[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"exercise\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:exercise":27},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,144,0,25,[9,44,71,103,128,164,187,215,240,260,285,311,341,361,384,419,442,463,498,523,549,568,592,621,646],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100652958","the-effect-of-an-aiot-based-smart-exercise-system-in-older-adults-100652958",false,"NCT07779824","The Effect of an AIoT-Based Smart Exercise System in Older Adults","Development of a Precision Exercise System for Older Adults and People With Stroke Using Deep Learning and Facial Action Units","Inclusion Criteria:\n\n* Adult over 50 years old\n* No significant limb disability or joint deformation\n* No history of cardiovascular disease\n* Never lost balance due to dizziness in the past 12 months\n\nExclusion Criteria:\n\n* Limb disability or joint deformation\n* History of cardiovascular disease\n* Lost balance due to dizziness in the past 12 months\n* Cognitive deficits","ALL","50 Years",{"count":20,"type":21},200,"ESTIMATED","INTERVENTIONAL",[24],"NA","This clinical trial aims to evaluate the effectiveness of an artificial intelligence of things (AIoT)-based exercise system for seniors. Participants will undergo a 12-week AIoT-based cycle ergometer training program. Physical fitness and functional performance will be assessed at baseline and after completion of the intervention. Throughout the intervention, exercise-related data, including exercise duration, workload, heart rate, oxygen consumption, perceived exertion, and facial expressions, will be continuously and simultaneously collected for analysis.",[27,28],"Exercise","Seniors",[28,27,30],"facial action unit","RECRUITING","2026-08-18",{"date":34,"type":35},"2026-08-21","ACTUAL",{"date":37,"type":35},"2026-02-20",{"date":39,"type":21},"2028-07-31",{"name":41,"class":42},"I-Shou University","OTHER",1,{"id":45,"slug":46,"hasResults":12,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":43},"100551657","a-digital-exercise-intervention-in-patients-with-spondyloarthritis-100551657","NCT06462937","A Digital Exercise Intervention in Patients With Spondyloarthritis","The SPARK Trial: a Digital Exercise Intervention in Patients With Spondyloarthritis","SPARK","Inclusion Criteria:\n\n* axSpA diagnosis within the last two years by a rheumatologist according to the ASAS criteria of 2009\n* active disease (ASDAS \\> 1.3)\n\nExclusion Criteria:\n\n* Active uveitis.\n* CRP \\> 30.\n* Former or current use of bDMARDs.\n* Pregnancy or planned pregnancy within 6 months from inclusion.\n* Absolute and relative contradictions to high intensity exercise according to the American College of Sports Medicine (ACSM)\n* Other serious disease such as cancer.\n* Patients incapable to follow the protocol or the control set-up with remote monitoring.","18 Years",{"count":54,"type":21},260,[24],"This protocol describes a 6-month randomised, controlled exercise trial in patients with axial spondyloarthritis (axSpA) with re-randomization after 3-months. The primary outcome of the trial (disease activity) will be evaluated at 3-months. The exercise programme on trial comprises high intensity interval training (HIIT), muscular strength exercise and aerobic physical activity sessions of specified duration, frequency, and intensity. It also includes brief knowledge videos to empower the patient. The intervention is remotely delivered by the SPARK application with personalised follow-up including monitoring to ensure exercise progression and adherence to exercise intensity. The SPARK application is built on a platform delivered by ABEL Technologies (trademark) and is customised for patients with axSpA.",[58,27],"Spondyloarthritis",[60,61,62],"Remote","Digital","High intensity interval training",{"date":64,"type":35},"2026-08-20",{"date":66,"type":35},"2024-07-01",{"date":68,"type":21},"2030-08-01",{"name":70,"class":42},"Diakonhjemmet Hospital",{"id":72,"slug":73,"hasResults":12,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":12,"sex":17,"minAge":78,"maxAge":4,"enrollmentInfo":79,"targetDuration":4,"studyType":22,"phases":81,"briefSummary":82,"conditions":83,"keywords":86,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":43},"100588956","creatine-and-resistance-training-in-older-adults-with-mild-cognitive-impairment-100588956","NCT06948149","Creatine and Resistance Training in Older Adults With Mild Cognitive Impairment","Examining the Effects of Creatine Supplementation and Resistance Training on Cognition and Brain Health in Older Adults With Mild Cognitive Impairment: a 26 Week Randomized Controlled Trial","We will include participants who: 1) are aged \\>60; 2) are living independently in the community; 3) have normal or corrected-to-normal vision and hearing; 4) read, write, and speak English fluently; 5) are right-handed (if participating in the MRI component); 6) have subjective feelings of memory decline in the past five years; 7) have telephone Montreal Cognitive Assessment (T-MoCA) scores \\\u003C19\u002F22; 8) have high independence, as indicated by Instrumental Activities of Daily Living (IADL) scale \\>6\u002F8; 9) have a Geriatric Depression Scale (GDS) score \\\u003C6\u002F15; 10) are able to exercise at a moderate pace using resistance training for 60 minutes 3x\u002Fweek; and 11) receive clearance from a physician to participate in an exercise program at baseline.\n\nWe will exclude participants who: 1) cannot partake or commit to exercise training 3x\u002Fweek for 26 weeks or have engaged in resistance training \\>1x\u002Fweek over the past three months; 2) cannot partake or commit to consuming a daily supplement for 26 weeks or have consumed nutritional supplements containing creatine monohydrate over the past three months; 3) have a known allergy to creatine monohydrate or dextrose; 4) have been diagnosed with a neurological disorder (e.g., Alzheimer's disease, Parkinson's disease); 5) have pre-existing kidney disease, heart disease, or liver abnormalities; 6) have one or more uncontrolled chronic or psychiatric conditions (e.g., hypertension, diabetes, depression, anxiety); 7) are taking medication that may impact kidney function (e.g., non-steroidal anti-inflammatory drugs, such as ibuprofen and naproxen); or 8) are ineligible or uncomfortable with blood sampling.","60 Years",{"count":80,"type":21},140,[24],"The goal of this 26-week trial is to learn if creatine supplementation and resistance training (i.e., weightlifting; exercise that increases muscle mass), alone and together, impact cognition, brain health, and physical function in older adults with mild cognitive impairment. Previous studies have shown that resistance training improves cognition and brain health in older adults. Creatine is naturally occurring in the human body and is known to decline with age. Studies have shown that creatine increases muscle mass and bone density in older adults when supplemented. Some research has suggested that creatine may also improve cognition and brain health. However, little is known about how creatine supplementation affects the aging brain and body alone and when combined with resistance training, especially in those with known cognitive impairment.\n\nIn this study, participants will be randomly assigned to one of four groups: 1) creatine and resistance training, 2) placebo and resistance training, 3) creatine and active control (balance and tone classes), or 4) placebo and active control. Participants in the creatine groups will take creatine every day during the study. Participants in the placebo groups will take a look-alike substance that contains no drug every day during the study. Participants in the resistance training groups will attend three 60-minute classes per week that target each major muscle group and will increase in difficulty during the study. Participants in the active control group will attend three 60-minute classes per week that will consist of balance, stretching, and range of motion exercises. This group accounts for variables such as physical training received by traveling to the training centres, social interaction, and changes in lifestyle secondary to study participation.\n\nResearchers will collect information before and after the 26 weeks to see if creatine supplementation and\u002For resistance training have any effects on cognition, brain health, and\u002For physical function. The investigators suspect that both creatine supplementation and resistance training will improve cognition, brain health, and physical function alone. However, it is thought that the combination of creatine supplementation and resistance training will improve cognition, brain health, and physical function more.",[84,27,85],"Creatine","Mild Cognitive Impairment (MCI)",[87,88,89,90,91,92,93,94],"older adults","physical activity","cognition","neuroimaging","mobility","mild cognitive impairment","creatine","dietary supplementation","2026-08-17",{"date":64,"type":35},{"date":98,"type":35},"2026-01-01",{"date":100,"type":21},"2027-12",{"name":102,"class":42},"Western University, Canada",{"id":104,"slug":105,"hasResults":12,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":4,"eligibilityCriteria":109,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":110,"targetDuration":4,"studyType":22,"phases":112,"briefSummary":113,"conditions":114,"keywords":118,"overallStatus":120,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":123,"completionDateStruct":124,"leadSponsor":126,"locationsCount":4},"100578920","ai-driven-personalized-exercise-feedback-program-on-exercise-adherence-in-traumatic-brain-injury-100578920","NCT06817564","AI-driven Personalized Exercise Feedback Program on Exercise Adherence in Traumatic Brain Injury","Effects of an AI-driven Personalized Exercise Feedback Program on Exercise Adherence and Health Outcomes in Patients With Traumatic Brain Injury","Inclusion Criteria:\n\n* Eligible participants are patients aged over 18 with mild TBI (GCS 13-15)\n* who can walk independently,\n* reside in the Greater Taipei area,\n* and possess sufficient Chinese or Taiwanese language proficiency to understand the trial\n* complete self-administered questionnaires.\n\nExclusion Criteria:\n\n* include individuals with severe medical conditions (e.g., respiratory failure, epilepsy, psychiatric disorders), musculoskeletal or neurological impairments\n* hindering physical activity in the 6-minute walk test,\n* cognitive impairments (MMSE \\\u003C 24),\n* frontal lobe injuries or penetrating injury causing significant psychological dysfunction.