intervention in patients suffering from non-small cell and small-cell lung cancer. It has widely been accepted that exercise is preventive against certain types of cancer. Individuals following an active lifestyle have a significantly lower risk for several chronic diseases, including cancer, as compared to sedentary ones. However, evidence is still lacking for exercise as part of routine cancer treatment. It has widely been accepted that exercise strongly impacts immune response, and might influence antitumor immune response as well. In this study, patients suffering from lung cancer undergo either a 12-week training program consisting of moderate-intensity continuous exercise (MICE), or a 12-week program with high-intensity interval exercise. Both groups will be compared to a control group receiving standard exercise recommendations. The immunologic response, i.e. cytokine profiles and changes in peripheral blood mononuclear cell (PBMC) characteristics will be the main endpoint. Blood will be taken from the patients at different timepoints, and blood samples will be tested for these immunologic changes. FACS analysis will be used to assess the properties of immune cells and potential changes upon the exercise regimen. Mitochondrial function will be assessed via the Seahorse machine, and mass spectrometry (lipidomics) will be used for the analysis of lipid profile changes.",[375,30,376,377],"Non-Small Cell Lung Cancer","Immunotherapy","Small Cell Cancer Of The Lung",[379,69,376,380,381],"Non-small cell lung cancer","Outcome","Small-cell lung cancer","2026-06-08",{"date":384,"type":44},"2026-06-09",{"date":386,"type":44},"2026-04-01",{"date":388,"type":24},"2029-05-01",{"name":390,"class":51},"Medical University of Graz",{"id":392,"slug":393,"hasResults":12,"nctId":394,"briefTitle":395,"officialTitle":395,"acronym":396,"eligibilityCriteria":397,"healthyVolunteers":18,"sex":398,"minAge":21,"maxAge":4,"enrollmentInfo":399,"targetDuration":4,"studyType":25,"phases":400,"briefSummary":401,"conditions":402,"keywords":404,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":414,"lastUpdatePostDateStruct":415,"startDateStruct":417,"completionDateStruct":419,"leadSponsor":421,"locationsCount":52},"100639209","effects-of-estrogen-on-muscle-gain-during-12-weeks-of-exercise-in-post-menopausal-women-100639209","NCT07617454","Effects of Estrogen on Muscle Gain During 12-weeks of Exercise in Post-menopausal Women","HER-MUSCLE","Inclusion Criteria:\n\n* 1-10 years since last menstrual bleeding\n* Age \\> 40 years old\n* BMI 20-30\n\nExclusion Criteria:\n\n* Follicular stimulating hormone \\\u003C 30 mmol\u002FL\n* Systematic strength training during the last year (\\> 1 strength training session per week)\n* Injuries to the legs which may prevent participation in the physical training program\n* Magnetizable metals or electrical devices implanted in the body, such as a pacemaker\n* Use of medication that can influence the effect of immobilization and\u002For training\n* Muscular or joint disorders which may affect the results\n* Metabolic diseases (such as diabetes and cardiovascular diseases)\n* Previous or present liver or cancer disease\n* Current or previous thrombosis\n* Porphyria\n* Epilepsia\n* Systemic autoimmune disease\n* Edema\n* Smoking or use of other nicotine containing products\n* Claustrophobia\n* Addictive behavior, defined as abuse of cannabis, opioids, or other intoxicating substances.\n* Lack of ability to cooperate\n* Blood parameters out of normal range at the health check\n* Blood pressure above 140\u002F90 mmHg","FEMALE",{"count":271,"type":24},[27],"As females age and transition through menopause, the decline in oestrogen level profoundly affects skeletal muscle mass and function. HER-MUSCLE aims to unravel the mechanisms by which oestrogen enhances muscle growth, providing insights for targeted therapies to improve the health and physical function of postmenopausal females.\n\nFocusing on postmenopausal females, an increasingly at-risk demographic, HER-MUSCLE addresses a critical gap in understanding how oestrogen influences muscle mass and function during anabolic (exercise) conditions.\n\nThe project involves:\n\n1. Clinical Trial: Postmenopausal females will receive either oestrogen or placebo, twelve weeks of exercise training to detect oestrogen regulatory role on muscle mass and function.\n2. Molecular Analysis: Advanced techniques will study the muscle microenvironment, focusing on muscle stem cells (MuSCs), fibro-adipogenic progenitors (FAPs), and other cells critical for muscle regeneration and maintenance.\n3. Mitochondrial Function assessed in vivo via magnetic resonance spectroscopy: The impact of oestrogen on mitochondrial health will be examined, exploring how it preserves mitochondrial function and ability to recovery and resist fatigue in response to muscle contractions.\n\nOur preliminary data indicate that oestrogen can promote muscle protein synthesis. HER-MUSCLE aims to pave the way for novel therapeutic strategies to manage sarcopenia in postmenopausal women, ultimately leading to better health outcomes and enhanced well-being for this growing population segment.",[403,30],"Menopause Related Conditions",[405,406,407,408,409,410,411,412,413],"Physical exercise","Strength training","Cardiovascular training","Muscle hypertrophy","Estrogen","Mitochondria function","Muscle strength","Menopause","Muscle mass","2026-05-23",{"date":416,"type":44},"2026-06-01",{"date":418,"type":44},"2026-02-01",{"date":420,"type":24},"2027-08-01",{"name":422,"class":51},"Mette