[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"extubation-time\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:extubation-time":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":5},"100657765","measurement-of-efferent-neural-drive-from-respiratory-centers-to-upper-airways-using-electromyography-emg-of-genioglossus-gg-in-patients-dependent-on-invasive-mechanical-ventilation-100657765",false,"NCT07842484","Measurement of Efferent Neural Drive From Respiratory Centers to Upper Airways Using Electromyography (EMG) of Genioglossus (GG) in Patients Dependent on Invasive Mechanical Ventilation","Inclusion Criteria:\n\n* Age 18 years or older.\n* Dependent on invasive mechanical ventilation in ICU\n* Awakening patient: improving neurological status (+2 points on the GCS compared to admission)\n* Patient weaning from mechanical ventilation: presence of ventilator-recorded weaning trigger.\n\nExclusion Criteria:\n\n* Known pregnancy\n* Unstable intracranial pressure\n* Pacemaker, internal defibrillator or pacing device wearers.\n* Aneurysms at risk of rupture\n* Severely impaired gas exchange despite optimal therapy\n* GCS \\\u003C 5 or clinical signs of poor prognosis","ALL","18 Years",{"count":18,"type":19},10,"ESTIMATED","INTERVENTIONAL",[22],"NA","Muscle activity in the upper airway is influenced by specific states such as anesthesia, sleep, wakefulness, and the phases of respiration. The hypoglossal nerve, which innervates the genioglossus muscle, receives input from the brain's sleep-wake center, respiratory pattern-generating neurons, chemoreceptors, and airway negative pressure receptors. Preliminary activation of the genioglossus muscle and other upper airway dilators by the hypoglossal nerve occurs approximately 50-200 ms before innervation of the phrenic motor neurons and the subsequent action of the diaphragm. The forward movement of the genioglossus increases the stiffness and diameter of the upper airway, effectively counteracting collapse forces during inspiration. Assessing genioglossus function could prove critical in determining the optimal timing for extubation. This requires a methodology to evaluate the upper airway by measuring genioglossus activity in intubated patients. In the future, this could provide an objective measure for assessing suitability for extubation. This study explores a method for measuring the electrical activity of the upper airway muscles and the diaphragm in ventilated patients and correlates the results in a systematic view.",[25,26],"Invasive Mechanical Ventilation","Extubation Time",[28,29],"genioglossus (GG) muscle activity","non-invasive EMG","NOT_YET_RECRUITING","2026-09-21",{"date":33,"type":34},"2026-09-25","ACTUAL",{"date":36,"type":19},"2026-09",{"date":38,"type":19},"2027-03",{"name":40,"class":41},"Fondazione IRCCS Policlinico San Matteo di Pavia","OTHER"]