\n* Patients regularly engaging in moderate-to-high-intensity aerobic exercise or participating in other studies will also be excluded to avoid bias.",{"count":111,"type":21},125,[24],"This study aims to develop and evaluate an AI-driven Personalized Exercise Feedback Program (AI-PEF) to enhance exercise adherence and health outcomes in mTBI patients.\n\nMethods: AI-PEF integrates the transtheoretical model and self-determination theory with machine learning algorithms to provide real-time, personalized feedback. A phased randomized controlled trial will be conducted: Phase I evaluates feasibility and acceptability through Delphi methods with expert consensus and patient feedback; Phase II validates preliminary outcomes with 30 participants in a 2-arm randomized trial; and Phase III assesses the program's impact on exercise adherence, exercise motivation, mHealth app usability, functional capacity, sleep quality, depressive symptoms, concussion symptoms, and quality of life with 90 participants in a 3-arm randomized trial. In Phase III, quantitative and qualitative data will be collected in parallel, with qualitative data collected through semi-structured interviews to explore participants' experiences and perceptions of the intervention.",[115,27,116,117],"Traumatic Brain Injury","AI (Artificial Intelligence)","Digital Health",[119],"AI-Driven Personalized Exercise Program","NOT_YET_RECRUITING","2026-08-13",{"date":95,"type":35},{"date":95,"type":21},{"date":125,"type":21},"2031-08-31",{"name":127,"class":42},"National Defense Medical Center, Taiwan",{"id":129,"slug":130,"hasResults":12,"nctId":131,"briefTitle":132,"officialTitle":133,"acronym":134,"eligibilityCriteria":135,"healthyVolunteers":136,"sex":137,"minAge":138,"maxAge":139,"enrollmentInfo":140,"targetDuration":4,"studyType":22,"phases":141,"briefSummary":142,"conditions":143,"keywords":146,"overallStatus":120,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":162,"locationsCount":43},"100650851","effects-of-basketball-specific-interval-exercise-on-metabolic-inflammatory-and-fatigue-responses-in-female-basketball-players-100650851","NCT07752459","Physiological Responses to Basketball-Specific Interval Exercise in Female Basketball Players","The Effect of Basketball-Specific Interval Exercise on Metabolic and Inflammatory Responses, Energy Substrate Utilization, and Perceived Fatigue in Female Basketball Players","INTER-BASKET","Inclusion Criteria:\n\n* Female, aged 16-22 years.\n* Regular participation in organized basketball training.\n* Current medical clearance for sports participation.\n* No contraindications to high-intensity physical exercise.\n* Willingness and ability to provide written informed consent (and parental\u002Flegal guardian consent where required for minors).\n* Willingness to comply with all study procedures.\n* Menstrual cycle phase will be recorded for all participants and considered as a potential covariate in the statistical analyses.\n\nExclusion Criteria:\n\n* Current musculoskeletal injury or any condition preventing maximal exercise.\n* Metabolic, cardiovascular, inflammatory, or other chronic diseases affecting exercise capacity or study outcomes.\n* Current use of anti-inflammatory medications.\n* Use of supplements or substances that may influence the measured metabolic or inflammatory parameters.\n* Refusal to undergo blood sampling.\n* Failure to comply with pre-test instructions (e.g., dietary or exercise restrictions).",true,"FEMALE","16 Years","22 Years",{"count":7,"type":21},[24],"This study aims to evaluate the effects of interval exercise on metabolic and inflammatory responses, energy substrate utilization, and fatigue in trained female basketball players. High-intensity intermittent exercise is a key component of basketball performance and induces substantial metabolic and physiological stress. However, the acute relationships between exercise-induced metabolic changes, inflammatory responses, substrate utilization, and fatigue in female basketball players remain insufficiently understood.\n\nIn this prospective interventional study, eligible female basketball players will complete a standardized interval exercise protocol designed to replicate the physiological demands of competitive basketball. Physiological, biochemical, and perceptual measurements will be collected before exercise, immediately after exercise, and during recovery. Primary outcomes include changes in metabolic and inflammatory biomarkers, energy substrate utilization, and fatigue-related responses. Secondary outcomes include selected physiological and performance-related variables associated with recovery from high-intensity interval exercise.\n\nThe findings of this study will improve the understanding of the physiological responses to interval exercise in female basketball players and may contribute to the development of evidence-based training and recovery strategies aimed at optimizing performance and athlete health.",[27,144,145],"Fatigue","Sport Physiology",[147,148,149,150,151,152,153,154],"basketball","Yo-Yo test","High-Intensity Interval Exercise","Reaction Time","Energy Metabolism","Free Fatty Acids","Exercise-Induced Fatigue","Female Athletes","2026-08-11",{"date":157,"type":35},"2026-08-12",{"date":159,"type":21},"2026-09-20",{"date":161,"type":21},"2026-12-30",{"name":163,"class":42},"Poznan University of Physical Education",{"id":165,"slug":166,"hasResults":12,"nctId":167,"briefTitle":168,"officialTitle":168,"acronym":4,"eligibilityCriteria":169,"healthyVolunteers":136,"sex":137,"minAge":52,"maxAge":170,"enrollmentInfo":171,"targetDuration":4,"studyType":22,"phases":173,"briefSummary":174,"conditions":175,"keywords":179,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":180,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":43},"100492831","the-impact-of-the-menstrual-cycle-on-physical-exercise-and-performance-100492831","NCT05697263","The Impact of the Menstrual Cycle on Physical Exercise and Performance","Inclusion Criteria:\n\n* Women exercising at least 3-4 times a week on a high level\n* Regular menstrual cycle with 26-32 cycle days.\n* Fully healthy and be able to follow the training program.\n\nExclusion Criteria:\n\n* Hormonal contraceptive users,\n* Users of regular medication\n* Chronic disease\n* Past or present neurological disorder\n* Recent musculoskeletal injury","35 Years",{"count":172,"type":21},111,[24],"The menstrual cycle implies a basic difference in the biology of women and men but the effect of the hormonal variation on training protocols and physical performance is still not fully understood. Despite no existing evidence, the advice to periodize exercise according to the menstrual cycle has been widely spread among elite athletes, coaches, and sports federations. The advice is based on underpowered studies with considerable methodological weaknesses regarding determination of cycle phase, inclusion of athletes and lack of adequate control groups.\n\nThe purpose of this randomized, controlled study is to evaluate the effect of exercise periodization on aerobic fitness during different phases of the menstrual cycle. Further, the effect will be related to premenstrual symptoms, body composition and skeletal muscle morphology, sex hormone receptors, metabolic enzymes, and markers of muscle protein synthesis. This study will be well controlled and follow methodology recommendations for menstrual cycle research in sports and exercise.\n\nFemale athletes of fertile age will be randomized to different training regimens during three menstrual cycles (12 weeks):\n\nGroup A: Training three times a week throughout the menstrual cycle. Group B: Follicular phase-based training five times a week during the follicular phase and thereafter once a week during the luteal phase.\n\nGroup C: Luteal phase-based training five times a week during the luteal phase and once a week in the follicular phase.\n\nThe exercise will consist of high intensity intermittent spinning classes. Assessment of aerobic fitness and power will be performed at baseline, and again after three completed menstrual cycles. On the same day, body composition will be examined by DXA and blood samples will be collected for analysis of hormones and binding proteins. To confirm menstrual cycle phase, blood samples will be collected for hormone determination, and urinary stick will be used for detection of ovulation. Subjective ratings of menstrual cycle related symptoms will be performed every day. In a subgroup of women, muscle biopsies will be collected from m vastus lateralis at baseline and at the end of the study. This study will contribute to improved knowledge about exercise periodization in relation to the menstrual cycle. Well-grounded data is crucial to give evidence-based recommendations to female athletes when planning their training protocol to optimize training results and performance.",[176,27,177,178],"Menstrual Cycle","Women's Health","Athletic Performance",[176,27,177,178],{"date":121,"type":35},{"date":182,"type":35},"2023-08-01",{"date":184,"type":21},"2027-07",{"name":186,"class":42},"Karolinska Institutet",{"id":188,"slug":189,"hasResults":12,"nctId":190,"briefTitle":191,"officialTitle":192,"acronym":193,"eligibilityCriteria":194,"healthyVolunteers":136,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":195,"targetDuration":4,"studyType":197,"phases":4,"briefSummary":198,"conditions":199,"keywords":202,"overallStatus":120,"whyStopped":4,"lastUpdateSubmitDate":207,"lastUpdatePostDateStruct":208,"startDateStruct":210,"completionDateStruct":212,"leadSponsor":213,"locationsCount":43},"100650860","acute-cardiac-effects-of-ultra-trail-running-100650860","NCT07753694","Acute Cardiac Effects of Ultra-Trail Running","Echocardiographic Assessment of the Acute Impact of an Ultra-Trail Race on Cardiac Function","ULTRA-ECHO","Inclusion Criteria:\n\n* Adults aged ≥18 years\n* Registered participants in the \"Trail des Échos\" ultra-trail race (80 km or 160 km)\n* Valid health clearance according to French Athletics Federation requirements\n* Affiliation with a national health insurance system\n* Able to understand study procedures and provide written informed consent\n\nExclusion Criteria:\n\n* Known or suspected cardiovascular disease at screening, including coronary artery disease, heart failure, clinically significant arrhythmias, moderate-to-severe valvular disease, uncontrolled hypertension, or prior stroke\n* Acute infection or unstable chronic medical condition (e.g., uncontrolled diabetes, renal, hepatic, respiratory, thyroid, or inflammatory disease)\n* Current treatments that may interfere with cardiovascular or biological assessments (including renin-angiotensin-aldosterone system blockers, chronic diuretics, anticoagulants, or systemic corticosteroids)\n* Use of systemic non-steroidal anti-inflammatory drugs within 3 days before the race or planned during the event\n* Participation in another ultra-endurance race (≥80 km) within 7 days before or after the study race\n* Pregnancy or breastfeeding\n* Inability to provide informed consent or legal protection status\n* Participation in another interventional clinical study",{"count":196,"type":21},60,"OBSERVATIONAL","This prospective observational study aims to investigate the acute cardiovascular effects of ultra-endurance running using comprehensive echocardiographic assessment combined with biological analyses. The main hypothesis is that participation in an ultra-trail race induces acute and transient changes in cardiac function involving both the left and right ventricles, associated with elevations in cardiac biomarkers, with physiological responses varying according to race distance and training level and showing spontaneous recovery within the days following the event.