Hansen",{"id":424,"slug":425,"hasResults":12,"nctId":426,"briefTitle":427,"officialTitle":428,"acronym":429,"eligibilityCriteria":430,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":431,"targetDuration":4,"studyType":25,"phases":433,"briefSummary":434,"conditions":435,"keywords":447,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":450,"lastUpdatePostDateStruct":451,"startDateStruct":453,"completionDateStruct":455,"leadSponsor":457,"locationsCount":459},"100640479","reaction-vad-trial-remote-exercise-training-via-telemedicine-in-patients-with-long-term-ventricular-assist-devices-100640479","NCT07611188","REACTION-VAD Trial: Remote Exercise Training Via Telemedicine in Patients With Long-Term Ventricular Assist Devices","Efficacy and Safety of a Remote Conditioning Program in Patients Supported With a Ventricular Assist Device: THE RE-ACTION-VAD TRIAL.","REACTION-VAD","Inclusion Criteria (must meet all):\n\n* Recent LVAD Implantation (\\\u003C6 months)\n* Clinical stability (defined as meeting all of the following criteria): discharge from the LVAD implantation hospitalization, absence of inotropic medication, hemoglobin \\>9 g\u002FdL, and no active infection.\n* Inability to participate in a supervised rehabilitation program (due to lack of availability, or inability because geographical reasons).\n\nExclusion Criteria (any):\n\n* Functional Inability to Perform Cardiopulmonary Exercise Testing\n* Prior Participation in a Supervised Rehabilitation Program (after the LVAD implantation)",{"count":432,"type":24},78,[27],"Current international guidelines recommend that patients with a heart pump (left ventricular assist device, LVAD) participate in supervised exercise cardiac rehabilitation programs. However, not all patients with a heart pump are able to attend to a supervised program on a daily basis.\n\nThe goal of this clinical trial is to determine whether a home-based exercise program helps patients with a heart pump improve their exercise capacity and quality of life, guided by telemedicine tools including a mobile app, smartwatch, and remote medical checkups. The study will also provide information about the safety of this program by monitoring for any issues or symptoms during home activity.\n\nThe trial aims to answer the following questions:\n\n* Does a 12-week remote exercise program improve patients' exercise capacity? This will be measured using the 6-minute walk test and a cardiopulmonary exercise test.\n* Is it safe for patients to follow this exercise plan at home while being monitored through a mobile app and smartwatch?\n* Does the program improve quality of life and reduce feelings of anxiety or depression? This will be assessed using widely validated questionnaires, such as the Kansas City Cardiomyopathy Questionnaire.\n\nResearchers will compare the remote exercise program to standard care, which usually does not include exercise for patients who are unable to attend the hospital daily.\n\nParticipants will:\n\n* Join the study voluntarily after signing a consent form.\n* Be randomly assigned, with a 50% chance of being in either the exercise group (following a structured plan with a mobile app) or the usual care group (receiving general written advice), to see which approach works best for recovery.\n* Follow a 12-week home-based routine if in the exercise group, including warm-up routine, walking or cycling, respiratory exercises, and light strength training, all supported by the mobile app, smartwatch, and professional monitoring.\n* Visit the hospital three times over six months for medical checkups, including walking and exercise tests, blood analyses, and questionnaires about physical and emotional health.",[436,437,438,439,101,440,441,442,30,443,444,445,102,446],"Heart Failure","Advanced Heart Failure","Left Ventricular Assist Device","LVAD","Telemedicine","Remote Exercise","Ventricular Assist Device","Conditioning Therapy","Cardiopulmonary Exercise Test","Six Minute Walk Test","Telerehabilitation",[438,437,436,101,448,440,449,102,444,446],"Remote rehabilitation","6 minute walking test","2026-05-20",{"date":452,"type":44},"2026-05-28",{"date":454,"type":24},"2026-05",{"date":456,"type":24},"2030-12",{"name":458,"class":51},"Puerta de Hierro University Hospital",10,{"id":461,"slug":462,"hasResults":12,"nctId":463,"briefTitle":464,"officialTitle":465,"acronym":466,"eligibilityCriteria":467,"healthyVolunteers":12,"sex":19,"minAge":21,"maxAge":4,"enrollmentInfo":468,"targetDuration":4,"studyType":25,"phases":469,"briefSummary":470,"conditions":471,"keywords":475,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":479,"lastUpdatePostDateStruct":480,"startDateStruct":482,"completionDateStruct":484,"leadSponsor":486,"locationsCount":52},"100640872","right-ventricular-response-to-exercise-among-patients-with-chronic-obstructive-pulmonary-disease-100640872","NCT07576894","Right Ventricular Response to Exercise Among Patients With Chronic Obstructive Pulmonary Disease","Phenotyping Resting and Exertional Right Ventricular Dysfunction Among Patients With Chronic Obstructive Pulmonary Disease","ReV UP COPD","Inclusion Criteria:\n\n* COPD (determined by ratio of forced expiratory volume in 1 second to forced vital capacity \\[FEV1\u002FFVC\\] \\\u003C0.7)\n* Age \\>= 40 years\n\nExclusion Criteria:\n\n* Exacerbation of COPD in the 3 months prior to enrollment\n* Change in COPD therapy in the 3 weeks prior to enrollment\n* Requirement of \\>6 LPM supplemental oxygen at rest\n* Requirement of \\>10 LPM supplemental oxygen with exertion\n* Active\u002Funcontrolled cardiovascular disease (e.g. hypertension with blood pressure \\>150\u002F100 despite antihypertensives; coronary artery disease with angina; left ventricular ejection fraction ≤40%; uncontrolled arrhythmia; pulmonic, mitral or aortic valvular abnormality greater than mild in severity; tricuspid regurgitation greater than moderate in severity)\n* Volume overload (jugular vascular distension or greater than trace peripheral edema)\n* World Health Organization Functional Class IV\n* Known pulmonary hypertension with mean pulmonary artery pressure \\>45 mmHg\n* Untreated severe obstructive sleep apnea and\u002For obesity hypoventilation syndrome\n* Active malignancy (other than skin)\n* Medical conditions that limit exercise on an upright stationary bicycle (e.g. severe osteoarthritis, imbalance\u002Fgait instability, etc.)