[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"exposure-keratopathy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:exposure-keratopathy":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100645432","clinical-predictors-of-visual-outcome-in-patients-affected-with-ocular-surface-diseases-100645432",false,"NCT07694817","Clinical Predictors of Visual Outcome in Patients Affected With Ocular Surface Diseases","Clinical Predictors of Visual Outcome in Patients Affected With Ocular Surface Diseases: Single Center Retrospective-prospective Clinical Study","OSD","Inclusion Criteria:\n\n* The participant is willing and able to provide written informed consent for study participation (prospective cohort).\n* Adult participants aged ≥18 years at the time of inclusion.\n* Clinically confirmed diagnosis of OSD, including but not limited to inflammatory keratopathies, neurotrophic keratopathy, exposure keratopathy, limbal stem cell deficiency, post-surgical or post-traumatic corneal alterations.\n* Measurable BSCVA obtained through standardized manifest refraction and ETDRS chart testing at baseline.\n* Available dataset for the diagnostic tests required by the study (e.g., corneal topography, pachymetry, confocal microscopy, corneal sensitivity testing, slit-lamp imaging, tear cytokine analysis, impression cytology).\n* Willingness and ability to attend follow-up visits and complete all study-related procedures according to the study schedule.\n\nExclusion Criteria:\n\n* Change of retinal, optic nerve, or macular pathology that may affect best spectacle-corrected visual acuity independently of the cornea or ocular surface (e.g., age-related macular degeneration, diabetic macular edema, optic neuropathy) in the period of study\n* History of intraocular or corneal surgery within 3 months prior to baseline evaluation.\n* Active intraocular inflammation, glaucoma with uncontrolled intraocular pressure, or corneal conditions not compatible with accurate imaging or measurement (e.g., severe scarring, leukoma).\n* Uncontrolled systemic diseases that may impair vision or corneal health (e.g., advanced diabetes, autoimmune disease in active phase).\n* Inability or unwillingness to attend follow-up visits or complete study assessments.\n* Pregnant or breastfeeding women will not be enrolled, as hormonal fluctuations can alter tear film and ocular surface physiology","ALL",{"count":19,"type":20},1000,"ESTIMATED","OBSERVATIONAL","This retrospective-prospective study aims to identify the diagnostic parameters most predictive of BSCVA in patients with OSD. Clinical, structural, and biochemical data will be collected from standard-of-care examinations and patient-reported outcome questionnaires. The goal is to determine the most informative biomarkers for visual prognosis, streamline diagnostic workflows, and support individualized management of OSD.",[24,25,26,27,28,29],"Neurotrophic Keratopathy","Exposure Keratopathy","Limbal Stem Cell Deficiency (LSCD)","Cornea Abnormality","Cornea Disease","Cornea Inflamed","NOT_YET_RECRUITING","2026-07-10",{"date":33,"type":34},"2026-07-14","ACTUAL",{"date":36,"type":20},"2026-07",{"date":38,"type":20},"2029-12",{"name":40,"class":41},"IRCCS San Raffaele","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":50,"sex":17,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":62,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":42},"100636200","eyelid-taping-alone-versus-taping-with-lubricant-eye-drops-for-perioperative-corneal-protection-100636200","NCT07562594","Eyelid Taping Alone Versus Taping With Lubricant Eye Drops for Perioperative Corneal Protection","Eyelid Taping Alone Versus Taping With Lubricant Eye Drops for Perioperative Corneal Protection During General Anesthesia: A Randomized Assessor-Blinded Trial With Cost-Effectiveness Analysis","Inclusion Criteria:\n\n* Age 18 to 75 years\n* ASA physical status I or II\n* Scheduled for elective non-ocular surgery under general anesthesia\n* Expected anesthesia duration between 30 and 180 minutes\n* Supine surgical position\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Preoperative corneal epithelial defect, keratitis, conjunctivitis, conjunctival hyperemia, or chemosis\n* Known ocular surface disease (dry eye syndrome, Sjögren syndrome, rheumatoid arthritis, systemic lupus erythematosus, or other systemic conditions associated with ocular surface involvement)\n* Use of topical or systemic medications known to affect tear production within the past 30 days\n* History of ocular surgery or ocular trauma\n* Contact lens use\n* Planned head and neck surgery\n* Prone or lateral decubitus surgical position\n* Patients requiring rapid sequence induction\n* Inability or refusal to provide written informed consent",true,"18 Years","75 Years",{"count":54,"type":20},200,"INTERVENTIONAL",[57],"NA","During general anesthesia, the eye's natural protective reflexes are suppressed, which can lead to corneal drying and injury. To prevent this, anesthesiologists routinely tape the eyelids closed. In many centers, lubricant eye drops are also applied in addition to taping, but whether this adds meaningful protection is unclear.This study will compare two approaches to eye protection during general anesthesia lasting 30 minutes to 3 hours: eyelid taping alone versus eyelid taping combined with lubricant eye drops. Two hundred adult patients undergoing elective, non-eye surgery in the supine position will be randomly assigned to one of the two groups.The main outcome is corneal surface damage measured by a standardized fluorescein staining score (NEI scale, 0-15) assessed by a blinded evaluator one hour after surgery. Secondary outcomes include tear film stability (TBUT), tear production (Schirmer test), patient-reported eye symptoms at 2 and 24 hours after surgery, and a cost-effectiveness analysis comparing the two approaches.If taping alone proves equally effective, routine use of lubricant eye drops may be unnecessary, reducing costs without compromising patient safety.",[60,25,61],"Corneal Injury","Perioperative Complications",[63,64,65,66,67,68,69,70,71,72,73],"Corneal protection","General anesthesia","Eyelid taping","Lubricant eye drops","Corneal fluorescein staining","NEI corneal staining scale","Perioperative eye care","Schirmer test","Tear break-up time","Cost-effectiveness","Randomized controlled trial","2026-05-04",{"date":76,"type":34},"2026-05-07",{"date":78,"type":20},"2026-06-01",{"date":80,"type":20},"2026-12-02",{"name":82,"class":41},"Fatih Sultan Mehmet Training and Research Hospital"]