\n\nAdult amateur runners participating in ultra-trail races of 80 km or 160 km will undergo standardized clinical evaluation, electrocardiography, and transthoracic echocardiography with myocardial deformation analysis at multiple time points, including baseline, pre-effort, during the race, immediately after exercise, and during early recovery approximately one week after the event. Biological sampling will be performed before the race, immediately after exercise, and at follow-up.\n\nThe primary objective is to evaluate acute changes in left ventricular systolic function assessed by global longitudinal strain. Secondary objectives include the assessment of biventricular and atrial function, cardiac and non-cardiac biomarkers, recovery patterns after ultra-endurance exercise, and the influence of race distance, training level, performance level, and sex on cardiovascular responses.\n\nThis exploratory single-center study conducted in France seeks to provide an integrative characterization of cardiac adaptations to extreme endurance exercise and to generate physiological insights that may guide future research and cardiovascular monitoring strategies in endurance athletes.",[27,200,201],"Cardiac Function","Echocardiography",[203,204,205,206],"Ultra-endurance exercise","Ultra-trail running","Myocardial strain","Cardiac biomarkers","2026-08-04",{"date":209,"type":35},"2026-08-07",{"date":211,"type":21},"2027-05",{"date":211,"type":21},{"name":214,"class":42},"Central Hospital, Nancy, France",{"id":216,"slug":217,"hasResults":12,"nctId":218,"briefTitle":219,"officialTitle":220,"acronym":4,"eligibilityCriteria":221,"healthyVolunteers":12,"sex":17,"minAge":222,"maxAge":52,"enrollmentInfo":223,"targetDuration":4,"studyType":22,"phases":225,"briefSummary":226,"conditions":227,"keywords":230,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":232,"lastUpdatePostDateStruct":233,"startDateStruct":234,"completionDateStruct":236,"leadSponsor":238,"locationsCount":43},"100650217","effects-of-progressive-neuromuscular-stabilization-exercises-versus-aerobic-exercises-on-body-composition-and-postural-balance-in-children-with-obesity-100650217","NCT07744022","Effects of Progressive Neuromuscular Stabilization Exercises Versus Aerobic Exercises on Body Composition and Postural Balance in Children With Obesity","Effects of Progressive Neuromuscular Stabilization Exercises Versus Aerobic Exercises on Body Composition and Postural Balance in Children With Obesity: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged 12 to 18 years\n* Classified as having Class I obesity (Body Mass Index \\[BMI\\] ≥95th percentile and \\\u003C120% of the 95th percentile for age and sex) or Class II obesity (BMI ≥120% and \\\u003C140% of the 95th percentile for age and sex), according to the Centers for Disease Control and Prevention (CDC) age- and sex-specific growth charts.\n* Able to maintain a single-leg stance on the non-dominant leg with eyes closed for less than 30 seconds.\n* Written informed consent provided by a parent or legal guardian, and assent obtained from the participant.\n* Willing and able to participate in the study.\n\nExclusion Criteria:\n\n* Classified as having Class III obesity (Body Mass Index \\[BMI\\] ≥140% of the 95th percentile for age and sex).\n* Presence of an orthopedic condition that would prevent participation in the exercise program.\n* History of any injury or surgery within the previous 6 months.\n* Presence of a chronic neurological disorder.\n* Presence of a psychiatric disorder.\n* Presence of a severe cognitive impairment.\n* Presence of cardiovascular disease.","12 Years",{"count":224,"type":21},54,[24],"Introduction: Childhood obesity can impair postural control, balance, and motor skills, thereby limiting participation in physical activity. Aerobic exercise is widely used to improve cardiovascular fitness and support weight management in children with obesity. In recent years, however, Progressive Neuromuscular Stabilization (PNS) exercises, which aim to retrain the neuromuscular system, have been suggested to have beneficial effects on core stability, balance, and postural control. Technology-assisted exercise interventions may increase children's participation and enhance motivation throughout the rehabilitation process. This study aims to compare the effectiveness of technology-assisted PNS exercises with conventional aerobic exercise in children with obesity.\n\nMethods: This study will be conducted among children attending the Department of Pediatrics, Istanbul University-Cerrahpaşa who meet the eligibility criteria. Children aged 12-18 years with obesity will be recruited. Participants will be randomly allocated into three groups: the Aerobic Exercise (AE) group, the Progressive Neuromuscular Stabilization (PNS) group, and the Control group.\n\nParticipants in the exercise groups will receive supervised exercise sessions twice weekly for 12 weeks in a clinical setting and will be instructed to perform home-based exercises on the remaining days. Home exercise programs will be delivered through the BeCure® mobile application, where exercise videos will be uploaded, and participants will be asked to perform progressively advancing exercises on a weekly basis. The control group will receive a single session of exercise counseling. Outcome assessments will be performed before and after the intervention.\n\nSample Size: The sample size was calculated using G\\*Power version 3.1. Based on moderate effect sizes reported in the literature (Lengkana et al., 2019), the effect size was set at f = 0.30, with a significance level of α = 0.05 and statistical power of 1 - β = 0.95. Power analysis for a repeated-measures design with three groups and two measurement time points (baseline and post-intervention) indicated a minimum total sample size of 48 participants. To account for potential dropouts, a total of 54 participants will be recruited. Participants will be assigned to the study groups using block randomization stratified by age and sex.\n\nPrimary Outcome Measure:\n\nBalance and postural control will be assessed using the Biodex Balance System.\n\nSecondary Outcome Measures:\n\nBody composition will be evaluated using Body Mass Index (BMI), triceps and subscapular skinfold thickness, waist circumference, and Bioelectrical Impedance Analysis (BIA) to determine body fat percentage. Core muscle endurance will be assessed using the Prone Plank Test and the Side Plank Test. Functional performance will be evaluated using the 6-Minute Walk Test (6MWT), the 30-Second Sit-to-Stand Test (30-s STS), and the 20-Meter Shuttle Run Test.\n\nPhysical activity level will be assessed using the Physical Activity Questionnaire for Children (PAQ-C). Self-perception and body image will be evaluated using the Self-Perception Profile for Children (SPPC). Health-related quality of life will be assessed using the Pediatric Quality of Life Inventory (PedsQL), while fatigue will be evaluated using the PedsQL Multidimensional Fatigue Scale. Posture will be assessed using the New York Posture Rating Scale.\n\nStudy Plan:\n\nEach exercise session will last approximately 40 minutes, consisting of a 5-minute warm-up, 30 minutes of the main exercise program, and a 5-minute cool-down.",[228,229,27],"Childhood Obesity","Aerobic Exercise",[231],"childhood obesity","2026-08-02",{"date":207,"type":35},{"date":235,"type":35},"2026-07-03",{"date":237,"type":21},"2027-08-15",{"name":239,"class":42},"Istanbul University - Cerrahpasa",{"id":241,"slug":242,"hasResults":12,"nctId":243,"briefTitle":244,"officialTitle":245,"acronym":4,"eligibilityCriteria":246,"healthyVolunteers":136,"sex":17,"minAge":52,"maxAge":170,"enrollmentInfo":247,"targetDuration":4,"studyType":22,"phases":249,"briefSummary":250,"conditions":251,"keywords":4,"overallStatus":120,"whyStopped":4,"lastUpdateSubmitDate":252,"lastUpdatePostDateStruct":253,"startDateStruct":254,"completionDateStruct":256,"leadSponsor":258,"locationsCount":43},"100650178","high-intensity-functional-training-hift-vs-moderate-intensity-continuous-training-mict-in-college-students-100650178","NCT07745270","High-Intensity Functional Training (HIFT) vs Moderate-Intensity Continuous Training (MICT) in College Students","The Effects of Interval Compared to Continuous Training on Physical Variables and Vascular Health in College Students: A Three-Arm Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 18 to 35 years.\n* Currently enrolled college or university student.\n* Able to provide written informed consent.\n* Able to attend baseline and post-intervention testing visits and participate in assigned intervention sessions.\n* Cleared for exercise participation based on the health screening form and investigator review.\n\nExclusion Criteria:\n\n* Known cardiovascular, metabolic, pulmonary, renal, neurological, musculoskeletal, or endocrine disorder that would make exercise unsafe or confound outcome measures.\n* Current pregnancy or planning pregnancy during the study period.\n* Current smoking, vaping nicotine products, or use of tobacco products.\n* Uncontrolled hypertension or resting blood pressure values that make exercise testing unsafe based on investigator judgment.\n* Use of medications known to substantially affect cardiovascular function, vascular tone, or exercise responses, unless approved by the PI.