\n* Pregnancy\n* Body mass index \\\u003C18 or \\>35\n* Hematocrit \\\u003C25% or \\>55%\n* For subset undergoing right heart catheterization, chronic anticoagulation that is unable to be held for the study visit\n* For subset undergoing right heart catheterization or exercise training, forced expiratory volume in 1 second of \\\u003C20%\n* For exercise training, already engaged in routine exercise training (\\>30 minutes at \\>3 METs 3 times\u002Fweek or more)\n* For exercise training, inability to complete initial in-person exercise training sessions for approximately 35 minutes 3x\u002Fweek for 3 weeks (followed by exercise training sessions with an option for hybrid remote\u002Fin-person participation)\n* For exercise training with an option for hybrid remote exercise training, any medical conditions which threaten the safety of remote exercise training (e.g. imbalance\u002Fgait instability, etc.).",{"count":123,"type":24},[27],"This study plans to learn more about heart function among individuals with chronic obstructive pulmonary disease (COPD). In particular, the investigators want to understand the different patterns of right ventricular response during rest and moderate- vs high-intensity exercise. By identifying patterns of right ventricular dysfunction, this study will help identify better treatments for patients with COPD in the future.",[472,473,69,474,30],"COPD","Pulmonary Hypertension","Right Ventricular (RV) Dysfunction",[472,476,69,477,478],"Pulmonary hypertension","Pulmonary rehabilitation","Exercise training","2026-05-04",{"date":481,"type":44},"2026-05-08",{"date":483,"type":44},"2025-08-01",{"date":485,"type":24},"2030-08-01",{"name":487,"class":51},"University of Colorado, Denver",{"id":489,"slug":490,"hasResults":12,"nctId":491,"briefTitle":465,"officialTitle":465,"acronym":4,"eligibilityCriteria":492,"healthyVolunteers":12,"sex":19,"minAge":21,"maxAge":4,"enrollmentInfo":493,"targetDuration":4,"studyType":25,"phases":494,"briefSummary":495,"conditions":496,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":479,"lastUpdatePostDateStruct":498,"startDateStruct":499,"completionDateStruct":501,"leadSponsor":503,"locationsCount":52},"100508144","phenotyping-resting-and-exertional-right-ventricular-dysfunction-among-patients-with-chronic-obstructive-pulmonary-disease-100508144","NCT05896579","Inclusion Criteria:\n\n* COPD (determined by ratio of forced expiratory volume in 1 second to forced vital capacity \\[FEV1\u002FFVC\\] \\\u003C0.7)\n* Age \\>= 40 years\n\nExclusion Criteria:\n\n* Exacerbation of COPD in the 3 months prior to enrollment\n* Change in COPD therapy in the 3 weeks prior to enrollment\n* Requirement of \\>6 LPM supplemental oxygen at rest\n* Requirement of \\>10 LPM supplemental oxygen with exertion\n* Active\u002Funcontrolled cardiovascular disease (e.g. hypertension with blood pressure \\>150\u002F100 despite antihypertensives; coronary artery disease with angina; left ventricular ejection fraction ≤40%; arrhythmia; pulmonic, mitral or aortic valvular abnormality greater than mild in severity; tricuspid regurgitation greater than moderate in severity)\n* Volume overload (jugular vascular distension or greater than trace peripheral edema)\n* World Health Organization Functional Class IV\n* Known pulmonary hypertension with mean pulmonary artery pressure \\>45 mmHg\n* Untreated severe obstructive sleep apnea or obesity hypoventilation syndrome\n* Active malignancy (other than skin)\n* Medical conditions that limit exercise on an upright stationary bicycle (e.g. severe osteoarthritis, imbalance\u002Fgait instability, etc.)\n* Pregnancy\n* Body mass index \\\u003C18 or \\>40\n* Hematocrit \\\u003C25% or \\>55%\n* For invasive CPET, chronic anticoagulation that is unable to be held for the study visit\n* For invasive CPET, forced expiratory volume in 1 second of \\\u003C20%",{"count":123,"type":24},[27],"This study plans to learn about heart function among individuals with chronic obstructive pulmonary disease (COPD). In particular, the investigators want to understand the different patterns of right ventricular response during rest and moderate- vs high-intensity exercise. By identifying patterns of right ventricular dysfunction, this study will help identify better treatments for patients with COPD in the future.",[472,473,497,69,30],"Right Ventricular Dysfunction",{"date":481,"type":44},{"date":500,"type":44},"2023-08-22",{"date":502,"type":24},"2030-08",{"name":487,"class":51},{"id":505,"slug":506,"hasResults":12,"nctId":507,"briefTitle":508,"officialTitle":509,"acronym":510,"eligibilityCriteria":511,"healthyVolunteers":18,"sex":512,"minAge":513,"maxAge":20,"enrollmentInfo":514,"targetDuration":4,"studyType":25,"phases":515,"briefSummary":516,"conditions":517,"keywords":520,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":524,"lastUpdatePostDateStruct":525,"startDateStruct":527,"completionDateStruct":529,"leadSponsor":531,"locationsCount":4},"100634992","the-effects-of-throwers-ten-exercises-performed-with-an-external-focus-100634992","NCT07546890","The Effects of Thrower's Ten Exercises Performed With an External Focus","The Effects of Thrower's Ten Exercises Performed With an External Focus on Functional Performance, Balance, and Shooting Performance in Adolescent Basketball Players","The Effects of","Inclusion Criteria:\n\n* Adolescent male basketball players aged 10-18 years\n* With at least one year of continuous participation in basketball\n* Basketball players who participate in regular training at least two days per week\n\nExclusion Criteria:\n\n* Participants will be excluded if they have a history of upper or lower extremity surgery within the past six months\n* do not regularly attend training sessions\n* do not consent to participate","MALE","10 Years",{"count":271,"type":24},[27],"The aim of this study is to comprehensively investigate the effects of the Thrower's Ten exercise program-commonly recommended to enhance shoulder stability and strength in athletes-when applied using an external focus of attention approach (i.e., directing attention toward an object or movement outside the body), on functional performance, shoulder stability, balance, and throwing performance in adolescent basketball players.