[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"extubation-failure-in-neonates\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:extubation-failure-in-neonates":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":5},"100657304","noninvasive-high-frequency-oscillatory-ventilation-versus-nasal-intermittent-mandatory-ventilation-after-extubation-in-neonates-100657304",false,"NCT07836166","Noninvasive High Frequency Oscillatory Ventilation Versus Nasal Intermittent Mandatory Ventilation After Extubation in Neonates","Effectiveness of Noninvasive High Frequency Oscillatory Ventilation Versus Nasal Intermittent Mandatory Ventilation as Post Extubation Respiratory Support in Neonates Born At ≥ 26 Weeks' Gestation: A Randomized Clinical Trial","NOV-A","Inclusion Criteria:\n\n* Gestational age at birth ≥26 weeks (inborn or outborn)\n* Postmenstrual age \\\u003C44 weeks at enrollment according to NICU AKUH admission criteria\n* Intubation for respiratory distress or respiratory failure\n* Intubated for ≥24 hours\n* Undergoing first planned extubation\n* Meets prespecified extubation readiness criteria\n* Written informed consent from a parent or legal guardian\n\nExclusion Criteria\n\n* Birth weight \\\u003C500 g\n* Major congenital anomaly affecting cardiac or respiratory function\n* Upper airway anomaly\n* Neuromuscular disorder affecting respiration\n* Requirement for surgical intervention during the study period\n* Grade IV intraventricular hemorrhage diagnosed before randomization\n* Intubation solely for an elective procedure in an otherwise healthy neonate previously breathing room air","ALL","1 Day","18 Weeks",{"count":21,"type":22},172,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to learn which breathing support works better after removing a newborn's breathing tube. Researchers will study newborns born at 26 weeks of gestation or later. Each newborn will have received breathing support through a tube for at least 24 hours.\n\nThe main questions it aims to answer are:\n\nDoes noninvasive high-frequency oscillatory ventilation (nHFOV) lower the need to replace the breathing tube within 72 hours? What breathing, feeding, or other medical problems occur with each type of support?\n\nResearchers will compare nHFOV with nasal intermittent mandatory ventilation (NIMV). nHFOV provides very rapid pressure waves through the nose. NIMV provides regular, timed breaths through the nose. The researchers will compare these methods to see which works better after breathing tube removal.\n\nParticipants will:\n\nBe assigned by chance to receive either nHFOV or NIMV Receive the assigned breathing support immediately after tube removal Have their breathing, oxygen level, and general condition closely monitored Have blood tests at 1, 12, and 24 hours post extubation to assess their breathing Be monitored for breathing pauses, feeding problems, and other medical problems during hospitalization",[28],"Extubation Failure in Neonates","NOT_YET_RECRUITING","2026-09-19",{"date":32,"type":33},"2026-09-23","ACTUAL",{"date":35,"type":22},"2026-10-01",{"date":37,"type":22},"2029-03-21",{"name":39,"class":40},"Aga Khan University","OTHER"]