\n* Any injury, orthopedic limitation, or medical condition preventing safe participation in HIFT, MICT, or physical fitness testing.\n* Currently participating in structured high-intensity interval, functional, or endurance training more than two days per week during the previous three months.\n* Do not speak English.",{"count":248,"type":21},90,[24],"The purpose of this study is to compare two types of exercise programs in college students: high-intensity functional training and moderate-intensity continuous training. The study evaluates whether these exercise programs improve body composition, physical fitness, and blood vessel health compared with a group that does not participate in exercise training. In addition, the study examines whether changes in body composition and physical fitness are associated with changes in blood vessel health.",[27],"2026-07-29",{"date":207,"type":35},{"date":255,"type":21},"2026-09",{"date":257,"type":21},"2028-06",{"name":259,"class":42},"University of Miami",{"id":261,"slug":262,"hasResults":12,"nctId":263,"briefTitle":264,"officialTitle":265,"acronym":266,"eligibilityCriteria":267,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":268,"targetDuration":4,"studyType":22,"phases":270,"briefSummary":271,"conditions":272,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":277,"lastUpdatePostDateStruct":278,"startDateStruct":280,"completionDateStruct":282,"leadSponsor":283,"locationsCount":43},"100649888","immersive-virtual-reality-and-exercise-programs-in-multiple-sclerosis-exerviem-iii-100649888","NCT07738120","Immersive Virtual Reality and Exercise Programs in Multiple Sclerosis: ExeRVIEM III","Effects of a Physiotherapy Program With High-Intensity Exercise and Immersive Virtual Reality in Multiple Sclerosis: Randomized Controlled Trial","ExeRVIEM III","Inclusion Criteria:\n\n* ≥18 years of age.\n* Confirmed diagnosis of MS.\n* Stable disease with no relapse in the previous 6 weeks.\n* Patients who will be take follow up by a neurologist at the referral hospital and will be members of the patient association.\n* Ability to perform moderate exercise.\n* Capacity to provide informed consent.\n\nExclusion Criteria:\n\n* Comorbidities that hinder the development of the VR program\n* Visual or vestibular impairment that would contraindicate VR use.\n* Recent changes in disease modifying therapy.",{"count":269,"type":21},30,[24],"TITLE: Immersive Virtual Reality and Exercise Programs in Multiple Sclerosis: ExeRVIEM III. INTRODUCTION: Multiple sclerosis (MS) is a chronic neuroimmunological and degenerative disease characterized by demyelination within the central nervous system. Its clinical course involves motor impairment, sensory disturbances, cognitive dysfunction, and a progressive decline in functional independence. MS is one of the leading causes of non-traumatic disability in young adults. This highlights the considerable impact of the disease, both in terms of healthcare burden and healthcare expenditure. Within this context, therapeutic exercise has evolved from being considered potentially harmful to being recognized as a safe and effective intervention capable of improving gait, balance, cardiorespiratory fitness, fatigue, and quality of life in people with MS. A model has been proposed for prescribing and progressing exercise at different stages of MS: passive range-of-motion exercises designed for patients with the most severe symptoms, a second stage incorporating active muscle-strengthening exercises, and finally, integrated exercise programs that incorporate strength, endurance, balance, and coordination training. Evidence from systematic reviews and meta-analyses shows that structured exercise (including high-intensity protocols when performed under supervision) is safe and can improve functional outcomes. Our ExeRVIEM III project (Physiotherapy program with High-Intensity Exercise Program and Immersive Virtual Reality in Multiple Sclerosis) represents a novel strategy to facilitate rehabilitation exercise programs using head-mounted virtual reality displays. HYPOTHESIS: The ExeRVIEM III project, based on training physical function in people with MS, is feasible and safe, and could have a potential clinical impact in the motor and cognitive domains, as well as applicability in community settings, such as patient associations. GENERAL OBJECTIVES: 1.1 To design and implement an ExeRVIEM III exercise program\u002Fprotocol for people with MS. 1.2 To evaluate the safety of the high-intensity virtual reality exercise program. SPECIFIC OBJECTIVES: 2.1 To analyze the possible changes in disability, functional variables, cognitive domains and biomarkers in the short and medium term in people who attend a patient association and carry out the ExeRVIEM III exercise program for people with MS. METHODOLOGY: A randomized controlled trial, double-arm (experimental and control group) study will be conducted at a patient association (Santiago de Compostela, Spain). The intervention will consist of an 6-month supervised virtual rehabilitation program, with two weekly sessions on alternate days, in addition to the standard rehabilitation prescribed by the patient association clinical team (physiotherapy, occupational therapy, and cognitive training sessions). An inmersive virtual reality (IVR) body combat exercise videogame will be used, administered via a virtual reality headset. In accordance with clinical guidelines for IVR, sessions will be intentionally brief (10 minutes) to minimize cybersickness and excessive fatigue. Assessments will be conducted at baseline (week 0) and immediately after the intervention (week 24). Demographic and clinical data will also be collected, including sex, age, comorbidities, disease duration, MS subtype, and pharmacological treatment. Assessments will be conducted at the patient association and in the Neurology Department of the referral hospital. Feasibility, safety, strength parameters, dual-task performance and fatigue levels assessments will be performed at the patient association by physiotherapists, while the remaining assessments will be completed at the hospital by a neurologist specializing in MS. The content of the assessments will be: Patient characteristics that will include data on age, sex, years since diagnosis, MS subtype, and pharmacological treatment. Feasibility: Number of virtual sessions attended by each participant (adherence rate via registration sheet). Rate Perceived Effort using the modified Borg scale, which measures the level of perceived exertion on a scale of 0 to 10 from no effort to maximum effort. Safety: adverse events using the Simulator Sickness Questionnaire (SSQ).Strength parameters using Five times sit to stand test (FTSST) and handgrip test. Functional mobility will be assessed using Timed and Go test (TUG) and with dual task performance using TUG-cog. Level of fatigue using the Fatigue Severity Scale (FSS). Level of disability: using the Expanded Disability Status Scale (EDSS).Gait will be evaluated using the 25Foot Walk Test (25FWT). Manual dexterity will be assessed using 9-Hole Peg Test (9HPT). Cognitive domains evaluated by the Symbol Digit Modalities Test (SDMT)Axonal injury biomarker evaluated by Neurofilament light chain (sNfL) concentrations.",[273,27,274,275,276],"Multiple Sclerosis","Physical Therapy","Virtual Reality Exposure Therapy","Rehabilitation Exercise","2026-07-28",{"date":279,"type":35},"2026-07-31",{"date":281,"type":35},"2025-10-06",{"date":209,"type":21},{"name":284,"class":42},"University of Vigo",{"id":286,"slug":287,"hasResults":12,"nctId":288,"briefTitle":289,"officialTitle":290,"acronym":4,"eligibilityCriteria":291,"healthyVolunteers":12,"sex":137,"minAge":292,"maxAge":78,"enrollmentInfo":293,"targetDuration":4,"studyType":22,"phases":295,"briefSummary":296,"conditions":297,"keywords":302,"overallStatus":120,"whyStopped":4,"lastUpdateSubmitDate":277,"lastUpdatePostDateStruct":304,"startDateStruct":306,"completionDateStruct":308,"leadSponsor":310,"locationsCount":43},"100649535","effect-of-hormone-replacement-therapy-on-physiotherapy-outcomes-in-postmenopausal-women-with-frozen-shoulder-100649535","NCT07736027","Effect of Hormone Replacement Therapy on Physiotherapy Outcomes in Postmenopausal Women With Frozen Shoulder","The Effects of Hormone Replacement Therapy on Clinical and Functional Outcomes in Postmenopausal Women With Frozen Shoulder","Inclusion Criteria:\n\n* Postmenopausal female patients aged 40 to 60 years.\n* Shoulder pain at rest and during activities of daily living lasting for more than 3 months.\n* Clinical diagnosis of Stage I or Stage II frozen shoulder (adhesive capsulitis).\n* Passive range of motion (ROM) loss of greater than 25% compared to the unaffected shoulder in at least two movement planes (flexion, abduction, internal rotation, or external rotation).\n* Reduced range of motion of less than 50% compared to the unaffected side in at least one movement direction (flexion, abduction, internal rotation, or external rotation).\n* Increased restriction of external and internal rotation during glenohumeral abduction from 45 to 90 degrees.\n\nExclusion Criteria:\n\n* Passive external rotation range of motion of less than 30 degrees (\\\u003C30°).\n* Presence of glenohumeral arthritis confirmed by radiography.\n* History or presence of inflammatory joint disease.\n* History of malignancy or active cancer diagnosis.\n* Previous treatment for the current shoulder condition (e.g., physiotherapy and rehabilitation, intra-articular injections, or surgical intervention).\n* Baseline shoulder pain score of less than 3 (\\\u003C3) on the Numeric Pain Rating Scale (NPRS).","40 Years",{"count":294,"type":21},56,[24],"The purpose of this study is to compare the effects of a physiotherapy program on pain levels, shoulder range of motion, functional status, pain catastrophizing, perceived change, sleep quality, and quality of life in postmenopausal women diagnosed with frozen shoulder, with and without Hormone Replacement Therapy (HRT). The findings are expected to contribute to personalized treatment planning for postmenopausal women with frozen shoulder and help fill the gap in current literature.",[298,299,300,301,27,274],"Frozen Shoulder","Adhesive Capsulitis","Adhesive Capsulitis of the Shoulder","Hormone Replacement Therapy, Post-Menopausal",[303],"Frozen Shoulder, Adhesive Capsulitis, Hormone Replacement Therapy, Postmenopause, Physical Therapy, Rehabilitation, Pain Catastrophizing, Range of Motion",{"date":305,"type":35},"2026-07-30",{"date":307,"type":21},"2026-09-01",{"date":309,"type":21},"2027-10-01",{"name":239,"class":42},{"id":312,"slug":313,"hasResults":12,"nctId":314,"briefTitle":315,"officialTitle":316,"acronym":317,"eligibilityCriteria":318,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":319,"targetDuration":4,"studyType":22,"phases":320,"briefSummary":322,"conditions":323,"keywords":327,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":331,"lastUpdatePostDateStruct":332,"startDateStruct":334,"completionDateStruct":336,"leadSponsor":338,"locationsCount":340},"100566653","phase-2-response-to-exercise-and-nitric-oxide-in-pad-100566653","NCT06657976","Response to Exercise and Nitric Oxide in PAD","Response to Exercise and Nitric Oxide in Peripheral Artery Disease: The RESIST PAD Trial","RESIST","Inclusion Criteria:\n\n1. An ABI less than or equal to 0.90 at baseline.