\n\nThis study has been designed to examine the effects of performing the Thrower's Ten exercises with an external focus of attention on functional performance, shoulder stability, balance, and throwing performance in adolescent basketball players. Athletes will be randomly assigned to two groups: the experimental group will perform the exercises using an external focus of attention, whereas the control group will perform the same exercises without any specific attentional focus.\n\nThe methods employed in this study are expected to effectively address the research objectives. The data collection tools and analytical techniques to be used are based on validated and widely accepted tests in the literature. Functional performance will be assessed using the Closed Kinetic Chain Upper Extremity Stability Test, balance will be evaluated using the Upper Extremity Y Balance Test, and throwing performance will be measured using the Medicine Ball Throw Test.",[518,30,519],"External Focus (e.g., Performing the Exercise by Directing the Individual's Attention to a Laser Beam)","Adolescent",[521,522,523],"basketball","throwers ten exercise","functional performance","2026-04-20",{"date":526,"type":44},"2026-04-23",{"date":528,"type":24},"2026-04-25",{"date":530,"type":24},"2026-07-20",{"name":362,"class":51},{"id":533,"slug":534,"hasResults":12,"nctId":535,"briefTitle":536,"officialTitle":537,"acronym":538,"eligibilityCriteria":539,"healthyVolunteers":18,"sex":512,"minAge":540,"maxAge":541,"enrollmentInfo":542,"targetDuration":4,"studyType":25,"phases":544,"briefSummary":545,"conditions":546,"keywords":4,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":549,"lastUpdatePostDateStruct":550,"startDateStruct":551,"completionDateStruct":553,"leadSponsor":555,"locationsCount":4},"100634528","microgreens-and-mirnas-100634528","NCT07540858","Microgreens and miRNAs","The Effect of Mikrofiliz Application on Serum miRNA Levels Associated With Muscle Damage, Recovery, and the Central Nervous System Following Eccentric Loading","GreenmiRNAs","Inclusion Criteria:Recreationally trained athletes were recruited and randomly allocated to either a microgreen supplementation group or a control group. Inclusion criteria were: (i) being an active athlete, (ii) absence of medical contraindications to exercise (verified by medical clearance), (iii) voluntary participation, and (iv) full adherence to the study protocol.\n\n\\-\n\nExclusion Criteria: Exclusion criteria included: recent musculoskeletal injury (within 6 months), chronic disease or regular medication use, lack of structured training in the previous year, and smoking or alcohol consumption. Participants failing to comply with the protocol, experiencing adverse events, or engaging in high-intensity physical activity during the follow-up period were withdrawn\n\n\\-","19 Years","24 Years",{"count":543,"type":24},15,[27],"In this study, we investigated the impact of a comprehensive microgreen and wheatgrass juice protocol on the miRNA response following a standardized EIMD model and whether microgreen consumption could modulate key miRNA markers of neuromuscular regeneration and metabolic adaptation, thereby offering a novel nutritional approach to enhancing holistic recovery in athletes.",[30,547,548],"Microgreens","miRNAs","2026-04-15",{"date":524,"type":44},{"date":552,"type":24},"2026-05-12",{"date":554,"type":24},"2026-07-30",{"name":556,"class":51},"Çanakkale Onsekiz Mart University",{"id":558,"slug":559,"hasResults":12,"nctId":560,"briefTitle":561,"officialTitle":562,"acronym":563,"eligibilityCriteria":564,"healthyVolunteers":18,"sex":19,"minAge":565,"maxAge":60,"enrollmentInfo":566,"targetDuration":4,"studyType":25,"phases":567,"briefSummary":568,"conditions":569,"keywords":576,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":581,"lastUpdatePostDateStruct":582,"startDateStruct":584,"completionDateStruct":586,"leadSponsor":588,"locationsCount":52},"100631596","pain-in-aging-former-athletes-masters-athletes-and-nonathletes-100631596","NCT07502742","Pain in Aging Former Athletes, Master's Athletes, and Nonathletes","Pain in Athletes INtervention (PAIN): A Randomized Crossover Clinical Trial in Aging Former Athletes, Master's Athletes, and Nonathletes","PAIN","Inclusion Criteria (General):\n\n* Age: 35 years through 65 years\n* Current master's athlete, former competitive athletes, or non-athlete control (see details below)\n* Ability to participate in exercise and exercise testing based on the Physical Activity Readiness Questionnaire (PAR-Q+)\n\nExclusion Criteria (General):\n\n* Currently pregnant or planning to become pregnant during the study\n* Currently taking heart rate lowering medications (e.g., betablockers) that would impact exercise testing\n* Contraindications to ice such as Raynaud's, cryoglobulinemia, cold urticaria, and\u002For impaired circulation or sensation\n* Fibromyalgia and\u002For chronic regional pain syndrome (CRPS)\n* Myocardial infarction or pulmonary embolism in the last 12 months, active cancer, a pacemaker, or