[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"extrapulmonary-tuberculosis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:extrapulmonary-tuberculosis":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100652870","mbla-to-differentiate-iris-from-treatment-failure-in-extrapulmonary-tuberculosis-100652870",false,"NCT07778082","MBLA to Differentiate IRIS From Treatment Failure in Extrapulmonary Tuberculosis","The Molecular Bacterial Load Assay (MBLA) to Differentiate Immune Reconstitution Inflammatory Syndrome (IRIS) From Treatment Failure in Extrapulmonary Tuberculosis With Paradoxical Lymph Node Swelling.","MBLA_IRIS","Inclusion Criteria:\n\n* Patient with extrapulmonary tuberculosis\n* Progressive or persistant lymphadenopathy\n* Treatment for tuberculosis for at least 3 months\n* Age ≥ 18 years\n* Capacity to provide informed consent\n* Written informed consent to participate in the study\n\nExclusion Criteria:\n\n* Lack of capacity to provide informed consent\n* Age \\\u003C 18 years","ALL","18 Years",{"count":20,"type":21},100,"ESTIMATED","OBSERVATIONAL","This prospective, multi-center study aims to evaluate the Molecular Bacterial Load Assay (MBLA) on lymph node aspirates as a tool to distinguish between late immune reconstitution inflammatory syndrome (IRIS) and treatment failure in patients with extrapulmonary tuberculosis (TB) presenting with paradoxical lymph node swelling. The study will compare MBLA results with Xpert MTB\u002FRIF and culture findings and assess their correlation with patient outcomes. By quantifying viable M. tuberculosis via 16S rRNA detection, MBLA may offer a rapid, culture-independent method to inform clinical decisions and reduce overtreatment.",[25],"Extrapulmonary Tuberculosis",[27,28,29],"MBLA","IRIS","Lymph node swelling","NOT_YET_RECRUITING","2026-08-17",{"date":33,"type":34},"2026-08-21","ACTUAL",{"date":36,"type":21},"2026-09",{"date":38,"type":21},"2030-09",{"name":40,"class":41},"Research Center Borstel","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":52,"conditions":53,"keywords":54,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":68},"100583362","a-multicentric-cohort-and-biomarker-study-for-improved-care-of-patients-with-extrapulmonary-tuberculosis-100583362","NCT06875336","A Multicentric Cohort and Biomarker Study for Improved Care of Patients with Extrapulmonary Tuberculosis","mEX-TB","Inclusion Criteria:\n\n1. Age ≥ 18 years\n2. Isolation of Mycobacterium tuberculosis complex from a bodily secretion or tissue by\n\n   1. PCR\n   2. culture or a presumptive clinical diagnosis based on epidemiologic exposure in combination with physical findings, radiographic findings and\u002For histopathology\n3. Patients with extrapulmonary TB\n\n   * pleura\n   * lymph nodes\n   * bones and joints\n   * larynx\n   * pericardial\n   * parotid gland\n   * abdominal sites\n   * kidneys\n   * genitourinary tract\n   * disseminated (miliary) TB\n   * other than pulmonary TB\n4. In the case of pulmonary and extrapulmonary involvement, the leading manifestation, clinically and radiographically, must be extrapulmonary.\n5. Written informed consent provided prior to inclusion\n\nExclusion Criteria:\n\n* 1\\. Age \\\u003C18 years 2. Patient with any social or logistical condition which, as anticipated by the investigator, may interfere with the conduct of the study, such as incapacity to well understand the study content and procedure (in case of any language barriers, a translator may be involved), not willing to collaborate, or anticipated inability to finish study due to physical weakness 3. Dependencies towards the study team (e.g. family members, employees of the same department) 4. Pregnant women 5. Patient in custodianship or guardianship 6. Leading pulmonary manifestation 7. Solitary CNS tuberculosis Patients may take part in other clinical studies and trials, as long as there is no conflict with the inclusion or exclusion criteria of the mEX-TB study and the protocol of the other study or trial does not conflict with the means of data and sample collection and publication of this protocol.",{"count":51,"type":21},150,"This is a prospective, multicenter, observational study (mEX-TB study) of patients with extrapulmonary tuberculosis (EPTB). Adult patients newly diagnosed with EPTB will prospectively be enrolled into the study. Clinical data will be collected using standardized questionnaires over the whole treatment period for each individual. Additionally, body fluids (blood, urine) will be collected and stored in a central biobank. Biomarkers in EPTB patients will be analyzed during the course of therapy and correlated with clinical data. In addition, a healthy control group will be added, to be used primarily as technical controls for complex laboratory procedures such as RNA-seq and T-cell based assays.",[25],[55,56,57],"extrapulmonary tuberculosis","biomarker","cohort study","RECRUITING","2025-03-07",{"date":61,"type":34},"2025-03-13",{"date":63,"type":34},"2023-03-06",{"date":65,"type":21},"2025-12-31",{"name":67,"class":41},"University of Cologne",6]