\n2. Vascular lab evidence of PAD (such as a toe brachial pressure less than or equal to 0.70 or an ankle brachial index less than or equal to 0.90), or angiographic evidence of PAD defined as at least 70% stenosis of an artery supplying the lower extremities.\n3. An ABI of more than 0.90 and less than 1.00 who experience a 20% or greater drop in ABI in either leg after the heel-rise test.\n\nExclusion Criteria:\n\n1. Above- or below-knee amputation\n2. Limb-threatening ischemia defined as an ABI less than 0.40 with symptoms of rest pain\n3. Wheelchair confinement or requiring a walker to ambulate\n4. Walking is limited by a condition other than PAD\n5. Current foot ulcer on bottom of foot\n6. Failure to complete study-run\n7. Unwilling to accept randomization into either group (supervised exercise or attention control)\n8. Planning to engage in new walking exercise outside of the study or unwilling to refrain from new walking exercise activity during the trial.\n9. Already exercising at a level consistent with exercise intervention, using investigator discretion.\n10. End-stage kidney disease (ESKD) that is treated with hemodialysis.\n11. Planned major surgery, coronary or leg revascularization during the next six months\n12. Major surgery, coronary or leg revascularization or major cardiovascular event in the previous three months\n13. Major medical illness including lung disease requiring oxygen, Parkinson's disease, a life-threatening illness with life expectancy less than six months, or cancer requiring treatment in the previous two years. \\[NOTE: potential participants may still qualify if they have had treatment for an early stage cancer in the past two years and the prognosis is excellent. Participants who require oxygen only at night may still qualify.\\]\n14. Mini-Mental Status Examination (MMSE) score less than 23 or dementia. If the MMSE is less than 23 and the Principal Investigator evaluation determines that the lower score is related to language barriers or education level, the Principal Investigator has discretion to allow a participant with MMSE less than 23 to participate, as appropriate. Dementia with sufficient impairment to prevent full engagement in all aspects of the trial will be an exclusion per the investigator's discretion.\n15. Allergy to beetroot juice\n16. Currently consuming beetroot juice, oral nitrate or nitrite, or a beetroot supplement and\u002For unwilling to avoid beetroot juice during the study. Participants will be asked to discontinue these items for 14 days before baseline testing and throughout the clinical trial. If the potential participant is unwilling to refrain from taking these items, they will not be eligible for the clinical trial.\n17. Currently consuming one cup or more of beets daily. Participants will be asked to discontinue beet ingestion of one cup or more of beets for 30 days before baseline testing and throughout the clinical trial. If the potential participant is unwilling to refrain from daily beet consumption of one cup or more for 30 days before the trial and during the trial, they will not be eligible for the clinical trial.\n18. Unstable angina\n19. Abnormal baseline stress test without subsequent clearance for exercise by physician\n20. Non-English speaking. The RESIST PAD interventions are delivered by interventionists who do not speak non-English languages. The integrity of the clinical trial requires clear and effective communication for data collection and intervention delivery. The trial does not have staff members who are fluent in non-English languages nor does it have the ability to translate all study materials into other languages.\n21. Participation in or completion of a clinical trial in the previous three months. \\[NOTE: after completing a stem cell or gene therapy intervention, participants will become eligible after the final study follow-up visit of the stem cell or gene therapy study so long as at least six months have passed since the final intervention administration. After completing a supplement or drug therapy (other than stem cell or gene therapy), participants will be eligible after the final study follow-up visit as long as at least three months have passed since the final intervention of the trial.\\] Participants in a study that involved up to three single doses of nitrate-rich beetroot juice administered on separate days may participate if a month has passed since their last dose of nitrate-rich beetroot juice.\n22. Visual impairment that limits walking ability.\n23. Baseline blood pressure less than 100\u002F45.\n24. Participation in a supervised treadmill exercise program in previous three months or planning to begin a supervised treadmill exercise program in the next six months.\n25. History of kidney stones that requires minimized intake of oxalate. Potential participants who need to minimize oxalate intake will be excluded from the trial.\n26. In addition to the above criteria, investigator discretion will be used to determine if the trial is unsafe or not a good fit for the potential participant.",{"count":20,"type":21},[321],"PHASE2","RESIST PAD is a randomized trial of 200 PAD patients to establish: 1) whether a 12-week exercise intervention significantly increases Δ nitrite at 12-week follow-up, compared to control; 2) whether exercise \"responders\" have greater Δ nitrite increases compared to \"non-responders\"; 3) among non-responders, whether supplementing exercise with nitrate-rich beetroot juice between weeks 13-24 increases Δ nitrite and improves 6-minute walk at 24-week follow-up.",[324,27,325,326],"Peripheral Artery Disease","Intermittent Claudication","Nitric Oxide",[328,329,330],"Peripheral artery disease","Claudication","Walking difficulty","2026-07-23",{"date":333,"type":35},"2026-07-27",{"date":335,"type":35},"2025-01-23",{"date":337,"type":21},"2029-10-01",{"name":339,"class":42},"Northwestern University",2,{"id":342,"slug":343,"hasResults":12,"nctId":344,"briefTitle":345,"officialTitle":346,"acronym":4,"eligibilityCriteria":347,"healthyVolunteers":136,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":348,"targetDuration":4,"studyType":22,"phases":350,"briefSummary":351,"conditions":352,"keywords":4,"overallStatus":120,"whyStopped":4,"lastUpdateSubmitDate":353,"lastUpdatePostDateStruct":354,"startDateStruct":355,"completionDateStruct":357,"leadSponsor":359,"locationsCount":4},"100583745","llm-generated-coaching-prompts-100583745","NCT06880315","LLM-Generated Coaching Prompts","Enhancing Physical Activity With LLM-Generated Coaching Prompts: A My Heart Counts Study","Inclusion Criteria:\n\n* Age: Participants must be 18 years or older.\n* Health Status: Participants must be healthy enough to engage in physical activity.\n* Language Proficiency: Participants must be able to read, understand, and consent in English or Spanish (dependent on which is being studied).\n* Device Ownership: Participants must possess an iPhone and an Apple Watch.\n* Data Sharing: Participants must be willing to share their HealthKit data via secure upload.\n\nExclusion Criteria:\n\n* Age: Participants under the age of 18.\n* Health Status: Participants who are not healthy enough to engage in physical activity.\n* Language Proficiency: Participants who cannot read, understand, or consent in English or Spanish.\n* Device Ownership: Participants who do not have both an iPhone and an Apple Watch.\n* Data Sharing: Participants unwilling to share their HealthKit data via secure upload.",{"count":349,"type":21},50,[24],"This pilot study aims to evaluate whether personalized coaching prompts generated by a large language model (LLM) can effectively increase physical activity levels among participants. The study will involve 50 participants who will receive daily text messages, either personalized by the LLM or generic, over a 14-day period. Participants will share their HealthKit data for analysis. The findings will inform the development of future versions of the My Heart Counts application, enhancing user engagement and health outcomes.",[27],"2026-07-21",{"date":331,"type":35},{"date":356,"type":21},"2027-01-20",{"date":358,"type":21},"2027-12-01",{"name":360,"class":42},"Stanford University",{"id":362,"slug":363,"hasResults":12,"nctId":364,"briefTitle":365,"officialTitle":365,"acronym":366,"eligibilityCriteria":367,"healthyVolunteers":136,"sex":17,"minAge":52,"maxAge":368,"enrollmentInfo":369,"targetDuration":4,"studyType":22,"phases":371,"briefSummary":372,"conditions":373,"keywords":4,"overallStatus":120,"whyStopped":4,"lastUpdateSubmitDate":376,"lastUpdatePostDateStruct":377,"startDateStruct":378,"completionDateStruct":380,"leadSponsor":382,"locationsCount":43},"100644490","methodological-study-of-exercise-and-hypoxic-conditions-in-healthy-subjects-100644490","NCT07671638","Methodological Study of Exercise and Hypoxic Conditions in Healthy Subjects","ExHyp","Inclusion Criteria:\n\n* Healthy male or female volunteers\n* Aged 18-55\n* Body Mass Index \\\u003C30 kg\u002Fm²\n* Participants covered by a social security scheme\n* Participants capable of signing an informed consent form\n* Negative pregnancy test and highly effective contraception for women of childbearing age\n\nExclusion Criteria:\n\n* Cardiorespiratory, metabolic and neurological disorders, or other conditions assessed during the inclusion consultation that may affect physiological responses to exercise or hypoxia\n* Pharmacological treatment taken during the study, other than oral or implantable contraceptive medication for female volunteers of childbearing age","55 Years",{"count":370,"type":21},305,[24],"The aim of this protocol is to assess physiological responses during various physical exercise protocols (whole-body exercise such as cycling or treadmill running, or