any additional condition or disease that would preclude the individual from being able to perform the tests safely\n\nParticipants will be enrolled into one of the following three mutually exclusive groups according to the following criteria:\n\n1. Former Competitive Athlete: Prior participation in competitive sports at the Tier 3 level or above as per McKay et al. (2022): i.e., \"national-level representatives who are performing structured and\u002For periodized training and are developing proficiency in skills required to perform their sport at the highest level; this tier includes individuals participating in Provincial\u002FState or Academy Programs\" or higher participation in sport; Not currently participating in any recreational or competitive sports over the last 5 years (Tier 2 or above)\n2. Master's Athlete: Currently (within the past year) participating in sports at the Tier 2 level or above (i.e., committed to sports-specific training at least 3 times per week with the intent to compete)(McKay et al., 2022)\n3. Nonathlete Control: No prior participation in sport at the Tier 3 (Highly Trained\u002FNational) Level or above and not currently participating in any competitive sports (i.e., Tier 2 or above) (McKay et al., 2022) for at least 5 years","35 Years",{"count":176,"type":24},[27],"The goal of this clinical trial is to determine how male and female former athletes experience pain and respond to moderate-intensity exercise (strength versus aerobic) compared with both current master's athletes and nonathletes.\n\nThe main questions this study aims to address are:\n\n1. How do former athletes, master's athletes, and nonathletes experience pain?\n2. How do different types of moderate-intensity exercise (strength versus aerobic exercise) influence pain in former athletes, master's athletes, and nonathletes?\n\nParticipants will complete 3 different testing sessions:\n\n1. Baseline testing including assessments of strength, cardiorespiratory fitness, and pain;\n2. Strength exercise: pain assessments will occur before and after moderate-intensity strength training exercise;\n3. Aerobic exercise: pain assessments will occur before and after moderate-intensity aerobic exercise.\n\nThere will be a washout period of approximately one week or greater between each of the three different testing sessions. The order of conditions (strength versus aerobic exercise) will be randomized (crossover randomized trial design).",[570,316,181,30,571,572,223,573,574,102,575],"Pain","Sports Medicine","Strength Training Effects","Strength Training","Aging","Sports",[577,578,570,579,580,69,317,574,182],"Former Athlete","Master's Athlete","Quantitative Sensory Testing","Randomized Crossover Clinical Trial","2026-03-27",{"date":583,"type":44},"2026-03-31",{"date":585,"type":44},"2026-03-02",{"date":587,"type":24},"2028-05",{"name":589,"class":51},"Marquette University",{"id":591,"slug":592,"hasResults":12,"nctId":593,"briefTitle":594,"officialTitle":595,"acronym":596,"eligibilityCriteria":597,"healthyVolunteers":18,"sex":19,"minAge":121,"maxAge":60,"enrollmentInfo":598,"targetDuration":4,"studyType":25,"phases":600,"briefSummary":601,"conditions":602,"keywords":603,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":606,"lastUpdatePostDateStruct":607,"startDateStruct":608,"completionDateStruct":610,"leadSponsor":612,"locationsCount":52},"100525549","guided-episodic-future-thinking-to-increase-physical-activity-adherence-and-promote-healthy-brain-aging-100525549","NCT06123182","Guided Episodic Future Thinking to Increase Physical Activity Adherence and Promote Healthy Brain Aging","Guided Episodic Future Thinking to Increase Physical Activity Adherence and Promote Healthy Brain Aging Among Mid-Life Adults: Phase II","GETActiveHIT","Inclusion Criteria:\n\n* speak English\n* have access to reliable communication (a telephone or cell phone, computer, etc.)\n* normal or corrected to normal vision and hearing\n* ambulatory (without the use of assistive devices)\n* physically underactive\n* able to give informed consent\n* able to exercise continuously on the recumbent stepper exercise device for 4 minutes greater than or equal to 25 watts to demonstrate ability to perform exercise on stepper \\& no aerobic exercise contraindications or other safety\u002Fphysical concerns\n* able to communicate with investigators, follow 2-step command \\& correctly answer consent comprehension questions\n* stable blood pressure and statin medication doses for 30 days as these affect vascular health\u002Fhemodynamics\n* willing and able to safely enter magnetic resonance (MR) scanner and attempt the MR scan\n* willing and able to attempt a blood draw\n\nExclusion Criteria:\n\n* patients with arrhythmias or acute cardiac events will be excluded due to potential complications with the supervised moderate exercise\n* at risk for hazard due to magnetic fields due to MR safety concerns\n* have any neurologic or psychiatric disorder except depression, anxiety (including post-traumatic stress disorder)\n* have history of seizures or head trauma due to MR data quality",{"count":599,"type":24},160,[27],"The goal of this behavioral clinical trial is to learn how to increase physical activity in mid-life adults. Specifically, can guided imagery that includes creating mental pictures increase excitement about working out.\n\nParticipants will be asked to complete testing at the beginning of the study, following 6-weeks of an in-person exercise program, and 6-weeks after finishing the exercise program. Testing will include an exercise test, MRI, questionnaires, computer tasks, and a blood draw.",[30,574],[604,605],"Adherence","Guided Imagery","2026-03-23",{"date":581,"type":44},{"date":609,"type":44},"2024-02-23",{"date":611,"type":24},"2027-05",{"name":613,"class":51},"University of Kansas Medical Center",{"id":615,"slug":616,"hasResults":12,"nctId":617,"briefTitle":618,"officialTitle":619,"acronym":4,"eligibilityCriteria":620,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":621,"targetDuration":4,"studyType":623,"phases":4,"briefSummary":624,"conditions":625,"keywords":634,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":636,"lastUpdatePostDateStruct":637,"startDateStruct":639,"completionDateStruct":641,"leadSponsor":642,"locationsCount":52},"100613051","adherence-to-home-based-exercises-in-musculoskeletal-disorders-100613051","NCT07261553","Adherence to Home-Based Exercises in Musculoskeletal Disorders","Adherence to Home-Based Exercise Programs Among Patients With Musculoskeletal Disorders and Its Influencing Factors","Inclusion criteria:\n\n* Be 18 years of age or older\n* To have a musculoskeletal disease (degenerative, neurological or orthopedic)\n* To be given a home exercise program\n* To have cognitive and language functions to communicate, to be a volunteer\n\nExclusion criteria:\n\n* Those with major psychiatric illness\n* Those with cognitive dysfunction\n* Those with communication disorders, reluctant\u002Freluctant to participate\n* Those with any condition other than a primary degenerative, orthopedic, or neurological disease that could significantly affect exercise adherence, including musculoskeletal or systemic disorders (e.g., severe anemia, heart failure, respiratory failure, uncontrolled diabetes, inflammatory rheumatic disease, recent fractures, or active infections).",{"count":622,"type":24},252,"OBSERVATIONAL","Home exercise program is recommended by physicians to patients and their relatives to do at home and It is a treatment option in which the physician describes how to do it. Home workout program to be completed at home to complement and reinforce their program in the clinic It is a personalized set of therapeutic exercises that are taught. There are factors that can change exercise compliance; There are some reasons why some patients adhere to the prescribed home exercise program and others do not.\n\nAdherence to home exercises is a major issue in rehabilitation and the reasons for this are multifactorial; It includes both psychological and specific conditions factors that vary between each individual and these conditions should be taken into account by clinicians in designing personalized exercise programs.\n\nHome exercise programs constitute a fundamental component of rehabilitation and are widely prescribed by physicians support therapeutic gains beyond the clinical environment. These individualized programs aim to maintain functional improvements, reduce symptoms, and promote self-management among individuals with musculoskeletal disorders. Although adherence to home-based exercises is recognized as a key determinant of rehabilitation outcomes, non-adherence remains a persistent challenge. Despite growing emphasis on the importance of exercise compliance, the existing literature provides relatively limited and insufficient evidence regarding the factors that influence adherence across different musculoskeletal conditions, including degenerative, orthopedic, and neurological disorders.\n\nAddressing this gap, the present prospective longitudinal cohort study aims to evaluate adherence to individualized home-based exercise programs among patients with diverse musculoskeletal conditions and to determine whether adherence behaviors differ across diagnostic groups. In addition, the study seeks to identify demographic, clinical, psychosocial, and functional factors associated with exercise compliance. By integrating structured clinical evaluations with validated outcome measures, this study aims not only to clarify the determinants of exercise adherence but also to contribute to the development of more effective, condition-specific strategies to enhance sustained engagement in home-based rehabilitation.",[30,626,627,628,629,630,631,632,633],"Adherence, Treatment","Musculoskeletal Disease","Rehabilitation Exercise","Adherence, Patient","Home Exercise Program","Stroke","Orthopedic Operations","Degeneration of Spine and Osteoarticular",[630,635,628,627,629],"adherence","2026-03-21",{"date":638,"type":44},"2026-03-25",{"date":640,"type":44},"2024-12-30",{"date":46,"type":24},{"name":643,"class":644},"Konya Beyhekim Training and Research Hospital","OTHER_GOV",{"id":646,"slug":647,"hasResults":12,"nctId":648,"briefTitle":649,"officialTitle":650,"acronym":4,"eligibilityCriteria":651,"healthyVolunteers":18,"sex":19,"minAge":60,"maxAge":4,"enrollmentInfo":652,"targetDuration":4,"studyType":25,"phases":654,"briefSummary":655,"conditions":656,"keywords":4,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":659,"lastUpdatePostDateStruct":660,"startDateStruct":662,"completionDateStruct":664,"leadSponsor":666,"locationsCount":4},"100535126","reducing-heart-failure-risk-in-late-life-with-physical-activity-100535126","NCT06247774","Reducing Heart Failure Risk in Late-Life With Physical Activity","Reducing Heart Failure Risk in Late-Life With Physical Activity: Impact on Cardiac Structure and Function and Proteomic Signatures","Inclusion Criteria:\n\n* Hypertension (controlled on stable medication regimen)\n* Structural heart abnormality (LVH or LA enlargement)\n* LVEF \\> 50%\n* Sedentary\n* BMI \\\u003C30\n\nExclusion Criteria:\n\n* Diabetes\n* Unable to exercise\n* Supplemental oxygen use\n* Pulmonary hypertension\n* Sleep apnea\n* Regular exercise training\n* Devices that limit ability to achieve target heart rate\n* Moderate to severe valve disease\n* Recent (within 3 months) major CV event or planned procedures (within 6 months)\n* Terminal illness, life expectancy \\\u003C6 months\n* Inability or unwillingness to comply with study requirements\n* No access to smart phone\u002Ftablet",{"count":653,"type":24},42,[27],"The goal of this clinical trial is to learn about the molecular pathways associated with the benefit of a regular exercise program in patients with high blood pressure and who don't already participate in regular exercise.