localised exercise such as knee extension) and during inhalation of a gas mixtures with various oxygen contents (similar to exposure at high altitude).",[374,27,375],"Healthy Subjects (HS)","Hypoxia","2026-07-17",{"date":353,"type":35},{"date":379,"type":21},"2026-09-15",{"date":381,"type":21},"2032-03-31",{"name":383,"class":42},"University Hospital, Grenoble",{"id":385,"slug":386,"hasResults":12,"nctId":387,"briefTitle":388,"officialTitle":389,"acronym":4,"eligibilityCriteria":390,"healthyVolunteers":136,"sex":137,"minAge":391,"maxAge":392,"enrollmentInfo":393,"targetDuration":4,"studyType":22,"phases":395,"briefSummary":396,"conditions":397,"keywords":402,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":411,"lastUpdatePostDateStruct":412,"startDateStruct":413,"completionDateStruct":415,"leadSponsor":417,"locationsCount":43},"100542041","phase-2-smart-walk-a-culturally-tailored-smartphone-delivered-physical-activity-intervention-for-african-american-women-100542041","NCT06337708","Smart Walk: A Culturally Tailored Smartphone-Delivered Physical Activity Intervention for African American Women","Smart Walk: An Efficacy Trial of a Culturally Tailored Smartphone-Delivered Physical Activity Intervention for African American Women","Inclusion Criteria:\n\n* Self-reported African American\u002FBlack female\n* Aged of 24-65 years\n* Insufficiently Active (\\\u003C 60 minutes of moderate-to-vigorous physical activity per week as measured by Exercise Vital Sign Questionnaire)\n* BMI \\> 25 kg\u002Fm2\n* English speaking and reading\n* Ownership of a smartphone with the ability to download applications (i.e., apps)\n* Ownership of a smartphone with the ability to receive text messages\n* Willingness to receive a physical activity intervention delivered through their smartphone\n* Willingness to include their first name or create an alias to be used on their profile page on the Smart Walk app\n\nExclusion Criteria:\n\n* Plans to relocate out of Phoenix area in next 12 months\n* Endorsing an item on the Physical Activity Readiness Questionnaire (PAR-Q), unless a doctor's note for study participation in provided\n* Resting systolic blood pressure greater than 180 mmHG and\u002For a diastolic blood pressure greater than 120 mmHG , as assessed at baseline or at any other study assessment\n* Self-reported participation in another diet or weight loss study at screening\n* Pregnant or planning to become pregnant in the next 12 months","24 Years","65 Years",{"count":394,"type":21},210,[321],"The purpose of this study is to test a culturally tailored, smartphone-delivered intervention designed to increase physical activity and reduce risk for heart disease and type 2 diabetes among African American women.",[398,27,399,400,401],"Physical Activity","Heart Diseases","Diabetes Mellitus","Physical Inactivity",[403,404,405,406,407,408,88,409,410],"mHealth","women's health","health equity","African American women","Black women","exercise","heart disease","diabetes","2026-07-16",{"date":376,"type":35},{"date":414,"type":35},"2024-04-08",{"date":416,"type":21},"2029-03-31",{"name":418,"class":42},"Arizona State University",{"id":420,"slug":421,"hasResults":12,"nctId":422,"briefTitle":423,"officialTitle":424,"acronym":4,"eligibilityCriteria":425,"healthyVolunteers":136,"sex":17,"minAge":426,"maxAge":392,"enrollmentInfo":427,"targetDuration":4,"studyType":22,"phases":428,"briefSummary":429,"conditions":430,"keywords":431,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":411,"lastUpdatePostDateStruct":436,"startDateStruct":437,"completionDateStruct":439,"leadSponsor":441,"locationsCount":43},"100514557","goal-setting-to-promote-physical-activity-adherence-in-midlife-adults-100514557","NCT05980052","Goal Setting to Promote Physical Activity Adherence in Midlife Adults","Goal Setting to Promote Physical Activity Adherence in Midlife to Reduce Risk of Alzheimer's Disease and Related-Dementias: A Randomized Mechanistic Proof-Of-Concept Trial","Inclusion Criteria:\n\n* Aged 45 to 65 years\n* BMI between 30 kg\u002Fm2 to 50 kg\u002Fm2\n* Participants must weigh a minimum of 110 pounds\n* Engaging in 60 minutes or less of self-reported moderate-to-vigorous physical activity at screening (based on Exercise Vital Sign Questionnaire)\n* Self-reported ownership of a smartphone with an iOS or Android operating system (necessary for participants to track their activity using a Fitbit activity monitor)\n\nExclusion Criteria:\n\n* Endorsing an item on the Physical Activity Readiness Questionnaire (PAR-Q), unless a physician's note is provided\n* Resting blood pressure greater than 200\u002F110 mmHG as assessed at the baseline study assessment (unless a physician's note is provided)\n* Pregnant or planning to become pregnant in next 8-months (Phase 1) or 12 months (Phase 2)\n* Plans to relocate out of metropolitan Phoenix, Arizona area in the next 8-months (Phase 1) or 12 months (Phase 2)\n* Participation in another physical activity, nutrition or weight loss program at time of screening or at any time during the intervention\n* Individuals with mild cognitive impairment (MCI), as determined by either a self-report of receiving a diagnosis of MCI from a health care provider or as assessed by the Montreal Cognitive Assessment (MoCA) at the study orientation session. A score \\\u003C 26 is an exclusion criterion for US born participants. A score of \\\u003C23 is an exclusion for participants born outside of the US who completed their high school education in a country where English is not the primary language.\n* Being previously prescribed one of the 5 approved Alzheimer's medications, including: Donepezil (Aricept), Rivastigmine (Exelon), Galantamine (Razadyne), Memantine (Namenda), Memantine + Donepezil (Namzaric)\n* Score of 16 or higher on the Center for Epidemiological Studies-Depression Scale (CES-D)\n* Self-reported current diagnosis of major depression\n* Currently taking 2 or more ant-depression drugs\n* History of stroke\n* Incarcerated individuals (i.e., Prisoners)","45 Years",{"count":5,"type":21},[24],"Engaging in regular physical activity during midlife is a key lifestyle behavior associated with reduced risk for Alzheimer's disease and related dementias (AD\u002FADRD). Yet nearly half of midlife adults (48%) do not meet national physical activity guidelines. The purpose of this mechanistic trial is to identify effective goal setting techniques to enhance psychosocial processes of self-regulation for the successful promotion of PA and adherence to national PA guidelines among midlife adults, with the long-term goal of reducing AD\u002FADRD risk",[398,27],[408,88,92,432,433,434,435],"Alzheimer's disease","dementia","behavior change","midlife",{"date":376,"type":35},{"date":438,"type":35},"2023-07-17",{"date":440,"type":21},"2027-05-31",{"name":418,"class":42},{"id":443,"slug":444,"hasResults":12,"nctId":445,"briefTitle":446,"officialTitle":447,"acronym":4,"eligibilityCriteria":448,"healthyVolunteers":136,"sex":17,"minAge":52,"maxAge":449,"enrollmentInfo":450,"targetDuration":4,"studyType":22,"phases":452,"briefSummary":453,"conditions":454,"keywords":4,"overallStatus":120,"whyStopped":4,"lastUpdateSubmitDate":456,"lastUpdatePostDateStruct":457,"startDateStruct":458,"completionDateStruct":460,"leadSponsor":462,"locationsCount":43},"100647612","diurnal-strength-variation-100647612","NCT07711340","Diurnal Strength Variation","Exercise Timing and Lower Limb Biomechanics","Inclusion Criteria:\n\n* Healthy\n* 18-25 years old\n* Lower body exercise three or more times per week, all at the same time of day (within 2 hour window)\n* Regular meal times (±1 hour window)\n* Regular sleep times (±1 hour window)\n\nExclusion Criteria:\n\n* Active or uncontrolled mental or physical health issues\n* Current musculoskeletal injury","25 Years",{"count":451,"type":21},20,[24],"Healthy individuals will be tested at different times of day to determine whether exercise at a non-expected time results in poorer performance.",[455,27],"Healthy Adult","2026-07-14",{"date":376,"type":35},{"date":459,"type":21},"2026-08-01",{"date":461,"type":21},"2026-12-31",{"name":360,"class":42},{"id":464,"slug":465,"hasResults":12,"nctId":466,"briefTitle":467,"officialTitle":468,"acronym":469,"eligibilityCriteria":470,"healthyVolunteers":12,"sex":137,"minAge":52,"maxAge":292,"enrollmentInfo":471,"targetDuration":4,"studyType":22,"phases":473,"briefSummary":474,"conditions":475,"keywords":487,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":489,"lastUpdatePostDateStruct":490,"startDateStruct":492,"completionDateStruct":494,"leadSponsor":496,"locationsCount":340},"100457248","better-lifestyle-counseling-for-african-american-women-during-pregnancy-100457248","NCT05234125","Better Lifestyle Counseling for African American Women During Pregnancy","A Randomized Control Trial to Improve Metabolic Outcomes in African American Pregnant Women","BETTER","Inclusion Criteria:\n\n* African American pregnant woman.\n* Women between 16 and 22 GWs.\n* Overweight or obese - pregravid Body Mass Index \\>25.0 kg\u002Fm2.\n* Singleton gestation.\n* Established prenatal care at The University of Illinois Hospital \\& Health Sciences.\n* System Obstetric (UIHHSS' OB) clinics. Able to understand, speak and write in English.\n\nExclusion Criteria:\n\n* Multiple gestations.\n* Night-shift work.\n* Diagnosed sleep disorders.\n* Known fetal chromosomal or anatomical abnormalities.\n* Diagnosed mood disorders.\n* Gestational diabetes in early pregnancy.\n* Glycated Hemoglobin (HbA1c) ≥ 6.5%.\n* Hypoglycemic medications.\n* Stimulant medication or taking a sleeping aid.