\n\nThe main question it aims to answer is to identify protein signatures associated with the benefits of a cardiac rehabilitation exercise program.\n\nThe trial will enroll 42 participants, who will be randomized to a 12 week cardiac rehabilitation exercise program versus control arm and asked to participate in the following at the beginning and end of study:\n\n* Cardiopulmonary exercise test (CPET)\n* Echocardiogram\n* Physical function test\n* 6-minute walk test\n* Hand grip strength\n* Quality of life questionnaire\n* Blood draws\n\nResearchers will compare results between those who do and don't participate in the exercise program.",[657,30,101,658],"Hypertension","Proteomics","2026-03-10",{"date":661,"type":44},"2026-03-12",{"date":663,"type":24},"2026-06",{"date":665,"type":24},"2029-05",{"name":667,"class":51},"Brigham and Women's Hospital",{"id":669,"slug":670,"hasResults":12,"nctId":671,"briefTitle":672,"officialTitle":672,"acronym":673,"eligibilityCriteria":674,"healthyVolunteers":12,"sex":19,"minAge":675,"maxAge":676,"enrollmentInfo":677,"targetDuration":678,"studyType":623,"phases":4,"briefSummary":679,"conditions":680,"keywords":686,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":693,"lastUpdatePostDateStruct":694,"startDateStruct":696,"completionDateStruct":698,"leadSponsor":700,"locationsCount":4},"100626161","walking-function-outcomes-following-surgical-correction-with-rehabilitation-versus-physical-therapy-alone-in-charcot-marie-tooth-disease-a-bidirectional-cohort-study-100626161","NCT07432035","Walking Function Outcomes Following Surgical Correction With Rehabilitation Versus Physical Therapy Alone in Charcot-Marie-Tooth Disease: A Bidirectional Cohort Study","CMT-WALK","Inclusion Criteria:\n\n* Participants aged 12 years or older at the time of enrollment\n* Genetically or clinically confirmed CMT, based on established diagnostic criteria\n* Presence of foot deformity and\u002For gait impairment attributable to CMT, as determined by a treating clinician\n* Ability to ambulate at least 10 meters, with or without assistive devices\n* Medically eligible for either functional surgical intervention or structured physical therapy, as determined by the treating team\n* Willingness and ability to participate in longitudinal follow-up assessments\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Previous major foot or ankle surgery that substantially altered lower-limb biomechanics\n* Presence of non-CMT-related neurological disorders affecting gait (eg, stroke, Parkinson disease, multiple sclerosis)\n* Severe musculoskeletal conditions unrelated to CMT that limit walking ability (eg, advanced hip or knee osteoarthritis)\n* Active lower-limb infection, ulceration, or acute injury at the time of enrollment\n* Severe cognitive impairment or psychiatric condition precluding reliable participation\n* Medical contraindications to surgery or exercise-based rehabilitation, when relevant\n* Inability to complete baseline functional assessments or anticipated inability to complete follow-up","12 Years","60 Years",{"count":303,"type":24},"5 Years","The goal of this study is to compare changes in walking ability in people with Charcot-Marie-Tooth disease (CMT) who receive two different treatment approaches for foot deformities that affect walking.\n\nCMT is an inherited nerve condition that can cause muscle weakness, loss of sensation, and foot deformities. These changes often make walking difficult and can reduce independence and quality of life. Treatment options commonly include physical therapy alone or surgery to correct foot alignment followed by rehabilitation. However, it is not clear whether one approach leads to better long-term walking outcomes.\n\nThe main question this study aims to answer is whether individuals who undergo functional foot surgery followed by rehabilitation experience different changes in walking ability over time compared with those who receive structured physical therapy alone.\n\nResearchers will compare walking performance between these two treatment groups over a period of up to two years. Walking ability will be evaluated using standardized walking tests and patient questionnaires.\n\nParticipants included in this study are individuals with CMT-related foot deformities that affect walking and who received either surgery followed by rehabilitation or physical therapy alone. Researchers will analyze changes in walking ability over time and determine how many participants achieve meaningful improvement.\n\nThe findings from this study may help clinicians and individuals with CMT better understand how different treatment strategies influence walking function over time.",[681,682,683,30,684,685],"Charcot Marie Tooth Disease (CMT)","Pes Cavovarus","Surgery","Neuromuscular Diseases (NMD)","Gait Disorders",[687,688,689,690,691,692],"Charcot Marie Tooth disease","Walking performance","Functional surgery","Physical therapy","Gait impairment","Propensity score matching","2026-02-24",{"date":695,"type":44},"2026-02-25",{"date":697,"type":24},"2026-02-11",{"date":699,"type":24},"2028-02-10",{"name":701,"class":51},"Peking University Third Hospital",{"id":703,"slug":704,"hasResults":12,"nctId":705,"briefTitle":706,"officialTitle":707,"acronym":4,"eligibilityCriteria":708,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":709,"enrollmentInfo":710,"targetDuration":4,"studyType":25,"phases":712,"briefSummary":713,"conditions":714,"keywords":717,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":722,"lastUpdatePostDateStruct":723,"startDateStruct":725,"completionDateStruct":726,"leadSponsor":728,"locationsCount":52},"100617770","effects-of-exercise-with-visual-feedback-in-parkinsons-disease-100617770","NCT07322939","Effects