\n* Active drug abuse\u002Fexcessive alcohol intake.",{"count":472,"type":21},150,[24],"The purpose of this randomized controlled trial is to establish the effectiveness of a culturally targeted and individually tailored behavioral intervention to promote maternal glucose metabolism in African American women.",[476,477,478,479,480,481,482,483,27,484,485,486],"Overweight or Obesity","Pregnancy Related","Sleep Disturbances","Sleep Hygiene","Pregnancy Complications","Diversity","Stress, Psychological","Fitness Trackers","African Americans","Disparities in Pregnancy Complications","Sleep Disparities",[488],"Sleep, Pregnancy, Intervention, glucose metabolism,","2026-07-07",{"date":491,"type":35},"2026-07-09",{"date":493,"type":35},"2022-08-16",{"date":495,"type":21},"2027-12-30",{"name":497,"class":42},"University of Illinois at Chicago",{"id":499,"slug":500,"hasResults":12,"nctId":501,"briefTitle":502,"officialTitle":503,"acronym":4,"eligibilityCriteria":504,"healthyVolunteers":136,"sex":17,"minAge":52,"maxAge":505,"enrollmentInfo":506,"targetDuration":4,"studyType":22,"phases":507,"briefSummary":508,"conditions":509,"keywords":511,"overallStatus":120,"whyStopped":4,"lastUpdateSubmitDate":515,"lastUpdatePostDateStruct":516,"startDateStruct":518,"completionDateStruct":520,"leadSponsor":522,"locationsCount":43},"100645413","yoga-vs-stretching-strengthening-physical-fitness-in-sedentary-young-adults-100645413","NCT07680712","Yoga vs. Stretching-Strengthening: Physical Fitness in Sedentary Young Adults","Comparative Effects of Yoga Versus Stretching-Strengthening Exercises on Physical Fitness in Sedentary Young Adults","Inclusion Criteria:\n\n* Being between 18 and 30 years of age,\n* Having a body mass index (BMI) of less than 30 kg\u002Fm²,\n* Being healthy (having no known systemic, neurological, psychological, or orthopedic diseases),\n* Not having participated in regular exercise within the last six months,\n* Having a sedentary lifestyle according to the World Health Organization (WHO) definition (not performing at least 150 minutes of moderate-intensity or 75 minutes of vigorous-intensity aerobic activity per week),\n* Agreeing not to participate regularly in any other physical activity or exercise program for the duration of the study,\n* Voluntarily participating in the study and agreeing to sign the written and verbal informed consent form in accordance with the principles of the Declaration of Helsinki.\n\nExclusion Criteria:\n\n* Individuals with a history of injury, surgery, or pain complaints affecting the musculoskeletal system within the last six months,\n* Individuals with neurological, cardiovascular, respiratory, endocrine, psychiatric, or metabolic diseases,\n* Individuals who participate in any regular sporting activity,\n* Female participants who are pregnant or have a suspected pregnancy,\n* Individuals who state that they will not be able to participate regularly in the exercise program or will not be able to complete the study,\n* Individuals who do not provide written and verbal informed consent to participate in the study.","30 Years",{"count":349,"type":21},[24],"The goal of this clinical trial is to learn if yoga or stretching-strengthening exercises are more effective in sedentary young adults who are currently healthy but at risk due to inactivity. The main questions it aims to answer are:\n\nWhich exercise type leads to better improvements in physical fitness, mental well-being, and sleep quality based on a person's starting profile?\n\nHow do initial levels of balance and muscle strength affect how well a person responds to these exercises?\n\nResearchers will compare a yoga group to a stretching-strengthening exercise group to see if one approach is more effective than the other for specific types of individuals.\n\nParticipants will:\n\nBe evaluated for their starting physical fitness (balance and strength) and psychological health.\n\nPerform either yoga or stretching-strengthening exercises regularly during the study period.\n\nComplete surveys about their mood, stress levels, and sleep quality.\n\nBe re-tested at the end of the program to measure changes and improvements.",[510,27],"Sedentary Lifestlye",[512,513,514],"physical exercise","physical inactivity","healthy lifestyle","2026-06-29",{"date":517,"type":35},"2026-07-02",{"date":519,"type":21},"2026-06-22",{"date":521,"type":21},"2027-03",{"name":239,"class":42},{"id":524,"slug":525,"hasResults":12,"nctId":526,"briefTitle":527,"officialTitle":528,"acronym":529,"eligibilityCriteria":530,"healthyVolunteers":136,"sex":17,"minAge":52,"maxAge":292,"enrollmentInfo":531,"targetDuration":4,"studyType":22,"phases":533,"briefSummary":534,"conditions":535,"keywords":537,"overallStatus":120,"whyStopped":4,"lastUpdateSubmitDate":541,"lastUpdatePostDateStruct":542,"startDateStruct":543,"completionDateStruct":545,"leadSponsor":547,"locationsCount":43},"100645350","effects-of-a-12-week-t10-exercise-program-on-shooting-performance-upper-extremity-function-balance-and-reaction-time-in-competitive-air-pistol-athletes-100645350","NCT07681427","Effects of a 12-week T10 Exercise Program on Shooting Performance, Upper Extremity Function, Balance and Reaction Time in Competitive Air Pistol Athletes","The Effects of a 12-Week T10 Exercise Program on Shooting Performance, Upper Extremity Function, Balance, and Reaction Time in Air Pistol Athletes: A Randomized Controlled Trial","Air pistol T10","Inclusion Criteria:\n\n* Age between 18 and 40 years.\n* Competitive air pistol athletes with at least 2 years of regular shooting experience.\n* Participating in shooting training for at least 6 hours per week.\n* Being in the preseason training period.\n* Willing to participate and able to provide written informed consent.\n\nExclusion Criteria:\n\n* Current upper extremity musculoskeletal injury or pain.\n* History of upper extremity orthopedic surgery.\n* Neurological or cognitive disorders affecting participation.\n* Visual or hearing impairments that may interfere with testing or shooting performance.\n* Inflammatory joint disease involving the lower extremities.\n* History of lower extremity orthopedic surgery or musculoskeletal deformity affecting performance.\n* Rheumatologic, metabolic, or cardiovascular disease.\n* Body mass index (BMI) \\>30 kg\u002Fm².\n* Current use of psychiatric medication.\n* Failure to attend two consecutive intervention sessions during the study period.",{"count":532,"type":21},24,[24],"Air pistol shooting requires a high level of postural stability, upper extremity neuromuscular control, and concentration to achieve optimal performance. Prolonged maintenance of the shooting position may lead to shoulder muscle fatigue, reduced joint stability, and impaired shooting accuracy. Although sport-specific exercise programs have been recommended to improve physical performance in shooters, the effectiveness of the T10 exercise program has not yet been investigated in this population. This randomized controlled trial aims to evaluate the effects of a 12-week T10 exercise program, in addition to routine training, on shooting performance in competitive air pistol athletes. Secondary outcomes include upper and lower extremity functional performance, balance, muscular endurance, upper extremity stability, grip strength, medicine ball throw performance, and visual and auditory reaction time. Participants will be randomly allocated to either an intervention group receiving the T10 exercise program plus routine training or a control group continuing routine training alone. Assessments will be performed at baseline and after the 12-week intervention. The findings of this study may provide evidence for the effectiveness of a sport-specific neuromuscular exercise program in enhancing shooting performance and physical function in competitive air pistol athletes.",[536,27],"Physiotherapy and Rehabilitation",[538,539,540],"air pistol","T10 exercise","performance","2026-06-26",{"date":517,"type":35},{"date":544,"type":21},"2026-07-10",{"date":546,"type":21},"2027-12-15",{"name":548,"class":42},"Hacettepe University",{"id":550,"slug":551,"hasResults":12,"nctId":552,"briefTitle":553,"officialTitle":553,"acronym":4,"eligibilityCriteria":554,"healthyVolunteers":136,"sex":17,"minAge":52,"maxAge":505,"enrollmentInfo":555,"targetDuration":4,"studyType":22,"phases":556,"briefSummary":557,"conditions":558,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":541,"lastUpdatePostDateStruct":561,"startDateStruct":562,"completionDateStruct":564,"leadSponsor":566,"locationsCount":43},"100526696","developing-a-nutritional-supplement-to-increase-collagen-synthesis-in-people-100526696","NCT06138106","Developing a Nutritional Supplement to Increase Collagen Synthesis in People","Inclusion Criteria:\n\n* Young healthy adults (18-30 y)\n\nExclusion Criteria:\n\n* Pregnancy\n* Smoking\n* Receiving any medication that may interfere with the study outcomes",{"count":451,"type":21},[24],"The purpose of this study is to test whether a natural product supplement can potentiate the increase in collagen synthesis following the ingestion of collagen protein. The investigators have developed a model of natural (GRAS certified) products that stimulate collagen synthesis, in vitro. The investigators will determine whether the natural product supplement can potentiate the collagen synthetic response to the ingestion of collagen protein. Basal and fed serum will be isolated and these samples will be used to treat human engineered ligaments.",[559,560,27],"Dietary Supplements","Connective Tissue",{"date":515,"type":35},{"date":563,"type":35},"2023-11-21",{"date":565,"type":21},"2026-12-01",{"name":567,"class":42},"University of California, Davis",{"id":569,"slug":570,"hasResults":12,"nctId":571,"briefTitle":572,"officialTitle":572,"acronym":573,"eligibilityCriteria":574,"healthyVolunteers":12,"sex":137,"minAge":52,"maxAge":4,"enrollmentInfo":575,"targetDuration":4,"studyType":22,"phases":577,"briefSummary":578,"conditions":579,"keywords":581,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":584,"lastUpdatePostDateStruct":585,"startDateStruct":586,"completionDateStruct":588,"leadSponsor":590,"locationsCount":43},"100644632","the-effect-of-a-post-operative-exercise-programme-versus-standard-care-on-physical-fitness-of-patients-with-breast-cancer-undergoing-deep-inferior-epigastric-perforator-diep-flap-reconstruction-surgery-100644632","NCT07672392","The Effect of a Post-operative Exercise Programme Versus Standard Care on Physical Fitness of Patients With Breast Cancer Undergoing Deep Inferior Epigastric Perforator (DIEP) Flap Reconstruction Surgery","EXERCISE DIEP","Inclusion Criteria:\n\n1. Women aged 18 years and older\n2. Candidates who have already been selected to undergo mastectomy and reconstruction by the breast MDT for the following indications:\n\n   1. Genetic mutation carriers undergoing risk-reducing mastectomy.\n   2. Ductal carcinoma in situ (DCIS) requiring mastectomy.\n   3. Early invasive breast cancer requiring mastectomy.\n   4. The tumour must not have skin involvement and no evidence of invasive disease within 1cm of skin, nipple or pectoralis major muscle (as proven on MRI).\n3. Candidates for breast reconstruction with DIEP.\n4. Fluent in English\n5. Fit for general anaesthetic Signed informed consent form\n\nExclusion Criteria:\n\n1. Advanced breast cancer with skin involvement.\n2. Undergoing bilateral DIEP reconstruction or other forms of breast reconstruction (e.g., TRAM, implant-based, LD flap).\n3. Pregnancy\n4. Lactation Patients with insufficient English to sign an informed consent (i.e. interpreter required).",{"count":576,"type":21},78,[24],"All patients undergoing mastectomy for breast cancer should be offered the option of reconstructive surgery. The Deep Inferior Epigastric Perforator Flap or DIEP reconstruction as it is commonly referred to, is becoming the favoured reconstruction by both patients and surgeons as it gives a great cosmetic outcome as well as being a good option for patients who may have to undergo radiotherapy treatment after their surgery.\n\nExercise has been demonstrated in previous research to improve tolerance of treatment (particularly chemotherapy), post operative fatigue and the overall quality of life in patients undergoing cancer treatment. Furthermore, it has shown to improve survival in patients who are being treated for breast cancer. The investigators are undertaking this study to investigate whether a structured exercise programme will improve patients fitness after surgery and ultimately improve their recovery after their reconstructive surgery. To do this, half of the people taking part will be undertaking a structured exercise programme and the other half will not and will be assessing which group recover better after their surgery. Currently, no breast reconstruction patients in Ireland are receiving a formal \"exercise prescription\" after their surgery so will be looking to see if this helps people recover better before it is made standard care for every breast patient in Ireland.",[580,27],"Breast Cancer",[582,583,27],"Breast cancer","DIEP Reconstruction","2026-06-23",{"date":541,"type":35},{"date":587,"type":35},"2024-08-01",{"date":589,"type":21},"2028-12-30",{"name":591,"class":42},"Royal College of Surgeons, Ireland",{"id":593,"slug":594,"hasResults":12,"nctId":595,"briefTitle":596,"officialTitle":597,"acronym":4,"eligibilityCriteria":598,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":392,"enrollmentInfo":599,"targetDuration":4,"studyType":22,"phases":601,"briefSummary":602,"conditions":603,"keywords":606,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":612,"lastUpdatePostDateStruct":613,"startDateStruct":615,"completionDateStruct":617,"leadSponsor":619,"locationsCount":43},"100643364","evaluation-of-the-effectiveness-of-capacitive-and-resistive-energy-transfer-therapy-for-lateral-epicondylitis-100643364","NCT07634224","Evaluation of the Effectiveness of Capacitive and Resistive Energy Transfer Therapy for Lateral Epicondylitis","Effectiveness of Capacitive and Resistive Energy Transfer Therapy in Patients With Lateral Epicondylitis: A Sham-Controlled, Double-Blind Randomized Clinical Trial","Inclusion Criteria:\n\n* Patients with lateral epicondylitis who have experienced elbow pain for at least 6 weeks and have at least two positive provocative tests (Cozen's, Mill's, or Maudsley's test).\n* Age between 18 and 65 years.\n* Unilateral pain and tenderness over the lateral epicondyle lasting longer than 6 weeks.\n* Clinically diagnosed lateral epicondylitis.\n* No cognitive impairment.\n* Willingness to participate and provide informed consent.\n\nExclusion Criteria:\n\n* History of interventional injection to the affected elbow within the previous 3 months.\n* Receipt of physical therapy for the affected elbow within the previous 3 months.\n* Regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) within the previous 2 weeks.\n* History of fracture or surgery involving the affected elbow.\n* Presence of a chronic inflammatory disease.\n* History of malignancy.\n* Active infection.\n* Pregnancy.\n* Presence of a cardiac pacemaker or other electronic implant.\n* Coagulation disorders.\n* Cervical radiculopathy, entrapment neuropathy, or peripheral nerve injury.\n* Body mass index (BMI) ≥ 35 kg\u002Fm².",{"count":600,"type":21},62,[24],"This prospective, randomized, double-blind, sham-controlled clinical trial aims to evaluate the efficacy of Capacitive and Resistive Energy Transfer (TECAR) therapy in patients with lateral epicondylitis. Participants will be randomly assigned to either a TECAR plus exercise group or a sham TECAR plus exercise group.\n\nBoth groups will receive a standardized home exercise program including elbow and wrist range-of-motion, stretching, eccentric strengthening, and handgrip strengthening exercises. The TECAR group will additionally receive active TECAR therapy, while the control group will receive sham TECAR treatment using the same device and treatment protocol without therapeutic energy delivery.\n\nOutcome assessments will be performed by a blinded evaluator at baseline, immediately after treatment, and at 1- and 2-month follow-up visits. The study aims to determine whether TECAR therapy provides additional benefits in pain relief, functional improvement, and clinical outcomes when combined with exercise therapy in patients with lateral epicondylitis.",[604,605,27],"Lateral Epicondylitis","Capacitive and Resistive Electric Transfer Therapy",[607,608,609,610,611],"Lateral epicondylitis","Capacitive and resistive energy transfer therapy (TECAR)","Exercise therapy","Rehabilitation","Randomized controlled trial","2026-06-09",{"date":614,"type":35},"2026-06-11",{"date":616,"type":35},"2026-05-11",{"date":618,"type":21},"2027-05-11",{"name":620,"class":42},"Gaziantep City Hospital",{"id":622,"slug":623,"hasResults":12,"nctId":624,"briefTitle":625,"officialTitle":626,"acronym":4,"eligibilityCriteria":627,"healthyVolunteers":12,"sex":17,"minAge":628,"maxAge":629,"enrollmentInfo":630,"targetDuration":4,"studyType":22,"phases":631,"briefSummary":632,"conditions":633,"keywords":636,"overallStatus":120,"whyStopped":4,"lastUpdateSubmitDate":612,"lastUpdatePostDateStruct":639,"startDateStruct":640,"completionDateStruct":642,"leadSponsor":644,"locationsCount":43},"100642620","active-airways-for-children-and-young-people-with-asthma-100642620","NCT07643753","Active Airways for Children and Young People With Asthma","The Feasibility of an Exercise and Asthma Educational Programme 'Active Airways' on Health Outcomes in Children and Young People With Asthma With All Severities","Inclusion Criteria:\n\nWilling and able to consent to participate in the trial\n\nAble to understand written and spoken English\n\nA diagnosis of Mild to Moderate Asthma or Severe Asthma based on the European Respiratory Society (ERS)\u002F American Thoracic Society (ATS) consensus statement on Severe Asthma\n\nAble to participate in a formal exercise programme\n\nAged 10-17 years\n\nAble to engage in focus groups\n\nApproximately 130cm tall (to be able to complete cardiopulmonary exercise testing (CPET))\n\nExclusion Criteria:\n\nSelf-reported uncontrolled severe exercise-induced breathlessness\n\nRequired a course of antibiotics or oral corticosteroids within the 4 weeks prior to the study commencing\n\nChildren with severe co-morbidities that will not allow them to participate in an exercise programme e.g. Severe neuromuscular disorders, recent fractures or surgeries, cognitive or behavioural conditions.\n\nParticipant is unable or unwilling, in the opinion of the investigator, to give informed consent","10 Years","17 Years",{"count":196,"type":21},[24],"What is this study about? The investigators want to see if exercise and education sessions can help children and young people (aged 10-17) with asthma, manage the participants asthma better.\n\nThe investigators will place participants that are recruited to this study into one of three groups by a computer (randomly):\n\nGroup 1:\n\nUsual Care: Continue with normal asthma treatment.\n\nGroup 2:\n\nEducation: Usual care + a 45-minute online asthma education class once a week.\n\nGroup 3:\n\nExercise \\& Education: Usual care + 3 exercise sessions a week and asthma education classes.",[634,27,635],"Asthma Childhood","Children",[637,638,408,88],"asthma","children",{"date":614,"type":35},{"date":641,"type":21},"2026-07",{"date":643,"type":21},"2030-09",{"name":645,"class":42},"University of Leicester",{"id":647,"slug":648,"hasResults":12,"nctId":649,"briefTitle":650,"officialTitle":651,"acronym":652,"eligibilityCriteria":653,"healthyVolunteers":12,"sex":17,"minAge":654,"maxAge":4,"enrollmentInfo":655,"targetDuration":4,"studyType":22,"phases":657,"briefSummary":658,"conditions":659,"keywords":665,"overallStatus":120,"whyStopped":4,"lastUpdateSubmitDate":669,"lastUpdatePostDateStruct":670,"startDateStruct":671,"completionDateStruct":672,"leadSponsor":674,"locationsCount":43},"100643674","from-exercise-oncology-research-to-clinical-practice-100643674","NCT07635589","From Exercise Oncology Research to Clinical Practice","Bridging the Gap Between Exercise Oncology Research and Its Implementation in Clinical Practice","PAC ICare","Inclusion Criteria:\n\n* Have received a cancer diagnosis (inclusive of primary, recurrent; and\u002For metastatic disease);\n* Over the age of 19 years;\n* Able to participate in mild levels of activity as a minimum;\n* Be pretreatment, or receiving active cancer treatment, or have received cancer treatment within the past six months and are still under active oncology care, or beyond six months if they continue to be under active oncology care;\n* Able to provide informed written consent in English; and\n* Have access to internet service and a device that can support video calling (for online programs).\n\nExclusion Criteria:\n\n* Severe cognitive, physical, psychiatric, or uncontrolled medical condition(s) resulting in an inability to provide consent and\u002For safely participate in the study.","19 Years",{"count":656,"type":21},500,[24],"Building on previous research that shows the benefits of exercise, this study aims to find out how best to implement exercise in real-world settings. The study will assess the feasibility and acceptability of an embedding an automated referral tool and an exercise professional into standard cancer care impacts clinician referral and patient uptake of exercise programming. The study will assess how effective the exercise program is at improving patients' physical health, quality of life, symptom management, and overall wellbeing during different stages of their cancer journey (e.g., before treatment, on treatment, after treatment).",[660,27,661,662,276,663,664],"Cancer","Implementation of Evidence Based Programs","Cost Effectiveness","Prehabilitation","Survivorship",[660,27,666,667,668,662],"Implementation Science","Mixed-Methods","Effectiveness-Implementation","2026-06-03",{"date":612,"type":35},{"date":307,"type":21},{"date":673,"type":21},"2029-12",{"name":675,"class":42},"Melanie Keats"]