of Exercise With Visual Feedback in Parkinson's Disease","Effects of Visual Indicator Exercises for the Trunk and Lower Extremities on Activity and Participation in Parkinson's Disease","Inclusion Criteria\n\n* Individuals diagnosed with idiopathic Parkinson's disease\n* Disease severity classified as stage 1 to 3 according to the Modified Hoehn and Yahr Scale\n* Patients receiving oral antiparkinsonian treatment only\n\nExclusion Critera\n\n* Presence of musculoskeletal, cardiovascular, or vestibular disorders that may interfere with the completion of the assessments or treatment protocol\n* Presence of additional neurological or psychiatric disorders other than Parkinson's disease\n* Presence of visual impairment insufficient to perceive visual feedback","85 Years",{"count":711,"type":24},32,[27],"Patients with Parkinson's disease who apply to the Hasan Kalyoncu University Application and Research Center and meet the inclusion criteria will be included in the study. The included participants will be randomly assigned into either the intervention group or the control group using a sealed-envelope method. Both groups will undergo a standard exercise program, consisting of posture, strengthening, and balance training, under the supervision of a physiotherapist for 8 weeks, 3 days per week. In addition to this, the intervention group will receive an additional exercise program incorporating visual feedback using a laser pointer, targeting the trunk and lower extremities, also under the supervision of a physiotherapist for 8 weeks, 3 days per week.",[249,715,30,716],"Balance Impairment","Postural Control",[718,719,720,721,131],"parkinson disease","balance","postural control","visual feedback","2026-01-24",{"date":724,"type":44},"2026-01-27",{"date":358,"type":44},{"date":727,"type":24},"2026-05-05",{"name":729,"class":51},"Hasan Kalyoncu University",{"id":731,"slug":732,"hasResults":12,"nctId":733,"briefTitle":734,"officialTitle":735,"acronym":736,"eligibilityCriteria":737,"healthyVolunteers":12,"sex":19,"minAge":21,"maxAge":344,"enrollmentInfo":738,"targetDuration":740,"studyType":623,"phases":4,"briefSummary":741,"conditions":742,"keywords":747,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":758,"lastUpdatePostDateStruct":759,"startDateStruct":761,"completionDateStruct":763,"leadSponsor":765,"locationsCount":52},"100605622","predictive-factors-of-response-to-phase-ii-cardiac-rehabilitation-in-heart-failure-with-reduced-ejection-fraction-100605622","NCT07164911","Predictive Factors of Response to Phase II Cardiac Rehabilitation in Heart Failure With Reduced Ejection Fraction","Prédiction Des réponses du Patient Porteur d'Une Insuffisance Cardiaque à Fraction d'éjection altérée à Une Phase II de réadaptation Cardiaque","PrédicRéa","Inclusion Criteria:\n\n* Heart failure with reduced ejection fraction \\\u003C 40%\n* NYHA functional class ≥ II\n* Clinically stable for at least 6 weeks\n* On optimized medical therapy for at least 6 weeks\n* Prescription for phase II cardiac rehabilitation\n* BMI between 20-30 kg·m-²\n* Physical activity level: sedentary or physically active but untrained\n* Signed informed consent to participate in the study\n* Affiliation to the French national health insurance system\n\nExclusion Criteria:\n\n* Contraindication to regular adapted physical activity\n* Uncontrolled arterial hypertension\n* Secondary respiratory disease such as emphysema or chronic obstructive pulmonary disease (COPD)\n* Secondary cardiovascular disease\n* Individuals under legal protection or deprived of liberty\n* Pregnant or breastfeeding women",{"count":739,"type":24},62,"1 Month","Exercise intolerance, measured as peak oxygen consumption (VO₂peak) during exercise in patients with heart failure with reduced ejection fraction (HFrEF). Change in VO₂peak (ΔVO₂peak), which serves as a prognostic marker for HFrEF engaged in exercise based cardiac rehabilitation program (ExCR). Responders to ExCR generally show improved cardiac function but some patients with HFrEF do not respond to ExCR. VO₂peak depends on three major components of oxygen transport: Pulmonary (lungs), circulatory (heart and vessels) and skeletal muscle (oxygen utilization) functions. These physiological responses to ExCR may be influenced by epigenetic regulation, specifically the expression of circulating microRNAs (c-miRNAs).\n\nLinking non-invasive measurements and epigenetic markers could 1) identify which component of the oxygen transport chain is most impaired and 2) allow personalized interventions to maximize VO₂peak improvements.\n\nThe primary objective of this stidy is to assess the association between changes in VO₂peak during exercise training and circulating microRNA expression (miR-146a, miR-191, miR-23a, miR-140, miR-1, miR-21, miR-133a, miR-17-5p, miR-3200-3p).\n\nThe secondary objective is to examine the relationship between pulmonary, cardiovascular, and neuromuscular adaptations to exercise and circulating microRNA expression.",[743,101,30,744,745,746],"HFrEF - Heart Failure With Reduced Ejection Fraction","Exercise Adaptations","Exercise Intolerance","Exercise Intervention",[748,749,750,751,752,753,754,755,756,757],"Exercise-based cardiac rehabilitation in patients with reduced left ventricular ejection fraction","VO2peak","MicroRNA","Muscle Oxygenation","arterial stiffness","cardiac output","stroke volume","Oxygen alveolar-arterial gradient","alveolar ventilation","minute ventilation","2025-12-08",{"date":760,"type":44},"2025-12-16",{"date":762,"type":44},"2025-11-25",{"date":764,"type":24},"2027-11-30",{"name":766,"class":644},"Centre Hospitalier de Corbie"]